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  1. Article: Neurodevelopmental Disorders: Role of Non-invasive Neuromodulation Therapies.

    Prasad, Barre Vijaya / Patil, Vaibhav / Sony, Krishan K

    Annals of neurosciences

    2024  Volume 31, Issue 2, Page(s) 77–79

    Language English
    Publishing date 2024-04-26
    Publishing country United States
    Document type Editorial
    ZDB-ID 2576191-2
    ISSN 0976-3260 ; 0972-7531
    ISSN (online) 0976-3260
    ISSN 0972-7531
    DOI 10.1177/09727531241245664
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Pathways to care and barriers in treatment among patients with Dissociative disorders.

    Shakya, Pooja / Sood, Mamta / Mathur, Rahul / Prajapati, Nisha / Patil, Vaibhav

    Asian journal of psychiatry

    2024  Volume 95, Page(s) 104000

    Abstract: Introduction: Dissociative disorder patients often present with sudden and embarrassing symptoms, and it is difficult for the patient and care giver to understand initially, recognize the need for help and reach for appropriate treatment timely. This ... ...

    Abstract Introduction: Dissociative disorder patients often present with sudden and embarrassing symptoms, and it is difficult for the patient and care giver to understand initially, recognize the need for help and reach for appropriate treatment timely. This can result in high risk of engaging in dangerous behaviors such as self-harm and suicidal acts, impaired global functioning, and poor quality of life. Knowledge about the types of barriers which are there in treatment seeking, can help in planning strategies for their removal and to facilitate the treatment process.
    Methods: Cross-sectional study among patients (n=133) with Dissociative disorders which were recruited from January 2023 to June 2023 in a tertiary care hospital. Pathways to care and barriers in treatment for Dissociative disorders were assessed by interviewing patients using semi-structured proforma. The Dissociative Experience Scale and World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0)) were used to assess disease severity and impact of illness on various domains of life respectively. Group comparison was made to assess differences in social- clinical profile of patients choosing different modalities of treatment.
    Results: 133 patients of Dissociative disorders with mean age 29.6±9.2, showed their first-choice of help seeking from general practitioner/ neurologist (40.6%), traditional faith healers (35.3%), psychiatrist (18.1%) and 5.2% preferred alternative treatments. This trend changed with 2nd and 3rd contact of help seeking with greater preference for psychiatrist in their 2nd (n=45, 33.8%) and 3rd (n=69, 51.8%) contact. The median duration of untreated illness was 56 weeks (IQR 24-182 weeks). Social-clinical profile of patients varied with their choice of treatment, having lower education level (P = 0.013), longer duration of untreated illness (p=0.003), more severity of symptoms (p=0.032) and greater disability scores(p=0.002) in patients whose first treatment choice was traditional faith healers. More than 70% patients faced availability barriers, stigma, unawareness about mental illness and influence of others in treatment of choice as barriers in initiating and continuing treatment.
    Conclusion: Patients with Dissociative disorders seek treatment from a multitude of healthcare providers including traditional faith healers, general physicians, and alternative medicine practitioners before reaching psychiatrist and undergoes various barriers in treatment. There is need to implement necessary measures for sensitization and awareness about Dissociative disorders to prevent prolonged and undue delays in initiation of appropriate management.
    MeSH term(s) Humans ; Dissociative Disorders/therapy ; Adult ; Male ; Female ; Cross-Sectional Studies ; Young Adult ; Patient Acceptance of Health Care/statistics & numerical data ; Health Services Accessibility ; Middle Aged ; India
    Language English
    Publishing date 2024-03-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2456678-0
    ISSN 1876-2026 ; 1876-2018
    ISSN (online) 1876-2026
    ISSN 1876-2018
    DOI 10.1016/j.ajp.2024.104000
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  3. Article: Comparative study between dynamic susceptibility contrast magnetic resonance imaging and arterial spin labelling perfusion in differentiating low-grade from high-grade brain tumours.

