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Article: Nanotechnological approaches in the treatment of schistosomiasis: an overview.

Carvalho, Lucas / Sarcinelli, Michelle / Patrício, Beatriz

2024 Volume 15, Page(s) 13–25

Abstract: Schistosomiasis causes over 200,000 deaths annually. The current treatment option, praziquantel, presents limitations, including low bioavailability and resistance. In this context, nanoparticles have emerged as a promising option for improving ... ...

Abstract	Schistosomiasis causes over 200,000 deaths annually. The current treatment option, praziquantel, presents limitations, including low bioavailability and resistance. In this context, nanoparticles have emerged as a promising option for improving schistosomiasis treatment. Several narrative reviews have been published on this topic. Unfortunately, the lack of clear methodologies presented in these reviews leads to the exclusion of many important studies without apparent justification. This integrative review aims to examine works published in this area with a precise and reproducible method. To achieve this, three databases (i.e., Pubmed, Web of Science, and Scopus) were searched from March 31, 2022, to March 31, 2023. The search results included only original research articles that used nanoparticles smaller than 1 µm in the treatment context. Additionally, a search was conducted in the references of the identified articles to retrieve works that could not be found solely using the original search formula. As a result, 65 articles that met the established criteria were identified. Inorganic and polymeric nanoparticles were the most prevalent nanosystems used. Gold was the primary material used to produce inorganic nanoparticles, while poly(lactic-
Language	English
Publishing date	2024-01-03
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2583584-1
ISSN	2190-4286
ISSN	2190-4286
DOI	10.3762/bjnano.15.2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Rectal Cancer and Radiation in Colitis.

Lynn, Patricio B / Cronin, Catherine / Rangarajan, Sriram / Widmar, Maria

Clinics in colon and rectal surgery

2023 Volume 37, Issue 1, Page(s) 30–36

Abstract: Inflammatory bowel disease (IBD) is associated with an increased risk of colorectal cancer. When IBD patients develop a rectal cancer, this should be treated with the same oncological principles and guidelines as the general population. Rectal cancer ... ...

Abstract	Inflammatory bowel disease (IBD) is associated with an increased risk of colorectal cancer. When IBD patients develop a rectal cancer, this should be treated with the same oncological principles and guidelines as the general population. Rectal cancer treatment includes surgery, chemotherapy, and radiation therapy (RT). Many IBD patients will require a total proctocolectomy with an ileal-pouch anal anastomosis (IPAA) and others, restoration of intestinal continuity may not be feasible or advisable. The literature is scarce regarding outcomes of IPAA after RT. In the present review, we will summarize the evidence regarding RT toxicity in IBD patients and review surgical strategies and outcomes of IPAA after RT.
Language	English
Publishing date	2023-02-22
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2048635-2
ISSN	1531-0043
ISSN	1531-0043
DOI	10.1055/s-0043-1762561
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Article: Pelvic Pouch Failure: Treatment Options.

Lynn, Patricio B / Brandstetter, Stephen / Schwartzberg, David M

Clinics in colon and rectal surgery

2022 Volume 35, Issue 6, Page(s) 487–494

Abstract: Up to 30% of patients with ulcerative colitis (UC) will require surgical management of their disease during their lifetime. An ileal pouch-anal anastomosis (IPAA) is the gold standard of care, giving patients the ability to be free from UC's bowel ... ...

Abstract	Up to 30% of patients with ulcerative colitis (UC) will require surgical management of their disease during their lifetime. An ileal pouch-anal anastomosis (IPAA) is the gold standard of care, giving patients the ability to be free from UC's bowel disease and avoid a permanent ostomy. Despite surgical advancements, a minority of patients will still experience pouch failure which can be debilitating and often require further surgical interventions. Signs and symptoms of pouch failure should be addressed with the appropriate workup and treatment plans formulated according with the patient's wishes. This article will discuss the identification, workup, and treatment options for pouch failure after IPAA.
Language	English
Publishing date	2022-11-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2048635-2
ISSN	1531-0043
ISSN	1531-0043
DOI	10.1055/s-0042-1758140
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Article ; Online: Characterization of a new extra-axonemal structure in the Giardia intestinalis flagella.

