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Article ; Online: Insights From the Eye for Patients With Kidney Transplant.

Xu, Christine / Prager, Alisa J / Alonso, Carolyn D / Pawar, Aditya S

2022 Volume 54, Issue 8, Page(s) 2182–2191

Abstract: The eye and the kidney share structural and developmental similarities on a cellular and clinical level, and they are often affected by the same disease processes. Performing an eye exam to look for signs of conditions such as hypertension and diabetes ... ...

Abstract	The eye and the kidney share structural and developmental similarities on a cellular and clinical level, and they are often affected by the same disease processes. Performing an eye exam to look for signs of conditions such as hypertension and diabetes can provide a helpful window into the health of the kidney. Patients with kidney transplants (KT) are a unique population that require close monitoring. These patients are maintained on a number of immunosuppressive medications and may face complications such as medication side effects, infections, and graft rejection. Patients with KT are at higher risk of both infectious and noninfectious eye conditions related to underlying systemic disease or use of immunosuppressive medications. Screening for eye conditions is important because preserving visual function is integral to quality of life, and also because the eye exam can help with early detection and treatment of systemic conditions. Here we describe some of the common eye findings and conditions in patients with KT. We recommend that patients with KT receive annual eye exams, and we hope that the information provided here can help nephrologists become more familiar with eye findings and identify situations where a referral to ophthalmology is warranted.
MeSH term(s)	Humans ; Kidney Transplantation/adverse effects ; Quality of Life ; Graft Rejection ; Diabetes Mellitus/etiology ; Hypertension/etiology ; Eye Diseases/etiology
Language	English
Publishing date	2022-09-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2022.07.008
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Article ; Online: Lithium-Induced Nephropathy.

Pawar, Aditya S / Kattah, Andrea G

The New England journal of medicine

2018 Volume 378, Issue 11, Page(s) 1042

MeSH term(s)	Cysts/diagnostic imaging ; Diabetes Insipidus, Nephrogenic/chemically induced ; Diabetes Insipidus, Nephrogenic/diagnosis ; Humans ; Kidney/diagnostic imaging ; Kidney/drug effects ; Kidney/pathology ; Kidney Diseases/chemically induced ; Kidney Diseases/diagnostic imaging ; Lithium/adverse effects ; Male ; Middle Aged ; Osmolar Concentration ; Tomography, X-Ray Computed ; Urine/chemistry
Chemical Substances	Lithium (9FN79X2M3F)
Language	English
Publishing date	2018-03-15
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMicm1709438
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Article ; Online: 63-Year-Old Woman With Abdominal Pain and Thrombocytopenia.

St-Pierre, Frederique / Pawar, Aditya S / Kumar, Rajiv

Mayo Clinic proceedings

2019 Volume 94, Issue 10, Page(s) 2122–2126

MeSH term(s)	Abdominal Pain/etiology ; Atypical Hemolytic Uremic Syndrome/complications ; Atypical Hemolytic Uremic Syndrome/diagnosis ; Female ; Humans ; Middle Aged ; Thrombocytopenia/etiology
Language	English
Publishing date	2019-10-01
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	124027-4
ISSN	1942-5546 ; 0025-6196
ISSN (online)	1942-5546
ISSN	0025-6196
DOI	10.1016/j.mayocp.2019.02.034
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Article ; Online: 72-Year-Old Woman With Fatigue, Confusion, and Severe Acute Renal Failure.

