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Book ; Online: Cultes et sanctuaires de l'île de Cos

Paul, Stéphanie

(Kernos suppléments)

2013

Series title	Kernos suppléments
Keywords	Ancient history: to c 500 CE ; polythéisme grec ; île de Cos
Language	fra
Size	1 electronic resource (442 pages)
Publisher	Presses universitaires de Liège
Publishing place	Liège
Document type	Book ; Online
Note	French
HBZ-ID	HT030381239
ISBN	9782875620293 ; 2875620290
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Introduction from Stephanie Paul, Executive Director of myFace.

Paul, Stephanie

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

2022 Volume 59, Issue 4_suppl2, Page(s) S5–S6

Language	English
Publishing date	2022-01-31
Publishing country	United States
Document type	Letter
ZDB-ID	1069409-2
ISSN	1545-1569 ; 0009-8701 ; 1055-6656
ISSN (online)	1545-1569
ISSN	0009-8701 ; 1055-6656
DOI	10.1177/10556656221075394
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Article ; Online: Locoregional lung ventilation distribution in girls with adolescent idiopathic scoliosis and healthy adolescents. The immediate effect of Schroth 'derotational breathing' exercise in a controlled-trial.

David, Mercedes / Raison, Maxime / Paul, Stéphanie / Cartiaux, Olivier / Detrembleur, Christine / Mahaudens, Philippe

Physiotherapy theory and practice

2022 Volume 39, Issue 5, Page(s) 938–953

Abstract: Background: Scoliosis curves present transverse plane deviations due to vertebral rotation. The Schroth method supports thoracic derotation by training patients to exert "derotational" breathing based on assumed enhanced ventilation in areas called " ... ...

Abstract	Background: Scoliosis curves present transverse plane deviations due to vertebral rotation. The Schroth method supports thoracic derotation by training patients to exert "derotational" breathing based on assumed enhanced ventilation in areas called "humps" in scoliosis and a patient's ability to voluntarily direct ventilation in less ventilated areas called "flats." Objective: To assess the asymmetric ventilation distribution and the ability of patients to direct their ventilation to perform derotational breathing. Methods: Twelve girls with adolescent idiopathic scoliosis and 12 healthy girls performed 3 × 3 min of rest, maximal, and derotational breathing. Electrical impedance tomography was used to record locoregional lung ventilation distribution (LLVD) within 4 thoracic regions of interest: anterior right (ROI 1), anterior left (ROI 2), posterior right (ROI 3), and posterior left (ROI 4) quadrants. Humps and flats were the sums of ROI '2 + 3' and ROI '1 + 4,' respectively. Results: Overall, no difference in LLVD was observed in the flats and humps between groups. At rest, the LLVD in the humps was more elevated than that in the flats (51.5 ± 8.1% versus 43.6 ± 7.9%; p = .021) when considering both groups. Maximal and derotational breathing led to a more homogeneous LLVD between the humps and flats. Conclusion: The postulated derotational breathing effect was not confirmed.
MeSH term(s)	Adolescent ; Female ; Humans ; Kyphosis ; Lung ; Scoliosis/therapy ; Spine ; Tomography, X-Ray Computed
Language	English
Publishing date	2022-02-02
Publishing country	England
Document type	Controlled Clinical Trial ; Journal Article
ZDB-ID	1045333-7
ISSN	1532-5040 ; 0959-3985
ISSN (online)	1532-5040
ISSN	0959-3985
DOI	10.1080/09593985.2022.2033896
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Convergent Biocatalytic Mediated Synthesis of siRNA.

Paul, Stephanie / Gray, Darren / Caswell, Jill / Brooks, Joshua / Ye, Wenjie / Moody, Thomas S / Radinov, Roumen / Nechev, Lubomir

ACS chemical biology

2023 Volume 18, Issue 10, Page(s) 2183–2187

Abstract: New technologies are required to combat the challenges faced with manufacturing commercial quantities of oligonucleotide drug substances which are required for treating large patient populations. Herein we report a convergent biocatalytic synthesis ... ...

