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  1. Article ; Online: p

    Paim, Raquel Teixeira Terceiro / Rodrigues, Paula Salmito Alves / Silva, José Ytalo Gomes da / Paula Junior, Valdir Ferreira de / Silva, Bruno Bezerra da / Freitas, Claísa Andréa Silva De / Oriá, Reinaldo Barreto / Florean, Eridan Orlando Pereira Tramontina / Rondina, Davide / Guedes, Maria Izabel Florindo

    Nutrients

    2020  Volume 12, Issue 1

    Abstract: The pursuit of cholesterol lowering natural products with less side effects is needed for controlling dyslipidemia and reducing the increasing toll of cardiovascular diseases that are associated with morbidity and mortality worldwide. The present study ... ...

    Abstract The pursuit of cholesterol lowering natural products with less side effects is needed for controlling dyslipidemia and reducing the increasing toll of cardiovascular diseases that are associated with morbidity and mortality worldwide. The present study aimed at the examining effects of
    MeSH term(s) Animals ; Antioxidants/pharmacology ; Antioxidants/toxicity ; Biomarkers/blood ; Cells, Cultured ; Cinnamates/pharmacology ; Cinnamates/toxicity ; Diet, High-Fat ; Disease Models, Animal ; Dyslipidemias/blood ; Dyslipidemias/etiology ; Dyslipidemias/prevention & control ; Humans ; Hypolipidemic Agents/pharmacology ; Hypolipidemic Agents/toxicity ; Lipid Peroxidation/drug effects ; Lipids/blood ; Liver/drug effects ; Liver/metabolism ; Lymphocytes/drug effects ; Lymphocytes/metabolism ; Lymphocytes/pathology ; Male ; Mice ; Oxidative Stress/drug effects ; Phosphatidylcholine-Sterol O-Acyltransferase/metabolism
    Chemical Substances Antioxidants ; Biomarkers ; Cinnamates ; Hypolipidemic Agents ; Lipids ; Phosphatidylcholine-Sterol O-Acyltransferase (EC 2.3.1.43)
    Language English
    Publishing date 2020-01-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu12010262
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: p-Methoxycinnamic Acid Diesters Lower Dyslipidemia, Liver Oxidative Stress and Toxicity in High-Fat Diet Fed Mice and Human Peripheral Blood Lymphocytes

    Paim, Raquel Teixeira Terceiro / Rodrigues, Paula Salmito Alves / Silva, José Ytalo Gomes da / Paula Junior, Valdir Ferreira de / Silva, Bruno Bezerra da / Freitas, Claísa Andréa Silva De / Oriá, Reinaldo Barreto / Florean, Eridan Orlando Pereira Tramontina / Rondina, Davide / Guedes, Maria Izabel Florindo

    Nutrients. 2020 Jan. 20, v. 12, no. 1

    2020  

    Abstract: The pursuit of cholesterol lowering natural products with less side effects is needed for controlling dyslipidemia and reducing the increasing toll of cardiovascular diseases that are associated with morbidity and mortality worldwide. The present study ... ...

    Abstract The pursuit of cholesterol lowering natural products with less side effects is needed for controlling dyslipidemia and reducing the increasing toll of cardiovascular diseases that are associated with morbidity and mortality worldwide. The present study aimed at the examining effects of p-methoxycinnamic acid diesters (PCO-C) from carnauba (Copernicia prunifera)-derived wax on cytotoxic, genotoxic responses in vitro and on dyslipidemia and liver oxidative stress in vivo, utilizing high-fat diet (HFD) chronically fed Swiss mice. In addition, we evaluated the effect of PCO-C on the expression of key cholesterol metabolism-related genes, as well as the structural interactions between PCO-C and lecithin-cholesterol acyl transferase (LCAT) in silico. Oral treatment with PCO-C was able to reduce total serum cholesterol and low-density lipoprotein (LDL) levels following HFD. In addition, PCO-C reduced excessive weight gain and lipid peroxidation, and increased the gene expression of LCAT following HFD. Furthermore, the high affinity of the studied compound (ΔG: -8.78 Kcal/mol) towards the active sites of mutant LCAT owing to hydrophobic and van der Waals interactions was confirmed using bioinformatics. PCO-C showed no evidence of renal and hepatic toxicity, unlike simvastatin, that elevated aspartate aminotransferase (AST) levels, a marker of liver dysfunction. Finally, PCO-C showed no cytotoxicity or genotoxicity towards human peripheral blood lymphocytes in vitro. Our results suggest that PCO-C exerts hypocholesterolemic effects. The safety of PCO-C in the toxicological tests performed and the reports of its beneficial biological effects render this a promising compound for the development of new cholesterol-lowering therapeutics to control dyslipidemia. More work is needed for further elucidating PCO-C role on lipid metabolism to support future clinical studies.
    Keywords Copernicia prunifera ; active sites ; adverse effects ; aspartate transaminase ; bioinformatics ; blood serum ; cardiovascular diseases ; cholesteremic effect ; cholesterol ; clinical trials ; computer simulation ; cytotoxicity ; esters ; genes ; genotoxicity ; high fat diet ; humans ; hydrophobicity ; hyperlipidemia ; lipid metabolism ; lipid peroxidation ; liver ; low density lipoprotein ; lymphocytes ; mice ; morbidity ; mortality ; mutagens ; mutants ; nutrients ; oral administration ; oxidative stress ; toxicity testing ; van der Waals forces ; weight gain
    Language English
    Dates of publication 2020-0120
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-light
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu12010262
    Database NAL-Catalogue (AGRICOLA)

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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