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  1. AU="Patrícia Cardoso, Ana"
  2. AU="Ferreira, Vivian Neuza Dos Santos"
  3. AU="Liu, Qingzhu"
  4. AU=Cherian Iype
  5. AU="Mohelsky, Romy"
  6. AU="Koop, J Orjuela"
  7. AU="Pakhomova, O. A"
  8. AU="Teich, René"
  9. AU=Zotzmann Viviane
  10. AU="Chen, Xiaoxiang"
  11. AU=Halperin Jonathan L
  12. AU="Soderquist, Ryan S"
  13. AU=Coppola Giangennaro
  14. AU="Ping, Xiaofang"
  15. AU="Suzuki, Kana"
  16. AU="Hackett, Fiona"
  17. AU="Berhe, T."
  18. AU="Rajesh, K S"
  19. AU=Nichols Kenneth J
  20. AU="Annarita, Santoro"
  21. AU="Fluerant, Marshall"
  22. AU="Di Marino, Luca"
  23. AU="Lu, Zonghong"
  24. AU="Saz-Leal, Paula"
  25. AU="Caillier, Stacy J"
  26. AU="Curran, Kathryn G"
  27. AU=Wu Jun
  28. AU="Singhal, Jyotsana"
  29. AU="Fossa, Paola"
  30. AU="Hu, Chung-Chi"
  31. AU="Azad, Rashid"
  32. AU="Bumcrot, David"
  33. AU="Jun, Yu Kyung"
  34. AU="Ganapathy, Kalaiselvan"
  35. AU=Laue Thomas
  36. AU="Yanlan Wang"

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  1. Artikel ; Online: Author Correction: Ionizing radiation modulates human macrophages towards a pro-inflammatory phenotype preserving their pro-invasive and pro-angiogenic capacities.

    Teresa Pinto, Ana / Laranjeiro Pinto, Marta / Patrícia Cardoso, Ana / Monteiro, Cátia / Teixeira Pinto, Marta / Filipe Maia, André / Castro, Patrícia / Figueira, Rita / Monteiro, Armanda / Marques, Margarida / Mareel, Marc / Dos Santos, Susana Gomes / Seruca, Raquel / Adolfo Barbosa, Mário / Rocha, Sónia / José Oliveira, Maria

    Scientific reports

    2022  Band 12, Heft 1, Seite(n) 4774

    Sprache Englisch
    Erscheinungsdatum 2022-03-21
    Erscheinungsland England
    Dokumenttyp Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-08498-1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Advances on colorectal cancer 3D models: The needed translational technology for nanomedicine screening.

    Castro, Flávia / Leite Pereira, Catarina / Helena Macedo, Maria / Almeida, Andreia / José Silveira, Maria / Dias, Sofia / Patrícia Cardoso, Ana / José Oliveira, Maria / Sarmento, Bruno

    Advanced drug delivery reviews

    2021  Band 175, Seite(n) 113824

    Abstract: Colorectal cancer (CRC) is a heterogeneous and molecularly complex disease, associated with high mortality worldwide, exposing the urgent need for novel therapeutic approaches. Their development and translation to the clinic have been hampered, partially ...

    Abstract Colorectal cancer (CRC) is a heterogeneous and molecularly complex disease, associated with high mortality worldwide, exposing the urgent need for novel therapeutic approaches. Their development and translation to the clinic have been hampered, partially due to the absence of reliable cellular models that resemble key features of the human disease. While traditional 2D models are not able to provide consistent and predictive responses about the in vivo efficiency of the formulation, animal models frequently fail to recapitulate cancer progression and to reproduce adverse effects. On its turn, multicellular 3D systems, by mimicking key genetic, physical and mechanical cues of the tumor microenvironment, constitute a promising tool in cancer research. In addition, they constitute more physiological and relevant environment for anticancer drugs screening and for predicting patient's response towards personalized approaches, bridging the gap between simplified 2D models and unrepresentative animal models. In this review, we provide an overview of CRC 3D models for translational research, with focus on their potential for nanomedicines screening.
    Mesh-Begriff(e) Animals ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/therapeutic use ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/pathology ; Humans ; Nanomedicine/methods ; Nanoparticle Drug Delivery System ; Organoids/drug effects ; Organoids/pathology ; Spheroids, Cellular/drug effects ; Spheroids, Cellular/pathology ; Tissue Scaffolds ; Translational Research, Biomedical/methods
    Chemische Substanzen Antineoplastic Agents ; Nanoparticle Drug Delivery System
    Sprache Englisch
    Erscheinungsdatum 2021-06-04
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 639113-8
    ISSN 1872-8294 ; 0169-409X
    ISSN (online) 1872-8294
    ISSN 0169-409X
    DOI 10.1016/j.addr.2021.06.001
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Ionizing radiation modulates human macrophages towards a pro-inflammatory phenotype preserving their pro-invasive and pro-angiogenic capacities.