Abstract	New technologies are required to combat the challenges faced with manufacturing commercial quantities of oligonucleotide drug substances which are required for treating large patient populations. Herein we report a convergent biocatalytic synthesis strategy for an Alnylam model siRNA. The siRNA chemical structure includes several of the unnatural modifications and conjugations typical of siRNA drug substances. Using Almac's 3-2-3-2 hybrid RNA ligase enzyme strategy that sequentially ligates short oligonucleotide fragments (blockmers), the target siRNA was produced to high purity at 1 mM concentration. Additional strategies were investigated including the use of polynucleotide kinase phosphorylation and the use of crude blockmer starting materials without chromatographic purification. These findings highlight a path toward a convergent synthesis of siRNAs for large-scale manufacture marrying both enzymatic liquid and classical solid-phase synthesis.
MeSH term(s)	Humans ; RNA, Small Interfering/genetics ; Biocatalysis ; Oligonucleotides/chemistry ; Phosphorylation
Chemical Substances	RNA, Small Interfering ; Oligonucleotides
Language	English
Publishing date	2023-04-16
Publishing country	United States
Document type	Journal Article
ISSN	1554-8937
ISSN (online)	1554-8937
DOI	10.1021/acschembio.3c00071
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Thesis: Cultes et sanctuaires de l'île de Cos

Paul, Stéphanie

(Kernos : Supplément ; 28)

2013

Author's details	Stéphanie Paul
Series title	Kernos : Supplément ; 28
Language	French
Size	438 S., Ill., Kt, 24 cm
Publisher	Presses Univ. de Liège
Publishing place	Liège
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Univ., Diss.--Liege, 2011
Note	The series is a periodical
ISBN	9782875620293 ; 2875620290
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: T-bet

Rauch, Eileen / Amendt, Timm / Lopez Krol, Aleksandra / Lang, Fabian B / Linse, Vincent / Hohmann, Michelle / Keim, Ann-Christin / Kreutzer, Susanne / Kawengian, Kevin / Buchholz, Malte / Duschner, Philipp / Grauer, Saskia / Schnierle, Barbara / Ruhl, Andreas / Burtscher, Ingo / Dehnert, Sonja / Kuria, Chege / Kupke, Alexandra / Paul, Stephanie /

Liehr, Thomas / Lechner, Marcus / Schnare, Markus / Kaufmann, Andreas / Huber, Magdalena / Winkler, Thomas H / Bauer, Stefan / Yu, Philipp

Nature communications

2024 Volume 15, Issue 1, Page(s) 1229

Abstract: Endogenous retroviruses (ERVs) are an integral part of the mammalian genome. The role of immune control of ERVs in general is poorly defined as is their function as anti-cancer immune targets or drivers of autoimmune disease. Here, we generate mouse- ... ...

Abstract	Endogenous retroviruses (ERVs) are an integral part of the mammalian genome. The role of immune control of ERVs in general is poorly defined as is their function as anti-cancer immune targets or drivers of autoimmune disease. Here, we generate mouse-strains where Moloney-Murine Leukemia Virus tagged with GFP (ERV-GFP) infected the mouse germline. This enables us to analyze the role of genetic, epigenetic and cell intrinsic restriction factors in ERV activation and control. We identify an autoreactive B cell response against the neo-self/ERV antigen GFP as a key mechanism of ERV control. Hallmarks of this response are spontaneous ERV-GFP
MeSH term(s)	Animals ; Mice ; Autoimmune Diseases/genetics ; B-Lymphocytes/immunology ; Endogenous Retroviruses/genetics ; Mammals/genetics
Language	English
Publishing date	2024-02-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-45201-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Insight into determinants of substrate binding and transport in a multidrug efflux protein.

Alegre, Kamela O / Paul, Stephanie / Labarbuta, Paola / Law, Christopher J

Scientific reports

2016 Volume 6, Page(s) 22833

Abstract: Multidrug resistance arising from the activity of integral membrane transporter proteins presents a global public health threat. In bacteria such as Escherichia coli, transporter proteins belonging to the major facilitator superfamily make a considerable ...

Abstract	Multidrug resistance arising from the activity of integral membrane transporter proteins presents a global public health threat. In bacteria such as Escherichia coli, transporter proteins belonging to the major facilitator superfamily make a considerable contribution to multidrug resistance by catalysing efflux of myriad structurally and chemically different antimicrobial compounds. Despite their clinical relevance, questions pertaining to mechanistic details of how these promiscuous proteins function remain outstanding, and the role(s) played by individual amino acid residues in recognition, binding and subsequent transport of different antimicrobial substrates by multidrug efflux members of the major facilitator superfamily requires illumination. Using in silico homology modelling, molecular docking and mutagenesis studies in combination with substrate binding and transport assays, we identified several amino acid residues that play important roles in antimicrobial substrate recognition, binding and transport by Escherichia coli MdtM, a representative multidrug efflux protein of the major facilitator superfamily. Furthermore, our studies suggested that 'aromatic clamps' formed by tyrosine and phenylalanine residues located within the substrate binding pocket of MdtM may be important for antimicrobial substrate recognition and transport by the protein. Such 'clamps' may be a structurally and functionally important feature of all major facilitator multidrug efflux proteins.
MeSH term(s)	Amino Acids/chemistry ; Anti-Bacterial Agents/chemistry ; Antiporters/chemistry ; Antiporters/genetics ; Antiporters/metabolism ; Biological Transport ; Chloramphenicol/chemistry ; Computer Simulation ; Drug Resistance, Multiple, Bacterial ; Escherichia coli/drug effects ; Escherichia coli/metabolism ; Escherichia coli Proteins/chemistry ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/metabolism ; Molecular Docking Simulation ; Mutagenesis, Site-Directed ; Mutation ; Onium Compounds/chemistry ; Organophosphorus Compounds/chemistry ; Protein Binding ; Protein Conformation
Chemical Substances	Amino Acids ; Anti-Bacterial Agents ; Antiporters ; Escherichia coli Proteins ; MdtM protein, E coli ; Onium Compounds ; Organophosphorus Compounds ; Chloramphenicol (66974FR9Q1) ; tetraphenylphosphonium (U9IF5Y5IND)
Language	English
Publishing date	2016-03-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/srep22833
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Disturbed cofactor binding by a novel mutation in UDP-galactose 4′-epimerase results in a type III galactosemia phenotype at birth

