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  1. Article ; Online: A Practical, Nenitzescu-Based Synthesis of LY311727, the First Potent and Selective s-PLA(2) Inhibitor.

    Pawlak, J. M. / Khau, V. V. / Hutchison, D. R. / Martinelli, M. J.

    The Journal of organic chemistry

    1996  Volume 61, Issue 25, Page(s) 9055–9059

    Language English
    Publishing date 1996-12-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/jo9614452
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4473: Show issues Location:
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  2. Article: Synthesis and biological evaluation of a new series of sterols as potential hypocholesterolemic agents.

    Lin, H S / Rampersaud, A A / Archer, R A / Pawlak, J M / Beavers, L S / Schmidt, R J / Kauffman, R F / Bensch, W R / Bumol, T F / Apelgren, L D

    Journal of medicinal chemistry

    1995  Volume 38, Issue 2, Page(s) 277–288

    Abstract: A new series of sterols was synthesized and tested in a CHO cell-based LDL receptor/luciferase (LDLR/Luc) assay to investigate the capability of derepressing the transcription of LDL receptor promoter in the presence of 25-hydroxycholesterol. The effect ... ...

    Abstract A new series of sterols was synthesized and tested in a CHO cell-based LDL receptor/luciferase (LDLR/Luc) assay to investigate the capability of derepressing the transcription of LDL receptor promoter in the presence of 25-hydroxycholesterol. The effect of various substitutions on antagonizing the repressing effect mediated by 25-hydroxycholesterol was also studied in terms of regio- and stereochemistry, lipophilicity, steric bulk, and pi-electron density. Except 12, compounds active in the primary LDLR/Luc assay were not active in the secondary simian virus 40/luciferase (SV40/Luc) assay, demonstrating the specificity of their in vitro activity. Eight active compounds of various structural types were selected and screened in a [1-14C-acetate]cholesterol biosynthesis inhibition assay; none has shown any interference with the cholesterol biosynthesis in CHO cells. In hypercholesterolemic hamsters, generally, compounds that were active in vitro were active in vivo and vice versa, with the exception of three in vitro inactive compounds: 3 beta-ols 3a' and 3c' as well as 3-ketone 2a. Experimental results from the livers of hamsters revealed that the in vivo conversion of 3a' or 2a to 3a has in part contributed to the observed in vivo activity, and it is also anticipated that 3c' may similarly be converted to 3c in hamsters.
    MeSH term(s) Animals ; Anticholesteremic Agents ; CHO Cells ; Cricetinae ; Hydroxycholesterols/pharmacology ; Lovastatin ; Mesocricetus ; Promoter Regions, Genetic ; Receptors, LDL/genetics ; Sterols/chemical synthesis ; Sterols/pharmacology ; Transcription, Genetic/drug effects
    Chemical Substances Anticholesteremic Agents ; Hydroxycholesterols ; Receptors, LDL ; Sterols ; 25-hydroxycholesterol (767JTD2N31) ; Lovastatin (9LHU78OQFD)
    Language English
    Publishing date 1995-01-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/jm00002a010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 151: Show issues Location:
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    Zs.MB 1: Show issues

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  3. Article: Inclusive K(S);(0)K(S);(0) resonance production in ep collisions at HERA.

