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  1. Article ; Online: Differential Impact of Calcitriol and Its Analogs on Tumor Stroma in Young and Aged Ovariectomized Mice Bearing 4T1 Mammary Gland Cancer.

    Anisiewicz, Artur / Pawlik, Agata / Filip-Psurska, Beata / Wietrzyk, Joanna

    International journal of molecular sciences

    2020  Volume 21, Issue 17

    Abstract: 1) Background: Vitamin D compounds (VDC) are extensively studied in the field of anticancer properties, including breast cancer. Previously, we showed that calcitriol and its analogs (PRI-2191 and PRI-2205) stimulate metastasis in 4T1 murine mammary ... ...

    Abstract (1) Background: Vitamin D compounds (VDC) are extensively studied in the field of anticancer properties, including breast cancer. Previously, we showed that calcitriol and its analogs (PRI-2191 and PRI-2205) stimulate metastasis in 4T1 murine mammary gland cancer models in young mice, whereas the reverse effect was observed in aged ovariectomized (OVX) mice; (2) Methods: We determined the phenotype of monocytes/macrophages using FACS and examined the expression of selected genes and proteins by Real-Time PCR and ELISA; (3) Results: Activities of VDC are accompanied by an increase in the percentage of Ly6C
    MeSH term(s) Animals ; Apoptosis ; Calcitriol/chemistry ; Calcitriol/pharmacology ; Calcium Channel Agonists/chemistry ; Calcium Channel Agonists/pharmacology ; Cell Movement ; Cell Proliferation ; Female ; Lung Neoplasms/drug therapy ; Lung Neoplasms/metabolism ; Lung Neoplasms/secondary ; Mammary Neoplasms, Experimental/drug therapy ; Mammary Neoplasms, Experimental/metabolism ; Mammary Neoplasms, Experimental/pathology ; Mice ; Mice, Inbred BALB C ; Ovariectomy ; Tumor Cells, Cultured ; Tumor Microenvironment/drug effects
    Chemical Substances Calcium Channel Agonists ; Calcitriol (FXC9231JVH)
    Language English
    Publishing date 2020-09-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21176359
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Divergent Effect of Tacalcitol (PRI-2191) on Th17 Cells in 4T1 Tumor Bearing Young and Old Ovariectomized Mice.

    Pawlik, Agata / Anisiewicz, Artur / Filip-Psurska, Beata / Klopotowska, Dagmara / Maciejewska, Magdalena / Mazur, Andrzej / Wietrzyk, Joanna

    Aging and disease

    2020  Volume 11, Issue 2, Page(s) 241–253

    Abstract: Vitamin D and its analogs are known for their role in the development of breast cancer and in immunomodulation. Our previous studies have shown the pro-metastatic effect of calcitriol and tacalcitol (PRI-2191) in young mice bearing 4T1 breast cancer and ... ...

    Abstract Vitamin D and its analogs are known for their role in the development of breast cancer and in immunomodulation. Our previous studies have shown the pro-metastatic effect of calcitriol and tacalcitol (PRI-2191) in young mice bearing 4T1 breast cancer and the anti-metastatic effect in aged ovariectomized (OVX) mice. Therefore, the aim of our work was to characterize Th17 cell population in young and aged OVX mice bearing 4T1 tumors treated with calcitriol and PRI-2191. The expression of genes typical for Th17 cells was examined in splenocytes, as well as splenocytes differentiated with IL-6 and TGF-β to Th17 cells (iTh17). Expression of genes encoding vitamin D receptor (
    Language English
    Publishing date 2020-03-09
    Publishing country United States
    Document type Journal Article
    ISSN 2152-5250
    ISSN 2152-5250
    DOI 10.14336/AD.2019.0618
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Calcitriol and Its Analogs Establish the Immunosuppressive Microenvironment That Drives Metastasis in 4T1 Mouse Mammary Gland Cancer.