Paul, Stephanie / McCorvie, Thomas J / Zschocke, Johannes / Timson, David J

RSC advances. 2016 Feb. 10, v. 6, no. 21

2016

Abstract: UDP-galactose 4′-epimerase (GALE) is an essential enzyme in galactose metabolism and its dysfunction results in type III galactosemia. Herein we report a patient born with abnormal blood galactose levels and reduced GALE activity who was shown to be ... ...

Abstract	UDP-galactose 4′-epimerase (GALE) is an essential enzyme in galactose metabolism and its dysfunction results in type III galactosemia. Herein we report a patient born with abnormal blood galactose levels and reduced GALE activity who was shown to be heterozygous for a c.266C>T missense mutation in the GALE gene, predicted to result in the amino acid exchange p.A89V. Over a period of months, the patient's blood galactose, galactose 1-phosphate and GALE activity levels reverted to normal, encouraging us to investigate this mutation. Structurally Ala89 is a highly conserved residue located close to the binding site of the cofactor, NAD+. Consequentially molecular modelling predicted that this mutation results in steric clashes between the cofactor and valine side chain, and bioinformatic predictions suggested that p.A89V is likely to be less stable than the wild-type. Biochemical studies on the recombinant p.A89V enzyme demonstrated lower activity than the wild type (Km increased by approximately 30-fold; kcat reduced approximately 180-fold), and additionally changes in stability and altered NAD+ binding were observed. Thus, a picture emerges in which this mutation leads to reduced stability, disturbed cofactor binding and subsequently reduced activity. Overall this study suggests that bioinformatics predictions are useful in assessing the effects of newly discovered mutations on enzyme function, but care should be taken in extending predictions to the clinical phenotype especially in cases of heterozygosity. It also raises interesting questions about a dominant negative effect of some GALE missense alleles and potential compensatory mechanisms occurring in people born with clinical chemistry measurements suggesting a diagnosis of galactosemia.
Keywords	alleles ; binding sites ; bioinformatics ; blood ; enzymes ; galactose ; galactosemia ; heterozygosity ; metabolism ; missense mutation ; patients ; phenotype ; prediction ; valine
Language	English
Dates of publication	2016-0210
Size	p. 17297-17301.
Publishing place	The Royal Society of Chemistry
Document type	Article
ISSN	2046-2069
DOI	10.1039/c6ra00306k
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Rural health systems' perceptions of referral to community pharmacists during transitions of care.

Paul, Stephanie / DiDonato, Kristen L / Liu, Yifei / Hartwig, D Matthew / May, Justin / Schramm, Andrew M

Journal of the American Pharmacists Association : JAPhA

2016 Volume 56, Issue 5, Page(s) 562–567.e2

Abstract: Objectives: To identify rural health systems' perceptions of value, benefits, barriers, and opportunities associated with community pharmacist involvement in patient transitions of care.: Setting: Rural health systems in northwest and central ... ...

