Article ; Online: Conditional Astrocyte Rac1KO Attenuates Hyperreflexia after Spinal Cord Injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience
2024 Volume 44, Issue 1
Abstract: Spasticity is a hyperexcitability disorder that adversely impacts functional recovery and rehabilitative efforts after spinal cord injury (SCI). The loss of evoked rate-dependent depression (RDD) of the monosynaptic H-reflex is indicative of ... ...
Abstract | Spasticity is a hyperexcitability disorder that adversely impacts functional recovery and rehabilitative efforts after spinal cord injury (SCI). The loss of evoked rate-dependent depression (RDD) of the monosynaptic H-reflex is indicative of hyperreflexia, a physiological sign of spasticity. Given the intimate relationship between astrocytes and neurons, that is, the tripartite synapse, we hypothesized that astrocytes might have a significant role in post-injury hyperreflexia and plasticity of neighboring neuronal synaptic dendritic spines. Here, we investigated the effect of selective Rac1KO in astrocytes (i.e., adult male and female mice, transgenic cre-flox system) on SCI-induced spasticity. Three weeks after a mild contusion SCI, control Rac1 |
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MeSH term(s) | Mice ; Male ; Female ; Animals ; Reflex, Abnormal ; Astrocytes/metabolism ; Spinal Cord Injuries ; Motor Neurons/physiology ; Spinal Cord/metabolism ; Animals, Genetically Modified ; H-Reflex ; Amino Acid Transport System X-AG/metabolism |
Chemical Substances | Amino Acid Transport System X-AG |
Language | English |
Publishing date | 2024-01-03 |
Publishing country | United States |
Document type | Journal Article |
ZDB-ID | 604637-x |
ISSN | 1529-2401 ; 0270-6474 |
ISSN (online) | 1529-2401 |
ISSN | 0270-6474 |
DOI | 10.1523/JNEUROSCI.1670-22.2023 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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