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  1. Article: Chirurgie du cancer colorectal chez la personne âgée.

    Patroni, Alexia / Moszkowicz, David / Morle, Dominique / Peschaud, Frédérique

    Soins. Gerontologie

    2018  Volume 23, Issue 132, Page(s) 24–25

    Abstract: Colorectal cancer risk factors increase with age, comorbidities, delayed diagnosis, obstruction, emergency and frailty. Surgery is the standard treatment as the survival rate for this pathology is the same as in young patients. It would appear that there ...

    Title translation Colorectal cancer surgery in the elderly.
    Abstract Colorectal cancer risk factors increase with age, comorbidities, delayed diagnosis, obstruction, emergency and frailty. Surgery is the standard treatment as the survival rate for this pathology is the same as in young patients. It would appear that there is an excess morbidity and mortality of colorectal cancer surgery in the elderly. Early rehabilitation is to be favoured during the postoperative period.
    MeSH term(s) Aged ; Colorectal Neoplasms/surgery ; Humans ; Postoperative Care ; Postoperative Complications/prevention & control
    Language French
    Publishing date 2018-12-03
    Publishing country France
    Document type Journal Article
    ZDB-ID 2246755-5
    ISSN 1268-6034
    ISSN 1268-6034
    DOI 10.1016/j.sger.2018.05.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Chirurgie du cancer colorectal chez la personne âgée

    Patroni, Alexia / Moszkowicz, David / Morle, Dominique

    Soins Gérontologie

    2018  , Issue 132, Page(s) 24

    Keywords Alter. ; Chirurgie. ; Krebs ; Darm. ; Prävention.
    Language French
    Document type Article
    ZDB-ID 2246755-5
    ISSN 1268-6034
    ISSN 1268-6034
    Database bibnet.org

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6353: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  3. Article ; Online: Droplet digital PCR of circulating tumor cells from colorectal cancer patients can predict KRAS mutations before surgery.

    Denis, Jérôme Alexandre / Patroni, Alexia / Guillerm, Erell / Pépin, Dominique / Benali-Furet, Naoual / Wechsler, Janine / Manceau, Gilles / Bernard, Maguy / Coulet, Florence / Larsen, Annette K / Karoui, Mehdi / Lacorte, Jean-Marc

    Molecular oncology

    2016  Volume 10, Issue 8, Page(s) 1221–1231

    Abstract: In colorectal cancer (CRC), KRAS mutations are a strong negative predictor for treatment with the EGFR-targeted antibodies cetuximab and panitumumab. Since it can be difficult to obtain appropriate tumor tissues for KRAS genotyping, alternative methods ... ...

    Abstract In colorectal cancer (CRC), KRAS mutations are a strong negative predictor for treatment with the EGFR-targeted antibodies cetuximab and panitumumab. Since it can be difficult to obtain appropriate tumor tissues for KRAS genotyping, alternative methods are required. Circulating tumor cells (CTCs) are believed to be representative of the tumor in real time. In this study we explored the capacity of a size-based device for capturing CTCs coupled with a multiplex KRAS screening assay using droplet digital PCR (ddPCR). We showed that it is possible to detect a mutant ratio of 0.05% and less than one KRAS mutant cell per mL total blood with ddPCR compared to about 0.5% and 50-75 cells for TaqMeltPCR and HRM. Next, CTCs were isolated from the blood of 35 patients with CRC at various stage of the disease. KRAS genotyping was successful for 86% (30/35) of samples with a KRAS codon 12/13 mutant ratio of 57% (17/30). In contrast, only one patient was identified as KRAS mutant when size-based isolation was combined with HRM or TaqMeltPCR. KRAS status was then determined for the 26 available formalin-fixed paraffin-embedded tumors using standard procedures. The concordance between the CTCs and the corresponding tumor tissues was 77% with a sensitivity of 83%. Taken together, the data presented here suggest that is feasible to detect KRAS mutations in CTCs from blood samples of CRC patients which are predictive for those found in the tumor. The minimal invasive nature of this procedure in combination with the high sensitivity of ddPCR might provide in the future an opportunity to monitor patients throughout the course of disease on multiple levels including early detection, prognosis, treatment and relapse as well as to obtain mechanistic insight with respect to tumor invasion and metastasis.
    MeSH term(s) Adult ; Base Sequence ; Cell Line, Tumor ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/surgery ; Female ; Gene Dosage ; Genotype ; Humans ; Male ; Mutation/genetics ; Neoplastic Cells, Circulating/pathology ; Polymerase Chain Reaction/methods ; Proto-Oncogene Proteins p21(ras)/genetics ; Reproducibility of Results
    Chemical Substances KRAS protein, human ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2)
    Language English
    Publishing date 2016-06-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2415106-3
    ISSN 1878-0261 ; 1574-7891
    ISSN (online) 1878-0261
    ISSN 1574-7891
    DOI 10.1016/j.molonc.2016.05.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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