    Pawlik, Agata / Anisiewicz, Artur / Filip-Psurska, Beata / Nowak, Marcin / Turlej, Eliza / Trynda, Justyna / Banach, Joanna / Gretkierewicz, Paweł / Wietrzyk, Joanna

    International journal of molecular sciences

    2018  Volume 19, Issue 7

    Abstract: In our previous study, calcitriol and its analogs PRI-2191 and PRI-2205 stimulated 4T1 mouse mammary gland cancer metastasis. Therefore, we aimed to analyze the inflammatory response in 4T1-bearing mice treated with these compounds. Gene expression ... ...

    Abstract In our previous study, calcitriol and its analogs PRI-2191 and PRI-2205 stimulated 4T1 mouse mammary gland cancer metastasis. Therefore, we aimed to analyze the inflammatory response in 4T1-bearing mice treated with these compounds. Gene expression analysis of the splenocytes and regional lymph nodes demonstrated prevalence of the T helper lymphocytes (Th2) response with an increased activity of regulatory T (Treg) lymphocytes in mice treated with these compounds. We also observed an increased number of mature granulocytes and B lymphocytes and a decreased number of TCD4⁺, TCD4⁺CD25⁺, and TCD8⁺, as well as natural killer (NK) CD335⁺, cells in the blood of mice treated with calcitriol and its analogs. Among the splenocytes, we observed a significant decrease in NK CD335⁺ cells and an increase in TCD8⁺ cells. Calcitriol and its analogs decreased the levels of interleukin (IL)-1β and IL-10 and increased the level of interferon gamma (IFN-γ) in the plasma. In the tumor tissue, they caused an increase in the level of IL-10. Gene expression analysis of lung tissue demonstrated an increased level of osteopontin (
    MeSH term(s) Animals ; B-Lymphocytes/drug effects ; B-Lymphocytes/metabolism ; CD4-Positive T-Lymphocytes/drug effects ; CD4-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/drug effects ; CD8-Positive T-Lymphocytes/metabolism ; Calcitriol/analogs & derivatives ; Calcitriol/pharmacology ; Cells, Cultured ; Dihydroxycholecalciferols/pharmacology ; Enzyme-Linked Immunosorbent Assay ; Female ; Flow Cytometry ; Granulocytes/drug effects ; Granulocytes/metabolism ; Immunosuppressive Agents/pharmacology ; Mammary Neoplasms, Experimental/metabolism ; Mammary Neoplasms, Experimental/pathology ; Mice ; Mice, Inbred BALB C ; Osteopontin/genetics ; Real-Time Polymerase Chain Reaction ; Transforming Growth Factor beta/genetics
    Chemical Substances Dihydroxycholecalciferols ; Immunosuppressive Agents ; Transforming Growth Factor beta ; Osteopontin (106441-73-0) ; calcipotriene (143NQ3779B) ; 1 alpha,24-dihydroxyvitamin D3 (60965-80-2) ; Calcitriol (FXC9231JVH)
    Language English
    Publishing date 2018-07-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms19072116
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Calcitriol Analogues Decrease Lung Metastasis but Impair Bone Metabolism in Aged Ovariectomized Mice Bearing 4T1 Mammary Gland Tumours.

    Anisiewicz, Artur / Filip-Psurska, Beata / Pawlik, Agata / Nasulewicz-Goldeman, Anna / Piasecki, Tomasz / Kowalski, Konrad / Maciejewska, Magdalena / Jarosz, Joanna / Banach, Joanna / Papiernik, Diana / Mazur, Andrzej / Kutner, Andrzej / Maier, Jeanette A / Wietrzyk, Joanna

    Aging and disease

    2019  Volume 10, Issue 5, Page(s) 977–991

    Abstract: Calcitriol and its analogues are considered drugs supporting the anticancer treatment of breast cancer and preventing the osteoporosis that results from the development of cancer or from chemotherapy or hormone therapy. Following the orthotopic ... ...

