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  1. Article ; Online: Neutron-encoded diubiquitins to profile linkage selectivity of deubiquitinating enzymes

    Bianca D. M. van Tol / Bjorn R. van Doodewaerd / Guinevere S. M. Lageveen-Kammeijer / Bas C. Jansen / Cami M. P. Talavera Ormeño / Paul J. M. Hekking / Aysegul Sapmaz / Robbert Q. Kim / Angeliki Moutsiopoulou / David Komander / Manfred Wuhrer / Gerbrand J. van der Heden van Noort / Huib Ovaa / Paul P. Geurink

    Nature Communications, Vol 14, Iss 1, Pp 1-

    2023  Volume 14

    Abstract: Most insights into deubiquitinase (DUB) substrate specificity originate from studies with isolated di-ubiquitins (diUb), but in cells diUbs with different linkage types coexist. Here, the authors develop a mass spectrometric DUB activity assay that can ... ...

    Abstract Most insights into deubiquitinase (DUB) substrate specificity originate from studies with isolated di-ubiquitins (diUb), but in cells diUbs with different linkage types coexist. Here, the authors develop a mass spectrometric DUB activity assay that can probe all diUbs simultaneously under substrate competition conditions.
    Keywords Science ; Q
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Identification and characterization of a SARS-CoV-2 specific CD8+ T cell response with immunodominant features

    Anastasia Gangaev / Steven L. C. Ketelaars / Olga I. Isaeva / Sanne Patiwael / Anna Dopler / Kelly Hoefakker / Sara De Biasi / Lara Gibellini / Cristina Mussini / Giovanni Guaraldi / Massimo Girardis / Cami M. P. Talavera Ormeno / Paul J. M. Hekking / Neubury M. Lardy / Mireille Toebes / Robert Balderas / Ton N. Schumacher / Huib Ovaa / Andrea Cossarizza /
    Pia Kvistborg

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 14

    Abstract: Many viral antigens have been identified in patients with COVID-19 patients, but which of these result in meaningful immune responses is unclear. Here the authors identify a range of SARS-CoV-2 CD8+ T cell responses across patients including a response ... ...

    Abstract Many viral antigens have been identified in patients with COVID-19 patients, but which of these result in meaningful immune responses is unclear. Here the authors identify a range of SARS-CoV-2 CD8+ T cell responses across patients including a response targeting an epitope of ORF1ab with immunodominant properties.
    Keywords Science ; Q
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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