    Patil, Vaibhav / Malik, Rajesh / Sarawagi, Radha

    Polish journal of radiology

    2023  Volume 88, Page(s) e521–e528

    Abstract: Purpose: Our aim was to distinguish between low-grade and high-grade brain tumours on the basis of dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) perfusion and arterial spin labelling (ASL) perfusion and to compare DSC and ASL ... ...

    Abstract Purpose: Our aim was to distinguish between low-grade and high-grade brain tumours on the basis of dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) perfusion and arterial spin labelling (ASL) perfusion and to compare DSC and ASL techniques.
    Material and methods: Forty-one patients with brain tumours were evaluated by 3-Tesla MRI. Conventional and perfusion MRI imaging with a 3D pseudo-continuous ASL (PCASL) and DSC perfusion maps were evaluated. Three ROIs were placed to obtain cerebral blood value (CBV) and cerebral blood flow (CBF) in areas of maximum perfusion in brain tumour and normal grey matter. Histopathological diagnosis was considered as the reference. ROC analysis was performed to compare the diagnostic performance and to obtain a feasible cut-off value of perfusion parameters to differentiate low-grade and high-grade brain tumours.
    Results: Normalised perfusion parameters with grey matter (rCBF or rCBV lesion/NGM) of malignant lesions were significantly higher than those of benign lesions in both DSC (normalised rCBF of 2.16 and normalised rCBV of 2.63) and ASL (normalised rCBF of 2.22) perfusion imaging. The normalised cut-off values of DSC (rCBF of 1.1 and rCBV of 1.4) and ASL (rCBF of 1.3) showed similar specificity and near similar sensitivity in distinguishing low-grade and high-grade brain tumours.
    Conclusions: Quantitative analysis of perfusion parameters obtained by both DSC and ASL perfusion techniques can be reliably used to distinguish low-grade and high-grade brain tumours. Normalisation of these values by grey matter gives us more reliable parameters, eliminating the different technical parameters involved in both the techniques.
    Language English
    Publishing date 2023-11-13
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2675143-4
    ISSN 1899-0967 ; 1733-134X
    ISSN (online) 1899-0967
    ISSN 1733-134X
    DOI 10.5114/pjr.2023.132889
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: When a Sibling Has Autism: Narrative Review of Interventions for Typically Developing Siblings.

    Godara, Karishma / Patil, Vaibhav / Phakey, Nisha

    Indian journal of psychological medicine

    2023  Volume 46, Issue 2, Page(s) 103–109

    Abstract: Being a typically developing sibling to a child with autism spectrum disorder (ASD-Sib) can be associated with several behavioral and mental health problems. With this understanding, researchers are beginning to focus on sibling-oriented interventions. ... ...

    Abstract Being a typically developing sibling to a child with autism spectrum disorder (ASD-Sib) can be associated with several behavioral and mental health problems. With this understanding, researchers are beginning to focus on sibling-oriented interventions. This review seeks to evaluate the current literature on such interventions. We searched digital databases and identified eight relevant studies. The sample (n = 247) had an age range of 4-16 years. The outcomes were generally positive, with improvements in different facets of ASD-Sibs. Results differed due to varied intervention styles, outcome variables, methods, and samples. Our findings highlight the potential for improvement in ASD-Sib's knowledge of autism and their psychological functioning and hence call for further research with robust methods.
    Language English
    Publishing date 2023-07-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2622378-8
    ISSN 0975-1564 ; 0253-7176
    ISSN (online) 0975-1564
    ISSN 0253-7176
    DOI 10.1177/02537176231176404
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Statistically-aided development of protein A affinity chromatography for enhancing recovery and controlling quality of a monoclonal antibody.

    Doltade, Shashikant / Saldanha, Marianne / Patil, Vaibhav / Dandekar, Prajakta / Jain, Ratnesh

    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

    2023  Volume 1227, Page(s) 123829

    Abstract: Protein A chromatography is widely used for isolation of monoclonal antibodies (mAbs) from cell culture components. In this study, the effect of different process parameters of the Protein A purification namely, binding pH, elution pH, flow rate, ... ...

