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Article ; Online: Respiratory questionnaire-based analysis of awareness of COPD in a large multicenter rural population-based study in India.

Patil, Shital / Patil, Rajesh / Bhise, Mukund / Jadhav, Anil

Chronic diseases and translational medicine

2022 Volume 8, Issue 4, Page(s) 322–330

Abstract: Background: Chronic obstructive pulmonary disease (COPD) is a more prevalent chronic lung disease with a significant health burden, and the majority of these cases receive inadequate treatment.: Methods: Prospective, observational, interview ( ... ...

Abstract	Background: Chronic obstructive pulmonary disease (COPD) is a more prevalent chronic lung disease with a significant health burden, and the majority of these cases receive inadequate treatment. Methods: Prospective, observational, interview (questionnaire) based complete workup COPD study, screened 12,000 cases with chronic respiratory symptoms with cough, sputum production, and shortness of breath. A total of 6000 COPD cases were enrolled after the spirometry test. COPD cases were assessed as disease knowledge and methods of treatment offered by applying questionnaires to patients and treating physicians. Results: In the present study, 3% of study cases were aware of their COPD illness, 54% were not having knowledge about the disease, and 43% cases were not accepting the COPD diagnosis ( Conclusion: "Doctor-patient-drug trio" discordance clubbed as "difficult doctor, difficult patient, and difficult treatment" is a very crucial issue observed during diagnosis and management of COPD in peripheral settings in India.
Language	English
Publishing date	2022-09-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2831148-6
ISSN	2589-0514 ; 2589-0514
ISSN (online)	2589-0514
ISSN	2589-0514
DOI	10.1002/cdt3.47
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Synergistic Inhibitory Effect of Quercetin and Cyanidin-3O-Sophoroside on ABCB1.

Singh, Kuljeet / Patil, Rajesh B / Patel, Vikas / Remenyik, Judit / Hegedűs, Tamás / Goda, Katalin

International journal of molecular sciences

2023 Volume 24, Issue 14

Abstract: The human ABCB1 (P-glycoprotein, Pgp) protein is an active exporter expressed in the plasma membrane of cells forming biological barriers. In accordance with its broad substrate spectrum and tissue expression pattern, it affects the pharmacokinetics of ... ...

Abstract	The human ABCB1 (P-glycoprotein, Pgp) protein is an active exporter expressed in the plasma membrane of cells forming biological barriers. In accordance with its broad substrate spectrum and tissue expression pattern, it affects the pharmacokinetics of numerous chemotherapeutic drugs and it is involved in unwanted drug-drug interactions leading to side effects or toxicities. When expressed in tumor tissues, it contributes to the development of chemotherapy resistance in malignancies. Therefore, the understanding of the molecular details of the ligand-ABCB1 interactions is of crucial importance. In a previous study, we found that quercetin (QUR) hampers both the transport and ATPase activity of ABCB1, while cyandin-3O-sophroside (C3S) stimulates the ATPase activity and causes only a weak inhibition of substrate transport. In the current study, when QUR and C3S were applied together, both a stronger ATPase inhibition and a robust decrease in substrate transport were observed, supporting their synergistic ABCB1 inhibitory effect. Similar to cyclosporine A, a potent ABCB1 inhibitor, co-treatment with QUR and C3S shifted the conformational equilibrium to the "inward-facing" conformer of ABCB1, as it was detected by the conformation-selective UIC2 mAb. To gain deeper insight into the molecular details of ligand-ABCB1 interactions, molecular docking experiments and MD simulations were also carried out. Our in silico studies support that QUR and C3S can bind simultaneously to ABCB1. The most favourable ligand-ABCB1 interaction is obtained when C3S binds to the central substrate binding site and QUR occupies the "access tunnel". Our results also highlight that the strong ABCB1 inhibitory effect of the combined treatment with QUR and C3S may be exploited in chemotherapy protocols for the treatment of multidrug-resistant tumors or for improving drug delivery through pharmacological barriers.
MeSH term(s)	Humans ; Adenosine Triphosphatases/metabolism ; Antineoplastic Agents/pharmacology ; ATP Binding Cassette Transporter, Subfamily B/antagonists & inhibitors ; Cell Line, Tumor ; Drug Resistance, Neoplasm ; Ligands ; Molecular Docking Simulation ; Quercetin/pharmacology
Chemical Substances	ABCB1 protein, human ; Adenosine Triphosphatases (EC 3.6.1.-) ; Antineoplastic Agents ; ATP Binding Cassette Transporter, Subfamily B ; cyanidin (7732ZHU564) ; Ligands ; Quercetin (9IKM0I5T1E)
Language	English
Publishing date	2023-07-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241411341
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Article ; Online: Decoding the therapeutic landscape of alpha-linolenic acid: a network pharmacology and bioinformatics investigation against cancer-related epigenetic modifiers.

