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Article ; Online: Physical characterization of a novel wireless DRX Plus 3543C using both a carbon nano tube (CNT) mobile x-ray system and a traditional x-ray system.

Nitrosi, A / Bertolini, M / Chendi, A / Trojani, V / Canovi, L / Pattacini, P / Iori, M

2020 Volume 65, Issue 11, Page(s) 11NT02

Abstract: This work aims to characterize the novel DRX Plus 3543C detector in terms of detective quantum efficiency (DQE) using both a mobile x-ray system called Carestream DRX Revolution Nano and a traditional x-ray system (Carestream DRX Evolution). We used the ... ...

Abstract	This work aims to characterize the novel DRX Plus 3543C detector in terms of detective quantum efficiency (DQE) using both a mobile x-ray system called Carestream DRX Revolution Nano and a traditional x-ray system (Carestream DRX Evolution). We used the commercial system DRX Revolution Nano, equipped with a new x-ray source based on CNT technology and field emission (FE) as the electron emitter (cathode). An innovative aspect of this device is its intrinsic selection of the focal spot size. We tested the system using three IEC-specified beam qualities (RQA3, 5 and 7) in terms of modulation transfer function (MTF), normalized noise power spectra (NNPS) and DQE as defined in the IEC 62220-1-1:2015. We compared the results obtained using DRX Revolution Nano and DRX Evolution with correlation and with Bland-Altman plots to study their agreement. RQA3 MTF is slightly lower than the RQA5 and 7 curves between 0.5 and 2.5 cycles mm
MeSH term(s)	Nanotubes, Carbon/chemistry ; Radiation Dosimeters/standards ; Radiography/instrumentation ; Radiography/methods ; Wireless Technology/instrumentation ; X-Rays
Chemical Substances	Nanotubes, Carbon
Language	English
Publishing date	2020-06-11
Publishing country	England
Document type	Journal Article
ZDB-ID	208857-5
ISSN	1361-6560 ; 0031-9155
ISSN (online)	1361-6560
ISSN	0031-9155
DOI	10.1088/1361-6560/ab8afb
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Article ; Online: Workload Balancing in Emergency Night Shifts for a Multicenter Diagnostic Imaging Department: a RIS-Integrated Solution.

Nitrosi, A / Pattacini, P / Bertolini, M / Trojani, V / Sghedoni, R / Spaggiari, L / Zanichelli, M / Besutti, G / Notari, P / Canovi, L / Colli, M / Iori, M

Journal of digital imaging

2023 Volume 36, Issue 5, Page(s) 1987–1994

Abstract: The purpose of this short report is to illustrate the implementation of a RIS function for balancing radiological activities and workloads between two different teams of radiologists from the same Diagnostic Department during emergency nights and holiday ...

Abstract	The purpose of this short report is to illustrate the implementation of a RIS function for balancing radiological activities and workloads between two different teams of radiologists from the same Diagnostic Department during emergency nights and holiday shifts. One group is from the main hospital, Arcispedale S.Maria Nuova di Reggio Emilia, and the other group belongs to the five minor hospitals in the district of Reggio Emilia.The implementation of a dedicated balancing function in the RIS system successfully allows the balancing of the radiological activity between two or more teams of different radiologists, while preserving the care continuity of care and the involved workers' experience and confidence in reporting.
MeSH term(s)	Humans ; Workload ; Emergency Service, Hospital ; Diagnostic Imaging
Language	English
Publishing date	2023-06-22
Publishing country	United States
Document type	Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1033897-4
ISSN	1618-727X ; 0897-1889
ISSN (online)	1618-727X
ISSN	0897-1889
DOI	10.1007/s10278-023-00869-y
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Article ; Online: European validation of an image-derived AI-based short-term risk model for individualized breast cancer screening-a nested case-control study.

Eriksson, Mikael / Román, Marta / Gräwingholt, Axel / Castells, Xavier / Nitrosi, Andrea / Pattacini, Pierpaolo / Heywang-Köbrunner, Sylvia / Rossi, Paolo G

The Lancet regional health. Europe

2023 Volume 37, Page(s) 100798

Abstract: Background: Image-derived artificial intelligence (AI)-based risk models for breast cancer have shown high discriminatory performances compared with clinical risk models based on family history and lifestyle factors. However, little is known about their ...

