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  1. Article ; Online: Carpe Diem

    Paul Trayhurn

    Journal of Nutritional Science, Vol

    an update on the Journal of Nutritional Science

    2023  Volume 12

    Keywords Nutrition. Foods and food supply ; TX341-641 ; Medicine ; R
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Cambridge University Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: ‘Big History’, history and citations in nutritional science

    Paul Trayhurn

    Journal of Nutritional Science, Vol

    2022  Volume 11

    Keywords Nutrition. Foods and food supply ; TX341-641 ; Medicine ; R
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Cambridge University Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: JNS

    Paul Trayhurn

    Journal of Nutritional Science, Vol

    an update on citation ‘impact’ and remit

    2020  Volume 9

    Keywords Nutrition. Foods and food supply ; TX341-641 ; Medicine ; R
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Cambridge University Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  4. Article ; Online: Open Access publishing

    Paul Trayhurn

    Journal of Nutritional Science, Vol

    the continuing development of the Journal of Nutritional Science

    2018  Volume 7

    Keywords Nutrition. Foods and food supply ; TX341-641 ; Medicine ; R
    Language English
    Publishing date 2018-01-01T00:00:00Z
    Publisher Cambridge University Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  5. Article ; Online: Is energy expenditure reduced in obese mice with mutations in the leptin/leptin receptor genes?

    Paul Trayhurn / Jonathan R. S. Arch

    Journal of Nutritional Science, Vol

    2020  Volume 9

    Abstract: Rodents with mutations in the leptin, or leptin receptor, genes have been extensively used to investigate the regulation of energy balance and the factors that underlie the development of obesity. The excess energy gain of these mutants has long been ... ...

    Abstract Rodents with mutations in the leptin, or leptin receptor, genes have been extensively used to investigate the regulation of energy balance and the factors that underlie the development of obesity. The excess energy gain of these mutants has long been considered as being due in part to increased metabolic efficiency, consequent to reduced energy expenditure, but this view has recently been challenged. We argue, particularly though not exclusively, from data on ob/ob mice, that three lines of evidence support the proposition that reduced expenditure is important in the aetiology of obesity in leptin pathway mutants (irrespective of the genetic background): (i) milk intake is similar in suckling ob/ob and +/? mice; (ii) ob/ob mice deposit excess energy when pair-fed to the ad libitum food intake of lean siblings; (iii) in several studies mutant mice have been shown to exhibit a lower RMR ‘per animal’ at temperatures below thermoneutrality. When metabolic rate is expressed ‘per unit body weight’ (inappropriately, because of body composition differences), then it is invariably lower in the obese than the lean. It is important to differentiate the causes from the consequences of obesity. Hyperphagic, mature obese animals weighing 2–3 times their lean siblings may well have higher expenditure ‘per animal’, reflecting the costs of being larger and of enhanced obligatory diet-induced thermogenesis resulting from the increased food intake. This cannot, however, be used to inform the aetiology of their obesity.
    Keywords Energy expenditure ; Gene mutations ; Leptin ; Leptin receptor ; Metabolic efficiency ; ob/ob mice ; Obesity ; Thermogenesis ; Nutrition. Foods and food supply ; TX341-641 ; Medicine ; R
    Subject code 630
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Cambridge University Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Prakash Sarvotham Shetty (1943–2018)

    Paul Trayhurn / W. Philip T. James

    Journal of Nutritional Science, Vol

    2018  Volume 7

    Keywords Nutrition. Foods and food supply ; TX341-641 ; Medicine ; R
    Language English
    Publishing date 2018-01-01T00:00:00Z
    Publisher Cambridge University Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  7. Article ; Online: Mining microarray datasets in nutrition

    Paul Trayhurn / Gareth Denyer

    Journal of Nutritional Science, Vol

    expression of the GPR120 (n-3 fatty acid receptor/sensor) gene is down-regulated in human adipocytes by macrophage secretions

    2012  Volume 1

    Abstract: Microarray datasets are a rich source of information in nutritional investigation. Targeted mining of microarray data following initial, non-biased bioinformatic analysis can provide key insight into specific genes and metabolic processes of interest. ... ...

