LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 74

Search options

  1. Article ; Online: Predictably unequal: understanding and addressing concerns that algorithmic clinical prediction may increase health disparities.

    Paulus, Jessica K / Kent, David M

    NPJ digital medicine

    2020  Volume 3, Page(s) 99

    Abstract: The machine learning community has become alert to the ways that predictive algorithms can inadvertently introduce unfairness in decision-making. Herein, we discuss how concepts of algorithmic fairness might apply in healthcare, where predictive ... ...

    Abstract The machine learning community has become alert to the ways that predictive algorithms can inadvertently introduce unfairness in decision-making. Herein, we discuss how concepts of algorithmic fairness might apply in healthcare, where predictive algorithms are being increasingly used to support decision-making. Central to our discussion is the distinction between algorithmic fairness and algorithmic bias. Fairness concerns apply specifically when algorithms are used to support polar decisions (i.e., where one pole of prediction leads to decisions that are generally more desired than the other), such as when predictions are used to allocate scarce health care resources to a group of patients that could all benefit. We review different fairness criteria and demonstrate their mutual incompatibility. Even when models are used to balance benefits-harms to make optimal decisions for individuals (i.e., for non-polar decisions)-and fairness concerns are not germane-model, data or sampling issues can lead to biased predictions that support decisions that are differentially harmful/beneficial across groups. We review these potential sources of bias, and also discuss ways to diagnose and remedy algorithmic bias. We note that remedies for algorithmic fairness may be more problematic, since we lack agreed upon definitions of fairness. Finally, we propose a provisional framework for the evaluation of clinical prediction models offered for further elaboration and refinement. Given the proliferation of prediction models used to guide clinical decisions, developing consensus for how these concerns can be addressed should be prioritized.
    Language English
    Publishing date 2020-07-30
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2398-6352
    ISSN (online) 2398-6352
    DOI 10.1038/s41746-020-0304-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article: Natural History of Keloids: A Sociodemographic Analysis Using Structured and Unstructured Data.

    Swenson, Anna / Paulus, Jessica K / Jung, Yoojin / Weiss, Stefan / Berman, Brian / Peeva, Elena / Yamaguchi, Yuji / George, Prethibha / Jagun, Oladayo

    Dermatology and therapy

    2023  Volume 14, Issue 1, Page(s) 131–149

    Abstract: Introduction: Keloids are lesions characterized by the growth of dense fibrous tissue extending beyond original wound boundaries. Research into the natural history of keloids and potential differences by sociodemographic factors in the USA is limited. ... ...

    Abstract Introduction: Keloids are lesions characterized by the growth of dense fibrous tissue extending beyond original wound boundaries. Research into the natural history of keloids and potential differences by sociodemographic factors in the USA is limited. This real-world, retrospective cohort study aimed to characterize a population of patients with keloids compared with matched dermatology and general cohorts.
    Methods: Patients with ≥ 2 International Classification of Diseases codes for keloid ≥ 30 days apart and a confirmed keloid diagnosis from clinical notes enrolled in the OM1 Real-World Data Cloud between 1 January 2013 and 18 March 2022 were age- and sex-matched 1:1:1 to patients without keloids who visited dermatologists ("dermatology cohort") and those who did not ("general cohort"). Results are presented using descriptive statistics and analysis stratified by cohort, race, ethnicity, household income, and education.
    Results: Overall, 24,453 patients with keloids were matched to 23,936 dermatology and 24,088 general patients. A numerically higher proportion of patients with keloids were Asian or Black. Among available data for patients with keloids, 67.7% had 1 keloid lesion, and 68.3% had keloids sized 0.5 to < 3 cm. Black patients tended to have larger keloids. Asian and Black patients more frequently had > 1 keloid than did white patients (30.6% vs. 32.5% vs. 20.5%). Among all patients with keloids who had available data, 56.4% had major keloid severity, with major severity more frequent in Black patients. Progression was not significantly associated with race, ethnicity, income, or education level; 29%, 25%, and 20% of the dermatology, keloid, and general cohorts were in the highest income bracket (≥ US$75,000). The proportion of patients with income below the federal poverty line (< US$22,000) and patterns of education level were similar across cohorts.
    Conclusion: A large population of patients in the USA with keloids was identified and characterized using structured/unstructured sources. A numerically higher proportion of patients with keloids were non-white; Black patients had larger, more severe keloids at diagnosis.
    Language English
    Publishing date 2023-12-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2680284-3
    ISSN 2190-9172 ; 2193-8210
    ISSN (online) 2190-9172
    ISSN 2193-8210
    DOI 10.1007/s13555-023-01070-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Race and Ethnicity: A Part of the Equation for Personalized Clinical Decision Making?

