Article ; Online: Chemical Induction of Trophoblast Hypoxia by Cobalt Chloride Leads to Increased Expression of DDIT3.
Doklady. Biochemistry and biophysics
2021 Volume 499, Issue 1, Page(s) 251–256
Abstract: Choriocarcinoma cells BeWo b30 are used to model human placental trophoblast hypoxia using cobalt (II) chloride and hydroxyquinoline derivative (HD) as chemical inducers of hypoxia-inducible factor (HIF). In this study, it was shown that both substances ... ...
| Abstract | Choriocarcinoma cells BeWo b30 are used to model human placental trophoblast hypoxia using cobalt (II) chloride and hydroxyquinoline derivative (HD) as chemical inducers of hypoxia-inducible factor (HIF). In this study, it was shown that both substances activate the hypoxic pathway and the epithelial-mesenchymal transition and inhibit the pathways of cell proliferation. However, CoCl |
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| MeSH term(s) | Caspase 3/metabolism ; Caspase 7/metabolism ; Cell Hypoxia/drug effects ; Cell Line, Tumor ; Cobalt/pharmacology ; Female ; Gene Expression Regulation/drug effects ; Humans ; Pregnancy ; Transcription Factor CHOP/metabolism ; Trophoblasts/cytology ; Trophoblasts/drug effects |
| Chemical Substances | DDIT3 protein, human ; Transcription Factor CHOP (147336-12-7) ; Cobalt (3G0H8C9362) ; Caspase 3 (EC 3.4.22.-) ; Caspase 7 (EC 3.4.22.-) ; cobaltous chloride (EVS87XF13W) |
| Language | English |
| Publishing date | 2021-08-23 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 2062390-2 |
| ISSN | 1608-3091 ; 1607-6729 |
| ISSN (online) | 1608-3091 |
| ISSN | 1607-6729 |
| DOI | 10.1134/S1607672921040104 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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