Ulhe, Amrita / Sharma, Nidhi / Mahajan, Akanksha / Patil, Rajesh / Hegde, Mahabaleshwar / Bhalerao, Supriya / Mali, Aniket

Journal of biomolecular structure & dynamics

2023 , Page(s) 1–26

Abstract: Omega-3 ( ...

Abstract	Omega-3 (
Language	English
Publishing date	2023-12-13
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2023.2293267
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Article ; Online: "Fleeting pulmonary infiltrates in allergic bronchopulmonary aspergillosis" Misdiagnosed as tuberculosis.

Patil, Shital / Patil, Rajesh

International journal of mycobacteriology

2018 Volume 7, Issue 2, Page(s) 186–190

Abstract: Allergic bronchopulmonary aspergillosis (ABPA) is underdiagnosed and underevaluated routinely because of clinical and radiological overlap with tuberculosis (TB), especially in tropical setting with high TB burden countries like India. ABPA is the best- ... ...

Abstract	Allergic bronchopulmonary aspergillosis (ABPA) is underdiagnosed and underevaluated routinely because of clinical and radiological overlap with tuberculosis (TB), especially in tropical setting with high TB burden countries like India. ABPA is the best-recognized manifestation of Aspergillus-associated hypersensitivity to Aspergillus antigens in patients with long-standing atopic asthma. ABPA with varied clinical presentation has been reported to occur in 20% of asthmatic patients admitted to hospitals and in 5% of all rhinitis cases. In this case report, we documented middle age male with known asthma case for many years with constitutional symptoms such as cough, fever, and shortness of breath diagnosed as TB and received anti-TB treatment for 4 weeks. Finally, we confirmed as a case of ABPA and documented complete clinical and radiological response to medical treatment with antifungals and systemic corticosteroids.
MeSH term(s)	Antifungal Agents/administration & dosage ; Aspergillosis, Allergic Bronchopulmonary/diagnosis ; Aspergillosis, Allergic Bronchopulmonary/diagnostic imaging ; Aspergillosis, Allergic Bronchopulmonary/drug therapy ; Aspergillosis, Allergic Bronchopulmonary/microbiology ; Aspergillus/physiology ; Diagnostic Errors ; Humans ; Male ; Middle Aged ; Tuberculosis/diagnosis ; Tuberculosis/diagnostic imaging
Chemical Substances	Antifungal Agents
Language	English
Publishing date	2018-06-12
Publishing country	Netherlands
Document type	Case Reports
ISSN	2212-554X
ISSN (online)	2212-554X
DOI	10.4103/ijmy.ijmy_57_18
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Article ; Online: Development and evaluation of India’s first intraspecific Gossypium barbadense cotton recombinant inbred mapping population for extra-long staple fibre traits

GOWDA, S. ANJAN / KATAGERI, ISHWARAPPA S. / KUMAR, N. V. MOHAN / PATIL, RAJESH S.

J Genet. 2022 June, v. 101, no. 1 p.4-4

2022

Abstract: Fibre quality improvement in Gossypium hirsutum is one of the long thought objectives for sustainability of cotton improvement. The efforts to transfer G. barbadense alleles in to G. hirsutum for enhanced fibre quality is still under process across the ... ...