Abstract	Objectives: To identify rural health systems' perceptions of value, benefits, barriers, and opportunities associated with community pharmacist involvement in patient transitions of care. Setting: Rural health systems in northwest and central Missouri. Practice description and innovation: Qualitative descriptive study of key informant interviews with self-identified decision makers of rural health systems within a 50-mile radius of 15 independent community pharmacy chain locations. Evaluation: Interviews were recorded, transcribed, and coded to evaluate themes in participant responses. Results: Fifteen interviews were conducted at 8 rural health systems. Participants expressed significant value in community pharmacist involvement in transitions of care and highlighted several benefits, barriers, and opportunities related to potential collaboration. Benefits that were identified included medication monitoring, resource for patient information, and desire among health care providers to work with community pharmacists. Barriers included legal and regulatory issues with referral, communication, and prescriber utilization. Opportunities described included: patient education, monitoring, and follow-up; targeted interventions; medication access assistance; bedside medication delivery; and collaboration between community pharmacies and health care entities. Conclusion: Rural health system informants perceived community pharmacy involvement to be valuable and were receptive to collaboration during transitional care to improve patient outcomes. They highlighted barriers to overcome to truly incorporate community pharmacists into the transitional care arena. Understanding these rural health systems' perceptions can guide community pharmacies in developing collaborative relationships and patient care services to assist with care transitions.
MeSH term(s)	Adult ; Attitude of Health Personnel ; Community Pharmacy Services/organization & administration ; Female ; Humans ; Interviews as Topic ; Male ; Middle Aged ; Patient Transfer/organization & administration ; Pharmacists/organization & administration ; Professional Role ; Referral and Consultation ; Rural Health Services/organization & administration
Language	English
Publishing date	2016-07-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2118585-2
ISSN	1544-3450 ; 1544-3191 ; 1086-5802
ISSN (online)	1544-3450
ISSN	1544-3191 ; 1086-5802
DOI	10.1016/j.japh.2016.04.562
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Article: Interventionsansätze bei hoch eskalierten Trennungskonflikten

Dietrich, Peter S. / Paul, Stephanie

(In: Weber, Matthias; Schilling, Herbert (Ed.), Eskalierte Elternkonflikte. Beratungsarbeit im Interesse des Kindes bei hoch strittigen Trennungen (S. 73-90). Weinheim: Juventa)

2006

Abstract: Es wird ein Überblick über integrative Interventionsansätze bei hoch eskalierten Trennungs- und Scheidungskonflikten gegeben, die aus einer validen theoretischen Modellierung scheidungsbezogener Hochstrittigkeit abgeleitet wurden. Dabei werden vor allem ... ...

Title translation	Intervention strategies in highly escalated separation conflicts
Series title	In: Weber, Matthias; Schilling, Herbert (Ed.), Eskalierte Elternkonflikte. Beratungsarbeit im Interesse des Kindes bei hoch strittigen Trennungen (S. 73-90). Weinheim: Juventa
Abstract	Es wird ein Überblick über integrative Interventionsansätze bei hoch eskalierten Trennungs- und Scheidungskonflikten gegeben, die aus einer validen theoretischen Modellierung scheidungsbezogener Hochstrittigkeit abgeleitet wurden. Dabei werden vor allem US-amerikanische Ansätze referiert, deren Wirksamkeitspotenzial über Evaluationsstudien abgesichert worden ist. Folgende Aspekte dieser US-amerikanischen Interventionsansätze werden erörtert: Präventionsorientierung; Elternprogramme für hoch strittige Scheidungspaare; Anwälte, Berater und Therapeuten, die als "Parent Coordinators" versuchen, im Bedarfsfall eine schnelle außergerichtliche Lösung zu ermöglichen; "Supervised Access" bzw. Wiederanbahnung und/oder Aufrechterhaltung der Eltern-Kind-Beziehung durch Sicherstellung der Kontakte in einem geschützten Umfeld (Hilfen zur Kontaktanbahnung für nichtsorgeberechtigte Eltern, Koordination von Elternschaft bei häuslicher Gewalt, therapeutische Umgangsbegleitung). Anschließend werden der begleitete Umgang und die integrative Beratung als zwei Ansätze beschrieben, die sich bisher in Deutschland im Umgang mit Hochkonfliktparteien etabliert haben. Auf die zentrale Bedeutung der interdisziplinären Zusammenarbeit zum Schutz der Kinder vor den destruktiven Auswirkungen hoch strittiger Elternkonflikte wird abschließend hingewiesen. In diesem Zusammenhang wird betont, dass US-amerikanische Erfahrungen belegen, dass obligatorische Programme mehr Eltern erreichen als solche auf freiwilliger Basis.
Keywords	Besuchsrecht (Kinder) ; Child Custody ; Child Visitation ; Child Welfare ; Divorce ; Domestic Violence ; Ehescheidung ; Häusliche Gewalt ; Jugendhilfe ; Marital Conflict ; Marital Separation ; Mediation ; Paartrennung ; Partnerschaftskonflikt ; Protective Services ; Schutzdienste ; Sorgerecht für Kinder
Language	German
Document type	Article
ISBN	3-7799-0769-0 ; 978-3-7799-0769-5
Database	PSYNDEX

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