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  1. Article: Assessment of risk of bias in randomized controlled trials published in Indian journals pertaining to pharmacology.

    Patil, Saurabh R / Bhide, Shruti Shripad

    Perspectives in clinical research

    2021  Volume 14, Issue 1, Page(s) 16–19

    Abstract: Context: Number of trials in India shows an increasing trend. As these trials will shape clinical practice, their quality is of utmost importance. Among many tools to assess the quality of randomized control trials (RCTs), risk of bias (RoB) is most ... ...

    Abstract Context: Number of trials in India shows an increasing trend. As these trials will shape clinical practice, their quality is of utmost importance. Among many tools to assess the quality of randomized control trials (RCTs), risk of bias (RoB) is most robust.
    Aims: To understand the quality of trials being carried out in India in terms of RoB.
    Settings and design: We aimed to assess the RoB in a set of RCTs published in Indian pharmacology of randomized trials from journals pertaining to pharmacology.
    Subjects and methods: We used published journal articles as source of information for randomized clinical trials and evaluated them using Cochrane RoB tool 2.0.
    Statistical analysis used: Descriptive statistics were used.
    Results: 158 trials published in seven journals were evaluated in six different domains. Overall evaluation for 97% (153) trials was "high risk," while 3% (5) were in "some concerns" category, with no trials categorized as "low risk. 74% articles showed a high risk of bias in the domain of 'selection of reported results. Nearly half articles scored "low risk" in domains of "missing data" and "deviations in assignment to intervention." The study results showed a slowly increasing trend of average RoB over the last 10 years.
    Conclusions: The study shows concerning rise in RoB in various domains RCTs published in Pharmacology journals in India.
    Language English
    Publishing date 2021-12-01
    Publishing country India
    Document type Journal Article
    ZDB-ID 2593231-7
    ISSN 2229-5488 ; 2229-3485
    ISSN (online) 2229-5488
    ISSN 2229-3485
    DOI 10.4103/picr.PICR_19_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Forecasting COVID-19 New Cases Using Transformer Deep Learning Model

    Patil, Saurabh / Mollaei, Parisa / Farimani, Amir Barati

    medRxiv

    Abstract: Making accurate forecasting of COVID-19 cases is essential for healthcare systems, with more than 650 million cases as of 4 January,1 making it one of the worst in history. The goal of this research is to improve the precision of COVID-19 case ... ...

    Abstract Making accurate forecasting of COVID-19 cases is essential for healthcare systems, with more than 650 million cases as of 4 January,1 making it one of the worst in history. The goal of this research is to improve the precision of COVID-19 case predictions in Russia, India, and Brazil, a transformer-based model was developed. Several researchers have implemented a combination of CNNs and LSTMs, Long Short-Term Memory (LSTMs), and Convolutional Neural Networks (CNNs) to calculate the total number of COVID-19 cases. In this study, an effort was made to improve the correctness of the models by incorporating recent advancements in attention-based models for time-series forecasting. The resulting model was found to perform better than other existing models and showed improved accuracy in forecasting. Using the data from different countries and adapting it to the model will enhance its ability to support the worldwide effort to combat the pandemic by giving more precise projections of cases.
    Keywords covid19
    Language English
    Publishing date 2023-11-03
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2023.11.02.23297976
    Database COVID19

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  3. Book ; Online: HNO

    Patil, Saurabh / Li, Zijie / Farimani, Amir Barati

    Hyena Neural Operator for solving PDEs

    2023  

    Abstract: Numerically solving partial differential equations (PDEs) typically requires fine discretization to resolve necessary spatiotemporal scales, which can be computationally expensive. Recent advances in deep learning have provided a new approach to solving ... ...

    Abstract Numerically solving partial differential equations (PDEs) typically requires fine discretization to resolve necessary spatiotemporal scales, which can be computationally expensive. Recent advances in deep learning have provided a new approach to solving PDEs that involves the use of neural operators. Neural operators are neural network architectures that learn mappings between function spaces and have the capability to solve partial differential equations based on data. This study utilizes a novel neural operator called Hyena, which employs a long convolutional filter that is parameterized by a multilayer perceptron. The Hyena operator is an operation that enjoys sub-quadratic complexity and state space model to parameterize long convolution that enjoys global receptive field. This mechanism enhances the model's comprehension of the input's context and enables data-dependent weight for different PDE instances. To measure how effective the layers are in solving PDEs, we conduct experiments on Burger's equation and Navier Stokes equation. Our findings indicate Hyena Neural operator can serve as an efficient and accurate model for learning PDEs' solution operator. The data and code used can be found at: https://github.com/Saupatil07/Hyena-Neural-Operator
    Keywords Computer Science - Machine Learning ; Computer Science - Artificial Intelligence ; Mathematics - Numerical Analysis
    Subject code 006
    Publishing date 2023-06-28
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Adverse Drug Reactions and Prescription Patterns of Antiretroviral Drugs: A Longitudinal Observational Study From a Tertiary Care Hospital in Western India.

