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  1. Article ; Online: Assessing the performance of different outcomes for tumor growth studies with animal models.

    Patten, Luke W / Blatchford, Patrick / Strand, Matthew / Kaizer, Alexander M

    Animal models and experimental medicine

    2022  Volume 5, Issue 3, Page(s) 248–257

    Abstract: The consistency of reporting results for patient-derived xenograft (PDX) studies is an area of concern. The PDX method commonly starts by implanting a derivative of a human tumor into a mouse, then comparing the tumor growth under different treatment ... ...

    Abstract The consistency of reporting results for patient-derived xenograft (PDX) studies is an area of concern. The PDX method commonly starts by implanting a derivative of a human tumor into a mouse, then comparing the tumor growth under different treatment conditions. Currently, a wide array of statistical methods (e.g., t-test, regression, chi-squared test) are used to analyze these data, which ultimately depend on the outcome chosen (e.g., tumor volume, relative growth, categorical growth). In this simulation study, we provide empirical evidence for the outcome selection process by comparing the performance of both commonly used outcomes and novel variations of common outcomes used in PDX studies. Data were simulated to mimic tumor growth under multiple scenarios, then each outcome of interest was evaluated for 10 000 iterations. Comparisons between different outcomes were made with respect to average bias, variance, type-1 error, and power. A total of 18 continuous, categorical, and time-to-event outcomes were evaluated, with ultimately 2 outcomes outperforming the others: final tumor volume and change in tumor volume from baseline. Notably, the novel variations of the tumor growth inhibition index (TGII)-a commonly used outcome in PDX studies-was found to perform poorly in several scenarios with inflated type-1 error rates and a relatively large bias. Finally, all outcomes of interest were applied to a real-world dataset.
    MeSH term(s) Animals ; Disease Models, Animal ; Humans ; Mice ; Neoplasms/therapy ; Tumor Burden
    Language English
    Publishing date 2022-06-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2576-2095
    ISSN (online) 2576-2095
    DOI 10.1002/ame2.12250
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Small target repeatability of

    Silosky, Michael S / Patten, Luke W / Chin, Bennett B

    American journal of nuclear medicine and molecular imaging

    2021  Volume 11, Issue 4, Page(s) 280–289

    Abstract: Quantification of tumor uptake using PET imaging is important for the evaluation of therapy response. ... ...

    Abstract Quantification of tumor uptake using PET imaging is important for the evaluation of therapy response. For
    Language English
    Publishing date 2021-08-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2623515-8
    ISSN 2160-8407
    ISSN 2160-8407
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Assessing the performance of different outcomes for tumor growth studies with animal models

    Patten, Luke W. / Blatchford, Patrick / Strand, Matthew / Kaizer, Alexander M.

    Animal models and experimental medicine. 2022 Sept., v. 5, no. 3

    2022  

    Abstract: The consistency of reporting results for patient‐derived xenograft (PDX) studies is an area of concern. The PDX method commonly starts by implanting a derivative of a human tumor into a mouse, then comparing the tumor growth under different treatment ... ...

    Abstract The consistency of reporting results for patient‐derived xenograft (PDX) studies is an area of concern. The PDX method commonly starts by implanting a derivative of a human tumor into a mouse, then comparing the tumor growth under different treatment conditions. Currently, a wide array of statistical methods (e.g., t‐test, regression, chi‐squared test) are used to analyze these data, which ultimately depend on the outcome chosen (e.g., tumor volume, relative growth, categorical growth). In this simulation study, we provide empirical evidence for the outcome selection process by comparing the performance of both commonly used outcomes and novel variations of common outcomes used in PDX studies. Data were simulated to mimic tumor growth under multiple scenarios, then each outcome of interest was evaluated for 10 000 iterations. Comparisons between different outcomes were made with respect to average bias, variance, type‐1 error, and power. A total of 18 continuous, categorical, and time‐to‐event outcomes were evaluated, with ultimately 2 outcomes outperforming the others: final tumor volume and change in tumor volume from baseline. Notably, the novel variations of the tumor growth inhibition index (TGII)—a commonly used outcome in PDX studies—was found to perform poorly in several scenarios with inflated type‐1 error rates and a relatively large bias. Finally, all outcomes of interest were applied to a real‐world dataset.
    Keywords data collection ; growth retardation ; humans ; medicine ; mice ; neoplasms ; t-test ; variance ; xenotransplantation
    Language English
    Dates of publication 2022-09
    Size p. 248-257.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ISSN 2576-2095
    DOI 10.1002/ame2.12250
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Mass-Like Fat at the Medial Midfoot: A Common Pseudolesion.

