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  1. Article ; Online: THE ENCEPHALOMYOCARDITIS VIRUS (EMCV) AND ITS ZOONOTIC POTENTIAL (A Literature Review) PART I. MODERN VIEWS ON THE EMCV STRUCTURE AND ITS VIRAL CYCLE

    Akop A. Kalajdzhjan / Azamat Kh. Kade / Pavel P. Polyakov / Alla A. Gudmanova

    Кубанский научный медицинский вестник, Vol 26, Iss 2, Pp 214-

    2019  Volume 223

    Abstract: There have been a growing number of the outbreaks of human diseases with typical zoonotic infections, which have previously occurred exclusively in veterinary practice. Among them is monkeypox, whose first occurrence outside the African continent was ... ...

    Abstract There have been a growing number of the outbreaks of human diseases with typical zoonotic infections, which have previously occurred exclusively in veterinary practice. Among them is monkeypox, whose first occurrence outside the African continent was registered in the USA in the spring of 2003. An important factor contributing to the penetration of infections into the human population is a close contact of people with fauna representatives in the context of intensively growing cities. Therefore, research into new zoonotic diseases, which are potentially dangerous to humans, seems to be critically important. Thus, retrospective studies carried out among the Peru population in 2009 revealed the cases of the encephalomyocarditis virus (EMCV) (Picornaviridae family, Cardiovirus genus) infection in people having suffered from acute febrile illness. A new virus strain belonging to the same genus was described during the infection outbreak among primates of the Sukhumi Monkey nursery (Republic of Abkhazia) in 1990–1999. This strain was also identified during the outbreak among the monkeys of the Primatological Centre in the Krasnodar Krai in 2012. In this review, we generalize the data available on the structure, virulence factors and distribution of EMCV.
    Keywords encephalomyocarditis virus ; emcv virion structure ; emcv rna structure ; emcv viral cycle ; Medicine ; R
    Language Russian
    Publishing date 2019-05-01T00:00:00Z
    Publisher Ministry of Healthcare of the Russian Federation. “Kuban State Medical University”
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: THE ENCEPHALOMYOCARDITIS VIRUS (EMCV) AND ITS ZOONOTIC POTENTIAL (A LITERATURE REVIEW). PART II. PATHOGENESIS. THE CIRCLE OF SUSCEPTIBLE ORGANISMS

    Akop A. Kalajdzhjan / Azamat Kh. Kade / Pavel P. Polyakov / Alla I. Gudmanova

    Кубанский научный медицинский вестник, Vol 26, Iss 3, Pp 117-

    2019  Volume 128

    Abstract: According to literature data, both the direct action of (B2 *, L, 2A) viral proteins and the inflammatory response of the body are distinguished among the Encephalomyocarditis virus (EMCV) virulence factors. Depending on the EMCV strain and the type of ... ...

    Abstract According to literature data, both the direct action of (B2 *, L, 2A) viral proteins and the inflammatory response of the body are distinguished among the Encephalomyocarditis virus (EMCV) virulence factors. Depending on the EMCV strain and the type of the infected animal, the severity and nature of the disease is shown to be characterized by specific clinical manifestations. Differences in the pathogenetic mechanisms of tissue lesions depending on the magnitude of the virus infectious dose are established, e.g., in the development of EMCV-induced diabetes. The EMCV action was studied in vivo on such experimental animals as pigs, rodents and monkeys. The range of affected animals is extremely wide, with the infection being common almost everywhere. Thus, numerous works describe a fairly high immunological stratum among people, as well as disease outbreaks among the population. It is concluded that EMCV is dangerous not only for zoos and primatological centres, but also has a clear zoonotic potential.
    Keywords encephalomyocarditis virus ; emcv-induced diabetes ; emcv-induced myocarditis ; emcv virulence factors ; Medicine ; R
    Subject code 630
    Language Russian
    Publishing date 2019-07-01T00:00:00Z
    Publisher Ministry of Healthcare of the Russian Federation. “Kuban State Medical University”
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  3. Article ; Online: Role and significance of asprosin in feeding behaviour and metabolism

    Rustam H. Salimkhanov / Vladislav R. Sharifullin / Yulia R. Kushnareva / Azamat Kh. Kade / Pavel P. Polyakov

    Кубанский научный медицинский вестник, Vol 27, Iss 1, Pp 96-

    2020  Volume 104

    Abstract: This article presents a review of available information on asprosin — a hormone of white adipose tissue discovered in 2016. The history of its discovery, as well as its action mechanisms and main targets are examined. Changes in the plasma level of ... ...

    Abstract This article presents a review of available information on asprosin — a hormone of white adipose tissue discovered in 2016. The history of its discovery, as well as its action mechanisms and main targets are examined. Changes in the plasma level of asprosin under some pathological conditions are analysed. The importance of studying asprosin is determined by its functions: asprosin regulates physiological processes during fasting and plays an important role in the development of metabolic disorders, such as insulin resistance. There are relatively few studies concerned with asprosin; however, this hormone can already be considered as a diagnostic marker and a potential target in the treatment of certain metabolic disorders, e.g. diabetes mellitus and obesity.
    Keywords fbn1 ; marfanoid-progeroid-lipodystrophy syndrome ; white adipose tissue ; insulin resistance ; Medicine ; R
    Language Russian
    Publishing date 2020-02-01T00:00:00Z
    Publisher Ministry of Healthcare of the Russian Federation. “Kuban State Medical University”
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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