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  1. AU="Patrignelli, Robert"
  2. AU="Muzamil shah"
  3. AU="Bhat, Aishwarya"
  4. AU="Hossain, Md Zakir"
  5. AU=Jiang Xianhan
  6. AU="Mousavi, Seyyed Meysam"
  7. AU=Paulson J C
  8. AU="Saif, Tahir"
  9. AU=Alam Sabiha AU=Alam Sabiha
  10. AU="Braniff, Julia"
  11. AU="Kasim, Sazzli"
  12. AU=Brown Samuel M
  13. AU="Daubenberger, Claudia A."
  14. AU="Esteban, L"
  15. AU=Tyrka Audrey R.
  16. AU="Álvarez-Valenzuela, Francisco D"
  17. AU="Akrofi, M.M."
  18. AU="Torres, Daiana Rodrigues"
  19. AU="Bercovici, Nicholas"
  20. AU="Di Maio, Ginevra"
  21. AU="Indelicarto, Matthew"
  22. AU="Ma, Yan"
  23. AU="Ngan, CDR Kelly"
  24. AU="Arzamendi, Dabit"
  25. AU="Rezende, Carlos Eduardo Borges"
  26. AU="Brunvand, E."
  27. AU="Gateno, Jaime"

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  1. Artikel ; Online: Vascular-Targeted Therapy for Systemic Lupus Erythematosus-Associated Vasculitis.

    Xu, Suzanne / Patrignelli, Robert J / Ramachandran, Sarika / Koumpouras, Fotios / Desir, Deborah / Ko, Christine J / Gehlhausen, Jeff R

    JAMA dermatology

    2023  Band 159, Heft 4, Seite(n) 460–462

    Mesh-Begriff(e) Humans ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/drug therapy ; Vasculitis/drug therapy ; Vasculitis/etiology
    Sprache Englisch
    Erscheinungsdatum 2023-03-08
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2701761-8
    ISSN 2168-6084 ; 2168-6068
    ISSN (online) 2168-6084
    ISSN 2168-6068
    DOI 10.1001/jamadermatol.2023.0077
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Perniosis during the COVID-19 pandemic: Negative anti-SARS-CoV-2 immunohistochemistry in six patients and comparison to perniosis before the emergence of SARS-CoV-2.

    Ko, Christine J / Harigopal, Malini / Damsky, William / Gehlhausen, Jeff R / Bosenberg, Marcus / Patrignelli, Robert / McNiff, Jennifer M

    Journal of cutaneous pathology

    2020  Band 47, Heft 11, Seite(n) 997–1002

    Abstract: Background: Acral inflammatory lesions that have some resemblance to idiopathic or autoimmune-associated perniosis (chilblains) have been described in multiple countries during the COVID-19 pandemic.: Methods: We examined histopathologic findings in ... ...

    Abstract Background: Acral inflammatory lesions that have some resemblance to idiopathic or autoimmune-associated perniosis (chilblains) have been described in multiple countries during the COVID-19 pandemic.
    Methods: We examined histopathologic findings in six consecutive such cases from five patients received in mid-May to mid-June of 2020, evaluating immunohistochemical staining for the SARS-CoV-2 nucleocapsid protein. We compared these six cases to eight cases diagnosed as perniosis between January and June of 2019.
    Results: Five of six lesions with perniosis-like histopathology during the COVID-19 pandemic had distinctive tight cuffing of lymphocytes; intravascular material was present in one case. SARS-CoV-2 immunohistochemical staining using an antibody directed at the nucleocapsid protein was negative in all six cases. Only one of eight specimens with microscopic findings of perniosis received prior to the COVID-19 pandemic had tightly cuffed perivascular lymphocytes, and none had obvious intravascular occlusion.
    Conclusions: A tightly cuffed pattern of perivascular lymphocytes is a feature of perniosis during the COVID-19 pandemic. The absence of SARS-CoV-2 nucleocapsid protein in these cases suggests against the virus being directly present in these lesions.
    Mesh-Begriff(e) Adult ; Aged ; Aged, 80 and over ; COVID-19/epidemiology ; Chilblains/epidemiology ; Female ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; SARS-CoV-2
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-09-09
    Erscheinungsland United States
    Dokumenttyp Comparative Study ; Journal Article
    ZDB-ID 187078-6
    ISSN 1600-0560 ; 0303-6987
    ISSN (online) 1600-0560
    ISSN 0303-6987
    DOI 10.1111/cup.13830
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Perniosis during the COVID-19 pandemic: Negative anti-SARS-CoV-2 immunohistochemistry in six patients and comparison to perniosis before the emergence of SARS-CoV-2

    Ko, Christine J / Harigopal, Malini / Damsky, William / Gehlhausen, Jeff R / Bosenberg, Marcus / Patrignelli, Robert / McNiff, Jennifer M

    J. cutan. pathol

    Abstract: BACKGROUND: Acral inflammatory lesions that have some resemblance to idiopathic or autoimmune-associated perniosis (chilblains) have been described in multiple countries during the COVID-19 pandemic. METHODS: We examined histopathologic findings in six ... ...