Verdan, Raphael / Patricio, Beatriz / Weismuller, Gilberto / Miranda, Kildare / de Souza, Wanderley / Benchimol, Marlene / Gadelha, Ana Paula

Journal of structural biology

2024 Volume 216, Issue 1, Page(s) 108064

Abstract: The inner structure of the flagella of Giardia intestinalis is similar to that of other organisms, consisting of nine pairs of outer microtubules and a central pair containing radial spokes. Although the 9+2 axonemal structure is conserved, it is not ... ...

Abstract	The inner structure of the flagella of Giardia intestinalis is similar to that of other organisms, consisting of nine pairs of outer microtubules and a central pair containing radial spokes. Although the 9+2 axonemal structure is conserved, it is not clear whether subregions, including the transition zone, are present in the flagella of this parasite. Giardia axonemes originate from basal bodies and have a lengthy cytosolic portion before becoming active flagella. The region of the emergence of the flagellum is not accompanied by any membrane specialization, as seen in other protozoa. Although Giardia is an intriguing model of study, few works focused on the ultrastructural analysis of the flagella of this parasite. Here, we analyzed the externalization region of the G. intestinalis flagella using ultra-high resolution scanning microscopy (with electrons and ions), atomic force microscopy in liquid medium, freeze fracture, and electron tomography. Our data show that this region possesses a distinctive morphological feature - it extends outward and takes on a ring-like shape. When the plasma membrane is removed, a structure surrounding the axoneme becomes visible in this region. This new extra-axonemal structure is observed in all pairs of flagella of trophozoites and remains attached to the axoneme even when the interconnections between the axonemal microtubules are disrupted. High-resolution scanning electron microscopy provided insights into the arrangement of this structure, contributing to the characterization of the externalization region of the flagella of this parasite.
MeSH term(s)	Axoneme ; Giardia lamblia/ultrastructure ; Microtubules/metabolism ; Flagella/metabolism ; Microscopy, Electron, Scanning
Language	English
Publishing date	2024-01-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	1032718-6
ISSN	1095-8657 ; 1047-8477
ISSN (online)	1095-8657
ISSN	1047-8477
DOI	10.1016/j.jsb.2024.108064
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Article: Rectal Cancer and Radiation in Colitis

Lynn, Patricio B. / Cronin, Catherine / Rangarajan, Sriram / Widmar, Maria

Clinics in Colon and Rectal Surgery

(Cancer in Inflammatory Bowel Disease)

2023 Volume 37, Issue 01, Page(s) 30–36

Series title	Cancer in Inflammatory Bowel Disease
Abstract	Inflammatory bowel disease (IBD) is associated with an increased risk of colorectal cancer. When IBD patients develop a rectal cancer, this should be treated with the same oncological principles and guidelines as the general population. Rectal cancer treatment includes surgery, chemotherapy, and radiation therapy (RT). Many IBD patients will require a total proctocolectomy with an ileal-pouch anal anastomosis (IPAA) and others, restoration of intestinal continuity may not be feasible or advisable. The literature is scarce regarding outcomes of IPAA after RT. In the present review, we will summarize the evidence regarding RT toxicity in IBD patients and review surgical strategies and outcomes of IPAA after RT.
Keywords	inflammatory bowel disease ; rectal cancer ; ileal pouch-anal anastomosis ; radiation therapy ; functional outcomes
Language	English
Publishing date	2023-02-22
Publisher	Thieme Medical Publishers, Inc.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2048635-2
ISSN	1530-9681 ; 1531-0043
ISSN (online)	1530-9681
ISSN	1531-0043
DOI	10.1055/s-0043-1762561
Database	Thieme publisher's database

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Zs.A 3931: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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ab Jg. 2022: Lesesaal (EG)

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Article: Pelvic Pouch Failure: Treatment Options

Lynn, Patricio B. / Brandstetter, Stephen / Schwartzberg, David M.

