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  1. Article: Population Neuroscience: Principles and Advances.

    Paus, Tomáš

    Current topics in behavioral neurosciences

    2024  

    Abstract: In population neuroscience, three disciplines come together to advance our knowledge of factors that shape the human brain: neuroscience, genetics, and epidemiology (Paus, Human Brain Mapping 31:891-903, 2010). Here, I will come back to some of the ... ...

    Abstract In population neuroscience, three disciplines come together to advance our knowledge of factors that shape the human brain: neuroscience, genetics, and epidemiology (Paus, Human Brain Mapping 31:891-903, 2010). Here, I will come back to some of the background material reviewed in more detail in our previous book (Paus, Population Neuroscience, 2013), followed by a brief overview of current advances and challenges faced by this integrative approach.
    Language English
    Publishing date 2024-04-09
    Publishing country Germany
    Document type Journal Article
    ISSN 1866-3370
    ISSN 1866-3370
    DOI 10.1007/7854_2024_474
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Population neuroscience

    Paus, Tomáš

    an introduction

    2013  

    Author's details Tomáš Paus
    Keywords Neuropsychologie ; Kognitionswissenschaft ; Genetik ; Umweltfaktor ; Sozialpsychologie
    Subject Umwelteinfluss ; Ökologischer Faktor ; Exogener Faktor ; Standortbedingungen ; Standortfaktor ; Allgemeine Genetik ; Erbbiologie ; Erbforschung ; Erblehre ; Vererbungslehre ; Vererbungswissenschaft ; Erblichkeitslehre ; Kognitive Wissenschaft ; Cognitive Science ; Kognitionsforschung
    Language English
    Size XI, 184 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Heidelberg u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT017615221
    ISBN 978-3-642-36449-5 ; 3-642-36449-7 ; 9783642364501 ; 3642364500
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2013 A 600 available for loan (reading room) Lesesaal EG

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  3. Article ; Online: Tracking Development of Connectivity in the Human Brain: Axons and Dendrites.

    Paus, Tomáš

    Biological psychiatry

    2022  Volume 93, Issue 5, Page(s) 455–463

    Abstract: The neuron doctrine laid the foundation for our current thinking about the structural and functional organization of the human brain. With the basic units of the nervous system-neurons-being physically separate, their connectivity relies on the ... ...

    Abstract The neuron doctrine laid the foundation for our current thinking about the structural and functional organization of the human brain. With the basic units of the nervous system-neurons-being physically separate, their connectivity relies on the conduction of action potentials in axons and their transmission across the synaptic cleft to the dendrites of other neurons. This study reviews available ex vivo data about the cellular composition of the human cerebral cortex, focusing on axons and dendrites, to conceptualize biological sources of signals detected in vivo with magnetic resonance imaging. To bridge the gap between ex vivo and in vivo observations, I then explain the basic principles of virtual histology, an approach that integrates spatially cell- or process-specific transcriptomic data with magnetic resonance signals to facilitate their neurobiological interpretation. Finally, I provide an overview of the initial insights gained in this manner in studies of brain development and maturation, in both health and disease.
    MeSH term(s) Humans ; Dendrites ; Axons ; Neurons/physiology ; Cerebral Cortex/diagnostic imaging ; Cerebral Cortex/physiology ; Synapses ; Brain/physiology
    Language English
    Publishing date 2022-08-28
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 209434-4
    ISSN 1873-2402 ; 0006-3223
    ISSN (online) 1873-2402
    ISSN 0006-3223
    DOI 10.1016/j.biopsych.2022.08.019
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    Zs.A 720: Show issues Location:
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  4. Book ; Conference proceedings: 4th International Conference on Functional Mapping of the Human Brain

    Paus, Tomáš

    June 7 - 12, 1998, Montreal, Quebec, Canada

    (NeuroImage ; 7,4, Pt. 2)

    1998  

    Event/congress International Conference on Functional Mapping of the Human Brain (4, 1998, Montréal)
    Author's details suppl. ed. Tomáš Paus
    Series title NeuroImage ; 7,4, Pt. 2
    Collection
    Language English
    Size XXXVIII, S1025 S. : Ill., graph. Darst.
    Publisher Acad. Press
    Publishing place San Diego u.a.
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT008804472
    Database Catalogue ZB MED Medicine, Health

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    Zs A 3664 -7,4,Pt.2- not available for loan Zeitschriften-Lesesaal

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  5. Article ; Online: Investigating the Role of Micronutrients in Brain Development and Psychiatric Disorders via Magnetic Resonance Imaging.

