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  1. Article: Single-Crystal X-ray and Solid-State NMR Characterisation of AND-1184 and Its Hydrochloride Form.

    Pawlak, Tomasz / Szczesio, Małgorzata / Potrzebowski, Marek J

    Materials (Basel, Switzerland)

    2021  Volume 14, Issue 23

    Abstract: In this study, we report on a structural investigation of AND-1184, with the chemical name N-[3-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]propyl]-3-methylbenzenesulfonamide ( ...

    Abstract In this study, we report on a structural investigation of AND-1184, with the chemical name N-[3-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]propyl]-3-methylbenzenesulfonamide (
    Language English
    Publishing date 2021-11-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma14237175
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Amorphization of Ethenzamide and Ethenzamide Cocrystals-A Case Study of Single and Binary Systems Forming Low-Melting Eutectic Phases Loaded on/in Silica Gel.

    Trzeciak, Katarzyna / Wielgus, Ewelina / Kaźmierski, Sławomir / Pawlak, Tomasz / Potrzebowski, Marek J

    Pharmaceutics

    2023  Volume 15, Issue 4

    Abstract: The applicability of different solvent-free approaches leading to the amorphization of active pharmaceutical ingredients (APIs) was tested. Ethenzamide (ET), an analgesic and anti-inflammatory drug, and two ethenzamide cocrystals with glutaric acid (GLU) ...

    Abstract The applicability of different solvent-free approaches leading to the amorphization of active pharmaceutical ingredients (APIs) was tested. Ethenzamide (ET), an analgesic and anti-inflammatory drug, and two ethenzamide cocrystals with glutaric acid (GLU) and ethyl malonic acid (EMA) as coformers were used as pharmaceutical models. Calcinated and thermally untreated silica gel was applied as an amorphous reagent. Three methods were used to prepare the samples: manual physical mixing, melting, and grinding in a ball mill. The ET:GLU and ET:EMA cocrystals forming low-melting eutectic phases were selected as the best candidates for testing amorphization by thermal treatment. The progress and degree of amorphousness were determined using instrumental techniques: solid-state NMR spectroscopy, powder X-ray diffraction, and differential scanning calorimetry. In each case, the API amorphization was complete and the process was irreversible. A comparative analysis of the dissolution profiles showed that the dissolution kinetics for each sample are significantly different. The nature and mechanism of this distinction are discussed.
    Language English
    Publishing date 2023-04-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15041234
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Solid-State Study of the Structure, Dynamics, and Thermal Processes of Safinamide Mesylate─A New Generation Drug for the Treatment of Neurodegenerative Diseases.

    Pawlak, Tomasz / Oszajca, Marcin / Szczesio, Małgorzata / Potrzebowski, Marek J

    Molecular pharmaceutics

    2021  Volume 19, Issue 1, Page(s) 287–302

    Abstract: Safinamide mesylate ( ...

    Abstract Safinamide mesylate (
    MeSH term(s) Alanine/analogs & derivatives ; Alanine/chemistry ; Alanine/therapeutic use ; Benzylamines/chemistry ; Benzylamines/therapeutic use ; Calorimetry, Differential Scanning ; Crystallography, X-Ray ; Humans ; Magnetic Resonance Spectroscopy ; Mesylates ; Molecular Structure ; Neurodegenerative Diseases/drug therapy ; Neuroprotective Agents/chemistry ; Neuroprotective Agents/therapeutic use ; Thermogravimetry ; X-Ray Diffraction
    Chemical Substances Benzylamines ; Mesylates ; Neuroprotective Agents ; safinamide (90ENL74SIG) ; Alanine (OF5P57N2ZX)
    Language English
    Publishing date 2021-12-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2138405-8
    ISSN 1543-8392 ; 1543-8384
    ISSN (online) 1543-8392
    ISSN 1543-8384
    DOI 10.1021/acs.molpharmaceut.1c00779
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6250: Show issues Location:
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  4. Article ; Online: New salts of teriflunomide (TFM) - Single crystal X-ray and solid state NMR investigation.

