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Article: Despite Distractions, Legislators Look to Address Opioid Crisis.

Patterson, Jonathan

2019 Volume 115, Issue 6, Page(s) 499–500

MeSH term(s)	Analgesics, Opioid/therapeutic use ; Drug Overdose/epidemiology ; Drug Overdose/mortality ; Drug Overdose/prevention & control ; Humans ; Legislation, Drug ; Missouri ; Opioid-Related Disorders/epidemiology ; Opioid-Related Disorders/prevention & control ; Pain/drug therapy ; Prescription Drug Monitoring Programs/legislation & jurisprudence ; State Government
Chemical Substances	Analgesics, Opioid
Language	English
Publishing date	2019-01-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	427362-x
ISSN	0026-6620
ISSN	0026-6620
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Stay Out of the Emergency Room - Or Else.

Patterson, Jonathan

Missouri medicine

2018 Volume 114, Issue 6, Page(s) 410

MeSH term(s)	Delivery of Health Care/economics ; Emergency Service, Hospital/economics ; Emergency Service, Hospital/statistics & numerical data ; Health Resources/economics ; Health Resources/statistics & numerical data ; Humans ; Insurance Coverage/economics ; Insurance Coverage/statistics & numerical data ; Missouri
Language	English
Publishing date	2018-09-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	427362-x
ISSN	0026-6620
ISSN	0026-6620
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Article ; Online: The Influence of Baseline Hemoglobin A1c on Digital Health Coaching Outcomes in Adults With Type 2 Diabetes: Real-World Retrospective Cohort Study.

Martin, Megan / Patterson, Jonathan / Allison, Matt / O'Connor, Blakely B / Patel, Dhiren

JMIR diabetes

2021 Volume 6, Issue 2, Page(s) e24981

Abstract: Background: Digital health coaching is an increasingly common diabetes self-management support strategy for individuals with type 2 diabetes and has been linked to positive mental and physical health outcomes. However, the relationship between baseline ... ...

Abstract	Background: Digital health coaching is an increasingly common diabetes self-management support strategy for individuals with type 2 diabetes and has been linked to positive mental and physical health outcomes. However, the relationship between baseline risk and outcomes is yet to be evaluated in a real-world setting. Objective: The purpose of this real-world study was to evaluate trends in digital health coaching outcomes by baseline hemoglobin A Methods: A retrospective cohort study design was used to evaluate program effect in a convenience sample of participants in a 12-week digital health coaching program administered by Pack Health. Participants were referred through their health care provider, payer, or employer. The program included patient-centered lifestyle counseling and psychosocial support delivered via telephone, text, and/or email. Self-reported HbA Results: Participants with complete HbA Conclusions: Acknowledging the limitations in this real-world study design, the results reported here suggest that adults with type 2 diabetes with a high baseline HbA
Language	English
Publishing date	2021-06-16
Publishing country	Canada
Document type	Journal Article
ISSN	2371-4379
ISSN (online)	2371-4379
DOI	10.2196/24981
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Article ; Online: Thérèse Raquin by Emile Zola: surgical method in psychiatry - reflection.

Rogers, Jonathan P / Patterson, Jonathan

The British journal of psychiatry : the journal of mental science

2015 Volume 207, Issue 1, Page(s) 36

MeSH term(s)	Famous Persons ; Humans ; Medicine in Literature ; Psychiatry
Language	English
Publishing date	2015-07
Publishing country	England
Document type	Journal Article
ZDB-ID	218103-4
ISSN	1472-1465 ; 0007-1250
ISSN (online)	1472-1465
ISSN	0007-1250
DOI	10.1192/bjp.bp.114.157982
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Article ; Online: Perspectives on life following a traumatic spinal cord injury.

Hall, Allyson G / Karabukayeva, Aizhan / Rainey, Carmen / Kelly, Reena J / Patterson, Jonathan / Wade, Jamie / Feldman, Sue S

Disability and health journal

2021 Volume 14, Issue 3, Page(s) 101067

Abstract: Background: Persons living with traumatic Spinal Cord Injury (SCI) face challenges when returning to their communities. The Spain Rehabilitation Center at the University of Alabama at Birmingham is developing a continuum of care for SCI patients. The ... ...

