Article ; Online: A liposomal bupivacaine infiltrative block reduces rescue analgesia administration compared to a bupivacaine splash block after canine ovariohysterectomy in a teaching laboratory.
Journal of the American Veterinary Medical Association
2023 Volume 261, Issue 11, Page(s) 1673–1682
Abstract: Objective: This study aimed to determine whether an infiltrative block with liposomal bupivacaine was associated with less rescue analgesia administration and lower pain scores than a bupivacaine splash block after ovariohysterectomy in dogs.: Animals! ...
| Abstract | Objective: This study aimed to determine whether an infiltrative block with liposomal bupivacaine was associated with less rescue analgesia administration and lower pain scores than a bupivacaine splash block after ovariohysterectomy in dogs. Animals: Eligible dogs included those that were spayed as part of a veterinary teaching laboratory. Dogs were up to 7 years old and otherwise healthy. A total of 136 dogs were analyzed. Methods: All dogs underwent ovariohysterectomy performed by veterinary students. Dogs received hydromorphone and acepromazine premedication, propofol induction, isoflurane maintenance, and an NSAID. Dogs were randomly allocated to receive either a splash block with standard bupivacaine or an infiltrative block with liposomal bupivacaine for incisional analgesia. Postoperatively, all dogs were assessed by a blinded evaluator using the Colorado State University-Canine Acute Pain Scale (CSU-CAPS) and Glasgow Composite Measures Pain Scale-Short Form (GCPS-SF). Dogs received rescue analgesia with buprenorphine if they scored ≥ 2 on the CSU-CAPS scale. Results: Dogs that received liposomal bupivacaine had a significantly lower incidence of (P = .04) and longer time to (P = .03) administration of rescue analgesia. There was an overall time-averaged significant difference between groups for CSU-CAPS (P = .049) and GCPS-SF scores (P = .015), with dogs in the bupivacaine group being more likely to have an elevated pain score at some point for both scales. Clinical relevance: The use of liposomal bupivacaine in an infiltrative block may decrease the need for rescue analgesia in dogs undergoing ovariohysterectomy compared to a bupivacaine splash block. |
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| MeSH term(s) | Animals ; Dogs ; Female ; Analgesia/veterinary ; Anesthetics, Local/therapeutic use ; Bupivacaine/therapeutic use ; Dog Diseases/drug therapy ; Dog Diseases/prevention & control ; Hysterectomy/veterinary ; Ovariectomy/veterinary ; Pain, Postoperative/drug therapy ; Pain, Postoperative/prevention & control ; Pain, Postoperative/veterinary ; Random Allocation |
| Chemical Substances | Anesthetics, Local ; Bupivacaine (Y8335394RO) |
| Language | English |
| Publishing date | 2023-07-05 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 390811-2 |
| ISSN | 1943-569X ; 0003-1488 |
| ISSN (online) | 1943-569X |
| ISSN | 0003-1488 |
| DOI | 10.2460/javma.23.01.0057 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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