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Article ; Online: In vitro antiviral effect of ethanolic extracts from Azadirachta indica and Melia azedarach against goat lentivirus in colostrum and milk

Ana Lidia Madeira de Sousa / Raymundo Rizaldo Pinheiro / Juscilania Furtado Araujo / Renato Mesquita Peixoto / Dalva Alana Aragao de Azevedo / Ana Milena Cesar Lima / Kirley Marques Canuto / Paulo Riceli Vasconcelos Ribeiro / Ana Sheila de Queiroz Souza / Samara Cristina Rocha Souza / Sara Lucena de Amorim / Gabriel Paula Amaral / Viviane de Souza / Selene Maia de Morais / Alice Andrioli / Maria Fatima da Silva Teixeira

Scientific Reports, Vol 13, Iss 1, Pp 1-

2023 Volume 19

Abstract: Abstract This study aimed to evaluate, in vitro, the use of leaf extracts of Azadirachta indica (A. indica) and Melia azedarach (M. azedarach) as antivirals against caprine lentivirus (CLV) in colostrum and milk of goat nannies. These were collected from ...

Abstract	Abstract This study aimed to evaluate, in vitro, the use of leaf extracts of Azadirachta indica (A. indica) and Melia azedarach (M. azedarach) as antivirals against caprine lentivirus (CLV) in colostrum and milk of goat nannies. These were collected from eight individuals and infected with the standard strain of CLV. Samples were then subdivided into aliquots and treated with 150 µg/mL of crude extract, and with ethyl acetate and methanol fractions for 30, 60, and 90 min. Next, somatic cells from colostrum and milk were co-cultured with cells from the ovine third eyelid. After this step, viral titers of the supernatants collected from treatments with greater efficacy in co-culture were assessed. The organic ethyl acetate fractions of both plants at 90 min possibly inhibited the viral activity of CLV by up to a thousandfold in colostrum. In milk, this inhibition was up to 800 times for the respective Meliaceae. In conclusion, the ethanolic fraction of ethyl acetate from both plants demonstrated efficacy against CLV in samples from colostrum and milk when subjected to treatment, which was more effective in colostrum.
Keywords	Medicine ; R ; Science ; Q
Subject code	630
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Drying kinetics and effect of air-drying temperature on chemical composition of Phyllanthus amarus and Phyllanthus niruri

Sousa, Adriana Dutra / Paulo Riceli Vasconcelos Ribeiro / Kirley Marques Canuto / Guilherme Julião Zocolo / Rita de Cassia Alves Pereira / Fabiano André Narciso Fernandes / Edy Sousa de Brito

Drying technology. 2018 Apr. 4, v. 36, no. 5

2018

Abstract: In this study, the drying kinetics of Phyllanthus amarus and Phyllanthus niruri were investigated experimentally in an air-drying oven as a function of drying temperature (50, 60, and 70°C). The effects of the air-drying temperature on the phenolic ... ...

Abstract	In this study, the drying kinetics of Phyllanthus amarus and Phyllanthus niruri were investigated experimentally in an air-drying oven as a function of drying temperature (50, 60, and 70°C). The effects of the air-drying temperature on the phenolic content and the LC–MS profile were also studied. Increases in air-drying temperature reduced the drying time and increased the effective moisture diffusivity. An Arrhenius relationship with activation energy values of 22.828 and 43.129 kJ/mol for P. niruri and P.amarus, respectively, expressed the effect of temperature on the diffusivity. Air drying at 70°C increased the availability of some phenolic compounds. However, the higher temperature negatively affected some sensitive components.
Keywords	Phyllanthus amarus ; Phyllanthus niruri ; activation energy ; air drying ; chemical composition ; diffusivity ; drying temperature ; liquid chromatography ; mass spectrometry ; ovens ; phenolic compounds
Language	English
Dates of publication	2018-0404
Size	p. 609-616.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	2049461-0
ISSN	1532-2300 ; 0737-3937
ISSN (online)	1532-2300
ISSN	0737-3937
DOI	10.1080/07373937.2017.1351454
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: UPLC–QTOF–MS and NMR analyses of graviola (Annona muricata) leaves

Ingrid Vieira Machado de Moraes / Paulo Riceli Vasconcelos Ribeiro / Flávio Luis Schmidt / Kirley Marques Canuto / Guilherme Julião Zocolo / Edy Sousa de Brito / Rensheng Luo / Kristy M. Richards / Kevin Tran / Robert E. Smith

Revista Brasileira de Farmacognosia, Vol 26, Iss 2, Pp 174-

2016 Volume 179

Abstract: ABSTRACT Graviola leaves (Annona muricata L., Annonaceae) are used by some people to try to treat or even cure cancer, even though over-consumption of the fruit, which contains the neurotoxins annonacin and squamocin has caused an atypical form of ... ...