Abstract	Background: Persons living with traumatic Spinal Cord Injury (SCI) face challenges when returning to their communities. The Spain Rehabilitation Center at the University of Alabama at Birmingham is developing a continuum of care for SCI patients. The perspectives of individuals with SCI are critical to designing a person-centered approach to the continuum. Objective: This study sought to explore the lived experiences of individuals with SCI after their injury, as well as obtain the perspectives of therapists working with SCI patients. Methods: Ten persons ranging in age from 23 to 65 years old and living with SCI were recruited to participate in in-depth interviews. We utilized a grounded theory approach to develop descriptive codes and themes. Results: Our analysis highlighted domains that are critical to the lives of individuals with SCI including: planning for life after SCI, intrinsic motivation, environmental barriers, financial barriers, role of family, friends, and social networks, and relationships with medical providers. A key theme was the need for more information about how to manage their health condition, including the development of plans that are tailored to their specific needs. Conclusions: Individuals with an SCI need access to a continuum of care that addresses both medical and social needs.
MeSH term(s)	Adult ; Aged ; Disabled Persons ; Grounded Theory ; Humans ; Middle Aged ; Qualitative Research ; Rehabilitation Centers ; Spinal Cord Injuries ; Young Adult
Language	English
Publishing date	2021-03-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2414615-8
ISSN	1876-7583 ; 1936-6574
ISSN (online)	1876-7583
ISSN	1936-6574
DOI	10.1016/j.dhjo.2021.101067
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Book ; Online: Insights from individuals with chronic conditions in the context of COVID-19

Burton, B. Stephen / Patterson, Jonathan / Robinson, Mackenzie / Patel, Dhiren / Allison, Matt / Brassil, Kelly J

Patient Experience Journal

2020

Abstract: The objective of this prospective survey series was to evaluate knowledge and concerns related to the COVID-19 pandemic among individuals with one or more chronic conditions, including cardiometabolic, autoimmune, respiratory and cancer diagnoses. Two ... ...

Abstract	The objective of this prospective survey series was to evaluate knowledge and concerns related to the COVID-19 pandemic among individuals with one or more chronic conditions, including cardiometabolic, autoimmune, respiratory and cancer diagnoses. Two surveys were distributed consisting of up to 55 items (March; n=1069) and up to 71 items (April, n=1126), with 24 items repeated from the first survey. Questions focused on healthcare access, barriers and concerns related to the COVID-19 virus. Descriptive analysis evaluated central tendencies, spread, and frequencies of the demographic data, disease states, and survey results within and between the two survey timepoints. Results from 416 individuals (38.9%) on survey 1 and 425 (37.7%) on survey 2 were analyzed. Participants were predominantly female (85%) and white (67%) with 7% residing in rural areas and 69% employed. Respondents reported an average of 2 chronic conditions and 62% would be classified as “at risk” for COVID-19 complications by the CDC. Only 20% reported a conversation about COVID-19 with a healthcare provider, 9% reported anxiety, 35% indicated loneliness. Level of concern about COVID-19 contracting the disease, cost of treatment/complications, medical access, and process of being treated was associated with increased anxiety (p<0.001) and wearing a facemask (p=0.01). Analysis suggests that analyzing concern and its association with health behaviors and anxiety should be a priority for innovative solutions. Insights into how the COVID-19 pandemic is impacting individuals with chronic conditions are imperative to inform tailored interventions to support individuals at higher risk of serious complications and death. Experience Framework This article is associated with the Patient, Family & Community Engagement lens of The Beryl Institute Experience Framework. (http://bit.ly/ExperienceFramework) Access other PXJ articles related to this lens. Access other resources related to this lens.
Keywords	COVID-19 ; coronavirus ; patient insights ; chronic conditions ; healthcare access ; Perceptions ; Integrated Nature ; Person-Centeredness ; Patient and Family Partnership (and Engagement) ; Cardiovascular Diseases ; Immune System Diseases ; Medicine and Health Sciences ; Mental and Social Health ; Nutritional and Metabolic Diseases ; Respiratory Tract Diseases ; Virus Diseases ; covid19
Subject code	360
Publishing date	2020-08-05T02:50:28Z
Publisher	Patient Experience Journal
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evaluation of the effects of repeated disinfection on medical exam gloves: Part 2. Changes in mechanical properties.

