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Article ; Online: The Lower Limb Assessment Score: A valid measure of hypermobility in elite football?

Paul Johnson, Adam / Ward, Sarah / Simmonds, Jane

Physical therapy in sport : official journal of the Association of Chartered Physiotherapists in Sports Medicine

2019 Volume 37, Page(s) 86–90

Abstract: Objective: This study aims to validate the Lower Limb Assessment Score against the current gold standard Beighton Scale within an adult elite footballing population to allow for future research to explore the influence of lower limb specific ... ...

Abstract	Objective: This study aims to validate the Lower Limb Assessment Score against the current gold standard Beighton Scale within an adult elite footballing population to allow for future research to explore the influence of lower limb specific hypermobility on injury incidence. Design: Observational cohort study. Setting: Thirty-six male, professional footballers aged between 18 and 37 years old. Main outcome measures: The Sensitivity, specificity, positive predictive value, negative predictive value and Spearman's rank correlation between the LLAS and Beighton Scale. Results: There was significant strong correlation between LLAS and Beighton Scale scores (ρ = 0.732; p < 0.001). The LLAS displayed a sensitivity of 67% and specificity of 94% when a cut off of ≥4/12 was applied to the screening data. This cut off point also yielded moderate Positive Predictive Validity (50%) and excellent Negative Predictive Validity (97%). Conclusions: The present study suggests that the LLAS is a valid test for identifying lower limb hypermobility within an adult male footballing population when a cut off of ≥4/12 is used.
MeSH term(s)	Adolescent ; Adult ; Arthrometry, Articular ; Cohort Studies ; Female ; Humans ; Joint Instability/diagnosis ; Joint Instability/physiopathology ; Lower Extremity/physiopathology ; Male ; Predictive Value of Tests ; Sampling Studies ; Sensitivity and Specificity ; Soccer ; Young Adult
Language	English
Publishing date	2019-03-15
Publishing country	England
Document type	Journal Article ; Observational Study ; Validation Study
ZDB-ID	2008604-0
ISSN	1873-1600 ; 1466-853X
ISSN (online)	1873-1600
ISSN	1466-853X
DOI	10.1016/j.ptsp.2019.03.007
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Article ; Online: Traumatic aortic injury from pellet gun

Paul Johnson, Bachelor of Science / Ryan Anderson, Bachelor of Science / Collin Gamble, MD / Eric van Bogaert, MD / Jonathan Joshi, MD

Radiology Case Reports, Vol 18, Iss 3, Pp 1368-

A case report

2023 Volume 1371

Abstract: Acute traumatic aortic injuries are of the most lethal sequelae of penetrating thoracic injuries and require rapid detection and management. The American College of Radiology currently recommends the use of noncontrast CT, followed by computed tomography ...

Abstract	Acute traumatic aortic injuries are of the most lethal sequelae of penetrating thoracic injuries and require rapid detection and management. The American College of Radiology currently recommends the use of noncontrast CT, followed by computed tomography angiography (CTA) as the first-line imaging modalities when traumatic aortic injury is suspected. Direct signs of aortic injury on CTA include pseudoaneurysm, focal contour abnormality, intimal flap, intramural hematoma, an abrupt change in aortic caliber, and contrast extravasation. Aortic pseudoaneurysms are most often caused by blunt or penetrating trauma that results in damage to the vessel wall, turbulent blood flow, and formation of a surrounding hematoma contained by a wall of products from the clotting cascade. This wall is weaker than those of a true aneurysm and will ultimately rupture over time if not repaired. Traumatic aortic pseudoaneurysms are preferably treated by thoracic endovascular aortic repair using a prosthetic stent graft. Here, we present a 44-yearold female with a history of homelessness, polysubstance use disorder, and HIV who presented to the emergency department after being found down. She reported being shot by a pellet gun, and physical examination revealed a penetrating left-sided chest wound that appeared to be several days old. A STAT CTA was obtained and revealed a hemopneumothorax and possible thoracic aortic pseudoaneurysm. A left-sided chest tube was placed and the patient underwent thoracic endovascular aortic repair through right femoral arterial access and tolerated the procedure well. The patient was placed on daily aspirin postoperatively and discharged on post-op day 5.
Keywords	Traumatic aortic injury ; Emergency radiology ; Pseudoaneurysm ; Pellet gun ; Hemopneumothorax ; Hemomediastinum ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	616
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Information Exchange and Transnational Environmental Problems

Kakeu, Johnson / Erik Paul Johnson

Environmental and resource economics. 2018 Oct., v. 71, no. 2

2018

Abstract: This paper analyzes information exchange in a model of transnational pollution control in which countries use private information in independently determining their domestic environmental policies. We show that countries may not always have an incentive ... ...