Zhang, Xin / Pawar, Aditya S / Greene, Eddie L

Mayo Clinic proceedings

2018 Volume 93, Issue 10, Page(s) 1520–1524

MeSH term(s)	Acute Kidney Injury/pathology ; Acute Kidney Injury/physiopathology ; Acute Kidney Injury/therapy ; Aged ; Antacids/administration & dosage ; Biopsy/methods ; Calcium Carbonate/administration & dosage ; Calcium Oxalate/metabolism ; Confusion/diagnosis ; Confusion/etiology ; Diagnosis, Differential ; Diet, Fat-Restricted/methods ; Fatigue/diagnosis ; Fatigue/etiology ; Female ; Gastric Bypass/adverse effects ; Humans ; Kidney Function Tests/methods ; Kidney Tubules/metabolism ; Kidney Tubules/pathology ; Kidney Tubules/physiopathology ; Nephritis, Interstitial/complications ; Nephritis, Interstitial/diagnosis ; Nephritis, Interstitial/physiopathology ; Postoperative Complications/pathology ; Postoperative Complications/physiopathology ; Postoperative Complications/therapy ; Renal Dialysis/methods ; Severity of Illness Index ; Treatment Outcome
Chemical Substances	Antacids ; Calcium Oxalate (2612HC57YE) ; Calcium Carbonate (H0G9379FGK)
Language	English
Publishing date	2018-08-10
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	124027-4
ISSN	1942-5546 ; 0025-6196
ISSN (online)	1942-5546
ISSN	0025-6196
DOI	10.1016/j.mayocp.2018.01.033
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Article: Recurrent renal calculi in coexistence of horseshoe kidney and medullary sponge kidney.

Cheungpasitporn, Wisit / Pawar, Aditya S / Erickson, Stephen B

Urology annals

2017 Volume 9, Issue 2, Page(s) 214–215

Language	English
Publishing date	2017-01-31
Publishing country	India
Document type	Journal Article
ISSN	0974-7796
ISSN	0974-7796
DOI	10.4103/UA.UA_173_16
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Article ; Online: Altered immune cell phenotypes within chronically ischemic human kidneys distal to occlusive renal artery disease.

Zhu, Xiang-Yang / Klomjit, Nattawat / Pawar, Aditya S / Puranik, Amrutesh S / Yang, Zhi-Zhang / Lutgens, Esther / Eirin, Alfonso / Lerman, Amir / Textor, Stephen C / Lerman, Lilach O

American journal of physiology. Renal physiology

2023 Volume 326, Issue 2, Page(s) F257–F264

Abstract: Renal artery stenosis (RAS) is a major cause of ischemic kidney disease, which is largely mediated by inflammation. Mapping the immune cell composition in ischemic kidneys might provide useful insight into the disease pathogenesis and uncover therapeutic ...

Abstract	Renal artery stenosis (RAS) is a major cause of ischemic kidney disease, which is largely mediated by inflammation. Mapping the immune cell composition in ischemic kidneys might provide useful insight into the disease pathogenesis and uncover therapeutic targets. We used mass cytometry (CyTOF) to explore the single-cell composition in a unique data set of human kidneys nephrectomized due to chronic occlusive vascular disease (RAS,
MeSH term(s)	Humans ; Aged ; Carcinoma, Renal Cell/pathology ; Renal Artery Obstruction/pathology ; Renal Artery ; Kidney/pathology ; Ischemia/pathology ; Phenotype ; Inflammation/pathology ; Kidney Neoplasms/pathology
Language	English
Publishing date	2023-11-30
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	603837-2
ISSN	1522-1466 ; 0363-6127
ISSN (online)	1522-1466
ISSN	0363-6127
DOI	10.1152/ajprenal.00234.2023
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Article ; Online: General Public's Information-Seeking Patterns of Topics Related to Obesity: Google Trends Analysis.

Pawar, Aditya S / Nagpal, Sajan / Pawar, Neha / Lerman, Lilach O / Eirin, Alfonso

JMIR public health and surveillance

2020 Volume 6, Issue 3, Page(s) e20923

Abstract: Background: Obesity is a major public health challenge, and recent literature sheds light on the concept of "normalization" of obesity.: Objective: We aimed to study the worldwide pattern of web-based information seeking by public on obesity and on ... ...

Abstract	Background: Obesity is a major public health challenge, and recent literature sheds light on the concept of "normalization" of obesity. Objective: We aimed to study the worldwide pattern of web-based information seeking by public on obesity and on its related terms and topics using Google Trends. Methods: We compared the relative frequency of obesity-related search terms and topics between 2004 and 2019 on Google Trends. The mean relative interest scores for these terms over the 4-year quartiles were compared. Results: The mean relative interest score of the search term "obesity" consistently decreased with time in all four quartiles (2004-2019), whereas the relative interest scores of the search topics "weight loss" and "abdominal obesity" increased. The topic "weight loss" was popular during the month of January, and its median relative interest score for January was higher than that for other months for the entire study period (P<.001). The relative interest score for the search term "obese" decreased over time, whereas those scores for the terms "body positivity" and "self-love" increased after 2013. Conclusions: Despite a worldwide increase in the prevalence of obesity, its popularity as an internet search term diminished over time. The reason for peaks in months should be explored and applied to the awareness campaigns for better effectiveness. These patterns suggest normalization of obesity in society and a rise of public curiosity about image-related obesity rather than its medical implications and harm.
MeSH term(s)	Data Mining/methods ; Data Mining/statistics & numerical data ; Humans ; Information Seeking Behavior ; Obesity/complications ; Obesity/epidemiology ; Search Engine/methods ; Search Engine/statistics & numerical data
Keywords	covid19
Language	English
Publishing date	2020-08-11
Publishing country	Canada
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	2369-2960
ISSN (online)	2369-2960
DOI	10.2196/20923
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Article ; Online: Upregulated tumor necrosis factor-α transcriptome and proteome in adipose tissue-derived mesenchymal stem cells from pigs with metabolic syndrome.