Abstract	Fibre quality improvement in Gossypium hirsutum is one of the long thought objectives for sustainability of cotton improvement. The efforts to transfer G. barbadense alleles in to G. hirsutum for enhanced fibre quality is still under process across the world. To meet the future fibre quality demand in India, here we report development of G. barbadense × G. barbadense recombinant inbred mapping population that has huge potential for precise mapping of extra-long staple traits. The two-location evaluation and variability analysis for extra-long staple traits such as fibre length (24.91 to 34.06 mm), fibre strength (25.02 to 35.86 g/tex), micronaire (2.89–4.57), uniformity index (64.08–98.83), fibre elongation (5.37–6.60) and maturity ratio (0.48–0.76) were highly satisfactory. The principal component analysis indicates that the principal component-1 explaining 23.12% variance had maximum values of Eigen vectors explained by fibre strength (–0.464), length (–0.469), elongation (–0.448), maturity ratio (0.312) and micronaire value (0.306) indicating the worth of the population for which it was developed. The correlation analysis indicated that the fibre length and strength could be simultaneously improved without any impact on seed cotton yield since both traits were positively associated with each other and also showed nonsignificant association with seed cotton yield. A total of 255 recombinant inbred lines (RILs) showed normal distribution from both Z-score of skewness/kurtosis analysis and quartile-quartile plots indicating that they can be readily utilized for genotyping with latest available technologies such as genotype-by-sequencing for effective mapping of extra-long staple traits in cotton.
Keywords	Gossypium barbadense ; Gossypium hirsutum ; genotyping ; micronaire ; normal distribution ; principal component analysis ; seed cotton ; variance ; India
Language	English
Dates of publication	2022-06
Size	p. 4.
Publishing place	Springer India
Document type	Article ; Online
ZDB-ID	3039-9
ISSN	0973-7731 ; 0958-8361 ; 0022-1333
ISSN (online)	0973-7731
ISSN	0958-8361 ; 0022-1333
DOI	10.1007/s12041-021-01338-7
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Article: A study to assess the clinico-radiological presentation and outcome predictors in cases of tubercular meningitis.

Jadaun, Priya / Patil, Rajesh / Ramteke, Sharmila / Goel, Manjusha

The Indian journal of tuberculosis

2020 Volume 68, Issue 3, Page(s) 384–388

Abstract: Introduction: Tubercular bacterial meningitis continues to be an important cause of morbidity (especially neurologic handicap) in children from resource-poor countries. The present study was planned to assess the clinical and radiological presentation ... ...

Abstract	Introduction: Tubercular bacterial meningitis continues to be an important cause of morbidity (especially neurologic handicap) in children from resource-poor countries. The present study was planned to assess the clinical and radiological presentation in cases of tubercular meningitis as well as to study the factors associated with mortality. Methodology: This study was done over a period of 12 months on children between 5 years and 13 years with suspected TBM. Staging of tubercular meningitis was done according to RNTCP Pediatric TB guideline 2019. Result: The study was conducted on a total of 47 pediatric patients with TBM. Mean age of children in present study was 8.77 ± 2.5 years. Our study documented male preponderance for TBM. Severe thinness was observed in 38.3% patients with TBM. Only 59.6% patients were immunized against tuberculosis and history of contact was documented in 40.5% patients. Maximum children belonged to stage I of TBM (59.6%) followed by stage III and stage II in 34% and 6.4% patients respectively. Montoux test positivity was observed in 14.9% patients only. CSF CBNAAT was positive in 6.4% patients. The most common finding was meningeal enhancement seen in 27.7% of patients followed by tuberculomas in 10.6%.Chest X ray was abnormal in 44.7% patients. In present study mortality was observed in 11 (23.4%) cases. Out of various risk factors, mortality was significantly associated with nutritional status and stage of TBM (p < 0.01). Conclusion: TBM is associated with high morbidity and mortality in children especially in India where Burden of TB is high. Our study emphasized on the risk factors associated with mortality in children with TBM and need for early diagnosis and appropriate treatment.
MeSH term(s)	Child ; Early Medical Intervention/standards ; Female ; Health Services Needs and Demand ; Humans ; India/epidemiology ; Male ; Mycobacterium tuberculosis/isolation & purification ; Nervous System Diseases/diagnosis ; Nervous System Diseases/etiology ; Nutritional Status ; Patient Acuity ; Prognosis ; Radiography, Thoracic/methods ; Risk Assessment/methods ; Risk Assessment/statistics & numerical data ; Tuberculosis, Meningeal/complications ; Tuberculosis, Meningeal/diagnostic imaging ; Tuberculosis, Meningeal/mortality ; Tuberculosis, Meningeal/physiopathology
Language	English
Publishing date	2020-12-31
Publishing country	India
Document type	Journal Article
ZDB-ID	603129-8
ISSN	0019-5707 ; 0019-5705
ISSN	0019-5707 ; 0019-5705
DOI	10.1016/j.ijtb.2020.12.010
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Article ; Online: Novel α-amylase and α-glucosidase inhibitors from selected Nigerian antidiabetic plants: an

Ogboye, Ruth M / Patil, Rajesh B / Famuyiwa, Samson O / Faloye, Kolade O

Journal of biomolecular structure & dynamics

2021 Volume 40, Issue 14, Page(s) 6340–6349

Abstract: This study aimed to identify novel α-amylase and α-glucosidase inhibitors from Nigerian antidiabetic plants ... ...