    Abstract Protein A chromatography is widely used for isolation of monoclonal antibodies (mAbs) from cell culture components. In this study, the effect of different process parameters of the Protein A purification namely, binding pH, elution pH, flow rate, neutralization pH and tween concentration, on the concentration and quality of the purified mAb were evaluated. Using design of experiments approach, the critical process parameters of protein A chromatography were identified and experimentally optimized. Their impact on quality attributes, such as size variants and charge variants, of the mAb was studied. Multivariate data analysis was subsequently performed using multiple linear regression and partial least squares regression methods. It was observed that the elution pH primarily governed the concentration of the purified mAb and the content of monomers and aggregates, while the tween concentration primarily influenced the main peak of the charge variants. This is the first study that evaluates the impact of tween concentration in buffers on the protein A chromatography purification step. These studies helped in identifying the design space and defining the target robust and optimal setpoints of the responses, which were subsequently verified experimentally. These setpoints not only passed the target criteria but also resulted in the highest recoveries during the investigation. Through this statistically-aided approach, an optimized and robust protein A chromatography process was rationally developed for purification of mAbs, while achieving the desired product quality. This study highlights the influence of multiple parameters of the protein A purification process on critical quality attributes of mAbs, such as the size and charge variants, which has been a very scarcely explored area.
    MeSH term(s) Antibodies, Monoclonal/chemistry ; Polysorbates ; Chromatography, Affinity/methods ; Staphylococcal Protein A ; Cell Culture Techniques ; Hydrogen-Ion Concentration
    Chemical Substances Antibodies, Monoclonal ; Polysorbates ; Staphylococcal Protein A
    Language English
    Publishing date 2023-07-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1180823-8
    ISSN 1873-376X ; 0378-4347 ; 1570-0232 ; 1387-2273
    ISSN (online) 1873-376X
    ISSN 0378-4347 ; 1570-0232 ; 1387-2273
    DOI 10.1016/j.jchromb.2023.123829
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: A Study of Correlation of Angiographic Evaluation of Coronary Artery Disease with Androgenetic Alopecia - TricoHeart Study.

    Patil, Vaibhav B / Lunge, Snehal B

    International journal of trichology

    2020  Volume 11, Issue 6, Page(s) 227–231

    Abstract: Background: Research on the association between androgenetic alopecia (AGA) and coronary artery disease (CAD) in women, with a focus on the evaluation of their angiographic association in the form of the severity of disease, has been lacking.: Aim: ... ...

    Abstract Background: Research on the association between androgenetic alopecia (AGA) and coronary artery disease (CAD) in women, with a focus on the evaluation of their angiographic association in the form of the severity of disease, has been lacking.
    Aim: The study aimed to evaluate the relation between CAD and AGA in women and to study their severity.
    Methods: This study, carried out with 438 women within 55 years of age and admitted for coronary angiography, had the case group (participants with CAD;
    Results: In the study group, 74 (33.79%) participants were treadmill test positive, 55 (25.11%) had unstable angina, 40 (18.26%) had ST-segment elevation myocardial infarction (STEMI), and 50 (22.83%) had non-ST-STEMI (NSTEMI). In the case group, Grade II female AGA was evidenced in 38 (43.18%) participants, whereas Grade III was present in 30 (34.09%) participants. Further on, 27 patients with triple vessel disease had Grade III female AGA. Whereas, in the control group, Grade I female AGA was evidenced in 23 (65.71%) participants.
    Conclusion: The hypothesis that female pattern baldness is a marker for increased risk of CAD events has been studied and established as part of the present study. Further, extensive studies on the effect of other variables with a larger sample size need to be conducted.
    Language English
    Publishing date 2020-01-24
    Publishing country India
    Document type Journal Article
    ZDB-ID 2570982-3
    ISSN 0974-9241 ; 0974-7753
    ISSN (online) 0974-9241
    ISSN 0974-7753
    DOI 10.4103/ijt.ijt_111_19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Percutaneous Balloon Mitral Valvuloplasty During Antenatal Care and Apgar Score: The ANC-Valve Study.