Abstract	This paper analyzes information exchange in a model of transnational pollution control in which countries use private information in independently determining their domestic environmental policies. We show that countries may not always have an incentive to exchange their private information. However, for a sufficiently high degree of predictability of domestic environmental policy processes, the expected welfare from sharing information is greater than the expected welfare from keeping it private. The minimum degree of policy predictability for which information sharing occurs increases with the level of environmental risk. Intuitively, information exchange can help mitigate the perception of global uncertainty (both political and scientific) that surrounds transnational environmental problems and potentially improve welfare if policymaking processes are sufficiently aligned with evidence-based approaches (predictable).
Keywords	environmental policy ; information exchange ; models ; politics ; pollution control ; risk ; uncertainty
Language	English
Dates of publication	2018-10
Size	p. 583-604.
Publishing place	Springer Netherlands
Document type	Article
ZDB-ID	1479788-4
ISSN	1573-1502 ; 0924-6460
ISSN (online)	1573-1502
ISSN	0924-6460
DOI	10.1007/s10640-017-0174-z
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Molecular prevalence and subtype distribution of Blastocystis sp. in Asia and in Australia

Sara Nemati / Mohammad Reza Zali / Paul Johnson / Hamed Mirjalali / Panagiotis Karanis

Journal of Water and Health, Vol 19, Iss 5, Pp 687-

2021 Volume 704

Abstract: Blastocystis is a prevalent protozoan parasite reported in humans, animals, and environmental samples. Over the past decade, numerous studies have investigated the prevalence and subtype distribution of Blastocystis sp. alongside with its genetic and ... ...

Abstract	Blastocystis is a prevalent protozoan parasite reported in humans, animals, and environmental samples. Over the past decade, numerous studies have investigated the prevalence and subtype distribution of Blastocystis sp. alongside with its genetic and biochemical features. However, studies on subtype distribution of this protozoan in humans, animals, and environmental samples represent the potential transmission routes. In this review, we evaluated studies performed in Asian countries and in Australia to provide an overview of environmental factors on the prevalence and subtype distribution of Blastocystis sp. among humans, animals, and the environment. HIGHLIGHTS Blastocystis sp. is a prevalent protozoan reported in humans, animals, and the environment.; Subtype distribution represents the potential transmission routes.; The prevalence and the distribution pattern of subtypes vary from the east to the west countries in Asia.;
Keywords	asia ; australia ; blastocystis ; distribution ; zoonotic transmission ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	IWA Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Variations in the anatomy of the vertebral artery cervical loop segment - a potential predisposing factor for traumatic basal subarachnoid hemorrhage?

Medcalf, Jonathan E / Paul Johnson, C / Taktak, Azzam / Grabherr, Silke

Forensic science, medicine, and pathology

2016 Volume 12, Issue 4, Page(s) 444–450

Abstract: Fatal traumatic basal subarachnoid hemorrhage (TBSAH) is a characteristic forensic pathological entity, the investigation of which requires special techniques. In Liverpool, post-mortem room angiography is undertaken, followed by complete removal of the ... ...

Abstract	Fatal traumatic basal subarachnoid hemorrhage (TBSAH) is a characteristic forensic pathological entity, the investigation of which requires special techniques. In Liverpool, post-mortem room angiography is undertaken, followed by complete removal of the vertebral arteries and histological examination. It has been observed that the arterial anatomy can be highly variable, particularly the length and course of the loop segments located between the C2 vertebra and the dura. In a number of cases of TBSAH the loop segments of torn vessels have appeared relatively short. Having observed this phenomenon subjectively in our case work, a radiological study was undertaken with the aim of quantifying vertebral artery loop anatomy variation in a 'normal' population. Multiphase post-mortem computed tomography angiography (MPMCTA) scans of 98 subjects were reviewed and the lengths of the different portions of the loop segments (foramen magnum to the upper border of C1, between C1 and C2, and the bony foramina themselves) of each vertebral artery were measured using semi-automated vessel analysis software. The measurements obtained provide objective evidence of marked anatomical variation, with some loop segments more than twice the length of others. These results are important because a short vertebral artery loop segment might be a significant factor in predisposing an individual to TBSAH following a blow to the head or neck.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Computed Tomography Angiography ; Female ; Humans ; Imaging, Three-Dimensional ; Male ; Middle Aged ; Retrospective Studies ; Subarachnoid Hemorrhage, Traumatic/etiology ; Vertebral Artery/abnormalities ; Vertebral Artery/diagnostic imaging ; Young Adult
Language	English
Publishing date	2016-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2195904-3
ISSN	1556-2891 ; 1547-769X
ISSN (online)	1556-2891
ISSN	1547-769X
DOI	10.1007/s12024-016-9819-4
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Article ; Online: In situ measurements of thermal diffusivity in sediments of the methane-rich zone of Cascadia Margin, NE Pacific Ocean

Kira Homola / H. Paul Johnson / Casey Hearn

Elementa: Science of the Anthropocene (2015)

2015

Abstract: Abstract Thermal diffusivity (TD) is a measure of the temperature response of a material to external thermal forcing. In this study, TD values for marine sediments were determined in situ at two locations on the Cascadia Margin using an instrumented ... ...