    Pawlak, Tomasz / Paluch, Piotr / Dolot, Rafał / Bujacz, Grzegorz / Potrzebowski, Marek J

    Solid state nuclear magnetic resonance

    2022  Volume 122, Page(s) 101820

    Abstract: New salts of teriflunomide TFM (drug approved for Multiple Sclerosis treatment) with inorganic counterions: lithium (TFM_Li), sodium (TFM_Na), potassium (TFM_K), rubidium (TFM_Rb), caesium (TFM_Cs) and ammonium ( ... ...

    Abstract New salts of teriflunomide TFM (drug approved for Multiple Sclerosis treatment) with inorganic counterions: lithium (TFM_Li), sodium (TFM_Na), potassium (TFM_K), rubidium (TFM_Rb), caesium (TFM_Cs) and ammonium (TFM_NH
    MeSH term(s) Salts/chemistry ; X-Rays ; Powders ; Magnetic Resonance Spectroscopy/methods ; Sodium/chemistry
    Chemical Substances teriflunomide (1C058IKG3B) ; Salts ; Powders ; Sodium (9NEZ333N27)
    Language English
    Publishing date 2022-08-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1122088-0
    ISSN 1527-3326 ; 0926-2040
    ISSN (online) 1527-3326
    ISSN 0926-2040
    DOI 10.1016/j.ssnmr.2022.101820
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4368: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: Combining heteronuclear correlation NMR with spin-diffusion to detect relayed Cl-H-H and N-H-H proximities in molecular solids.

    Raval, Parth / Trébosc, Julien / Pawlak, Tomasz / Nishiyama, Yusuke / Brown, Steven P / Manjunatha Reddy, G N

    Solid state nuclear magnetic resonance

    2022  Volume 120, Page(s) 101808

    Abstract: Analysis of short-to-intermediate range intermolecular interactions offers a great way of characterizing the solid-state organization of small molecules and materials. This can be achieved by two-dimensional (2D) homo- and heteronuclear correlation NMR ... ...

    Abstract Analysis of short-to-intermediate range intermolecular interactions offers a great way of characterizing the solid-state organization of small molecules and materials. This can be achieved by two-dimensional (2D) homo- and heteronuclear correlation NMR spectroscopy, for example, by carrying out experiments at high magnetic fields in conjunction with fast magic-angle spinning (MAS) techniques. But, detecting 2D peaks for heteronuclear dipolar coupled spin pairs separated by greater than 3 Å is not always straightforward, particularly when low-gamma quadrupolar nuclei are involved. Here, we present a 2D correlation NMR experiment that combines the advantages of heteronuclear-multiple quantum coherence (HMQC) and proton-based spin-diffusion (SD) pulse sequences using radio-frequency-driven-recouping (RFDR) to probe inter and intramolecular
    MeSH term(s) Dopamine ; Histidine/chemistry ; Magnetic Resonance Spectroscopy/methods ; Nuclear Magnetic Resonance, Biomolecular ; Protons
    Chemical Substances Protons ; Histidine (4QD397987E) ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2022-06-16
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1122088-0
    ISSN 1527-3326 ; 0926-2040
    ISSN (online) 1527-3326
    ISSN 0926-2040
    DOI 10.1016/j.ssnmr.2022.101808
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4368: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: A clinical audit on the management of inpatient hyperglycaemia in diabetic patients at Scarborough Hospital.

    Abraham, Santhosh Cheruvillil / Pawlak, Tadeusz / Uddin, Mohammad Salah / Habiba, Humaira / McGhie, Audrey / Plamkoottathil, Santhi

    Future healthcare journal

    2022  Volume 9, Issue Suppl 2, Page(s) 110

    Language English
    Publishing date 2022-10-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 3016427-8
    ISSN 2514-6653 ; 2514-6645
    ISSN (online) 2514-6653
    ISSN 2514-6645
    DOI 10.7861/fhj.9-2-s110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Online ; Thesis: Analyse von Anzahl und Leistung der an der Sektion des Institutes für Pathologie der Charité während des Zeitraums vom 01. Januar 1900 bis 31. Dezember 1999 beteiligten Ärzte