    Paulus, Jessica K / Kent, David M

    Circulation. Cardiovascular quality and outcomes

    2017  Volume 10, Issue 7

    MeSH term(s) Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/ethnology ; Cardiovascular Diseases/genetics ; Cardiovascular Diseases/prevention & control ; Clinical Decision-Making ; Continental Population Groups/genetics ; Culturally Competent Care/ethnology ; Decision Support Techniques ; Ethnic Groups/genetics ; Genetic Predisposition to Disease ; Health Status Disparities ; Healthcare Disparities/ethnology ; Humans ; Patient Selection ; Phenotype ; Precision Medicine/methods ; Prognosis ; Risk Assessment ; Risk Factors
    Language English
    Publishing date 2017-07-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2483197-9
    ISSN 1941-7705 ; 1941-7713
    ISSN (online) 1941-7705
    ISSN 1941-7713
    DOI 10.1161/CIRCOUTCOMES.117.003823
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: When predictions are used to allocate scarce health care resources: three considerations for models in the era of Covid-19.

    Kent, David M / Paulus, Jessica K / Sharp, Richard R / Hajizadeh, Negin

    Diagnostic and prognostic research

    2020  Volume 4, Page(s) 11

    Abstract: Background: The need for life-saving interventions such as mechanical ventilation may threaten to outstrip resources during the Covid-19 pandemic. Allocation of these resources to those most likely to benefit can be supported by clinical prediction ... ...

    Abstract Background: The need for life-saving interventions such as mechanical ventilation may threaten to outstrip resources during the Covid-19 pandemic. Allocation of these resources to those most likely to benefit can be supported by clinical prediction models. The ethical and practical considerations relevant to predictions supporting decisions about microallocation are distinct from those that inform shared decision-making in ways important for model design.
    Main body: We review three issues of importance for microallocation: (1) Prediction of benefit (or of medical futility) may be technically very challenging; (2) When resources are scarce, calibration is less important for microallocation than is ranking to prioritize patients, since capacity determines thresholds for resource utilization; (3) The concept of group fairness, which is not germane in shared decision-making, is of central importance in microallocation. Therefore, model transparency is important.
    Conclusion: Prediction supporting allocation of life-saving interventions should be explicit, data-driven, frequently updated and open to public scrutiny. This implies a preference for simple, easily understood and easily applied prognostic models.
    Keywords covid19
    Language English
    Publishing date 2020-05-20
    Publishing country England
    Document type Editorial
    ISSN 2397-7523
    ISSN (online) 2397-7523
    DOI 10.1186/s41512-020-00079-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Breast cancer and thrombosis: timing matters.

    Paulus, Jessica K / Rosenberg, Aaron S

    Blood

    2016  Volume 127, Issue 7, Page(s) 793–794

    MeSH term(s) Breast Neoplasms/drug therapy ; Breast Neoplasms/epidemiology ; Female ; Humans ; Registries ; Venous Thromboembolism/epidemiology
    Language English
    Publishing date 2016-02-17
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2015-12-683482
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Sex Versus Gender in Recurrent Events Following Acute Coronary Syndrome: A "Femininity Paradox?".

    Paulus, Jessica K / Kent, David M

    Journal of the American College of Cardiology

    2016  Volume 68, Issue 12, Page(s) 1371–1372

    MeSH term(s) Acute Coronary Syndrome ; Female ; Femininity ; Gender Identity ; Humans ; Sex Factors ; Surveys and Questionnaires
    Language English
    Publishing date 2016--20
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2016.03.612
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article: Does case misclassification threaten the validity of studies investigating the relationship between neck manipulation and vertebral artery dissection stroke? Yes.

    Paulus, Jessica K / Thaler, David E

    Chiropractic & manual therapies

    2016  Volume 24, Page(s) 42

    Abstract: Background: For patients and health care providers who are considering spinal manipulative therapy of the neck, it is crucial to establish if it is a trigger for cervical artery dissection and/or stroke, and if it is, the magnitude of the risk.: ... ...

    Abstract Background: For patients and health care providers who are considering spinal manipulative therapy of the neck, it is crucial to establish if it is a trigger for cervical artery dissection and/or stroke, and if it is, the magnitude of the risk.
    Discussion: We discuss the biological plausibility of how neck manipulation could cause cervical artery dissection. We also discuss how case misclassification threatens the validity of influential published studies that have investigated the relationship between neck manipulation and dissection. Our position is supported by the fact that the largest epidemiologic studies of neck manipulation safety with respect to neurological outcomes have relied on International Classification of Diseases-9 codes for case identification. However, the application of these codes in prior studies failed to identify dissections (rather than strokes in general) and so conclusions from those studies are invalid.
    Conclusion: There are several methodological challenges to understanding the association between neck manipulation and vertebral artery dissection. Addressing these issues is critical because even a modest association between neck manipulation and cervical artery dissection could translate into a significant number of avoidable dissections given the widespread use of neck manipulation by providers from various backgrounds. We believe that valid case classification, accurate measurement of manipulative procedures, and addressing reverse causation bias should be top priorities for future research.
    Language English
    Publishing date 2016-11-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2590836-4
    ISSN 2045-709X
    ISSN 2045-709X
    DOI 10.1186/s12998-016-0123-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Healthcare workers' perspectives on coronavirus testing availability: a cross sectional survey.

    Byhoff, Elena / Paulus, Jessica K / Guardado, Rubeen / Zubiago, Julia / Wurcel, Alysse G

    BMC health services research

    2021  Volume 21, Issue 1, Page(s) 719

    Abstract: Background: Studies on the impact of the novel SARS-CoV-2 virus (COVID) for healthcare workers (HCWs) rarely include the full spectrum of hospital workers, including less visible patient support roles. In the early days of the pandemic, COVID testing ... ...