    Abstract Microarray datasets are a rich source of information in nutritional investigation. Targeted mining of microarray data following initial, non-biased bioinformatic analysis can provide key insight into specific genes and metabolic processes of interest. Microarrays from human adipocytes were examined to explore the effects of macrophage secretions on the expression of the G-protein-coupled receptor (GPR) genes that encode fatty acid receptors/sensors. Exposure of the adipocytes to macrophage-conditioned medium for 4 or 24 h had no effect on GPR40 and GPR43 expression, but there was a marked stimulation of GPR84 expression (receptor for medium-chain fatty acids), the mRNA level increasing 13·5-fold at 24 h relative to unconditioned medium. Importantly, expression of GPR120, which encodes an n-3 PUFA receptor/sensor, was strongly inhibited by the conditioned medium (15-fold decrease in mRNA at 24 h). Macrophage secretions have major effects on the expression of fatty acid receptor/sensor genes in human adipocytes, which may lead to an augmentation of the inflammatory response in adipose tissue in obesity.
    Keywords Adipocytes ; Fatty acid receptors ; Inflammation ; Microarrays ; Nutrition. Foods and food supply ; TX341-641 ; Medicine ; R
    Language English
    Publishing date 2012-06-01T00:00:00Z
    Publisher Cambridge University Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Lipopolysaccharide induces a downregulation of adiponectin receptors in-vitro and in-vivo

    Alison Hall / Martin Leuwer / Paul Trayhurn / Ingeborg D. Welters

    PeerJ, Vol 3, p e

    2015  Volume 1428

    Abstract: Background. Adipose tissue contributes to the inflammatory response through production of cytokines, recruitment of macrophages and modulation of the adiponectin system. Previous studies have identified a down-regulation of adiponectin in pathologies ... ...

    Abstract Background. Adipose tissue contributes to the inflammatory response through production of cytokines, recruitment of macrophages and modulation of the adiponectin system. Previous studies have identified a down-regulation of adiponectin in pathologies characterised by acute (sepsis and endotoxaemia) and chronic inflammation (obesity and type-II diabetes mellitus). In this study, we investigated the hypothesis that LPS would reduce adiponectin receptor expression in a murine model of endotoxaemia and in adipoocyte and myocyte cell cultures.Methods. 25 mg/kg LPS was injected intra-peritoneally into C57BL/6J mice, equivalent volumes of normal saline were used in control animals. Mice were killed at 4 or 24 h post injection and tissues harvested. Murine adipocytes (3T3-L1) and myocytes (C2C12) were grown in standard culture, treated with LPS (0.1 µg/ml–10 µg/ml) and harvested at 4 and 24 h. RNA was extracted and qPCR was conducted according to standard protocols and relative expression was calculated.Results. After LPS treatment there was a significant reduction after 4 h in gene expression of adipo R1 in muscle and peri-renal fat and of adipo R2 in liver, peri-renal fat and abdominal wall subcutaneous fat. After 24 h, significant reductions were limited to muscle. Cell culture extracts showed varied changes with reduction in adiponectin and adipo R2 gene expression only in adipocytes.Conclusions. LPS reduced adiponectin receptor gene expression in several tissues including adipocytes. This reflects a down-regulation of this anti-inflammatory and insulin-sensitising pathway in response to LPS. The trend towards base line after 24 h in tissue depots may reflect counter-regulatory mechanisms. Adiponectin receptor regulation differs in the tissues investigated.
    Keywords Adiponectin receptors ; Adipose tissue ; Adiponectin ; Lipopolysaccharide ; Medicine ; R ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2015-11-01T00:00:00Z
    Publisher PeerJ Inc.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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