Abstract	ABSTRACT Graviola leaves (Annona muricata L., Annonaceae) are used by some people to try to treat or even cure cancer, even though over-consumption of the fruit, which contains the neurotoxins annonacin and squamocin has caused an atypical form of Parkinson's disease. In previous analyses, the fruits were extracted with methanol under ambient conditions before analyses. In the present study, UPLC–QTOF–MS and NMR were used to analyze freeze-dried graviola leaves that were extracted using dry methanol and ethanol at 100 ºC and 10 MPa (100 atm) pressure in a sealed container. Methanol solubilized 33% of the metabolites in the lyophilized leaves. Ethanol solubilized 41% of metabolites in the lyophilized leaves. The concentrations of total phenolic compounds were 100.3 ± 2.8 and 93.2 ± 2.0 mg gallic acid equivalents per g of sample, for the methanolic and ethanolic extracts, respectively. Moreover, the toxicophore (unsaturated γ-lactone) that is present in neurotoxic acetogenins was found in the lipophilic portion of this extract. The concentrations of the neurotoxins annonacin and squamocin were found by UPLC–QTOF–MS to be 305.6 ± 28.3 and 17.4 ± 0.89 µg/g-dw, respectively, in the dried leaves. Pressurized methanol solubilized more annonacin and squamocin than ethanol. On the other hand, a hot, aqueous infusion solubilized only 0.213% of the annonacin and too little of the squamocin to be detected. So, graviola leaves contain significant amounts of the neurotoxins annonacin and squamocin, as well as some potentially healthy phenolic compounds. Finally, the potential neurotoxicity of whole leaves in dietary supplements could be much higher than that of a tea (hot aqueous infusion) that is made from them.
Keywords	Graviola ; Annona muricata ; UPLC–QTOF–MS ; Parkinson's disease ; NMR ; Pharmacy and materia medica ; RS1-441 ; Medicine ; R
Subject code	660
Language	Portuguese
Publishing date	2016-04-01T00:00:00Z
Publisher	Sociedade Brasileira de Farmacognosia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Chemical composition, antiparasitic and cytotoxic activities of aqueous extracts of Ziziphus joazeiro Mart.

Jacqueline Cosmo Andrade / Ana Raquel Pereira da Silva / Antônia Thassya Lucas dos Santos / Maria Audilene Freitas / Yedda Maria Lobo Soares de Matos / Maria Flaviana Bezerra Morais Braga / Camila Fonseca Bezerra / Maria Isabeli Pereira Gonçalo / Maria Celeste Vega Gomez / Míriam Rolóm / Cathia Coronel / Paulo Riceli Vasconcelos Ribeiro / Edy Sousa de Brito / Henrique Douglas Melo Coutinho

Asian Pacific Journal of Tropical Biomedicine, Vol 9, Iss 5, Pp 222-

2019 Volume 226

Abstract: Objective: To compare the in vitro antiparasitic activity of aqueous extracts from Ziziphus joazeiro leaves and stem bark against Trypanosoma cruzi, Leishmania braziliensis, and Leishmania infantum, as well as to evaluate its cytotoxicity in mammalian ... ...