Abstract	Background: Image-derived artificial intelligence (AI)-based risk models for breast cancer have shown high discriminatory performances compared with clinical risk models based on family history and lifestyle factors. However, little is known about their generalizability across European screening settings. We therefore investigated the discriminatory performances of an AI-based risk model in European screening settings. Methods: Using four European screening populations in three countries (Italy, Spain, Germany) screened between 2009 and 2020 for women aged 45-69, we performed a nested case-control study to assess the predictive performance of an AI-based risk model. In total, 739 women with incident breast cancers were included together with 7812 controls matched on year of study-entry. Mammographic features (density, microcalcifications, masses, left-right breast asymmetries of these features) were extracted using AI from negative digital mammograms at study-entry. Two-year absolute risks of breast cancer were predicted and assessed after two years of follow-up. Adjusted risk stratification performance metrics were reported per clinical guidelines. Findings: The overall adjusted Area Under the receiver operating characteristic Curve (aAUC) of the AI risk model was 0.72 (95% CI 0.70-0.75) for breast cancers developed in four screening populations. In the 6.2% [529/8551] of women at high risk using the National Institute of Health and Care Excellence (NICE) guidelines thresholds, cancers were more likely diagnosed after 2 years follow-up, risk-ratio (RR) 6.7 (95% CI 5.6-8.0), compared with the 69% [5907/8551] of women classified at general risk by the model. Similar risk-ratios were observed across levels of mammographic density. Interpretation: The AI risk model showed generalizable discriminatory performances across European populations and, predicted ∼30% of clinically relevant stage 2 and higher breast cancers in ∼6% of high-risk women who were sent home with a negative mammogram. Similar results were seen in women with fatty and dense breasts. Funding: Swedish Research Council.
Language	English
Publishing date	2023-12-06
Publishing country	England
Document type	Journal Article
ISSN	2666-7762
ISSN (online)	2666-7762
DOI	10.1016/j.lanepe.2023.100798
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Article: Desmoplastic fibroma of the distal tibia: A case report of a minimally invasive histological diagnosis.

Levrini, Gabriele / Pattacini, Pierpaolo

Molecular and clinical oncology

2016 Volume 5, Issue 5, Page(s) 537–539

Abstract: Desmoplastic fibroma (DF) is a benign, rare fibroblastic intraosseous neoplasm histologically resembling a desmoid soft tissue tumor. Although classified as benign, DF frequently exhibits an aggressive behavior, has a moderate-to-high recurrence rate, ... ...

Abstract	Desmoplastic fibroma (DF) is a benign, rare fibroblastic intraosseous neoplasm histologically resembling a desmoid soft tissue tumor. Although classified as benign, DF frequently exhibits an aggressive behavior, has a moderate-to-high recurrence rate, and often causes pathological fractures and extensive bone destruction. This case report presents an incidentally detected DF of the tibia, which was diagnosed using a minimally invasive approach. A 36-year-old African female patient was referred to the Department of Diagnostic Imaging of Arcispedale Santa Maria Nuova-IRCCS (Reggio Emilia, Italy), to be examined by a computed tomography scan on an outpatient basis, after an x-ray examination of the tibia, which was performed after an injury to exclude the presence of a fracture, revealed a hyperlucency of unknown origin. The aim of this study was to discuss the clinical, histological, immunohistochemical and radiographic characteristics of this rare neoplasm, with a focus on image-guided bone biopsy.
Language	English
Publishing date	2016-09-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2796865-0
ISSN	2049-9469 ; 2049-9450
ISSN (online)	2049-9469
ISSN	2049-9450
DOI	10.3892/mco.2016.1022
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Article: 18

Zizzo, Maurizio / Zanelli, Magda / Sanguedolce, Francesca / Versari, Annibale / Pattacini, Pierpaolo / Morini, Andrea / Mereu, Federica / Zuliani, Antonia Lavinia / Giunta, Alessandro

Hepatobiliary surgery and nutrition

2022 Volume 11, Issue 5, Page(s) 789–792

Language	English
Publishing date	2022-01-28
Publishing country	China (Republic : 1949- )
Document type	Journal Article
ZDB-ID	2812398-0
ISSN	2304-389X ; 2304-3881
ISSN (online)	2304-389X
ISSN	2304-3881
DOI	10.21037/hbsn-22-273
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Article ; Online: Prevalence and distribution of vascular calcifications at CT scan in patients with and without large vessel vasculitis: a matched cross-sectional study.

Besutti, Giulia / Marvisi, Chiara / Mancuso, Pamela / Farì, Roberto / Monelli, Filippo / Revelli, Matteo / Durmo, Rexhep / Galli, Elena / Muratore, Francesco / Spaggiari, Lucia / Ottone, Marta / Luminari, Stefano / Pattacini, Pierpaolo / Giorgi Rossi, Paolo / Salvarani, Carlo

RMD open

2023 Volume 9, Issue 3

Abstract: Objectives: The aim of this study was to compare the prevalence, entity and local distribution of arterial wall calcifications evaluated on CT scans in patients with large vessel vasculitis (LVV) and patients with lymphoma as reference for the ... ...