    Abstract Background: Studies on the impact of the novel SARS-CoV-2 virus (COVID) for healthcare workers (HCWs) rarely include the full spectrum of hospital workers, including less visible patient support roles. In the early days of the pandemic, COVID testing was preferentially available to HCWs. The objective of this study was to understand how individual experiences for all HCWs during the pandemic were associated with perceptions of access to, and receipt of COVID testing .
    Methods: All hospital employees (n = 6736) in a single academic medical center in Boston, Massachusetts were invited to participate in a cross-sectional survey regarding perceived access to, and receipt of COVID testing during the first wave of the pandemic (March - August 2020). Responses were linked to human resources data. Log binomial univariate and multivariable models were used to estimate associations between individual and employment variables and COVID testing.
    Results: A total of 2543 employees responded to the survey (38 %). The mean age was 40 years (± 14). Respondents were female (76 %), white (55 %), worked as nurses (27 %), administrators (22 %) and patient support roles (22 %); 56 % of respondents wanted COVID testing. Age (RR 0.91, CI 0.88-0.93), full time status (RR 0.85, CI 0.79-0.92), employment tenure (RR 0.96, CI 0.94-0.98), changes in quality of life (RR 0.94, CI 0.91-0.96), changes in job duties (RR 1.19, CI 1.03-1.37), and worry about enough paid sick leave (RR 1.21, CI 1.12-1.30) were associated with interest in testing. Administrators (RR 0.64, CI 0.58-0.72) and patient support staff (RR 0.85, CI 0.78-0.92) were less likely than nurses to want testing. Age (RR 1.04, CI 1.01-1.07), material hardships (RR 0.87, CI 0.79-0.96), and employer sponsored insurance (RR 1.10, CI 1.00-1.22) were associated with receiving a COVID test. Among all employees, only administrative/facilities staff were less likely to receive COVID testing (RR 0.69, CI 0.59-0.79).
    Conclusions: This study adds to our understanding of how hospital employees view availability of COVID testing. Hazard pay or other supports for hospital workers may increase COVID testing rates. These findings may be applicable to perceived barriers towards vaccination receipt.
    MeSH term(s) Adult ; Boston ; COVID-19 ; COVID-19 Testing ; Cross-Sectional Studies ; Female ; Health Personnel ; Humans ; Massachusetts ; Quality of Life ; SARS-CoV-2
    Language English
    Publishing date 2021-07-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050434-2
    ISSN 1472-6963 ; 1472-6963
    ISSN (online) 1472-6963
    ISSN 1472-6963
    DOI 10.1186/s12913-021-06741-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Reassessment of 4-Cycle Etoposide and Cisplatin as the Standard of Care for Good-Risk Metastatic Germ Cell Tumors.

    Fein, Daniel E / Paulus, Jessica K / Mathew, Paul

    JAMA oncology

    2018  Volume 4, Issue 12, Page(s) 1661–1662

    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Bleomycin/administration & dosage ; Bleomycin/adverse effects ; Choice Behavior ; Cisplatin/administration & dosage ; Cisplatin/adverse effects ; Dose-Response Relationship, Drug ; Etoposide/administration & dosage ; Etoposide/adverse effects ; Guideline Adherence/standards ; Humans ; Male ; Neoplasm Metastasis ; Neoplasms, Germ Cell and Embryonal/drug therapy ; Neoplasms, Germ Cell and Embryonal/mortality ; Neoplasms, Germ Cell and Embryonal/pathology ; Quality of Life ; Standard of Care ; Survival Rate ; Testicular Neoplasms/drug therapy ; Testicular Neoplasms/mortality ; Testicular Neoplasms/pathology ; Treatment Outcome
    Chemical Substances Bleomycin (11056-06-7) ; Etoposide (6PLQ3CP4P3) ; Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 2018-10-16
    Publishing country United States
    Document type Journal Article
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2018.4316
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: More than half of patients with a rheumatic disease or immunologic condition undergoing methotrexate treatment reside in states in which the overturning of Roe v. Wade can jeopardize access to medications with abortifacient potential.

    Starzyk, Kathryn / Hoffman, Veena / Su, Zhaohui / Meng, Roger / Bhartia, Mudit / Curhan, Gary / Yoshida, Kazuki / Paulus, Jessica K

    Arthritis & rheumatology (Hoboken, N.J.)

    2022  Volume 75, Issue 2, Page(s) 328–329

    MeSH term(s) Humans ; United States ; Methotrexate/therapeutic use ; Abortifacient Agents ; Immune System Diseases ; Rheumatic Diseases/drug therapy ; Health Services Accessibility
    Chemical Substances Methotrexate (YL5FZ2Y5U1) ; Abortifacient Agents
    Language English
    Publishing date 2022-12-09
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2756371-6
    ISSN 2326-5205 ; 2326-5191
    ISSN (online) 2326-5205
    ISSN 2326-5191
    DOI 10.1002/art.42398
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top