Abstract	Objective: To compare the in vitro antiparasitic activity of aqueous extracts from Ziziphus joazeiro leaves and stem bark against Trypanosoma cruzi, Leishmania braziliensis, and Leishmania infantum, as well as to evaluate its cytotoxicity in mammalian cells, in addition to identifying the chemical composition of the extracts. Methods: Ziziphus joazeiro leaf and stem bark aqueous extracts were prepared by cold extraction maceration and subjected to ultra-efficient liquid chromatography coupled to a quadrupole/time of flight system. The susceptibility assays used Trypanosoma cruzi CL-B5 strains and promastigote forms of Leishmania braziliensis and Leishmania infantum for antiparasitic activity of the extracts. Moreover, mammalian fibroblasts NCTC clone 929 were used for cytotoxicity analysis. Results: Terpenoid compounds, flavonoids and phenolic acid were identified in extracts. The stem bark aqueous extracts presented more significant results in terms of antiparasitic activity compared with the leaf aqueous extracts, especially against Leishmania braziliensis and Leishmania infantum promastigote forms with an IC50 < 500 μg/mL. The cytotoxicity evaluation showed moderate toxicity of the stem bark aqueous extracts, which is relevant information for the rational use of this plant part since it is widely used by the population. Conclusions: These preliminary results may contribute to the formulation of new therapeutic agents against this group of neglected diseases, so further investigations are required to delineate the mechanisms of action mainly of the aqueous extract of stem bark of Ziziphus joazeiro.
Keywords	Antiepimastigote ; Antipromastigote ; UPLC-MS-ESI-QTOF ; Arctic medicine. Tropical medicine ; RC955-962 ; Biology (General) ; QH301-705.5
Subject code	500
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Chemical profiling of guarana seeds (Paullinia cupana) from different geographical origins using UPLC-QTOF-MS combined with chemometrics

da Silva, Givaldo Souza / Edy Sousa de Brito / Guilherme Julião Zocolo / Janclei Pereira Coutinho / Kirley Marques Canuto / Madson Moreira Nascimento / Paulo Riceli Vasconcelos Ribeiro / Raildo Mota de Jesus

Food research international. 2017 Dec., v. 102

2017

Abstract: Paullinia cupana, commonly known as guarana, is an Amazonian fruit whose seeds are used to produce the powdered guarana, which is rich in caffeine and consumed for its stimulating activity. The metabolic profile of guarana from the two largest producing ... ...

Abstract	Paullinia cupana, commonly known as guarana, is an Amazonian fruit whose seeds are used to produce the powdered guarana, which is rich in caffeine and consumed for its stimulating activity. The metabolic profile of guarana from the two largest producing regions was investigated using UPLC-MS combined with multivariate statistical analysis. The principal component analysis (PCA) showed significant differences between samples produced in the states of Bahia and Amazonas. The metabolites responsible for the differentiation were identified by orthogonal partial least squares discriminant analysis (OPLS-DA). Fourteen phenolic compounds were characterized in guarana powder samples, and catechin, epicatechin, B-type procyanidin dimer, A-type procyanidin trimer and A-type procyanidin dimer were the main compounds responsible for the geographical variation of the samples.
Keywords	caffeine ; catechin ; chemometrics ; discriminant analysis ; epicatechin ; geographical variation ; mass spectrometry ; metabolites ; multivariate analysis ; Paullinia cupana ; principal component analysis ; procyanidins ; provenance ; seeds ; ultra-performance liquid chromatography ; Brazil
Language	English
Dates of publication	2017-12
Size	p. 700-709.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2017.09.055
Database	NAL-Catalogue (AGRICOLA)

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Article: UPLC–QTOF–MS and NMR analyses of graviola (Annona muricata) leaves

de Moraes, Ingrid Vieira Machado / Edy Sousa de Brito / Flávio Luis Schmidt / Guilherme Julião Zocolo / Kevin Tran / Kirley Marques Canuto / Kristy M. Richards / Paulo Riceli Vasconcelos Ribeiro / Rensheng Luo / Robert E. Smith

Sociedade Brasileira de Farmacognosia Revista Brasileira de Farmacognosia. 2016 Mar., Apr., v. 26, no. 2

2016

Abstract: Graviola leaves (Annona muricata L., Annonaceae) are used by some people to try to treat or even cure cancer, even though over-consumption of the fruit, which contains the neurotoxins annonacin and squamocin has caused an atypical form of Parkinson's ... ...