    Sekar, Vijaya Dhaarani / Joshi, Kavita / Bhide, Shruti / Rao, Shirish / Phirke, Chetan / Patil, Saurabh / Kothari, Rahul / Patel, Mudra / Shankar, Arun

    Cureus

    2024  Volume 16, Issue 3, Page(s) e56424

    Abstract: Background In 2018, the World Health Organisation (WHO) released interim guidelines, advising a change of regimens to dolutegravir-based first- and second-line antiretroviral therapy (ART), based on which, in 2021, the National Aids Control Organisation ( ...

    Abstract Background In 2018, the World Health Organisation (WHO) released interim guidelines, advising a change of regimens to dolutegravir-based first- and second-line antiretroviral therapy (ART), based on which, in 2021, the National Aids Control Organisation (NACO) updated its guidelines to include the tenofovir + lamivudine + dolutegravir (TLD) regimen as a first line of therapy for all people living with HIV (PLHIV) and second- and third-line regimens to dolutegravir-based regimens. Considering this change of regimen, the adverse drug reaction (ADR) profiling and longitudinal prescription pattern of antiretroviral and concomitant medications in adult patients at the ART centre of a tertiary care hospital were assessed in this study. Methods Ninety-seven PLHIV out of all the patients who attended the ART centre from September 2021 to July 2022 were enrolled and followed up for six months. The ADRs that occurred during this period were collected along with details of prescription patterns and analyzed by descriptive statistics. Causality assessment for ADR was done using the World Health Organisation-Uppsala Monitoring Centre (WHO-UMC) scale. Results Seventy-eight percent (n=76 out of 97) of patients experienced at least one ADR, and 128 ADRs were seen in 97 patients. The most common ADRs were increased alkaline phosphatase (39.0%, n=128), dyslipidaemia (12.5%, n=128), and nephrotoxicity (10.1%, n=128). The drug most suspected of causing ADRs was dolutegravir (27.5%, n=342). The most common therapeutic regimen was TLD (71.2%, n=97). The most prescribed drug was lamivudine (30.6%, n=1183). The most prescribed concomitant medication was cotrimoxazole (15%, n=312). Conclusions Dolutegravir-based regimens have been implemented for PLHIV in a phased-out manner from previous non-dolutegravir-based ART regimens, which is in line with the recent NACO guidelines. However, it has also led to an increase in dolutegravir-associated ADRs like increased alkaline phosphatase, dyslipidaemia, and nephrotoxicity. Continuous monitoring of prescriptions and ADRs can add to our knowledge regarding their use and ADRs.
    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.56424
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Comparative Analysis of Trifecta Outcomes in Robot-Assisted Partial Nephrectomy for cT1a Versus cT1b + Renal Tumours-a Single-Centre Study.

    Khanna Dilip, Sunny / Darlington Carbin, Danny / Singh, Surendra / Patil, Saurabh / Ahluwalia, Puneet / Gautam, Gagan

    Indian journal of surgical oncology

    2022  Volume 13, Issue 4, Page(s) 674–680

    Abstract: Robotic assistance is being increasingly utilised for nephron-sparing surgery for complex renal masses. We evaluated the outcomes of robot-assisted partial nephrectomy (RAPN) for cT1a versus cT1b + renal masses by a comparative analysis of trifecta ... ...