    Patil, Vaibhav Bansidhar / Patted, Suresh

    The Journal of invasive cardiology

    2020  Volume 32, Issue 11, Page(s) 427–432

    Abstract: Objectives: The present study aimed to evaluate maternal and fetal outcomes in patients who underwent percutaneous balloon mitral valvuloplasty (PBMV) during antenatal care.: Methods: Analysis of 117 pregnant women who underwent PBMV for rheumatic ... ...

    Abstract Objectives: The present study aimed to evaluate maternal and fetal outcomes in patients who underwent percutaneous balloon mitral valvuloplasty (PBMV) during antenatal care.
    Methods: Analysis of 117 pregnant women who underwent PBMV for rheumatic mitral stenosis. Demographic, clinical, echocardiographic, hemodynamic, and Doppler examinations were performed. The pregnant women were stratified according to New York Heart Association classification. Apgar scores were recorded at 1, 5, and 10 minutes to assess the neonatal outcomes.
    Results: In our study cohort, 74.36% underwent PBMV during their second trimester, at gestational age of 22.49 ± 5.82. Term birth, mode of delivery, birth weight, and Apgar score at 5 minutes were significantly associated with pregnancy and neonatal outcomes. Mitral valve area, mitral valve gradient, and pulmonary artery systolic pressure were significantly improved (P<.001) after PBMV. Pulmonary edema, medical termination of pregnancy, hypothyroidism, hepatitis B infection, pneumonia, and postprocedural delivery, as well as postprocedure severe mitral regurgitation requiring surgery in 2 patients, were the few complications observed. Mean fluoroscopy time was 4 minutes, 50 seconds, with 100% success rate. No maternal mortality was observed.
    Conclusion: PBMV is a safe and effective intervention for mitral stenosis in pregnant women, with favorable maternal and short-term neonatal outcomes. PBMV offers excellent results in terms of symptomatic relief, hemodynamic improvement, and 100% success rate. Hence, it could be regarded as a preferred choice of intervention in managing symptomatic moderate to severe rheumatic mitral stenosis in pregnant women.
    MeSH term(s) Apgar Score ; Balloon Valvuloplasty/adverse effects ; Echocardiography ; Female ; Humans ; Infant, Newborn ; Mitral Valve/diagnostic imaging ; Mitral Valve Stenosis/diagnosis ; Mitral Valve Stenosis/surgery ; Pregnancy ; Prenatal Care
    Language English
    Publishing date 2020-09-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1154372-3
    ISSN 1557-2501 ; 1042-3931
    ISSN (online) 1557-2501
    ISSN 1042-3931
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  8. Article ; Online: Statistically-aided development of protein A affinity chromatography for enhancing recovery and controlling quality of a monoclonal antibody

    Doltade, Shashikant / Saldanha, Marianne / Patil, Vaibhav / Dandekar, Prajakta / Jain, Ratnesh

    Journal of Chromatography B. 20232023 July 15, July 15, v. 1227 p.123829-

    2023  

    Abstract: Protein A chromatography is widely used for isolation of monoclonal antibodies (mAbs) from cell culture components. In this study, the effect of different process parameters of the Protein A purification namely, binding pH, elution pH, flow rate, ... ...