Abstract	Graviola leaves (Annona muricata L., Annonaceae) are used by some people to try to treat or even cure cancer, even though over-consumption of the fruit, which contains the neurotoxins annonacin and squamocin has caused an atypical form of Parkinson's disease. In previous analyses, the fruits were extracted with methanol under ambient conditions before analyses. In the present study, UPLC–QTOF–MS and NMR were used to analyze freeze-dried graviola leaves that were extracted using dry methanol and ethanol at 100°C and 10MPa (100atm) pressure in a sealed container. Methanol solubilized 33% of the metabolites in the lyophilized leaves. Ethanol solubilized 41% of metabolites in the lyophilized leaves. The concentrations of total phenolic compounds were 100.3±2.8 and 93.2±2.0mg gallic acid equivalents per g of sample, for the methanolic and ethanolic extracts, respectively. Moreover, the toxicophore (unsaturated γ-lactone) that is present in neurotoxic acetogenins was found in the lipophilic portion of this extract. The concentrations of the neurotoxins annonacin and squamocin were found by UPLC–QTOF–MS to be 305.6±28.3 and 17.4±0.89μg/g-dw, respectively, in the dried leaves. Pressurized methanol solubilized more annonacin and squamocin than ethanol. On the other hand, a hot, aqueous infusion solubilized only 0.213% of the annonacin and too little of the squamocin to be detected. So, graviola leaves contain significant amounts of the neurotoxins annonacin and squamocin, as well as some potentially healthy phenolic compounds. Finally, the potential neurotoxicity of whole leaves in dietary supplements could be much higher than that of a tea (hot aqueous infusion) that is made from them.
Keywords	acetogenins ; Annona muricata ; dietary supplements ; ethanol ; freeze drying ; fruits ; gallic acid ; leaves ; metabolites ; methanol ; neoplasms ; neurotoxicity ; neurotoxins ; nuclear magnetic resonance spectroscopy ; Parkinson disease ; people ; solubilization ; tea
Language	English
Dates of publication	2016-03
Size	p. 174-179.
Publishing place	Elsevier Editora Ltda.
Document type	Article
ISSN	0102-695X
DOI	10.1016/j.bjp.2015.12.001
Database	NAL-Catalogue (AGRICOLA)

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Article: Ultrasound-assisted and pressurized liquid extraction of phenolic compounds from Phyllanthus amarus and its composition evaluation by UPLC-QTOF

Sousa, Adriana Dutra / Ana Isabel Vitorino Maia / Edy Sousa de Brito / Kirley Marques Canuto / Paulo Riceli Vasconcelos Ribeiro / Rita de Cassia Alves Pereira / Roberto Fontes Vieira / Tigressa Helena Soares Rodrigues

Industrial crops and products. 2016 Jan., v. 79

2016

Abstract: Phyllanthus amarus Schum & Thonn is an herb rich in bioactive compounds, mainly phenols, and it is widely used for its medicinal properties. In this study, aqueous extraction from aerial parts of P. amarus was performed using ultrasound-assisted ... ...

Abstract	Phyllanthus amarus Schum & Thonn is an herb rich in bioactive compounds, mainly phenols, and it is widely used for its medicinal properties. In this study, aqueous extraction from aerial parts of P. amarus was performed using ultrasound-assisted extraction (UAE), pressurized liquid extraction (PLE), and conventional extraction (CE). Response surface methodology was used to assess the effect of the time, ultrasonic intensity, and liquid/solid (L/S) ratio in UAE and of time and temperature in PLE on total phenolics and gallic acid extraction. The chemical composition of the extracts obtained through the three techniques was also analyzed using UPLC-ESI-QTOF-MS/MS. The UAE operational condition that afforded the highest phenolic content (27.23mg/g plant) used time of 7min, ultrasonic intensity of 301W/cm2, and L/S ratio of 40mL/g. This value was lower than the one obtained by the conventional extraction method (42.78mg/g plant). However, PLE at 192.4°C and time of 15min yielded the highest total phenolic content (52.97mg/g plant). Regarding the extraction of gallic acid, the non-conventional methods yielded contents three times higher than the conventional extraction. The chemical composition of P. amarus extracts had mainly hydrolysable tannins, flavonoids, and lignans. The most significant difference was found in UAE, which proved to be inefficient to extract ellagitannins.
Keywords	aerial parts ; chemical composition ; flavonoids ; gallic acid ; lignans ; medicinal properties ; phenols ; Phyllanthus amarus ; response surface methodology ; tannins ; temperature ; ultrasonic treatment ; ultrasonics
Language	English
Dates of publication	2016-01
Size	p. 91-103.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1132158-1
ISSN	1872-633X ; 0926-6690
ISSN (online)	1872-633X
ISSN	0926-6690
DOI	10.1016/j.indcrop.2015.10.045
Database	NAL-Catalogue (AGRICOLA)

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Article: Evaluation of nutritional and chemical composition of yacon syrup using 1H NMR and UPLC-ESI-Q-TOF-MSE

Silva, Maria de Fátima Gomes da / Ana Paula Dionísio / Fernando Antonio Pinto de Abreu / Edy Sousa de Brito / Nedio Jair Wurlitzer / Lorena Mara Alexandre e Silva / Paulo Riceli Vasconcelos Ribeiro / Sueli Rodrigues / Carlos Alberto Kenji Taniguchi / Dorasilvia Ferreira Pontes

Food chemistry. 2018 Apr. 15, v. 245

2018

Abstract: A complete characterization of yacon syrup was performed by analytical techniques, including NMR and UPLC-QTOF-MSE. The effect of the different stages of yacon syrup production on fructooligosaccharides (FOS) and chlorogenic acid (CGA) contents were also ...