    Abstract Robotic assistance is being increasingly utilised for nephron-sparing surgery for complex renal masses. We evaluated the outcomes of robot-assisted partial nephrectomy (RAPN) for cT1a versus cT1b + renal masses by a comparative analysis of trifecta outcomes between these two groups of patients. We utilised our prospectively maintained database to identify patients undergoing RAPN for cT1a (group 1,
    Language English
    Publishing date 2022-05-02
    Publishing country India
    Document type Journal Article
    ZDB-ID 2568289-1
    ISSN 0976-6952 ; 0975-7651
    ISSN (online) 0976-6952
    ISSN 0975-7651
    DOI 10.1007/s13193-022-01541-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Fluticasone Furoate/Vilanterol Use Trends and Characteristics in Patients With Obstructive Airway Disease: A Real-World Study of 10,374 Patients From India.

    Prabhudesai, Prahlad / Singh, Bhanu P / Agrawal, Gyanendra / Singh, Ashok Kumar / Jadhav, Amit Y / Patil, Saurabh R / Bhagat, Sagar / Patil, Saiprasad / Barkate, Hanmant

    Cureus

    2023  Volume 15, Issue 2, Page(s) e34825

    Abstract: Introduction Obstructive Airway Diseases (OADs) are the leading cause of death among chronic respiratory diseases worldwide, and novel therapies are direly needed. Fluticasone furoate/vilanterol (FF/Vi) (100/25 µg) is the first once-daily ICS/uLABA ... ...

    Abstract Introduction Obstructive Airway Diseases (OADs) are the leading cause of death among chronic respiratory diseases worldwide, and novel therapies are direly needed. Fluticasone furoate/vilanterol (FF/Vi) (100/25 µg) is the first once-daily ICS/uLABA marketed in India for COPD since 2021. Considering its limited real-world experience in OAD patients in Indian clinical settings, a large drug utilization study (DUS) was planned. Methodology We conducted a cross-sectional, observational DUS at 1900 outpatient clinics in India from October 2021 to March 2022. Prescription data and medical history of patients who were prescribed the FF/Vi combination were collected. Results It was observed that FF/Vi was prescribed in an almost equal number of patients with COPD (44.2%) and asthma (42.9%). The majority of the patients (74%) were switched from previous ICS/LABA to this ICS/uLABA, while 26% of patients were treatment naïve. The average CAT score was 19.5±7.8 (43.2% GOLD Group C and 32.2% GOLD Group B) in COPD patients, while the average ACQ-5 score was 2.6±1.3 (33.1% GINA Step 3, 29.5% GINA Step 2) in asthmatic patients. Most of the patients (63.9%) had raised biomarkers (Blood eosinophil count >300 cells/μl). Prior history of exacerbation was present in 65% of patients with annual exacerbation rates of 1.2 in COPD, 1.1 in asthma, and 1.2 in asthma-COPD overlap syndrome (ACOS). Leukotriene inhibitors (42%) and LAMAs (30.8%) were common add-on medications. Conclusion We observed a trend towards a shift to once-daily ICS/uLABA (FF/Vi) by physicians, especially in symptomatic and exacerbating OAD patients with underlying comorbidities.
    Language English
    Publishing date 2023-02-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.34825
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  7. Article: Investigator knowledge, awareness, and registrations of academic clinical trials with the Clinical Trial Registry of India: An observational study.

    Bhide, Shruti / Patil, Saurabh / Sohal, Amitoj / Kadhe, Neha / Munshi, Renuka / Phirke, Chetan / Ambre, Snehal / Pawar, Sudhir / Patil, Ruchita

    Perspectives in clinical research

    2023  Volume 14, Issue 4, Page(s) 187–193

    Abstract: Introduction: In 2019, the Central Drugs Standard Control Organization (CDSCO) introduced the New Drugs and Clinical Trials Rules 2019 (NDCTR), which separated the research guidelines for "Clinical Trials" and "Biomedical and Health Research." As a ... ...