    Pawlak, Tamara

    2014  

    Title variant Quantitative and qualitative analysis of pathologists involved in autopsies at the Institute of Pathology of the Charité from 1 January 1900 to 31 December 1999
    Author's details vorgelegt von Tamara Pawlak
    Language German
    Size Online-Ressource, Ill., graph. Darst.
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ.-Medizin, Diss.--Berlin, 2014
    Database Former special subject collection: coastal and deep sea fishing

    Full text online

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  8. Article ; Online: Structure and Microbiological Activity of 1

    Olczak, Andrzej / Pawlak, Tomasz / Kałużyńska, Sylwia / Gobis, Katarzyna / Korona-Głowniak, Izabela / Suśniak, Katarzyna / Zaborowski, Marcin / Szczesio, Małgorzata

    International journal of molecular sciences

    2023  Volume 24, Issue 4

    Abstract: Three new crystal structures of ... ...

    Abstract Three new crystal structures of 1
    MeSH term(s) Antifungal Agents/pharmacology ; Imidazoles/chemistry ; Anti-Bacterial Agents/pharmacology ; Nitroimidazoles ; Gram-Negative Bacteria ; Microbial Sensitivity Tests ; Molecular Structure ; Structure-Activity Relationship
    Chemical Substances Antifungal Agents ; Imidazoles ; Anti-Bacterial Agents ; Nitroimidazoles
    Language English
    Publishing date 2023-02-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24043319
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  9. Article ; Online: Polymer network comprised of steroidal rotors as promising storage material.

    Wysocka, Joanna / Malinowska, Marta / Pawlak, Tomasz / Zgardzińska, Bożena / Markiewicz, Karolina H / Misiak, Paweł / Wilczewska, Agnieszka Z / Potrzebowski, Marek / Santillan, Rosa / Flórez-López, Edwin / Farfán, Norberto / Jastrzebska, Izabella

    Chemphyschem : a European journal of chemical physics and physical chemistry

    2024  Volume 25, Issue 6, Page(s) e202300793

    Abstract: In this paper, we report a new generation of polymeric networks as potential functional material based on changes in molecular dynamics in the solid state. The material is obtained by free radical polymerization of a diacrylate derivative bearing a ... ...

    Abstract In this paper, we report a new generation of polymeric networks as potential functional material based on changes in molecular dynamics in the solid state. The material is obtained by free radical polymerization of a diacrylate derivative bearing a steroid (stator) and a 1,4-diethynyl-phenylene-d
    Language English
    Publishing date 2024-02-20
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2025223-7
    ISSN 1439-7641 ; 1439-4235
    ISSN (online) 1439-7641
    ISSN 1439-4235
    DOI 10.1002/cphc.202300793
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Polymer Network Comprised of Steroidal Rotors as a Promising Storage Material.

    Wysocka, Joanna / Malinowska, Marta / Pawlak, Tomasz / Zgardzińska, Bożena / Markiewicz, Karolina H / Misiak, Paweł / Wilczewska, Agnieszka Z / Potrzebowski, Marek / Santillan, Rosa / Flórez-López, Edwin / Farfán, Norberto / Jastrzebska, Izabella

    Chemphyschem : a European journal of chemical physics and physical chemistry

    2024  Volume 25, Issue 6, Page(s) e202400184

    Abstract: The front cover artwork is provided by Dr habil. Izabella Jastrzebska's group from the University of Białystok, Poland. The image shows a polymeric network with molecular rotors (MR) as crosslinks. The MR rotation is slowed or inhibited when a molecule ... ...

    Abstract The front cover artwork is provided by Dr habil. Izabella Jastrzebska's group from the University of Białystok, Poland. The image shows a polymeric network with molecular rotors (MR) as crosslinks. The MR rotation is slowed or inhibited when a molecule of stored gas is placed inside the polymer material. Read the full text of the Research Article at 10.1002/cphc.202300793.
    Language English
    Publishing date 2024-03-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2025223-7
    ISSN 1439-7641 ; 1439-4235
    ISSN (online) 1439-7641
    ISSN 1439-4235
    DOI 10.1002/cphc.202400184
    Database MEDical Literature Analysis and Retrieval System OnLINE

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