    Paus, Tomáš

    JAMA psychiatry

    2018  Volume 75, Issue 9, Page(s) 880–882

    MeSH term(s) Adolescent ; Cerebral Cortex ; Female ; Folic Acid ; Humans ; Magnetic Resonance Imaging ; Mental Disorders ; Micronutrients ; Pregnancy ; Prenatal Exposure Delayed Effects
    Chemical Substances Micronutrients ; Folic Acid (935E97BOY8)
    Language English
    Publishing date 2018-06-30
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2701203-7
    ISSN 2168-6238 ; 2168-622X
    ISSN (online) 2168-6238
    ISSN 2168-622X
    DOI 10.1001/jamapsychiatry.2018.1255
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  6. Article ; Online: Intrauterine growth and the tangential expansion of the human cerebral cortex in times of food scarcity and abundance.

    Vosberg, Daniel E / Jurisica, Igor / Pausova, Zdenka / Paus, Tomáš

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 1205

    Abstract: Tangential growth of the human cerebral cortex is driven by cell proliferation during the first and second trimester of pregnancy. Fetal growth peaks in mid-gestation. Here, we explore how genes associated with fetal growth relate to cortical growth. We ... ...

    Abstract Tangential growth of the human cerebral cortex is driven by cell proliferation during the first and second trimester of pregnancy. Fetal growth peaks in mid-gestation. Here, we explore how genes associated with fetal growth relate to cortical growth. We find that both maternal and fetal genetic variants associated with higher birthweight predict larger cortical surface area. The relative dominance of the maternal vs. fetal variants in these associations show striking variations across birth years (1943 to 1966). The birth-year patterns vary as a function of the epigenetic status near genes differentially methylated in individuals exposed (or not) to famine during the Dutch Winter of 1944/1945. Thus, it appears that the two sets of molecular processes contribute to early cortical development to a different degree in times of food scarcity or its abundance.
    MeSH term(s) Pregnancy ; Female ; Humans ; Birth Weight ; Fetal Development/genetics ; Prenatal Care ; Family
    Language English
    Publishing date 2024-02-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-45409-6
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  7. Article ; Online: The genetics of a "femaleness/maleness" score in cardiometabolic traits in the UK biobank.

    Vosberg, Daniel E / Pausova, Zdenka / Paus, Tomáš

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 9109

    Abstract: We recently devised continuous "sex-scores" that sum up multiple quantitative traits, weighted by their respective sex-difference effect sizes, as an approach to estimating polyphenotypic "maleness/femaleness" within each binary sex. To identify the ... ...

    Abstract We recently devised continuous "sex-scores" that sum up multiple quantitative traits, weighted by their respective sex-difference effect sizes, as an approach to estimating polyphenotypic "maleness/femaleness" within each binary sex. To identify the genetic architecture underlying these sex-scores, we conducted sex-specific genome-wide association studies (GWASs) in the UK Biobank cohort (females: n = 161,906; males: n = 141,980). As a control, we also conducted GWASs of sex-specific "sum-scores", simply aggregating the same traits, without weighting by sex differences. Among GWAS-identified genes, while sum-score genes were enriched for genes differentially expressed in the liver in both sexes, sex-score genes were enriched for genes differentially expressed in the cervix and across brain tissues, particularly for females. We then considered single nucleotide polymorphisms with significantly different effects (sdSNPs) between the sexes for sex-scores and sum-scores, mapping to male-dominant and female-dominant genes. Here, we identified brain-related enrichment for sex-scores, especially for male-dominant genes; these findings were present but weaker for sum-scores. Genetic correlation analyses of sex-biased diseases indicated that both sex-scores and sum-scores were associated with cardiometabolic, immune, and psychiatric disorders.
    MeSH term(s) Humans ; Male ; Female ; Genome-Wide Association Study ; Biological Specimen Banks ; Mental Disorders ; Cardiovascular Diseases ; United Kingdom ; Polymorphism, Single Nucleotide
    Language English
    Publishing date 2023-06-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-36132-1
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  8. Article ; Online: Imaging microstructure in the living human brain: A viewpoint.