    Teresa Pinto, Ana / Laranjeiro Pinto, Marta / Patrícia Cardoso, Ana / Monteiro, Cátia / Teixeira Pinto, Marta / Filipe Maia, André / Castro, Patrícia / Figueira, Rita / Monteiro, Armanda / Marques, Margarida / Mareel, Marc / Dos Santos, Susana Gomes / Seruca, Raquel / Adolfo Barbosa, Mário / Rocha, Sónia / José Oliveira, Maria

    Scientific reports

    2016  Band 6, Seite(n) 18765

    Abstract: In order to improve the efficacy of conventional radiotherapy, attention has been paid to immune cells, which not only modulate cancer cell response to therapy but are also highly recruited to tumours after irradiation. Particularly, the effect of ... ...

    Abstract In order to improve the efficacy of conventional radiotherapy, attention has been paid to immune cells, which not only modulate cancer cell response to therapy but are also highly recruited to tumours after irradiation. Particularly, the effect of ionizing radiation on macrophages, using therapeutically relevant doses, is not well understood. To evaluate how radiotherapy affects macrophage behaviour and macrophage-mediated cancer cell activity, human monocyte derived-macrophages were subjected, for a week, to cumulative ionizing radiation doses, as used during cancer treatment (2 Gy/fraction/day). Irradiated macrophages remained viable and metabolically active, despite DNA damage. NF-kappaB transcription activation and increased Bcl-xL expression evidenced the promotion of pro-survival activity. A significant increase of pro-inflammatory macrophage markers CD80, CD86 and HLA-DR, but not CCR7, TNF and IL1B was observed after 10 Gy cumulative doses, while anti-inflammatory markers CD163, MRC1, VCAN and IL-10 expression decreased, suggesting the modulation towards a more pro-inflammatory phenotype. Moreover, ionizing radiation induced macrophage morphological alterations and increased their phagocytic rate, without affecting matrix metalloproteases (MMP)2 and MMP9 activity. Importantly, irradiated macrophages promoted cancer cell-invasion and cancer cell-induced angiogenesis. Our work highlights macrophage ability to sustain cancer cell activities as a major concern that needs to be addressed to improve radiotherapy efficacy.
    Mesh-Begriff(e) Cell Line, Tumor ; Cell Movement ; Cell Polarity ; Cell Shape ; Cell Survival ; DNA Damage ; Humans ; Inflammation/immunology ; Inflammation/metabolism ; Interleukin-10/metabolism ; Lipopolysaccharides/pharmacology ; Macrophage Activation/immunology ; Macrophages/physiology ; Macrophages/radiation effects ; Matrix Metalloproteinase 2/metabolism ; Matrix Metalloproteinase 9/metabolism ; Neoplasm Invasiveness ; Neovascularization, Pathologic/immunology ; Phenotype ; Signal Transduction ; bcl-X Protein/metabolism
    Chemische Substanzen BCL2L1 protein, human ; IL10 protein, human ; Lipopolysaccharides ; bcl-X Protein ; Interleukin-10 (130068-27-8) ; MMP2 protein, human (EC 3.4.24.24) ; Matrix Metalloproteinase 2 (EC 3.4.24.24) ; MMP9 protein, human (EC 3.4.24.35) ; Matrix Metalloproteinase 9 (EC 3.4.24.35)
    Sprache Englisch
    Erscheinungsdatum 2016-01-06
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/srep18765
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

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