Artikel ; Online: Systematic use of carbetocin during cesarean delivery of multiple pregnancies: a before-and-after study.
Archives of gynecology and obstetrics
2013 Band 287, Heft 5, Seite(n) 875–880
Abstract: Purpose: Cesarean deliveries of multiple pregnancies are associated with a high risk of hemorrhage. The aim of this study is to evaluate the efficacy of carbetocin administered systematically during cesarean deliveries of multiple pregnancies.: ... ...
| Abstract | Purpose: Cesarean deliveries of multiple pregnancies are associated with a high risk of hemorrhage. The aim of this study is to evaluate the efficacy of carbetocin administered systematically during cesarean deliveries of multiple pregnancies. Methods: Single-center retrospective before-and-after study comparing the use of carbetocin to that of oxytocin during cesareans during two consecutive 6-month periods. A composite variable was predefined as the principal endpoint: any one or more of bleeding ≥1,500 mL, transfusion, hemoglobin reduction of 4 g/dL or more or operative intervention (surgery, embolization). Results: In an intention-to-treat analysis, the comparison of the two groups (n = 24 before and n = 39 after) showed no difference for the occurrence of the composite variable (16.7 vs. 15.4 %, p = 0.89). Nor did the per-protocol analysis (n = 24 before and n = 27 after) differ for it (16.7 vs. 14.8 %, p = 0.86). Moreover, none of the secondary outcome measures studied-moderate blood loss, prescription of sulprostone, cell-saver use, and intravenous iron infusion-differed significantly between the two periods. Conclusion: In our population of multiple pregnancies delivered by cesarean, carbetocin did not appear more effective than oxytocin in preventing severe postpartum hemorrhage. |
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| Mesh-Begriff(e) | Adult ; Cesarean Section/adverse effects ; Cesarean Section/methods ; Female ; Humans ; Oxytocics/therapeutic use ; Oxytocin/analogs & derivatives ; Oxytocin/therapeutic use ; Postpartum Hemorrhage/epidemiology ; Postpartum Hemorrhage/prevention & control ; Postpartum Hemorrhage/therapy ; Pregnancy ; Pregnancy, Multiple ; Retrospective Studies ; Treatment Outcome | |||||
| Chemische Substanzen | Oxytocics ; Oxytocin (50-56-6) ; carbetocin (88TWF8015Y) | |||||
| Sprache | Englisch | |||||
| Erscheinungsdatum | 2013-05 | |||||
| Erscheinungsland | Germany | |||||
| Dokumenttyp | Comparative Study ; Journal Article | |||||
| ZDB-ID | 896455-5 | |||||
| ISSN | 1432-0711 ; 0932-0067 | |||||
| ISSN (online) | 1432-0711 | |||||
| ISSN | 0932-0067 | |||||
| DOI | 10.1007/s00404-012-2646-2 | |||||
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| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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