    Strickland, Colin D / Patten, Luke W / Durst, Michael J / Merkle, Alexander N

    The Indian journal of radiology & imaging

    2021  Volume 31, Issue 2, Page(s) 245–251

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2021-07-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 605869-3
    ISSN 0971-3026 ; 0970-2016
    ISSN 0971-3026 ; 0970-2016
    DOI 10.1055/s-0041-1732826
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 430: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Book ; Online: Mass-Like Fat at the Medial Midfoot

    Strickland, Colin D. / Patten, Luke W. / Durst, Michael J. / Merkle, Alexander N.

    Indian J Radiol Imaging

    A Common Pseudolesion

    2021  

    Abstract: Background Fatty masses are common and may be encountered in the foot and ankle. In some cases, normal subcutaneous fat may be mistaken for a discrete mass. Aims The aim of this study was to evaluate the common finding of prominent subcutaneous fat at ... ...

    Abstract Background Fatty masses are common and may be encountered in the foot and ankle. In some cases, normal subcutaneous fat may be mistaken for a discrete mass. Aims The aim of this study was to evaluate the common finding of prominent subcutaneous fat at the medial midfoot resembling a lipoma and to determine the prevalence of this pseudolesion by applying a series of potential size cutoff criteria. Materials and Methods Three musculoskeletal radiologists retrospectively evaluated 91 sequentially performed magnetic resonance imaging examinations of the ankle to measure fat resembling a discrete lipoma at the medial midfoot. Each blinded reader measured the largest area of continuous subcutaneous fat in orthogonal axial, coronal craniocaudal, and coronal transverse dimensions. Patient age, sex, and study indications were also recorded. Statistical analysis was performed with R and SAS 9.4 software Results A discrete fatty pseudolesion as defined by measuring at least 1 cm in all planes by measurements of at least two of three readers was present in 87% of cases (79 of 91). When a size criterion of 1.5 cm was used, a pseudolesion was documented in 14% of cases (13 of 91). There was a significant correlation between larger pseudolesion size and female sex in the axial plane; however, there was no correlation in the coronal craniocaudal and coronal transverse dimensions. Conclusions Subcutaneous fat at the medial midfoot often has a mass-like appearance that could be mistaken for a lipoma. It is important to recognize this pseudolesion variant and not to confuse the imaging appearance for a discrete mass.
    Subject code 796
    Language English
    Publisher Thieme Medical and Scientific Publishers Private Ltd.
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Article: Mass-Like Fat at the Medial Midfoot: A Common Pseudolesion

    Strickland, Colin D. / Patten, Luke W. / Durst, Michael J. / Merkle, Alexander N.

    Indian Journal of Radiology and Imaging

    2021  Volume 31, Issue 02, Page(s) 245–251

    Abstract: Background: Fatty masses are common and may be encountered in the foot and ankle. In some cases, normal subcutaneous fat may be mistaken for a discrete mass.: Aims: The aim of this study was to evaluate the common finding of prominent subcutaneous ... ...

    Abstract Background: Fatty masses are common and may be encountered in the foot and ankle. In some cases, normal subcutaneous fat may be mistaken for a discrete mass.
    Aims: The aim of this study was to evaluate the common finding of prominent subcutaneous fat at the medial midfoot resembling a lipoma and to determine the prevalence of this pseudolesion by applying a series of potential size cutoff criteria.
    Materials and Methods: Three musculoskeletal radiologists retrospectively evaluated 91 sequentially performed magnetic resonance imaging examinations of the ankle to measure fat resembling a discrete lipoma at the medial midfoot. Each blinded reader measured the largest area of continuous subcutaneous fat in orthogonal axial, coronal craniocaudal, and coronal transverse dimensions. Patient age, sex, and study indications were also recorded. Statistical analysis was performed with R and SAS 9.4 software
    Results: A discrete fatty pseudolesion as defined by measuring at least 1 cm in all planes by measurements of at least two of three readers was present in 87% of cases (79 of 91). When a size criterion of 1.5 cm was used, a pseudolesion was documented in 14% of cases (13 of 91). There was a significant correlation between larger pseudolesion size and female sex in the axial plane; however, there was no correlation in the coronal craniocaudal and coronal transverse dimensions.
    Conclusions: Subcutaneous fat at the medial midfoot often has a mass-like appearance that could be mistaken for a lipoma. It is important to recognize this pseudolesion variant and not to confuse the imaging appearance for a discrete mass.
    Keywords lipoma ; midfoot ; mass
    Language English
    Publishing date 2021-04-01
    Publisher Thieme Medical and Scientific Publishers Private Ltd.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 605869-3
    ISSN 1998-3808 ; 0971-3026 ; 0970-2016
    ISSN (online) 1998-3808
    ISSN 0971-3026 ; 0970-2016
    DOI 10.1055/s-0041-1732826
    Database Thieme publisher's database

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    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 430: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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