Abstract	Abstract Thermal diffusivity (TD) is a measure of the temperature response of a material to external thermal forcing. In this study, TD values for marine sediments were determined in situ at two locations on the Cascadia Margin using an instrumented sediment probe deployed by a remotely operated vehicle. TD measurements in this area of the NE Pacific Ocean are important for characterizing the upslope edge of the methane hydrate stability zone, which is the climate-sensitive boundary of a global-scale carbon reservoir. The probe was deployed on the Cascadia Margin at water depths of 552 and 1049 m for a total of 6 days at each site. The instrumented probe consisted of four thermistors aligned vertically, one sensor exposed to the bottom water and one each at 5, 10, and 15 cm within the sediment. Results from each deployment were analyzed using a thermal conduction model applying a range of TD values to obtain the best fit with the experimental data. TD values corresponding to the lowest standard deviations from the numerical model runs were selected as the best approximations. Overall TDs of Cascadia Margin sediments of 4.33 and 1.15 × 10–7 m2 s–1 were calculated for the two deployments. These values, the first of their kind to be determined from in situ measurements on a methane hydrate-rich continental margin, are expected to be useful in the development of models of bottom-water temperature increases and their implications on a global scale.
Keywords	thermal diffusivity ; marine sediments ; Cascadia Margin ; Environmental sciences ; GE1-350
Subject code	550
Language	English
Publishing date	2015-02-01T00:00:00Z
Publisher	BioOne
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Participatory mapping identifies risk areas and environmental predictors of endemic anthrax in rural Africa

Olubunmi R. Aminu / Taya L. Forde / Divine Ekwem / Paul Johnson / Luca Nelli / Blandina T. Mmbaga / Deogratius Mshanga / Mike Shand / Gabriel Shirima / Markus Walsh / Ruth N. Zadoks / Roman Biek / Tiziana Lembo

Scientific Reports, Vol 12, Iss 1, Pp 1-

2022 Volume 13

Abstract: Abstract Disease mapping reveals geographical variability in incidence, which can help to prioritise control efforts. However, in areas where this is most needed, resources to generate the required data are often lacking. Participatory mapping, which ... ...

Abstract	Abstract Disease mapping reveals geographical variability in incidence, which can help to prioritise control efforts. However, in areas where this is most needed, resources to generate the required data are often lacking. Participatory mapping, which makes use of indigenous knowledge, is a potential approach to identify risk areas for endemic diseases in low- and middle-income countries. Here we combine this method with Geographical Information System-based analyses of environmental variables as a novel approach to study endemic anthrax, caused by the spore-forming bacterium Bacillus anthracis, in rural Africa. Our aims were to: (1) identify high-risk anthrax areas using community knowledge; (2) enhance our understanding of the environmental characteristics associated with these areas; and (3) make spatial predictions of anthrax risk. Community members from the Ngorongoro Conservation Area (NCA), northern Tanzania, where anthrax is highly prevalent in both animals and humans, were asked to draw areas they perceived to pose anthrax risks to their livestock on geo-referenced maps. After digitisation, random points were generated within and outside the defined areas to represent high- and low-risk areas, respectively. Regression analyses were used to identify environmental variables that may predict anthrax risk. Results were combined to predict how the probability of being a high-risk area for anthrax varies across space. Participatory mapping identified fourteen discrete high-risk areas ranging from 0.2 to 212.9 km2 in size and occupying 8.4% of the NCA. Areas that pose a high risk of anthrax were positively associated with factors that increase contact with Bacillus anthracis spores rather than those associated with the pathogen’s survival: close proximity to inland water bodies, where wildlife and livestock congregate, and low organic carbon content, which may indicate an increased likelihood of animals grazing close to soil surface and ingesting spores. Predicted high-risk areas were located in the centre of ...
Keywords	Medicine ; R ; Science ; Q
Subject code	333
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Randomised controlled trial for high-dose intravenous zinc as adjunctive therapy in SARS-CoV-2 (COVID-19) positive critically ill patients

Paul Johnson / John El Khoury / Vidyasagar Chinni / Damien Bolton / Daryl Jones / Oneel Patel / Joseph Ischia

BMJ Open, Vol 10, Iss

trial protocol

2020 Volume 12

Abstract: Introduction SARS-CoV-2 (COVID-19) has caused an international pandemic of respiratory illness, resulting in significant healthcare and economic turmoil. To date, no robust vaccine or treatment has been identified. Elemental zinc has previously been ... ...