    Chekanov, S / Derrick, M / Magill, S / Musgrave, B / Nicholass, D / Repond, J / Yoshida, R / Mattingly, M C K / Antonioli, P / Bari, G / Bellagamba, L / Boscherini, D / Bruni, A / Bruni, G / Cindolo, F / Corradi, M / Iacobucci, G / Margotti, A / Nania, R /
    Polini, A / Antonelli, S / Basile, M / Bindi, M / Cifarelli, L / Contin, A / De Pasquale, S / Sartorelli, G / Zichichi, A / Bartsch, D / Brock, I / Hartmann, H / Hilger, E / Jakob, H-P / Jüngst, M / Nuncio-Quiroz, A E / Paul, E / Samson, U / Schönberg, V / Shehzadi, R / Wlasenko, M / Brook, N H / Heath, G P / Morris, J D / Capua, M / Fazio, S / Mastroberardino, A / Schioppa, M / Susinno, G / Tassi, E / Kim, J Y / Ibrahim, Z A / Kamaluddin, B / Wan Abdullah, W A T / Ning, Y / Ren, Z / Sciulli, F / Chwastowski, J / Eskreys, A / Figiel, J / Galas, A / Gil, M / Olkiewicz, K / Stopa, P / Zawiejski, L / Adamczyk, L / Bołd, T / Grabowska-Bołd, I / Kisielewska, D / Lukasik, J / Przybycień, M / Suszycki, L / Kotański, A / Słomiński, W / Behrens, U / Blohm, C / Bonato, A / Borras, K / Ciesielski, R / Coppola, N / Fang, S / Fourletova, J / Geiser, A / Göttlicher, P / Grebenyuk, J / Gregor, I / Haas, T / Hain, W / Hüttmann, A / Januschek, F / Kahle, B / Katkov, I I / Klein, U / Kötz, U / Kowalski, H / Lobodzinska, E / Löhr, B / Mankel, R / Melzer-Pellmann, I-A / Miglioranzi, S / Montanari, A / Namsoo, T / Notz, D / Parenti, A / Rinaldi, L / Roloff, P / Rubinsky, I / Santamarta, R / Schneekloth, U / Spiridonov, A / Szuba, D / Szuba, J / Theedt, T / Wolf, G / Wrona, K / Yagües Molina, A G / Youngman, C / Zeuner, W / Drugakov, V / Lohmann, W / Schlenstedt, S / Barbagli, G / Gallo, E / Pelfer, P G / Bamberger, A / Dobur, D / Karstens, F / Vlasov, N N / Bussey, P J / Doyle, A T / Dunne, W / Forrest, M / Rosin, M / Saxon, D H / Skillicorn, I O / Gialas, I / Papageorgiu, K / Holm, U / Klanner, R / Lohrmann, E / Schleper, P / Schörner-Sadenius, T / Sztuk, J / Stadie, H / Turcato, M / Foudas, C / Fry, C / Long, K R / Tapper, A D / Matsumoto, T / Nagano, K / Tokushuku, K / Yamada, S / Yamazaki, Y / Barakbaev, A N / Boos, E G / Pokrovskiy, N S / Zhautykov, B O / Aushev, V / Borodin, M / Kadenko, I / Kozulia, A / Libov, V / Lisovyi, M / Lontkovskyi, D / Makarenko, I / Sorokin, Iu / Verbytskyi, A / Volynets, O / Son, D / de Favereau, J / Piotrzkowski, K / Barreiro, F / Glasman, C / Jimenez, M / Labarga, L / Del Peso, J / Ron, E / Soares, M / Terrón, J / Zambrana, M / Corriveau, F / Liu, C / Schwartz, J / Walsh, R / Zhou, C / Tsurugai, T / Antonov, A / Dolgoshein, B A / Gladkov, D / Sosnovtsev, V / Stifutkin, A / Suchkov, S / Dementiev, R K / Ermolov, P F / Gladilin, L K / Golubkov, Yu A / Khein, L A / Korzhavina, I A / Kuzmin, V A / Levchenko, B B / Lukina, O Yu / Proskuryakov, A S / Shcheglova, L M / Zotkin, D S / Abt, I / Caldwell, A / Kollar, D / Reisert, B / Schmidke, W B / Grigorescu, G / Keramidas, A / Koffeman, E / Kooijman, P / Pellegrino, A / Tiecke, H / Vázquez, M / Wiggers, L / Brümmer, N / Bylsma, B / Durkin, L S / Lee, A / Ling, T Y / Allfrey, P D / Bell, M A / Cooper-Sarkar, A M / Devenish, R C E / Ferrando, J / Foster, B / Korcsak-Gorzo, K / Oliver, K / Robertson, A / Uribe-Estrada, C / Walczak, R / Bertolin, A / Dal Corso, F / Dusini, S / Longhin, A / Stanco, L / Bellan, P / Brugnera, R / Carlin, R / Garfagnini, A / Limentani, S / Oh, B Y / Raval, A / Ukleja, J / Whitmore, J J / Iga, Y / D'Agostini, G / Marini, G / Nigro, A / Cole, J E / Hart, J C / Abramowicz, H / Ingbir, R / Kananov, S / Levy, A / Stern, A / Kuze, M / Maeda, J / Hori, R / Kagawa, S / Okazaki, N / Shimizu, S / Tawara, T / Hamatsu, R / Kaji, H / Kitamura, S / Ota, O / Ri, Y D / Costa, M / Ferrero, M I / Monaco, V / Sacchi, R / Solano, A / Arneodo, M / Ruspa, M / Fourletov, S / Martin, J F / Stewart, T P / Boutle, S K / Butterworth, J M / Gwenlan, C / Jones, T W / Loizides, J H / Wing, M / Brzozowska, B / Ciborowski, J / Grzelak, G / Kulinski, P / Luzniak, P / Malka, J / Nowak, R J / Pawlak, J M / Tymieniecka, T / Ukleja, A / Zarnecki, A F / Adamus, M / Plucinski, P / Eisenberg, Y / Hochman, D / Karshon, U / Brownson, E / Danielson, T / Everett, A / Kçira, D / Reeder, D D / Ryan, P / Savin, A A / Smith, W H / Wolfe, H / Bhadra, S / Catterall, C D / Cui, Y / Hartner, G / Menary, S / Noor, U / Standage, J / Whyte, J

    Physical review letters

    2008  Volume 101, Issue 11, Page(s) 112003

    Abstract: Inclusive K_{S};{0}K_{S};{0} production in ep collisions at the DESY ep collider HERA was studied with the ZEUS detector using an integrated luminosity of 0.5 fb;{-1}. Enhancements in the mass spectrum were observed and are attributed to the production ... ...

    Abstract Inclusive K_{S};{0}K_{S};{0} production in ep collisions at the DESY ep collider HERA was studied with the ZEUS detector using an integrated luminosity of 0.5 fb;{-1}. Enhancements in the mass spectrum were observed and are attributed to the production of f_{2}(1270)/a_{2};{0}(1320), f_{2};{'}(1525) and f_{0}(1710). Masses and widths were obtained using a fit which takes into account theoretical predictions based on SU(3) symmetry arguments, and are consistent with the Particle Data Group values. The f_{0}(1710) state, which has a mass consistent with a glueball candidate, was observed with a statistical significance of 5 standard deviations. However, if this state is the same as that seen in gammagamma-->K_{S};{0}K_{S};{0}, it is unlikely to be a pure glueball state.
    Language English
    Publishing date 2008-09-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.101.112003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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