Clinics in Colon and Rectal Surgery

(Surgical Treatment of Mucosal Ulcerative Colitis)

2022 Volume 35, Issue 06, Page(s) 487–494

Series title	Surgical Treatment of Mucosal Ulcerative Colitis
Abstract	Up to 30% of patients with ulcerative colitis (UC) will require surgical management of their disease during their lifetime. An ileal pouch-anal anastomosis (IPAA) is the gold standard of care, giving patients the ability to be free from UC's bowel disease and avoid a permanent ostomy. Despite surgical advancements, a minority of patients will still experience pouch failure which can be debilitating and often require further surgical interventions. Signs and symptoms of pouch failure should be addressed with the appropriate workup and treatment plans formulated according with the patient's wishes. This article will discuss the identification, workup, and treatment options for pouch failure after IPAA.
Keywords	ulcerative colitis ; total proctocolectomy ; ileal pouch-anal anastomosis ; redo pouch ; pouch failure
Language	English
Publishing date	2022-11-01
Publisher	Thieme Medical Publishers, Inc.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2048635-2
ISSN	1530-9681 ; 1531-0043
ISSN (online)	1530-9681
ISSN	1531-0043
DOI	10.1055/s-0042-1758140
Database	Thieme publisher's database

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Effects of nandrolone decanoate on femur morphology. Experimental study.

Souza, Diogo Benchimol de / Brasil, Flavia Bittencourt / Marchon, Roger Gaspar / Félix-Patrício, Bruno

Acta cirurgica brasileira

2021 Volume 36, Issue 5, Page(s) e360507

Abstract: Purpose: To evaluate the immediate and late effects of nandrolone on femur morphology of rats.: Methods: Twenty-eight animals with 20 weeks of age were divided into four groups: C28, control animals that were euthanized eight weeks after the ... ...

Abstract	Purpose: To evaluate the immediate and late effects of nandrolone on femur morphology of rats. Methods: Twenty-eight animals with 20 weeks of age were divided into four groups: C28, control animals that were euthanized eight weeks after the experiment started; C40, control animals euthanized 20 weeks after the experiment started; T28, treated animals receiving nandrolone during eight weeks and euthanized immediately after the treatment period; and T40, animals treated during eight weeks and euthanized 12 weeks after the end of the treatment. Treated animals received nandrolone decanoate during eight weeks and control groups received peanut oil by intramuscular injection. After euthanasia, femurs were removed, dissected, weighted and measured by digital pachymeter. Results: The T40 group presented an increase on distal epiphysis diameter when compared to C40 group. There was no difference between treated and control groups in relation to body and femur absolute weight, relative weight and length of femur. There was also no difference in relation to diameter of proximal epiphysis and diameter of diaphysis among the groups. Conclusions: Nandrolone decanoate does not produce significant effect on femur, exception on its distal extremity at late period. The effects of such drug may depend on the time after administration.
MeSH term(s)	Anabolic Agents/pharmacology ; Animals ; Femur ; Nandrolone/pharmacology ; Nandrolone Decanoate ; Rats
Chemical Substances	Anabolic Agents ; Nandrolone (6PG9VR430D) ; Nandrolone Decanoate (H45187T098)
Language	English
Publishing date	2021-06-18
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2012156-8
ISSN	1678-2674 ; 1678-2674
ISSN (online)	1678-2674
ISSN	1678-2674
DOI	10.1590/ACB360507
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Small Bowel to Ileal-Pouch Anastomosis as a Pouch Salvage Procedure in Crohn's Disease.

Lynn, Patricio B / Diskin, Brian / Esen, Eren / Erkan, Arman / Kirat, Hasan T / Remzi, Feza

Diseases of the colon and rectum

2021 Volume 64, Issue 9, Page(s) e519

MeSH term(s)	Adult ; Colitis, Ulcerative/drug therapy ; Colitis, Ulcerative/surgery ; Crohn Disease/complications ; Crohn Disease/diagnosis ; Crohn Disease/surgery ; Female ; Humans ; Ileal Diseases/etiology ; Ileal Diseases/surgery ; Intestinal Obstruction/etiology ; Intestinal Obstruction/surgery ; Proctocolectomy, Restorative/adverse effects ; Salvage Therapy/methods
Language	English
Publishing date	2021-05-17
Publishing country	United States
Document type	Case Reports ; Journal Article ; Video-Audio Media
ZDB-ID	212581-x
ISSN	1530-0358 ; 0012-3706
ISSN (online)	1530-0358
ISSN	0012-3706
DOI	10.1097/DCR.0000000000001940
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Article ; Online: Operative, long-term and quality of life outcomes after salvage of failed re-do ileal pouch anal anastomosis.