    Abstract Protein A chromatography is widely used for isolation of monoclonal antibodies (mAbs) from cell culture components. In this study, the effect of different process parameters of the Protein A purification namely, binding pH, elution pH, flow rate, neutralization pH and tween concentration, on the concentration and quality of the purified mAb were evaluated. Using design of experiments approach, the critical process parameters of protein A chromatography were identified and experimentally optimized. Their impact on quality attributes, such as size variants and charge variants, of the mAb was studied. Multivariate data analysis was subsequently performed using multiple linear regression and partial least squares regression methods. It was observed that the elution pH primarily governed the concentration of the purified mAb and the content of monomers and aggregates, while the tween concentration primarily influenced the main peak of the charge variants. This is the first study that evaluates the impact of tween concentration in buffers on the protein A chromatography purification step. These studies helped in identifying the design space and defining the target robust and optimal setpoints of the responses, which were subsequently verified experimentally. These setpoints not only passed the target criteria but also resulted in the highest recoveries during the investigation. Through this statistically-aided approach, an optimized and robust protein A chromatography process was rationally developed for purification of mAbs, while achieving the desired product quality. This study highlights the influence of multiple parameters of the protein A purification process on critical quality attributes of mAbs, such as the size and charge variants, which has been a very scarcely explored area.
    Keywords affinity chromatography ; cell culture ; monoclonal antibodies ; neutralization ; pH ; product quality ; purification methods ; regression analysis ; Monoclonal antibody ; Protein A affinity chromatography ; Process optimization ; Design of experiments ; Multivariate analysis ; Quality attribute
    Language English
    Dates of publication 2023-0715
    Publishing place Elsevier B.V.
    Document type Article ; Online
    ZDB-ID 1180823-8
    ISSN 1570-0232 ; 1387-2273
    ISSN 1570-0232 ; 1387-2273
    DOI 10.1016/j.jchromb.2023.123829
    Database NAL-Catalogue (AGRICOLA)

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  9. Article: Design, synthesis and application of spiro[4.5]cyclohexadienones via one-pot sequential p-hydroxybenzylation/oxidative dearomatization

    Patil, Vaibhav B / Nanubolu, Jagadeesh Babu / Chegondi, Rambabu

    Chemical communications. 2021 June 3, v. 57, no. 45

    2021  

    Abstract: One-pot sequential p-hydroxybenzylation/oxidative dearomatization/spiroannulation has been designed for the efficient construction of tetrahydrofuran containing spiro-cyclohexadienones. This reaction proceeds through the p-hydroxybenzylation of 1,3- ... ...

    Abstract One-pot sequential p-hydroxybenzylation/oxidative dearomatization/spiroannulation has been designed for the efficient construction of tetrahydrofuran containing spiro-cyclohexadienones. This reaction proceeds through the p-hydroxybenzylation of 1,3-diketones with p-hydroxybenzyl alcohol via quinone methide formation followed by oxidative dearomatization/spiroannulation with suitable alcohols. The Friedel–Crafts alkylation of spiro[4.5]cyclohexadienones with indoles provided a broad array of highly diastereoselective C-3 alkylated spirocycles and cyclohepta[b]indoles depending upon the ring size of the fused cyclic ketones.
    Keywords alcohols ; alkylation ; diastereoselectivity ; indoles ; quinones ; tetrahydrofuran
    Language English
    Dates of publication 2021-0603
    Size p. 5574-5577.
    Publishing place The Royal Society of Chemistry
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d1cc01752g
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  10. Article ; Online: CuH-Catalyzed Enantioselective Desymmetrization of Cyclic 1,3-Diketones.

    Patil, Vaibhav B / Jadhav, Sandip B / Nanubolu, Jagadeesh Babu / Chegondi, Rambabu

    Organic letters

    2022  Volume 24, Issue 44, Page(s) 8233–8238

    Abstract: Herein, we report a CuH-catalyzed asymmetric desymmetrization of prochiral cyclopentane-1,3-diones to access cyclic 3-hydroxy ketones having an all-carbon quaternary center with high diastereoselectivity via hydrosilylation using PMHS as an inexpensive ... ...

    Abstract Herein, we report a CuH-catalyzed asymmetric desymmetrization of prochiral cyclopentane-1,3-diones to access cyclic 3-hydroxy ketones having an all-carbon quaternary center with high diastereoselectivity via hydrosilylation using PMHS as an inexpensive hydride source. This reaction displays high functional group tolerance including reducible alkyne, alkene, and ester groups with a broad substrate scope. The importance of chiral cyclic 3-hydroxy ketone building blocks was also demonstrated through the synthesis of (-)-estrone, the toxicodenane E core, and fused indoles.
    MeSH term(s) Stereoisomerism ; Catalysis ; Ketones ; Alkenes ; Indoles
    Chemical Substances Ketones ; Alkenes ; Indoles
    Language English
    Publishing date 2022-11-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.2c03359
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