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  1. Article ; Online: Primary Extra-Pleura Leiomyoma: A Case Report and Literature Review.

    Ullah, Asad / Patterson, G Taylor / Ghleilib, Intisar / Elhelf, Islam A / Patel, Nikhil G / Karim, Nagla A

    Current oncology (Toronto, Ont.)

    2022  Volume 29, Issue 5, Page(s) 2935–2940

    Abstract: Leiomyomas are a common type of benign soft tissue tumor arising from smooth muscle, most often occurring within females' genitourinary and gastrointestinal tract. However, primary leiomyomas of the chest wall residing in the extra-pleural space are an ... ...

    Abstract Leiomyomas are a common type of benign soft tissue tumor arising from smooth muscle, most often occurring within females' genitourinary and gastrointestinal tract. However, primary leiomyomas of the chest wall residing in the extra-pleural space are an extremely rare subset of leiomyomatous lesion presentation. We present a case of a fifty-two-year-old male who initially presented complaining of dyspnea worsening with exertion. Computed tomography imaging was performed showing an extra-pleural mass residing under the left sixth rib. Subsequent core needle biopsy and immunohistochemical staining were performed, and the definitive diagnosis of primary leiomyoma of the posterior mediastinal chest wall. Although extremely rare, this neoplastic condition should be included in your differential diagnosis when diagnostic imaging reveals a benign mass residing in the extra-pleural space, and subsequent biopsy specimens consist of smooth muscle fibers.
    MeSH term(s) Female ; Humans ; Leiomyoma/diagnostic imaging ; Leiomyoma/surgery ; Male ; Middle Aged ; Pleura/pathology ; Soft Tissue Neoplasms ; Thoracic Wall ; Tomography, X-Ray Computed
    Language English
    Publishing date 2022-04-20
    Publishing country Switzerland
    Document type Case Reports ; Review
    ZDB-ID 1236972-x
    ISSN 1718-7729 ; 1198-0052
    ISSN (online) 1718-7729
    ISSN 1198-0052
    DOI 10.3390/curroncol29050240
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: Double-Negative T-Cell Reaction in a Case of

    Ullah, Asad / Patterson, G Taylor / Mattox, Samantha N / Cotter, Thomas / Patel, Nikhil G / Savage, Natasha M

    International journal of environmental research and public health

    2021  Volume 18, Issue 12

    Abstract: Gamma delta T-cells are commonly found in response ... ...

    Abstract Gamma delta T-cells are commonly found in response to
    MeSH term(s) Animals ; CD8-Positive T-Lymphocytes ; Flow Cytometry ; Humans ; Listeria monocytogenes ; Listeriosis ; Meningitis, Listeria/diagnosis ; Mice
    Language English
    Publishing date 2021-06-16
    Publishing country Switzerland
    Document type Case Reports
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph18126486
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Vitamin C supplementation for the treatment of osteoarthritis: perspectives on the past, present, and future.

    Dunlap, Burton / Patterson, G Taylor / Kumar, Sandeep / Vyavahare, Sagar / Mishra, Samarth / Isales, Carlos / Fulzele, Sadanand

    Therapeutic advances in chronic disease

    2021  Volume 12, Page(s) 20406223211047026

    Abstract: According to the US Centers for Disease Control and Prevention (CDC), an estimated 14% of adults in the United States have either been diagnosed with osteoarthritis (OA) or have symptoms suggestive of the disease. The CDC also points out that the ... ...

    Abstract According to the US Centers for Disease Control and Prevention (CDC), an estimated 14% of adults in the United States have either been diagnosed with osteoarthritis (OA) or have symptoms suggestive of the disease. The CDC also points out that the incidence of OA has been gradually increasing over the past 30 years. What is more worrisome is that this trend is going to accelerate due to the aging demographics of the United States and the increasing prevalence of obesity seen in the country. The need for better preventive treatments and efficacious therapeutics are direly needed to combat this public health crisis. Among the possible treatments being hypothesized, antioxidant supplementation has become one of the most widely studied over the past decade due to its ability to attenuate reactive oxygen species (ROS) formation within chondrocytes, a critical step in the pathogenesis of this disease. Vitamin C has emerged as among the most promising of the antioxidant group, with many animal and human studies having been conducted in recent years. Although many of the studies have shown encouraging results in terms of preventing OA, others have reached opposite conclusions, thus making the data controversial. However, after reviewing several of these studies, we hypothesize that certain parameters may not have been properly considered during data collection. In the end, more randomized placebo-controlled trials in humans are desperately needed in order to fully understand whether vitamin C therapy is efficacious in treating and/or preventing OA.
    Language English
    Publishing date 2021-10-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2554816-5
    ISSN 2040-6231 ; 2040-6223
    ISSN (online) 2040-6231
    ISSN 2040-6223
    DOI 10.1177/20406223211047026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Alteration in Nasopharyngeal Microbiota Profile in Aged Patients with COVID-19.

