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  1. Article ; Online: Thermostability profiling of MHC-bound peptides

    Emma C. Jappe / Christian Garde / Sri H. Ramarathinam / Ethan Passantino / Patricia T. Illing / Nicole A. Mifsud / Thomas Trolle / Jens V. Kringelum / Nathan P. Croft / Anthony W. Purcell

    Nature Communications, Vol 11, Iss 1, Pp 1-

    a new dimension in immunopeptidomics and aid for immunotherapy design

    2020  Volume 9

    Abstract: Thermostability of the peptide-MHC interaction is important for immunogenicity. Here the authors present a mass spectrometry method to measure thermostability among thousands of peptide-MHC complexes in parallel and a trained artificial neural network to ...

    Abstract Thermostability of the peptide-MHC interaction is important for immunogenicity. Here the authors present a mass spectrometry method to measure thermostability among thousands of peptide-MHC complexes in parallel and a trained artificial neural network to predict immunogenenicity of cancer antigens.
    Keywords Science ; Q
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: HLA-A*11:01-restricted CD8+ T cell immunity against influenza A and influenza B viruses in Indigenous and non-Indigenous people.

    Jennifer R Habel / Andrea T Nguyen / Louise C Rowntree / Christopher Szeto / Nicole A Mifsud / E Bridie Clemens / Liyen Loh / Weisan Chen / Steve Rockman / Jane Nelson / Jane Davies / Adrian Miller / Steven Y C Tong / Jamie Rossjohn / Stephanie Gras / Anthony W Purcell / Luca Hensen / Katherine Kedzierska / Patricia T Illing

    PLoS Pathogens, Vol 18, Iss 3, p e

    2022  Volume 1010337

    Abstract: HLA-A*11:01 is one of the most prevalent human leukocyte antigens (HLAs), especially in East Asian and Oceanian populations. It is also highly expressed in Indigenous people who are at high risk of severe influenza disease. As CD8+ T cells can provide ... ...

    Abstract HLA-A*11:01 is one of the most prevalent human leukocyte antigens (HLAs), especially in East Asian and Oceanian populations. It is also highly expressed in Indigenous people who are at high risk of severe influenza disease. As CD8+ T cells can provide broadly cross-reactive immunity to distinct influenza strains and subtypes, including influenza A, B and C viruses, understanding CD8+ T cell immunity to influenza viruses across prominent HLA types is needed to rationally design a universal influenza vaccine and generate protective immunity especially for high-risk populations. As only a handful of HLA-A*11:01-restricted CD8+ T cell epitopes have been described for influenza A viruses (IAVs) and epitopes for influenza B viruses (IBVs) were still unknown, we embarked on an epitope discovery study to define a CD8+ T cell landscape for HLA-A*11:01-expressing Indigenous and non-Indigenous Australian people. Using mass-spectrometry, we identified IAV- and IBV-derived peptides presented by HLA-A*11:01 during infection. 79 IAV and 57 IBV peptides were subsequently screened for immunogenicity in vitro with peripheral blood mononuclear cells from HLA-A*11:01-expressing Indigenous and non-Indigenous Australian donors. CD8+ T cell immunogenicity screening revealed two immunogenic IAV epitopes (A11/PB2320-331 and A11/PB2323-331) and the first HLA-A*11:01-restricted IBV epitopes (A11/M41-49, A11/NS1186-195 and A11/NP511-520). The immunogenic IAV- and IBV-derived peptides were >90% conserved among their respective influenza viruses. Identification of novel immunogenic HLA-A*11:01-restricted CD8+ T cell epitopes has implications for understanding how CD8+ T cell immunity is generated towards IAVs and IBVs. These findings can inform the development of rationally designed, broadly cross-reactive influenza vaccines to ensure protection from severe influenza disease in HLA-A*11:01-expressing individuals.
    Keywords Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
    Subject code 570 ; 610
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  3. Article ; Online: HLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome

    Patricia T. Illing / Phillip Pymm / Nathan P. Croft / Hugo G. Hilton / Vladimir Jojic / Alex S. Han / Juan L. Mendoza / Nicole A. Mifsud / Nadine L. Dudek / James McCluskey / Peter Parham / Jamie Rossjohn / Julian P. Vivian / Anthony W. Purcell

    Nature Communications, Vol 9, Iss 1, Pp 1-

    2018  Volume 13

    Abstract: Human leukocyte antigens (HLA) are multi-allelic and polymorphic genes that present antigens to immune cells for inducing protective immunity. Here, using systems biology and structural approaches, the authors show that micropolymorphism of three HLA has ...

    Abstract Human leukocyte antigens (HLA) are multi-allelic and polymorphic genes that present antigens to immune cells for inducing protective immunity. Here, using systems biology and structural approaches, the authors show that micropolymorphism of three HLA has effects beyond the modulation of antigen diversity.
    Keywords Science ; Q
    Language English
    Publishing date 2018-11-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  4. Article ; Online: HLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome

    Patricia T. Illing / Phillip Pymm / Nathan P. Croft / Hugo G. Hilton / Vladimir Jojic / Alex S. Han / Juan L. Mendoza / Nicole A. Mifsud / Nadine L. Dudek / James McCluskey / Peter Parham / Jamie Rossjohn / Julian P. Vivian / Anthony W. Purcell

    Nature Communications, Vol 9, Iss 1, Pp 1-

    2018  Volume 13

    Abstract: Human leukocyte antigens (HLA) are multi-allelic and polymorphic genes that present antigens to immune cells for inducing protective immunity. Here, using systems biology and structural approaches, the authors show that micropolymorphism of three HLA has ...

    Abstract Human leukocyte antigens (HLA) are multi-allelic and polymorphic genes that present antigens to immune cells for inducing protective immunity. Here, using systems biology and structural approaches, the authors show that micropolymorphism of three HLA has effects beyond the modulation of antigen diversity.
    Keywords Science ; Q
    Language English
    Publishing date 2018-11-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: CD8+ T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph

    Luca Hensen / Patricia T. Illing / E. Bridie Clemens / Thi H. O. Nguyen / Marios Koutsakos / Carolien E. van de Sandt / Nicole A. Mifsud / Andrea T. Nguyen / Christopher Szeto / Brendon Y. Chua / Hanim Halim / Simone Rizzetto / Fabio Luciani / Liyen Loh / Emma J. Grant / Phillipa M. Saunders / Andrew G. Brooks / Steve Rockman / Tom C. Kotsimbos /
    Allen C. Cheng / Michael Richards / Glen P. Westall / Linda M. Wakim / Thomas Loudovaris / Stuart I. Mannering / Michael Elliott / Stuart G. Tangye / David C. Jackson / Katie L. Flanagan / Jamie Rossjohn / Stephanie Gras / Jane Davies / Adrian Miller / Steven Y. C. Tong / Anthony W. Purcell / Katherine Kedzierska

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 20

    Abstract: The immunology of Indigenous populations is generally understudied outside the context of diseases that are prevalent in these communities. Here the authors identify prevalence of influenza CD8+ T cell epitopes in an Indigenous Australian population ... ...

    Abstract The immunology of Indigenous populations is generally understudied outside the context of diseases that are prevalent in these communities. Here the authors identify prevalence of influenza CD8+ T cell epitopes in an Indigenous Australian population expressing the susceptibility allomorph HLA A*24:02 and validate immunodominance of some of these epitopes in mice.
    Keywords Science ; Q
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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