Abstract	Introduction SARS-CoV-2 (COVID-19) has caused an international pandemic of respiratory illness, resulting in significant healthcare and economic turmoil. To date, no robust vaccine or treatment has been identified. Elemental zinc has previously been demonstrated to have beneficial effects on coronaviruses and other viral respiratory infections due to its effect on RNA polymerase. Additionally, zinc has well-demonstrated protective effects against hypoxic injury—a clear mechanism of end-organ injury in respiratory distress syndrome. We aimed to assess the effect of high-dose intravenous zinc (HDIVZn) on SARS-CoV-2 infection. The end of study analyses will evaluate the reduction of impact of oxygen saturations or requirement of oxygen supplementation.Methods and analysis We designed a double-blind randomised controlled trial of daily HDIVZn (0.5 mg/kg) versus placebo. Primary outcome measures are lowest oxygen saturation (or greatest level of supplemental oxygenation) for non-ventilated patients and worst PaO2/FiO2 for ventilated patients. Following power calculations, 60 hospitalised patients and 100 ventilated patients will be recruited to demonstrate a 20% difference. The duration of follow-up is up to the point of discharge.Ethics and dissemination Ethical approval was obtained through the independent Human Research Ethics Committee. Participant recruitment will commence in May 2020. Results will be published in peer-reviewed medical journals.Trial registration number ACTRN126200000454976.
Keywords	Medicine ; R
Subject code	610
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Standardized Geomorphic Classification of Seafloor Within the United States Atlantic Canyons and Continental Margin

Derek C. Sowers / Giuseppe Masetti / Larry A. Mayer / Paul Johnson / James V. Gardner / Andrew A. Armstrong

Frontiers in Marine Science, Vol

2020 Volume 7

Abstract: Accurate seafloor maps serve as a critical component for understanding marine ecosystems and guiding informed ocean management decisions. From 2004 to 2015, the Atlantic Ocean continental margin offshore of the United States has been systematically ... ...

Abstract	Accurate seafloor maps serve as a critical component for understanding marine ecosystems and guiding informed ocean management decisions. From 2004 to 2015, the Atlantic Ocean continental margin offshore of the United States has been systematically mapped using multibeam sonars. This work was done in support of the U.S. Extended Continental Shelf (ECS) Project and for baseline characterization of the Atlantic canyons, but the question remains as to the relevance of these margin-wide data sets for conservation and management decisions pertaining to these areas. This study utilized an automatic segmentation approach to initially identify landform features from the bathymetry of the region, then translated these results into complete coverage geomorphology maps of the region utilizing the coastal and marine ecological classification standard (CMECS) to define geoforms. Abyssal flats make up more than half of the area (53%), with the continental slope flat class making up another 30% of the total area. Flats of any geoform class (including continental shelf flats and guyot flats) make up 83.06% of the study area. Slopes of any geoform class make up a cumulative total of 13.26% of the study region (8.27% abyssal slopes, 3.73% continental slopes, and 1.25% seamount slopes). While ridge features comprise only 1.82% of the total study area (1.03% abyssal ridges, 0.63 continental slope ridge, and 0.16% seamount ridges). Key benefits of the study’s semi-automated approach include computational efficiency for large datasets, and the ability to apply the same methods to large regions with consistent results.
Keywords	geomorphology ; seafloor ; classification ; coastal and marine ecological classification standard ; Atlantic ; bathymorphon ; Science ; Q ; General. Including nature conservation ; geographical distribution ; QH1-199.5
Subject code	710
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Ion currents through Kir potassium channels are gated by anionic lipids

Ruitao Jin / Sitong He / Katrina A. Black / Oliver B. Clarke / Di Wu / Jani R. Bolla / Paul Johnson / Agalya Periasamy / Ahmad Wardak / Peter Czabotar / Peter M. Colman / Carol V. Robinson / Derek Laver / Brian J. Smith / Jacqueline M. Gulbis

Nature Communications, Vol 13, Iss 1, Pp 1-

2022 Volume 11

Abstract: The Kir potassium channels are known to operate and gate without a major conformational change. Here, the authors identify the permeation gate of Kir channels as a steric plug within the conduction pathway, describing how tightly associated anionic ... ...

Abstract	The Kir potassium channels are known to operate and gate without a major conformational change. Here, the authors identify the permeation gate of Kir channels as a steric plug within the conduction pathway, describing how tightly associated anionic lipids pushing into fenestrations in the pore walls engage with the plug to operate the gate.
Keywords	Science ; Q
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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