    Abstract Introduction: In 2019, the Central Drugs Standard Control Organization (CDSCO) introduced the New Drugs and Clinical Trials Rules 2019 (NDCTR), which separated the research guidelines for "Clinical Trials" and "Biomedical and Health Research." As a result, guidelines issued by
    Methodology: The study was conducted in two phases after obtaining approval from the Institutional Ethics Committee (EC) of three tertiary care hospitals in Mumbai. In the first phase, the number of ACTs was assessed from the clinical trial registry India website, while the number of registered and re-registered ECs were assessed from the CDSCO website. The second phase involved assessing investigator awareness and knowledge about ACTs using a prevalidated questionnaire with a content validity index score of 0.93.
    Results: In 2020, the highest numbers of studies were registered, with the highest numbers of registered and re-registered ECs from Maharashtra. All participants completed the questionnaire and were aware of the need to follow guidelines for clinical trials. Sixty-seven percent of participants knew that the guidelines for ACTs differed from those of sponsored clinical trials, but only 58% were aware of the exact definition of an ACT as per NDCTR, 2019. Eighty-five percent of participants knew who could initiate an ACT, but only 27% knew about the applicability of results of an ACT and 33% had in-depth knowledge about the required approvals, while only 10% knew the archival period. Although 71% of participants had knowledge about serious adverse event reporting, few answered in-depth questions correctly. Only 31 participants reported facing varied challenges.
    Conclusion: To conduct ACTs effectively and contribute to healthcare and scientific advancement, it is crucial to enhance investigators' existing knowledge about ACTs.
    Language English
    Publishing date 2023-08-08
    Publishing country India
    Document type Journal Article
    ZDB-ID 2593231-7
    ISSN 2229-5488 ; 2229-3485
    ISSN (online) 2229-5488
    ISSN 2229-3485
    DOI 10.4103/picr.picr_68_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Selecting lymph node-positive patients for adjuvant therapy after radical prostatectomy and extended pelvic lymphadenectomy: An outcome analysis of 100 node-positive patients managed without adjuvant therapy.

    Tamhankar, Ashwin Sunil / Patil, Saurabh / Singh, Shanky / Carbin, Danny Darlington / Mokal, Smruti / Ahluwalia, Puneet / Gautam, Gagan

    Current urology

    2022  Volume 16, Issue 4, Page(s) 232–239

    Abstract: Objective: The aim of the study is to evaluate the effect of deferred androgen deprivation therapy on biochemical recurrence (BCR) and other survival parameters in node-positive prostate cancer patients after robot-assisted radical prostatectomy with ... ...

    Abstract Objective: The aim of the study is to evaluate the effect of deferred androgen deprivation therapy on biochemical recurrence (BCR) and other survival parameters in node-positive prostate cancer patients after robot-assisted radical prostatectomy with bilateral extended pelvic lymph node dissection (RARP + EPLND).
    Materials and methods: Of the 453 consecutive RARP procedures performed from 2011 to 2018, 100 patients with no prior use of androgen deprivation therapy were found to be lymph node (LN) positive and were observed, with initiation of salvage treatment at the time of BCR only. Patients were divided into 1 or 2 LNs (67)-and more than 2 LNs (33)-positive groups to assess survival outcomes.
    Results: At a median follow-up of 21 months (1-70 months), the LN group (
    Conclusions: Nearly one fourth and one fifth of 1/2 node-positive patients were BCR-free at 3 and 5 years after RARP + EPLND. Further substratification using PSA, TV, and LN density may help in providing individualized care regarding the initiation of adjuvant therapy.
    Language English
    Publishing date 2022-09-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2253664-4
    ISSN 1661-7657 ; 1661-7649
    ISSN (online) 1661-7657
    ISSN 1661-7649
    DOI 10.1097/CU9.0000000000000129
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: A simple technique of tissue collection after morcellation during holmium laser enucleation of the prostate.

    Maheshwari, Pankaj N / Patil, Saurabh / Okwi, Nick / Pore, Anant

    Asian journal of urology

    2019  Volume 7, Issue 1, Page(s) 68–69

    Language English
    Publishing date 2019-03-15
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2831144-9
    ISSN 2214-3882
    ISSN 2214-3882
    DOI 10.1016/j.ajur.2019.03.002
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  10. Article: Transurethral

    Maheshwari, Pankaj N / Pore, Anant P / Patil, Saurabh R / Okwi, Nick

    Journal of Indian Association of Pediatric Surgeons

    2019  Volume 24, Issue 3, Page(s) 203–205

    Abstract: A 12-year-old male child, during evaluation of chronic constipation, was incidentally diagnosed to have a fronded bladder growth. ... ...

    Abstract A 12-year-old male child, during evaluation of chronic constipation, was incidentally diagnosed to have a fronded bladder growth. Transurethral
    Language English
    Publishing date 2019-01-25
    Publishing country India
    Document type Case Reports
    ZDB-ID 2164528-0
    ISSN 1998-3891 ; 0971-9261
    ISSN (online) 1998-3891
    ISSN 0971-9261
    DOI 10.4103/jiaps.JIAPS_244_17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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