Pawar, Aditya S / Eirin, Alfonso / Tang, Hui / Zhu, Xiang-Yang / Lerman, Amir / Lerman, Lilach O

Cytokine

2020 Volume 130, Page(s) 155080

Abstract: Introduction: Mesenchymal stem cells (MSCs) have endogenous reparative properties, and may constitute an exogenous therapeutic intervention in patients with chronic kidney disease. The microenvironment of metabolic syndrome (MetS) induces fat ... ...

Abstract	Introduction: Mesenchymal stem cells (MSCs) have endogenous reparative properties, and may constitute an exogenous therapeutic intervention in patients with chronic kidney disease. The microenvironment of metabolic syndrome (MetS) induces fat inflammation, with abundant expression of tumor necrosis factor (TNF)-α. MetS may also alter the content of adipose tissue-derived MSCs, and we hypothesized that the inflammatory profile of MetS manifests via upregulating MSC mRNAs and proteins of the TNF-α pathway. Methods: Domestic pigs were fed a 16-week Lean or MetS diet (n = 4 each). MSCs were harvested from abdominal subcutaneous fat, and their extracellular vesicles (EVs) isolated. Expression profiles of mRNAs and proteins in MSCs and EVs were obtained by high-throughput sequencing and proteomics. Nuclear translocation of the pro-inflammatory transcription factor (NF)-kB was evaluated in MSC and in pig renal tubular cells (TEC) co-incubated with EVs. Results: We found 13 mRNAs and 4 proteins in the TNF-α pathway upregulated in MetS- vs. Lean-MSCs (fold-change > 1.4, p < 0.05), mostly via TNF-α receptor-1 (TNF-R1) signaling. Three mRNAs were upregulated in MetS-EVs. MetS-MSCs, as well as TECs co-incubated with MetS-EVs, showed increased nuclear translocation of NF-kB. Using qPCR, JUNB, MAP2K7 and TRAF2 genes followed the same direction of RNA-sequencing findings. Conclusions: MetS upregulates the TNF-α transcriptome and proteome in swine adipose tissue-derived MSCs, which are partly transmitted to their EV progeny, and are associated with activation of NF-kB in target cells. Hence, the MetS milieu may affect the profile of endogenous MSCs and their paracrine vectors and limit their use as an exogenous regenerative therapy. Anti-inflammatory strategies targeting the TNF-α pathway might be a novel strategy to restore MSC phenotype, and in turn function.
Language	English
Publishing date	2020-03-30
Publishing country	England
Document type	Journal Article
ZDB-ID	1018055-2
ISSN	1096-0023 ; 1043-4666
ISSN (online)	1096-0023
ISSN	1043-4666
DOI	10.1016/j.cyto.2020.155080
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Article ; Online: Decisional Regret Surrounding Dialysis Initiation: A Comparative Analysis.

Pawar, Aditya S / Thorsteinsdottir, Bjorg / Whitman, Sam / Pine, Katherine / Lee, Alexander / Espinoza Suarez, Nataly R / Organick Lee, Paige / Thota, Anjali / Lorenz, Elizabeth / Beck, Annika / Albright, Robert / Feely, Molly / Williams, Amy / Behnken, Emma / Boehmer, Kasey R

Kidney medicine

2023 Volume 6, Issue 3, Page(s) 100785

Abstract: Rationale & objective: Dialysis comes with a substantial treatment burden, so patients must select care plans that align with their preferences. We aimed to deepen the understanding of decisional regret with dialysis choices.: Study design: This ... ...