Abstract	Objectives: The aim of this study was to compare the prevalence, entity and local distribution of arterial wall calcifications evaluated on CT scans in patients with large vessel vasculitis (LVV) and patients with lymphoma as reference for the population without LVV. Methods: All consecutive patients diagnosed with LVVs with available baseline positron emission tomography-CT (PET-CT) scan performed between 2007 and 2019 were included; non-LVV patients were lymphoma patients matched by age (±5 years), sex and year of baseline PET-CT (≤2013; >2013). CT images derived from baseline PET-CT scans of both patient groups were retrospectively reviewed by a single radiologist who, after setting a threshold of minimum 130 Hounsfield units, semiautomatically computed vascular calcifications in three separate locations (coronaries, thoracic and abdominal arteries), quantified as Agatston and volume scores. Results: A total of 266 patients were included. Abdominal artery calcifications were equally distributed (mean volume 3220 in LVVs and 2712 in lymphomas). Being in the LVVs group was associated with the presence of thoracic calcifications after adjusting by age and year of diagnosis (OR 4.13, 95% CI 1.35 to 12.66; p=0.013). Similarly, LVVs group was significantly associated with the volume score in the thoracic arteries (p=0.048). In patients >50 years old, calcifications in the coronaries were more extended in non-LVV patients (p=0.027 for volume). Conclusion: When compared with patients without LVVs, LVVs patients have higher calcifications in the thoracic arteries, but not in coronary and abdominal arteries.
MeSH term(s)	Humans ; Middle Aged ; Cross-Sectional Studies ; Prevalence ; Positron Emission Tomography Computed Tomography ; Retrospective Studies ; Vascular Calcification/diagnostic imaging ; Vascular Calcification/epidemiology ; Tomography, X-Ray Computed ; Vasculitis
Language	English
Publishing date	2023-08-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2812592-7
ISSN	2056-5933 ; 2056-5933
ISSN (online)	2056-5933
ISSN	2056-5933
DOI	10.1136/rmdopen-2023-003278
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Article ; Online: Abdominal Fat Characteristics and Mortality in Rectal Cancer: A Retrospective Study.

Pellegrini, Massimo / Besutti, Giulia / Ottone, Marta / Canovi, Simone / Bonelli, Efrem / Venturelli, Francesco / Farì, Roberto / Damato, Angela / Bonelli, Candida / Pinto, Carmine / Ligabue, Guido / Pattacini, Pierpaolo / Giorgi Rossi, Paolo / El Ghoch, Marwan

Nutrients

2023 Volume 15, Issue 2

Abstract: The aim of this study was to evaluate the association of adipose tissue characteristics with survival in rectal cancer patients. All consecutive patients, diagnosed with stage II-IV rectal cancer between 2010-2016 using baseline unenhanced Computed ... ...

Abstract	The aim of this study was to evaluate the association of adipose tissue characteristics with survival in rectal cancer patients. All consecutive patients, diagnosed with stage II-IV rectal cancer between 2010-2016 using baseline unenhanced Computed Tomography (CT), were included. Baseline total, subcutaneous and visceral adipose tissue areas (TAT, SAT, VAT) and densities (TATd, SATd, VATd) at third lumbar vertebra (L3) were retrospectively measured. The association of these tissues with cancer-specific and progression-free survival (CCS, PFS) was assessed by using competitive risk models adjusted by age, sex and stage. Among the 274 included patients (median age 70 years, 41.2% females), the protective effect of increasing adipose tissue area on survival could be due to random fluctuations (e.g., sub-distribution hazard ratio-SHR for one cm
MeSH term(s)	Female ; Humans ; Aged ; Male ; Retrospective Studies ; Subcutaneous Fat ; Abdominal Fat ; Adipose Tissue ; Rectal Neoplasms/diagnostic imaging ; Intra-Abdominal Fat/diagnostic imaging
Language	English
Publishing date	2023-01-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15020374
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Article ; Online: CCL18, CHI3L1, ANG2, IL-6 systemic levels are associated with the extent of lung damage and radiomic features in SARS-CoV-2 infection.

Inflammation research : official journal of the European Histamine Research Society ... [et al.

2024 Volume 73, Issue 4, Page(s) 515–530

Abstract: Objective and design: We aimed to identify cytokines whose concentrations are related to lung damage, radiomic features, and clinical outcomes in COVID-19 patients.: Material or subjects: Two hundred twenty-six patients with SARS-CoV-2 infection and ... ...