    Abstract Calcitriol and its analogues are considered drugs supporting the anticancer treatment of breast cancer and preventing the osteoporosis that results from the development of cancer or from chemotherapy or hormone therapy. Following the orthotopic implantation of 4T1 mammary carcinoma cells into aged ovariectomized (OVX) mice, we evaluated the effects of calcitriol and its two analogues, PRI-2191 and PRI-2205, on metastatic spread and bone homeostasis. Calcitriol and its analogues temporarily inhibited the formation of metastases in the lungs. Unexpectedly, only mice treated with calcitriol analogues showed a deterioration of bone-related parameters, such as bone column density, marrow column density and the CaPO
    Language English
    Publishing date 2019-10-01
    Publishing country United States
    Document type Journal Article
    ISSN 2152-5250
    ISSN 2152-5250
    DOI 10.14336/AD.2018.0921
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Inter-library loan at ZB MED

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  5. Article ; Online: Unfavorable effect of calcitriol and its low-calcemic analogs on metastasis of 4T1 mouse mammary gland cancer.

    Anisiewicz, Artur / Pawlik, Agata / Filip-Psurska, Beata / Turlej, Eliza / Dzimira, Stanisław / Milczarek, Magdalena / Gdesz, Katarzyna / Papiernik, Diana / Jarosz, Joanna / Kłopotowska, Dagmara / Kutner, Andrzej / Mazur, Andrzej / Wietrzyk, Joanna

    International journal of oncology

    2018  Volume 52, Issue 1, Page(s) 103–126

    Abstract: Low vitamin D status is considered as a risk factor for breast cancer and has prognostic significance. Furthermore, vitamin D deficiency increases after adjuvant cancer therapy, which alters bone metabolism increasing the risk of osteoporosis. It is now ... ...

    Abstract Low vitamin D status is considered as a risk factor for breast cancer and has prognostic significance. Furthermore, vitamin D deficiency increases after adjuvant cancer therapy, which alters bone metabolism increasing the risk of osteoporosis. It is now postulated that vitamin D supplementation in breast cancer treatment delays the recurrence of cancer thereby extending survival. We evaluated the impact of calcitriol and its low-calcemic analogs, PRI‑2191 and PRI‑2205, on the tumor growth, angiogenesis, and metastasis of 4T1 mouse mammary gland cancer. Gene expression analysis related to cancer invasion/metastasis, real‑time PCR, ELISA, western blotting, and histochemical studies were performed. In vitro studies were conducted to compare the effects of calcitriol and its analogs on 4T1 and 67NR cell proliferation and expression of selected proteins. Calcitriol and its analogs increased lung metastasis without influencing the growth of primary tumor. The levels of plasma 17β-estradiol and transforming growth factor β (TGFβ) were found to be elevated after treatment. Moreover, the results showed that tumor blood perfusion improved and osteopontin (OPN) levels increased, whereas vascular endothelial growth factor (VEGF) and TGFβ levels decreased in tumors from treated mice. All the studied treatments resulted in increased collagen content in the tumor tissue in the early step of tumor progression, and calcitriol caused an increase in collagen content in lung tissue. In addition, in vitro proliferation of 4T1 tumor cells was not found to be affected by calcitriol or its analogs in contrast to non-metastatic 67NR cells. Calcitriol and its analogs enhanced the metastatic potential of 4T1 mouse mammary gland cancer by inducing the secretion of OPN probably via host cells. In addition, OPN tumor overexpression prevailed over the decreasing tumor TGFβ level and blood vessel normalization via tumor VEGF deprivation induced by calcitriol and its analogs. Moreover, the increased plasma TGFβ and 17β-estradiol levels contributed to the facilitation of metastatic process.
    Language English
    Publishing date 2018-01
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 1154403-x
    ISSN 1791-2423 ; 1019-6439
    ISSN (online) 1791-2423
    ISSN 1019-6439
    DOI 10.3892/ijo.2017.4185
    Database MEDical Literature Analysis and Retrieval System OnLINE

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