Abstract	A complete characterization of yacon syrup was performed by analytical techniques, including NMR and UPLC-QTOF-MSE. The effect of the different stages of yacon syrup production on fructooligosaccharides (FOS) and chlorogenic acid (CGA) contents were also evaluated. As a result, in addition to higher levels of FOS and CGA, some mineral elements, such as K, Ca and P, and essential amino acids, such as tryptophan, valine, and threonine, were determined in yacon syrup. Twenty-five compounds were putatively identified, and the main compounds were phenolics derived from quinic and trans-cinnamic acids. Considering the different stages of yacon syrup production, the results indicate that the contents of FOS and CGA were maintained in the pulping, enzymatic maceration and microfiltration, leading to a concentration of these components in the last stage of processing (vacuum concentration). These results will be used to fortify this innovative and promising product in the area of functional foods.
Keywords	Smallanthus sonchifolius ; calcium ; chemical composition ; chlorogenic acid ; essential amino acids ; fructooligosaccharides ; functional foods ; maceration ; microfiltration ; minerals ; nuclear magnetic resonance spectroscopy ; phenolic compounds ; potassium ; pulping ; syrups ; threonine ; tryptophan ; valine
Language	English
Dates of publication	2018-0415
Size	p. 1239-1247.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2017.11.092
Database	NAL-Catalogue (AGRICOLA)

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Article: Analysis by UPLC-MS-QTOF and antifungal activity of guava (Psidium guajava L.)

Bezerra, Camila Fonseca / Janaína Esmeraldo Rocha / Maria Karollyna do Nascimento Silva / Thiago Sampaio de Freitas / Amanda Karine de Sousa / Antônia Thassya Lucas dos Santos / Rafael Pereira da Cruz / Maciel Horácio Ferreira / Josefa Carolaine Pereira da Silva / Antonio Judson Targino Machado / Joara Nályda Pereira Carneiro / Débora Lima Sales / Henrique Douglas Melo Coutinho / Paulo Riceli Vasconcelos Ribeiro / Edy Sousa de Brito / Maria Flaviana Bezerra Morais-Braga

Food and chemical toxicology. 2018 Sept., v. 119

2018

Abstract: Psidium guajava L. is a plant widely used for food and in folk medicine all over the world. Studies have shown that guava leaves have antifungal properties. In this study, Flavonoid and Tannic fractions were tested to investigate their chemical ... ...

Abstract	Psidium guajava L. is a plant widely used for food and in folk medicine all over the world. Studies have shown that guava leaves have antifungal properties. In this study, Flavonoid and Tannic fractions were tested to investigate their chemical composition and antifungal potential in vitro.21 compounds in the two fractions, presenting a higher content of phenolic compounds. The antifungal assays were performed against Candida albicans, Candida tropicalis and Candida krusei by microdilution to determine the IC50 and the cell viability curve. Minimal Fungicidal Concentration(MFC) and the inhibitory effects of the association of the fractions with Fluconazole, as well as the assays used to verify any morphological changes were performed in microculture chambers based on the concentrations from the microdilution. The IC50 of the isolated fractions and the fractions associated with each other were calculated, varying from 69.29 to 3444.62 μg/mL and the fractions associated with fluconazole varied from 925.56 to 1.57 μg/mL, it was clear that the association of the natural product with the antifungal presented a synergism. The fractions affected pleomorphism capacity and have a potential antifungal activity as they caused fungal inhibition in isolated use, potentiated the action of Fluconazole, reducing its concentration and impeding morphological transition, one of the virulence factors of the genus.
Keywords	Candida albicans ; Candida krusei ; Candida tropicalis ; Psidium guajava ; antifungal properties ; cell viability ; chemical composition ; flavonoids ; fluconazole ; fungi ; guavas ; inhibitory concentration 50 ; leaves ; phenolic compounds ; synergism ; traditional medicine ; virulence
Language	English
Dates of publication	2018-09
Size	p. 122-132.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2018.05.021
Database	NAL-Catalogue (AGRICOLA)

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