Abstract	Objective and design: We aimed to identify cytokines whose concentrations are related to lung damage, radiomic features, and clinical outcomes in COVID-19 patients. Material or subjects: Two hundred twenty-six patients with SARS-CoV-2 infection and chest computed tomography (CT) images were enrolled. Methods: CCL18, CHI3L1/YKL-40, GAL3, ANG2, IP-10, IL-10, TNFα, IL-6, soluble gp130, soluble IL-6R were quantified in plasma samples using Luminex assays. The Mann-Whitney U test, the Kruskal-Wallis test, correlation and regression analyses were performed. Mediation analyses were used to investigate the possible causal relationships between cytokines, lung damage, and outcomes. AVIEW lung cancer screening software, pyradiomics, and XGBoost classifier were used for radiomic feature analyses. Results: CCL18, CHI3L1, and ANG2 systemic levels mainly reflected the extent of lung injury. Increased levels of every cytokine, but particularly of IL-6, were associated with the three outcomes: hospitalization, mechanical ventilation, and death. Soluble IL-6R showed a slight protective effect on death. The effect of age on COVID-19 outcomes was partially mediated by cytokine levels, while CT scores considerably mediated the effect of cytokine levels on outcomes. Radiomic-feature-based models confirmed the association between lung imaging characteristics and CCL18 and CHI3L1. Conclusion: Data suggest a causal link between cytokines (risk factor), lung damage (mediator), and COVID-19 outcomes.
MeSH term(s)	Humans ; COVID-19 ; Interleukin-6 ; SARS-CoV-2 ; Chitinase-3-Like Protein 1 ; Early Detection of Cancer ; Radiomics ; Lung Neoplasms ; Lung/diagnostic imaging ; Cytokines ; Chemokines, CC
Chemical Substances	Interleukin-6 ; Chitinase-3-Like Protein 1 ; Cytokines ; CHI3L1 protein, human ; CCL18 protein, human ; Chemokines, CC
Language	English
Publishing date	2024-02-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1221794-3
ISSN	1420-908X ; 1023-3830
ISSN (online)	1420-908X
ISSN	1023-3830
DOI	10.1007/s00011-024-01852-1
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Article: Impact of low skeletal muscle mass and quality on clinical outcomes in patients with head and neck cancer undergoing (chemo)radiation.

Bardoscia, Lilia / Besutti, Giulia / Pellegrini, Massimo / Pagano, Maria / Bonelli, Candida / Bonelli, Efrem / Braglia, Luca / Cozzi, Salvatore / Roncali, Massimo / Iotti, Cinzia / Pinto, Carmine / Pattacini, Pierpaolo / Ciammella, Patrizia

Frontiers in nutrition

2022 Volume 9, Page(s) 994499

Abstract: The study aimed to explore the impact of low skeletal muscle mass and quality on survival outcomes and treatment tolerance in patients undergoing radical chemo-radiation therapy for head and neck cancer (HNC). This is significant given the growing ... ...

Abstract	The study aimed to explore the impact of low skeletal muscle mass and quality on survival outcomes and treatment tolerance in patients undergoing radical chemo-radiation therapy for head and neck cancer (HNC). This is significant given the growing interest in sarcopenia as a possible negative predictive/prognostic factor of disease progression and survival. From 2010 to 2017, 225 patients were included in the study. Pre-treatment computed tomography (CT) scans of HNC patients undergoing (chemo)radiation therapy were retrospectively reviewed. The skeletal muscle area, normalized for height to obtain the skeletal muscle index (SMI), the skeletal muscle density (SMD) and the intramuscular adipose tissue area (IMAT) were measured at the level of the L3 vertebra. Low SMD and low SMI were defined according to previously reported thresholds, while high IMAT was defined using population-specific cut-point analysis. SMI, SMD, and IMAT were also measured at the proximal thigh (PT) level and tested as continuous variables. Clinical morpho-functional parameters, baseline nutritional markers with a known or suspected impact on HNC treatment, clinical outcomes and sarcopenia were also collected. In multivariate analyses, adjusted by age, sex, stage, diabetes, body mass index (BMI), and weight loss, L3-SMI was not significantly associated with survival, while poor muscle quality was negatively associated with overall survival (OS) (HR = 1.88, 95% CI = 1.09-3.23,
Language	English
Publishing date	2022-11-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2022.994499
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Article: Fusion radiology in interventional endoscopy (FRIend): a new approach for pancreatic fluid collections.

Sassatelli, Romano / Grillo, Simone / Ottone, Marta / Besutti, Giulia / Cecinato, Paolo / Sereni, Giuliana / Mirante, Vincenzo Giorgio / Iori, Veronica / Pattacini, Pierpaolo / Rossi, Paolo Giorgi

Endoscopy international open

2022 Volume 10, Issue 5, Page(s) E622–E633

Abstract: Background and study ... ...

Abstract	Background and study aims
Language	English
Publishing date	2022-05-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2761052-4
ISSN	2196-9736 ; 2364-3722
ISSN (online)	2196-9736
ISSN	2364-3722
DOI	10.1055/a-1797-8681
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