Phalen, Robert N / Patterson, Jonathan / Cuadros Olave, John / Mansfield, Samuel A / Shless, Jared S / Crider, Yoshika S / Pitchik, Helen O / Qazi, Alliya S / Styczynski, Ashley / LeMesurier, Roger / Haik, Daniel / Kwong, Laura H / LeBoa, Christopher / Bhattacharya, Arnab / Hamidi, Youssef K

Journal of occupational and environmental hygiene

2022 Volume 19, Issue 2, Page(s) 111–121

Abstract: Many healthcare professionals have been forced, under acute shortages, to extend medical exam gloves beyond their intended single use. Despite limited available literature, the CDC proposed a set of guidelines for repeated exam gloves use, indicating a ... ...

Abstract	Many healthcare professionals have been forced, under acute shortages, to extend medical exam gloves beyond their intended single use. Despite limited available literature, the CDC proposed a set of guidelines for repeated exam gloves use, indicating a maximum number of treatments for three widely available disinfectants. This study examines how these treatments affect the mechanical properties of latex and nitrile gloves. Furthermore, an acceptability threshold is proposed for changes in tensile property, specifically elastic modulus, as an indication of degradation. This proposed criterion was also applied to similar studies available in the literature to determine applicability and aid in recommendation development. Three different latex glove brands and three nitrile brands were exposed to repeated treatments of an alcohol-based hand rub, diluted bleach, or soap and water. Tensile tests of samples cut from untreated and treated gloves were performed to assess the change in elastic modulus induced by each treatment. The findings suggest that latex gloves performed well within the CDC recommended guidelines of six repeated treatments for an ethanol-based hand rub and 10 repeated treatments of either dilute bleach or soap and water. Nitrile exam gloves, on the other hand, showed significant changes in elastic modulus, with more inconclusive results among brands. This was especially true for treatment with dilute bleach and soap and water. Further research is needed to investigate the effects of disinfection products on the mechanical integrity of nitrile exam gloves. The results support the use of five repeated treatments of ethanol-based hand rub for nitrile exam gloves, a lower threshold than currently recommended by the CDC. This research also supports that the CDC recommendation of 10 repeated treatment with soap and water is appropriate for latex exam gloves, but not for nitrile exam gloves. Occupational safety and health professionals involved in the selection of disposable exam gloves for infection control should consider the compatibility of the glove polymer type with available disinfectants, especially if extended use with repeated disinfection becomes necessary.
MeSH term(s)	2-Propanol ; Disinfectants ; Disinfection ; Gloves, Protective ; Latex
Chemical Substances	Disinfectants ; Latex ; 2-Propanol (ND2M416302)
Language	English
Publishing date	2022-01-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2131820-7
ISSN	1545-9632 ; 1545-9624
ISSN (online)	1545-9632
ISSN	1545-9624
DOI	10.1080/15459624.2021.2015073
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Article ; Online: Impact of ketamine as an adjunct sedative in acute respiratory distress syndrome due to COVID-19 Pneumonia.

Garner, Orlando / Patterson, Jonathan / Mejia, Julieta Muñoz / Anand, Vijay / Deleija, Juan / Nemeh, Christopher / Vallabh, Meghna / Staggers, Kristen A / Howard, Christopher M / Treviño, Sergio Enrique / Siddique, Muhammad Asim / Morgan, Christopher K

Respiratory medicine

2021 Volume 189, Page(s) 106667

Abstract: Purpose: Deep sedation is sometimes needed in acute respiratory distress syndrome. Ketamine is a sedative that has been shown to have analgesic and sedating properties without having a detrimental impact on hemodynamics. This pharmacological profile ... ...

