Article ; Online: Rapid-dissolving electrospun nanofibers for intra-vaginal antibiotic or probiotic delivery.
2023 Volume 190, Page(s) 81–93
Abstract: The emergence of probiotics as an alternative and adjunct to antibiotic treatment for microbiological disturbances of the female genitourinary system requires innovative delivery platforms for vaginal applications. This study developed a new, rapid- ... ...
| Abstract | The emergence of probiotics as an alternative and adjunct to antibiotic treatment for microbiological disturbances of the female genitourinary system requires innovative delivery platforms for vaginal applications. This study developed a new, rapid-dissolving form using electrospun polyethylene oxide (PEO) fibers for delivery of antibiotic metronidazole or probiotic Lactobacillus acidophilus, and performed evaluation in vitro and in vivo. Fibers did not generate overt pathophysiology or encourage Gardnerella growth in a mouse vaginal colonization model, inducing no alterations in vaginal mucosa at 24 hr post-administration. PEO-fibers incorporating metronidazole (100 µg MET/mg polymer) effectively prevented and treated Gardnerella infections (∼3- and 2.5-log reduction, respectively, 24 hr post treatment) when administered vaginally. Incorporation of live Lactobacillus acidophilus (10 |
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| MeSH term(s) | Female ; Animals ; Mice ; Anti-Bacterial Agents/therapeutic use ; Metronidazole ; Nanofibers ; Treatment Outcome ; Lactobacillus acidophilus/physiology ; Probiotics | |||||
| Chemical Substances | Anti-Bacterial Agents ; Metronidazole (140QMO216E) | |||||
| Language | English | |||||
| Publishing date | 2023-07-19 | |||||
| Publishing country | Netherlands | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 1065368-5 | |||||
| ISSN | 1873-3441 ; 0939-6411 | |||||
| ISSN (online) | 1873-3441 | |||||
| ISSN | 0939-6411 | |||||
| DOI | 10.1016/j.ejpb.2023.07.009 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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