Abstract	This study aimed to identify novel α-amylase and α-glucosidase inhibitors from Nigerian antidiabetic plants through
MeSH term(s)	Glycoside Hydrolase Inhibitors/chemistry ; Glycoside Hydrolase Inhibitors/pharmacology ; Hypoglycemic Agents/chemistry ; Hypoglycemic Agents/pharmacology ; Molecular Docking Simulation ; Nigeria ; Plants ; alpha-Amylases/chemistry
Chemical Substances	Glycoside Hydrolase Inhibitors ; Hypoglycemic Agents ; alpha-Amylases (EC 3.2.1.1)
Language	English
Publishing date	2021-02-13
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2021.1883480
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Article ; Online: Development and evaluation of India's first intraspecific

Gowda, S Anjan / Katageri, Ishwarappa S / Kumar, N V Mohan / Patil, Rajesh S

Journal of genetics

2022 Volume 101

Abstract: Fibre quality improvement ... ...

Abstract	Fibre quality improvement in
MeSH term(s)	Cotton Fiber ; Genotype ; Gossypium/genetics ; Phenotype ; Quantitative Trait Loci
Language	English
Publishing date	2022-02-09
Publishing country	India
Document type	Journal Article
ZDB-ID	3039-9
ISSN	0973-7731 ; 0958-8361 ; 0022-1333
ISSN (online)	0973-7731
ISSN	0958-8361 ; 0022-1333
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Article ; Online: Structural Characteristics of PON1 with Leu55Met and Gln192Arg Variants Influencing Oxidative-Stress-Related Diseases: An Integrated Molecular Modeling and Dynamics Study.

M, Sudhan / V, Janakiraman / Ahmad, Sheikh F / Attia, Sabry M / Emran, Talha Bin / Patil, Rajesh B / Ahmed, Shiek S S J

Medicina (Kaunas, Lithuania)

2023 Volume 59, Issue 12

Abstract: Background and ... ...

Abstract	Background and Objectives
MeSH term(s)	Humans ; Antioxidants/metabolism ; Aryldialkylphosphatase/genetics ; Aryldialkylphosphatase/chemistry ; Aryldialkylphosphatase/metabolism ; Molecular Docking Simulation ; Oxidative Stress/genetics
Chemical Substances	Antioxidants ; Aryldialkylphosphatase (EC 3.1.8.1) ; PON1 protein, human (EC 3.1.8.1)
Language	English
Publishing date	2023-11-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina59122060
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Article ; Online: Sappanin-type homoisoflavonoids from

Famuyiwa, Samson O / Patil, Rajesh B / Faloye, Kolade O / Awotuya, Iyanu O / Gadhawe, Sandeep P / Oladiran, Oluyemi J / Bello, Oyenike I

Journal of biomolecular structure & dynamics

2023 Volume 41, Issue 20, Page(s) 10957–10968

Abstract: Alzheimer's disease is among the major health challenges that currently attract the attention of health care givers and drug discovery and development experts worldwide. This study investigated the acetylcholinesterase inhibitory activity of sappanin- ... ...

Abstract	Alzheimer's disease is among the major health challenges that currently attract the attention of health care givers and drug discovery and development experts worldwide. This study investigated the acetylcholinesterase inhibitory activity of sappanin-type homisoflavonoids isolated from the inter-bulb surface of
MeSH term(s)	Humans ; Acetylcholinesterase/chemistry ; Molecular Docking Simulation ; Scilla/metabolism ; Cholinesterase Inhibitors/pharmacology ; Cholinesterase Inhibitors/chemistry ; Molecular Dynamics Simulation
Chemical Substances	Acetylcholinesterase (EC 3.1.1.7) ; Cholinesterase Inhibitors
Language	English
Publishing date	2023-03-20
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2023.2190825
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