Esen, Eren / Lynn, Patricio B / Da Luz Moreira, Andre / Erkan, Arman / Aytac, Erman / Grieco, Michael J / Kirat, Hasan T / Remzi, Feza H

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

2022 Volume 24, Issue 6, Page(s) 790–792

Abstract: Aim: Approximately 20%-40% of the patients with re-do ileal pouch anal anastomosis (IPAA) experience pouch failure. Salvage surgery can be attempted in this patient group with severe aversion to permanent ileostomy. The literature regarding secondary ... ...

Abstract	Aim: Approximately 20%-40% of the patients with re-do ileal pouch anal anastomosis (IPAA) experience pouch failure. Salvage surgery can be attempted in this patient group with severe aversion to permanent ileostomy. The literature regarding secondary IPAA revision after re-do IPAA failure is scarce. Methods: All patients who underwent a secondary IPAA revision after re-do IPAA failure between September 2016 and July 2021 in a single centre were included. Short- and long-term outcomes and quality of life in this patient group are reported. Results: Ten patients who had secondary IPAA revision for re-do IPAA failure were included. All patients had ulcerative colitis. Nine of these patients had pelvic sepsis and one patient had a mechanical issue. Mucosectomy and handsewn anastomosis was performed in nine patients. The existing pouch was salvaged in six patients and four patients had pouch excision and re-creation. Two patients had postoperative pelvic sepsis. Pouch retention rate was 78% in a median of 28 months. None of the patients had short-gut syndrome. The procedure was associated with good quality of life (median Cleveland Global Quality of Life Index 0.8). All patients would undergo the same surgery if needed. Conclusion: Secondary IPAA revision after a failed re-do IPAA can be an option in patients with severe aversion to permanent ileostomy if re-do IPAA fails and it is associated with good outcomes. This patient group should be carefully evaluated and referred to specialized centres if required.
MeSH term(s)	Colitis, Ulcerative/surgery ; Colonic Pouches/adverse effects ; Humans ; Ileostomy ; Postoperative Complications/etiology ; Postoperative Complications/surgery ; Proctocolectomy, Restorative/adverse effects ; Proctocolectomy, Restorative/methods ; Quality of Life ; Reoperation/methods ; Sepsis/surgery ; Treatment Outcome
Language	English
Publishing date	2022-02-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1440017-0
ISSN	1463-1318 ; 1462-8910
ISSN (online)	1463-1318
ISSN	1462-8910
DOI	10.1111/codi.16080
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 5799: Show issues

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Article ; Online: Gut-Pancreas-Liver Axis as a Target for Treatment of NAFLD/NASH.

Svegliati-Baroni, Gianluca / Patrício, Bárbara / Lioci, Gessica / Macedo, Maria Paula / Gastaldelli, Amalia

International journal of molecular sciences

2020 Volume 21, Issue 16

Abstract: Non-alcoholic fatty liver disease (NAFLD) represents the most common form of chronic liver disease worldwide. Due to its association with obesity and diabetes and the fall in hepatitis C virus morbidity, cirrhosis in NAFLD is becoming the most frequent ... ...

Abstract	Non-alcoholic fatty liver disease (NAFLD) represents the most common form of chronic liver disease worldwide. Due to its association with obesity and diabetes and the fall in hepatitis C virus morbidity, cirrhosis in NAFLD is becoming the most frequent indication to liver transplantation, but the pathogenetic mechanisms are still not completely understood. The so-called gut-liver axis has gained enormous interest when data showed that its alteration can lead to NAFLD development and might favor the occurrence of non-alcoholic steatohepatitis (NASH). Moreover, several therapeutic approaches targeting the gut-pancreas-liver axis, e.g., incretins, showed promising results in NASH treatment. In this review, we describe the role of incretin hormones in NAFLD/NASH pathogenesis and treatment and how metagenomic/metabolomic alterations in the gut microbiota can lead to NASH in the presence of gut barrier modifications favoring the passage of bacteria or bacterial products in the portal circulation, i.e., bacterial translocation.
MeSH term(s)	Animals ; Gastrointestinal Microbiome ; Gastrointestinal Tract/pathology ; Humans ; Incretins/metabolism ; Liver/pathology ; Non-alcoholic Fatty Liver Disease/microbiology ; Non-alcoholic Fatty Liver Disease/pathology ; Non-alcoholic Fatty Liver Disease/therapy ; Pancreas/pathology
Chemical Substances	Incretins
Language	English
Publishing date	2020-08-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms21165820
Database	MEDical Literature Analysis and Retrieval System OnLINE

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