    Kolhe, Ravindra / Sahajpal, Nikhil Shri / Vyavahare, Sagar / Dhanani, Akhilesh S / Adusumilli, Satish / Ananth, Sudha / Mondal, Ashis K / Patterson, G Taylor / Kumar, Sandeep / Rojiani, Amyn M / Isales, Carlos M / Fulzele, Sadanand

    Diagnostics (Basel, Switzerland)

    2021  Volume 11, Issue 9

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) is an infectious virus that causes coronavirus disease 2019 (COVID-19) transmitted mainly through droplets and aerosol affecting the respiratory tract and lungs. Little is known regarding why ... ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) is an infectious virus that causes coronavirus disease 2019 (COVID-19) transmitted mainly through droplets and aerosol affecting the respiratory tract and lungs. Little is known regarding why some individuals are more susceptible than others and develop severe symptoms. In this study, we analyzed the nasopharyngeal microbiota profile of aged patients with COVID-19 (asymptomatic vs. symptomatic) vs. healthy individuals. We examined the nasopharynx swab of 84 aged-matched patients, out of which 27 were negative asymptomatic (NegA), 30 were positive asymptomatic (PA), and 27 patients were positive symptomatic (PSY). Our analysis revealed the presence of abundant Cyanobacterial taxa at phylum level in PA (
    Language English
    Publishing date 2021-09-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics11091622
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A Tryptophan-Deficient Diet Induces Gut Microbiota Dysbiosis and Increases Systemic Inflammation in Aged Mice.

    Yusufu, Ibrahim / Ding, Kehong / Smith, Kathryn / Wankhade, Umesh D / Sahay, Bikash / Patterson, G Taylor / Pacholczyk, Rafal / Adusumilli, Satish / Hamrick, Mark W / Hill, William D / Isales, Carlos M / Fulzele, Sadanand

    International journal of molecular sciences

    2021  Volume 22, Issue 9

    Abstract: The gut microflora is a vital component of the gastrointestinal (GI) system that regulates local and systemic immunity, inflammatory response, the digestive system, and overall health. Older people commonly suffer from inadequate nutrition or poor diets, ...

    Abstract The gut microflora is a vital component of the gastrointestinal (GI) system that regulates local and systemic immunity, inflammatory response, the digestive system, and overall health. Older people commonly suffer from inadequate nutrition or poor diets, which could potentially alter the gut microbiota. The essential amino acid (AA) tryptophan (TRP) is a vital diet component that plays a critical role in physiological stress responses, neuropsychiatric health, oxidative systems, inflammatory responses, and GI health. The present study investigates the relationship between varied TRP diets, the gut microbiome, and inflammatory responses in an aged mouse model. We fed aged mice either a TRP-deficient (0.1%), TRP-recommended (0.2%), or high-TRP (1.25%) diet for eight weeks and observed changes in the gut bacterial environment and the inflammatory responses via cytokine analysis (IL-1a, IL-6, IL-17A, and IL-27). The mice on the TRP-deficient diets showed changes in their bacterial abundance of Coriobacteriia class,
    MeSH term(s) Aging/blood ; Aging/pathology ; Animals ; Bacteria/classification ; Biodiversity ; Cytokines/blood ; Diet ; Feces/microbiology ; Gastrointestinal Microbiome ; Inflammation/blood ; Inflammation/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Phylogeny ; Tryptophan/deficiency
    Chemical Substances Cytokines ; Tryptophan (8DUH1N11BX)
    Language English
    Publishing date 2021-05-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22095005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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