Abstract	Purpose: Deep sedation is sometimes needed in acute respiratory distress syndrome. Ketamine is a sedative that has been shown to have analgesic and sedating properties without having a detrimental impact on hemodynamics. This pharmacological profile makes ketamine an attractive sedative, potentially reducing the necessity for other sedatives and vasopressors, but there are no studies evaluating its effect on these medications in patients requiring deep sedation for acute respiratory distress syndrome. Materials and methods: This is a retrospective, observational study in a single center, quaternary care hospital in southeast Texas. We looked at adults with COVID-19 requiring mechanical ventilation from March 2020 to September 2020. Results: We found that patients had less propofol requirements at 72 h after ketamine initiation when compared to 24 h (median 34.2 vs 54.7 mg/kg, p = 0.003). Norepinephrine equivalents were also significantly lower at 48 h than 24 h after ketamine initiation (median 38 vs 62.8 mcg/kg, p = 0.028). There was an increase in hydromorphone infusion rates at all three time points after ketamine was introduced. Conclusions: In this cohort of patients with COVID-19 ARDS who required mechanical ventilation receiving ketamine we found propofol sparing effects and vasopressor requirements were reduced, while opioid infusions were not.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Analgesics, Opioid/therapeutic use ; COVID-19/epidemiology ; COVID-19/therapy ; Deep Sedation ; Drug Utilization/statistics & numerical data ; Female ; Humans ; Hydromorphone/therapeutic use ; Hypnotics and Sedatives/administration & dosage ; Ketamine/administration & dosage ; Male ; Middle Aged ; Norepinephrine/therapeutic use ; Propofol/therapeutic use ; Respiration, Artificial ; Respiratory Distress Syndrome/epidemiology ; Respiratory Distress Syndrome/therapy ; Retrospective Studies ; Texas/epidemiology
Chemical Substances	Analgesics, Opioid ; Hypnotics and Sedatives ; Ketamine (690G0D6V8H) ; Hydromorphone (Q812464R06) ; Norepinephrine (X4W3ENH1CV) ; Propofol (YI7VU623SF)
Language	English
Publishing date	2021-10-28
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	1003348-8
ISSN	1532-3064 ; 0954-6111
ISSN (online)	1532-3064
ISSN	0954-6111
DOI	10.1016/j.rmed.2021.106667
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Article: All-trans retinoic acid induces durable tumor immunity in IDH-mutant gliomas by rescuing transcriptional repression of the CRBP1-retinoic acid axis.

Rao, Aparna / Zhang, Xiaoran / Cillo, Anthony R / Sussman, Jonathan H / Sandlesh, Poorva / Tarbay, Antonio Corral / Mallela, Arka N / Cardello, Carly / Krueger, Katharine / Xu, Jessica / Li, Alex / Xu, Jason / Patterson, Jonathan / Akca, Ebrar / Angione, Angelo / Jaman, Emade / Kim, Wi Jin / Allen, Jordan / Venketeswaran, Abhishek /

Zinn, Pascal O / Parise, Robert / Beumer, Jan / Duensing, Anette / Holland, Eric C / Ferris, Robert / Bagley, Stephen J / Bruno, Tullia C / Vignali, Dario A A / Agnihotri, Sameer / Amankulor, Nduka M

bioRxiv : the preprint server for biology

2024

Abstract: Diffuse gliomas are epigenetically dysregulated, immunologically cold, and fatal tumors characterized by mutations in isocitrate dehydrogenase (IDH). Although IDH mutations yield a uniquely immunosuppressive tumor microenvironment, the regulatory ... ...

Abstract	Diffuse gliomas are epigenetically dysregulated, immunologically cold, and fatal tumors characterized by mutations in isocitrate dehydrogenase (IDH). Although IDH mutations yield a uniquely immunosuppressive tumor microenvironment, the regulatory mechanisms that drive the immune landscape of IDH mutant (IDHm) gliomas remain unknown. Here, we reveal that transcriptional repression of retinoic acid (RA) pathway signaling impairs both innate and adaptive immune surveillance in IDHm glioma through epigenetic silencing of retinol binding protein 1 (RBP1) and induces a profound anti-inflammatory landscape marked by loss of inflammatory cell states and infiltration of suppressive myeloid phenotypes. Restorative retinoic acid therapy in murine glioma models promotes clonal CD4
Language	English
Publishing date	2024-04-13
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.04.09.588752
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Article ; Online: Primary chondrosarcoma of the breast: report of a case and review of the literature.

Patterson, Jonathan D / Wilson, Jonathan E / Dim, Daniel / Talboy, Glenn E

Breast disease

2011 Volume 33, Issue 4, Page(s) 189–191

Abstract: Sarcomas of the breast are rare, comprising 1% of all breast tumors. Primary chondrosarcomas of the breast account for an extremely rare subset of such tumors, with few reports in the literature. We report the case of a 52 year-old woman with a primary ... ...

Abstract	Sarcomas of the breast are rare, comprising 1% of all breast tumors. Primary chondrosarcomas of the breast account for an extremely rare subset of such tumors, with few reports in the literature. We report the case of a 52 year-old woman with a primary chondrosarcoma of the breast and review the current literature.
MeSH term(s)	Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Chondrosarcoma/pathology ; Chondrosarcoma/surgery ; Female ; Humans ; Middle Aged
Language	English
Publishing date	2011
Publishing country	Netherlands
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	639267-2
ISSN	1558-1551 ; 0888-6008
ISSN (online)	1558-1551
ISSN	0888-6008
DOI	10.3233/BD-2009-0303
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