    Paus, Tomáš

    NeuroImage

    2017  Volume 182, Page(s) 3–7

    Abstract: This special issue summarizes an impressive body of work concerned with in vivo imaging of brain microstructure. Collectively, papers included here demonstrate the power of multi-modal magnetic resonance imaging (MRI) for mapping various structural ... ...

    Abstract This special issue summarizes an impressive body of work concerned with in vivo imaging of brain microstructure. Collectively, papers included here demonstrate the power of multi-modal magnetic resonance imaging (MRI) for mapping various structural properties of brain tissue. In this introduction, I provide a user's perspective vis-à-vis motivations for these efforts, review briefly the cellular composition of grey and white matter in the human brain, and provide a few examples of how we can bridge the gap between ex vivo and in vivo datasets to facilitate interpretation of studies measuring brain macro- and microstructure.
    MeSH term(s) Gray Matter/anatomy & histology ; Gray Matter/diagnostic imaging ; Humans ; Magnetic Resonance Imaging/methods ; Neuroimaging/methods ; White Matter/anatomy & histology ; White Matter/diagnostic imaging
    Language English
    Publishing date 2017-10-09
    Publishing country United States
    Document type Introductory Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1147767-2
    ISSN 1095-9572 ; 1053-8119
    ISSN (online) 1095-9572
    ISSN 1053-8119
    DOI 10.1016/j.neuroimage.2017.10.013
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    Zs.A 3664: Show issues Location:
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    Zs.MO 7: Show issues

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  9. Article ; Online: Prediabetic HbA1c and Cortical Atrophy: Underlying Neurobiology.

    Shin, Jean / Patel, Yash / Parker, Nadine / Paus, Tomas / Pausova, Zdenka

    Diabetes care

    2023  Volume 46, Issue 12, Page(s) 2267–2272

    Abstract: Objective: To investigate the relationship between blood glycated hemoglobin (HbA1c) and cerebral cortical thickness (CT) and identify potential cellular mechanisms involved.: Research design and methods: A cohort of 30,579 adults age 45 to 81 (mean ± ...

    Abstract Objective: To investigate the relationship between blood glycated hemoglobin (HbA1c) and cerebral cortical thickness (CT) and identify potential cellular mechanisms involved.
    Research design and methods: A cohort of 30,579 adults age 45 to 81 (mean ± SD: 64 ± 7.5) years with available data on brain MRI and blood HbA1c levels was analyzed. The relationship between HbA1c and CT was probed using independent spatial profiles of cell-specific gene expression. Lastly, a genome-wide association study was conducted on the shared variance between HbA1c and CT.
    Results: The HbA1c-CT association was noncontinuous, emerging negatively within the prediabetic range (39.6 mmol/mol). This association was strongest in brain regions with higher expression of genes specific to excitatory neurons and lower expression of genes specific to astrocytes and microglia. A significant locus implicated mitochondrial maintenance and ATP generation.
    Conclusions: Effective glycemia control at prediabetic levels is warranted to preserve brain health and prevent prediabetes-related neurobiologic perturbations.
    MeSH term(s) Adult ; Humans ; Middle Aged ; Aged ; Aged, 80 and over ; Prediabetic State/genetics ; Glycated Hemoglobin ; Blood Glucose/metabolism ; Genome-Wide Association Study ; Neurobiology ; Atrophy
    Chemical Substances Glycated Hemoglobin ; Blood Glucose
    Language English
    Publishing date 2023-10-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 441231-x
    ISSN 1935-5548 ; 0149-5992
    ISSN (online) 1935-5548
    ISSN 0149-5992
    DOI 10.2337/dc23-1105
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    Zs.MO 365: Show issues

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  10. Article: Editorial: Population Neuroscience of Development and Aging.

    Paus, Tomáš / Debette, Stephanie / Seshadri, Sudha

    Frontiers in systems neuroscience

    2022  Volume 16, Page(s) 897943

    Language English
    Publishing date 2022-04-25
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2453005-0
    ISSN 1662-5137
    ISSN 1662-5137
    DOI 10.3389/fnsys.2022.897943
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