Abstract	Rationale & objective: Dialysis comes with a substantial treatment burden, so patients must select care plans that align with their preferences. We aimed to deepen the understanding of decisional regret with dialysis choices. Study design: This study had a mixed-methods explanatory sequential design. Setting & participants: All patients from a single academic medical center prescribed maintenance in-center hemodialysis or presenting for home hemodialysis or peritoneal dialysis check-up during 3 weeks were approached for survey. A total of 78 patients agreed to participate. Patients with the highest (15 patients) and lowest decisional regret (20 patients) were invited to semistructured interviews. Predictors: Decisional regret scale and illness intrusiveness scale were used in this study. Analytical approach: Quantitatively, we examined correlations between the decision regret scale and illness intrusiveness scale and sorted patients into the highest and lowest decision regret scale quartiles for further interviews; then, we compared patient characteristics between those that consented to interview in high and low decisional regret. Qualitatively, we used an adapted grounded theory approach to examine differences between interviewed patients with high and low decisional regret. Results: Of patients invited to participate in the interviews, 21 patients (8 high regret, 13 low regret) agreed. We observed that patients with high decisional regret displayed resignation toward dialysis, disruption of their sense of self and social roles, and self-blame, whereas patients with low decisional regret demonstrated positivity, integration of dialysis into their identity, and self-compassion. Limitations: Patients with the highest levels of decisional regret may have already withdrawn from dialysis. Patients could complete interviews in any location (eg, home, dialysis unit, and clinical office), which may have influenced patient disclosure. Conclusions: Although all patients experienced disruption after dialysis initiation, patients' approach to adversity differs between patients experiencing high versus low regret. This study identifies emotional responses to dialysis that may be modifiable through patient-support interventions.
Language	English
Publishing date	2023-12-20
Publishing country	United States
Document type	Journal Article
ISSN	2590-0595
ISSN (online)	2590-0595
DOI	10.1016/j.xkme.2023.100785
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Article: Incidence and characteristics of kidney stones in patients with horseshoe kidney: A systematic review and meta-analysis.

Pawar, Aditya S / Thongprayoon, Charat / Cheungpasitporn, Wisit / Sakhuja, Ankit / Mao, Michael A / Erickson, Stephen B

Urology annals

2018 Volume 10, Issue 1, Page(s) 87–93

Abstract: Introduction: The horseshoe kidney (HSK) is the most common type of renal fusion anomaly. The incidence and characteristics of kidney stones in patients with HSK are not well studied. The aim of this meta-analysis was to evaluate the incidence and types ...

Abstract	Introduction: The horseshoe kidney (HSK) is the most common type of renal fusion anomaly. The incidence and characteristics of kidney stones in patients with HSK are not well studied. The aim of this meta-analysis was to evaluate the incidence and types of kidney stones in patients with HSK. Methods: A systematic literature search was performed using MEDLINE, EMBASE, and Cochrane Database of Systematic Reviews from the databases' inception through November 2016. Studies assessing the incidence and types of kidney stones in patients with HSK were included. We applied a random-effects model to estimate the incidence of kidney stones. The study protocol was registered with PROSPERO (International Prospective Register of Systematic Reviews; no. CRD42016052037). Results: A total of 14 observational studies with 943 patients (522 adults and 421 pediatric) with HSK were enrolled. The estimated pooled incidence of kidney stones was 36% (95% confidence interval [CI], 15%-59%) in adults with the HSK. Kidney stones were less common in pediatric patients with HSK with an estimated pooled incidence of 3% (95% CI, 2%-5%). The mean age of adult stone formers with HSK was 44.9 ± 6.2 years, and 75% were males. Within reported studies, 89.2% of kidney stones were calcium-based stones (64.2% calcium oxalate [CaOx], 18.8% calcium phosphate [CaP], and 6.2% mixed CaOx/CaP), followed by struvite stones (4.2%), uric acid stones (3.8%), and others (2.8%). Conclusions: Kidney stones are very common in adult patients with HSK with an estimated incidence of 36%. Calcium-based stones are the most prevalent kidney stones in adults with HSKs. These findings may impact the prevention and clinical management of kidney stones in patients with HSK.
Language	English
Publishing date	2018-01-25
Publishing country	India
Document type	Journal Article
ISSN	0974-7796
ISSN	0974-7796
DOI	10.4103/UA.UA_76_17
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