    Abstract BACKGROUND: Acral inflammatory lesions that have some resemblance to idiopathic or autoimmune-associated perniosis (chilblains) have been described in multiple countries during the COVID-19 pandemic. METHODS: We examined histopathologic findings in six consecutive such cases from five patients received in mid-May to mid-June of 2020, evaluating immunohistochemical staining for the SARS-CoV-2 nucleocapsid protein. We compared these six cases to eight cases diagnosed as perniosis between January and June of 2019. RESULTS: Five of six lesions with perniosis-like histopathology during the COVID-19 pandemic had distinctive tight cuffing of lymphocytes; intravascular material was present in one case. SARS-CoV-2 immunohistochemical staining using an antibody directed at the nucleocapsid protein was negative in all six cases. Only one of eight specimens with microscopic findings of perniosis received prior to the COVID-19 pandemic had tightly cuffed perivascular lymphocytes, and none had obvious intravascular occlusion. CONCLUSIONS: A tightly cuffed pattern of perivascular lymphocytes is a feature of perniosis during the COVID-19 pandemic. The absence of SARS-CoV-2 nucleocapsid protein in these cases suggests against the virus being directly present in these lesions.
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #692199
    Datenquelle COVID19

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  4. Artikel ; Online: Perniosis during the COVID ‐19 pandemic

    Ko, Christine J. / Harigopal, Malini / Damsky, William / Gehlhausen, Jeff R. / Bosenberg, Marcus / Patrignelli, Robert / McNiff, Jennifer M.

    Journal of Cutaneous Pathology ; ISSN 0303-6987 1600-0560

    Negative anti‐SARS‐CoV ‐2 immunohistochemistry in six patients and comparison to perniosis before the emergence of SARS‐CoV ‐2

    2020  

    Schlagwörter Pathology and Forensic Medicine ; Histology ; Dermatology ; covid19
    Sprache Englisch
    Verlag Wiley
    Erscheinungsland us
    Dokumenttyp Artikel ; Online
    DOI 10.1111/cup.13830
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

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  5. Artikel ; Online: Lack of association between pandemic chilblains and SARS-CoV-2 infection.

    Gehlhausen, Jeff R / Little, Alicia J / Ko, Christine J / Emmenegger, Marc / Lucas, Carolina / Wong, Patrick / Klein, Jon / Lu, Peiwen / Mao, Tianyang / Jaycox, Jillian / Wang, Eric / Ugwu, Nelson / Muenker, Cate / Mekael, Dilgash / Klein, Rhonda Q / Patrignelli, Robert / Antaya, Richard / McNiff, Jennifer / Damsky, William /
    Kamath, Kathy / Shon, John / Ring, Aaron M / Yildirim, Inci / Omer, Saad / Ko, Albert I / Aguzzi, Adriano / Iwasaki, Akiko

    Proceedings of the National Academy of Sciences of the United States of America

    2022  Band 119, Heft 9

    Abstract: An increased incidence of chilblains has been observed during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic and attributed to viral infection. Direct evidence of this relationship has been limited, however, as most cases do ... ...

    Abstract An increased incidence of chilblains has been observed during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic and attributed to viral infection. Direct evidence of this relationship has been limited, however, as most cases do not have molecular evidence of prior SARS-CoV-2 infection with PCR or antibodies. We enrolled a cohort of 23 patients who were diagnosed and managed as having SARS-CoV-2-associated skin eruptions (including 21 pandemic chilblains [PC]) during the first wave of the pandemic in Connecticut. Antibody responses were determined through endpoint titration enzyme-linked immunosorbent assay and serum epitope repertoire analysis. T cell responses to SARS-CoV-2 were assessed by T cell receptor sequencing and in vitro SARS-CoV-2 antigen-specific peptide stimulation assays. Immunohistochemical and PCR studies of PC biopsies and tissue microarrays for evidence of SARS-CoV-2 were performed. Among patients diagnosed and managed as "covid toes" during the pandemic, we find a percentage of prior SARS-CoV-2 infection (9.5%) that approximates background seroprevalence (8.5%) at the time. Immunohistochemistry studies suggest that SARS-CoV-2 staining in PC biopsies may not be from SARS-CoV-2. Our results do not support SARS-CoV-2 as the causative agent of pandemic chilblains; however, our study does not exclude the possibility of SARS-CoV-2 seronegative abortive infections.
    Mesh-Begriff(e) Adult ; COVID-19/complications ; COVID-19/epidemiology ; Chilblains/epidemiology ; Chilblains/immunology ; Chilblains/virology ; Connecticut/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; SARS-CoV-2/immunology ; Young Adult
    Sprache Englisch
    Erscheinungsdatum 2022-02-25
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2122090119
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1148: Hefte anzeigen Standort:
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  6. Artikel ; Online: Henoch-Schönlein purpura.

    Patrignelli, Robert / Sheikh, Shahzad H / Shaw-Stiffel, Thomas A

    Postgraduate medicine

    1995  Band 97, Heft 5, Seite(n) 123–134

    Abstract: Preview As the name implies, Henoch-Schönlein purpura is a vasculitic disease, but it also affects multiple organ systems. Although the exact cause of the disease has not been determined, recent studies have shed some light on its pathogenesis. This ... ...

    Abstract Preview As the name implies, Henoch-Schönlein purpura is a vasculitic disease, but it also affects multiple organ systems. Although the exact cause of the disease has not been determined, recent studies have shed some light on its pathogenesis. This article reviews these studies and discusses the various manifestations and possible complications. Two classification systems are also included.
    Sprache Englisch
    Erscheinungsdatum 1995-05
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 410138-8
    ISSN 1941-9260 ; 0032-5481
    ISSN (online) 1941-9260
    ISSN 0032-5481
    DOI 10.1080/00325481.1995.11945996
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.407: Hefte anzeigen Standort:
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