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  1. Article ; Online: Symbiotic Beams: Using Non-microscopy Electron Sources to Bring LPTEM's Puzzles into Better Focus.

    Gibson, Wyeth / Mulvey, Justin / Patterson, Joe

    Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada

    2023  Volume 29, Issue Supplement_1, Page(s) 1491–1492

    Language English
    Publishing date 2023-08-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1385710-1
    ISSN 1435-8115 ; 1431-9276
    ISSN (online) 1435-8115
    ISSN 1431-9276
    DOI 10.1093/micmic/ozad067.766
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Physical and chemical stability of esomeprazole sodium solutions.

    Kupiec, Thomas C / Aloumanis, Vasileios / Ben, Michel / Trissel, Lawrence A / Chan, Pak / Patterson, Joe

    The Annals of pharmacotherapy

    2008  Volume 42, Issue 9, Page(s) 1247–1251

    Abstract: Background: Esomeprazole sodium (Nexium IV, AstraZeneca) is the S-isomer of omeprazole and acts as a proton pump inhibitor gastric antisecretory agent indicated for the short-term treatment of gastroesophageal reflux disease in patients with a history ... ...

    Abstract Background: Esomeprazole sodium (Nexium IV, AstraZeneca) is the S-isomer of omeprazole and acts as a proton pump inhibitor gastric antisecretory agent indicated for the short-term treatment of gastroesophageal reflux disease in patients with a history of erosive esophagitis. Currently, there is no information on the long-term stability of esomeprazole sodium in infusion solutions beyond 12 hours.
    Objective: To evaluate the stability of esomeprazole sodium in 5% dextrose, 0.9% sodium chloride, and lactated Ringer's injection, at 2 concentrations, at room temperature and when refrigerated.
    Methods: Triplicate samples of esomeprazole 0.4 and 0.8 mg/mL as the sodium salt were prepared in the solutions required. Stability evaluations were performed initially, over 2 days stored at 23 degrees C, and over 5 days stored at 4 degrees C. Physical stability was assessed using turbidimetric and particulate measurement, as well as visual observation. Chemical stability was evaluated by stability-indicating high-performance liquid chromatography.
    Results: The samples in all 3 infusion solutions were physically stable throughout the study. None of the samples had evidence of visible haze or particulates. Most samples developed a slight yellow discoloration within 24 hours, but this discoloration was not accompanied by an excessive loss of drug content. The esomeprazole sodium samples in all 3 infusion solutions exhibited less than 7% loss over 2 days at 23 degrees C and over 5 days at 4 degrees C.
    Conclusions: Esomeprazole 0.4 and 0.8 mg/mL as the sodium salt in the infusion solutions tested is chemically and physically stable for at least 2 days at room temperature and 5 days under refrigeration.
    MeSH term(s) Anti-Ulcer Agents/chemistry ; Drug Stability ; Drug Storage ; Esomeprazole/chemistry ; Glucose/chemistry ; Humans ; Isotonic Solutions/chemistry ; Omeprazole/chemistry ; Polyvinyl Chloride/chemistry ; Sodium Chloride/chemistry ; Solutions/chemistry ; Time Factors
    Chemical Substances Anti-Ulcer Agents ; Isotonic Solutions ; Solutions ; Sodium Chloride (451W47IQ8X) ; Ringer's lactate (8022-63-7) ; Polyvinyl Chloride (9002-86-2) ; Glucose (IY9XDZ35W2) ; Omeprazole (KG60484QX9) ; Esomeprazole (N3PA6559FT)
    Language English
    Publishing date 2008-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1101370-9
    ISSN 1542-6270 ; 1060-0280
    ISSN (online) 1542-6270
    ISSN 1060-0280
    DOI 10.1345/aph.1L079
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 900: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Staphylococcus aureus TargetArray: comprehensive differential essential gene expression as a mechanistic tool to profile antibacterials.

    Xu, H Howard / Trawick, John D / Haselbeck, Robert J / Forsyth, R Allyn / Yamamoto, Robert T / Archer, Rich / Patterson, Joe / Allen, Molly / Froelich, Jamie M / Taylor, Ian / Nakaji, Danny / Maile, Randy / Kedar, G C / Pilcher, Marshall / Brown-Driver, Vickie / McCarthy, Melissa / Files, Amy / Robbins, David / King, Paula /
    Sillaots, Susan / Malone, Cheryl / Zamudio, Carlos S / Roemer, Terry / Wang, Liangsu / Youngman, Philip J / Wall, Daniel

    Antimicrobial agents and chemotherapy

    2010  Volume 54, Issue 9, Page(s) 3659–3670

    Abstract: The widespread emergence of antibiotic-resistant bacteria and a lack of new pharmaceutical development have catalyzed a need for new and innovative approaches for antibiotic drug discovery. One bottleneck in antibiotic discovery is the lack of a rapid ... ...

    Abstract The widespread emergence of antibiotic-resistant bacteria and a lack of new pharmaceutical development have catalyzed a need for new and innovative approaches for antibiotic drug discovery. One bottleneck in antibiotic discovery is the lack of a rapid and comprehensive method to identify compound mode of action (MOA). Since a hallmark of antibiotic action is as an inhibitor of essential cellular targets and processes, we identify a set of 308 essential genes in the clinically important pathogen Staphylococcus aureus. A total of 446 strains differentially expressing these genes were constructed in a comprehensive platform of sensitized and resistant strains. A subset of strains allows either target underexpression or target overexpression by heterologous promoter replacements with a suite of tetracycline-regulatable promoters. A further subset of 236 antisense RNA-expressing clones allows knockdown expression of cognate targets. Knockdown expression confers selective antibiotic hypersensitivity, while target overexpression confers resistance. The antisense strains were configured into a TargetArray in which pools of sensitized strains were challenged in fitness tests. A rapid detection method measures strain responses toward antibiotics. The TargetArray antibiotic fitness test results show mechanistically informative biological fingerprints that allow MOA elucidation.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Gene Expression Regulation, Bacterial/drug effects ; Gene Expression Regulation, Bacterial/genetics ; Genes, Essential/genetics ; RNA, Antisense/genetics ; Staphylococcus aureus/drug effects ; Staphylococcus aureus/genetics
    Chemical Substances Anti-Bacterial Agents ; RNA, Antisense
    Language English
    Publishing date 2010-06-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.00308-10
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 809: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Einzelsignatur: Show issues

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