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  1. Article ; Online: De novo PLA2R positive membranous nephropathy following BNT162b2 mRNA COVID-19 vaccine.

    Paxton, Lisa / McMahon, Lawrence / Wong, Limy

    Internal medicine journal

    2022  Volume 52, Issue 12, Page(s) 2191–2192

    MeSH term(s) Humans ; Glomerulonephritis, Membranous ; BNT162 Vaccine ; RNA, Messenger ; COVID-19 Vaccines/adverse effects ; COVID-19/prevention & control ; Autoantibodies ; Receptors, Phospholipase A2
    Chemical Substances BNT162 Vaccine ; RNA, Messenger ; COVID-19 Vaccines ; Autoantibodies ; Receptors, Phospholipase A2
    Language English
    Publishing date 2022-10-20
    Publishing country Australia
    Document type Letter
    ZDB-ID 2045436-3
    ISSN 1445-5994 ; 1444-0903
    ISSN (online) 1445-5994
    ISSN 1444-0903
    DOI 10.1111/imj.15915
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Granulomatosis with polyangiitis complicated by genital involvement: sustained response to rituximab.

    Paxton, Lisa / Champion De Crespigny, Paul / Nicholls, Kathleen

    Internal medicine journal

    2021  Volume 51, Issue 3, Page(s) 444–445

    MeSH term(s) Genitalia ; Granulomatosis with Polyangiitis/complications ; Granulomatosis with Polyangiitis/diagnosis ; Granulomatosis with Polyangiitis/drug therapy ; Humans ; Immunologic Factors ; Immunosuppressive Agents ; Rituximab ; Treatment Outcome
    Chemical Substances Immunologic Factors ; Immunosuppressive Agents ; Rituximab (4F4X42SYQ6)
    Language English
    Publishing date 2021-03-19
    Publishing country Australia
    Document type Letter
    ZDB-ID 2045436-3
    ISSN 1445-5994 ; 1444-0903
    ISSN (online) 1445-5994
    ISSN 1444-0903
    DOI 10.1111/imj.15224
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: 3D printed reproductions of orbital dissections: a novel mode of visualising anatomy for trainees in ophthalmology or optometry.

    Adams, Justin W / Paxton, Lisa / Dawes, Kathryn / Burlak, Kateryna / Quayle, Michelle / McMenamin, Paul G

    The British journal of ophthalmology

    2015  Volume 99, Issue 9, Page(s) 1162–1167

    Abstract: Background: The teaching of human head, neck and orbital anatomy forms a critical part of undergraduate and postgraduate medical and allied health professional training, including optometry. While still largely grounded in cadaveric dissection, this ... ...

    Abstract Background: The teaching of human head, neck and orbital anatomy forms a critical part of undergraduate and postgraduate medical and allied health professional training, including optometry. While still largely grounded in cadaveric dissection, this method of instruction is constrained in some countries and regional areas by access to real human cadavers, costs of cadaver bequest programmes, health and safety of students and staff and the shortage of adequate time in modern curricula. Many candidates choosing a postgraduate pathway in ophthalmological training, such as those accepted into the Royal Colleges of Ophthalmology in the UK, Australia and New Zealand programmes and the American Academy of Ophthalmologists in the USA, are compelled as adult learners to revise or revisit human orbital anatomy, ocular anatomy and select areas of head and neck anatomy. These candidates are often then faced with the issue of accessing facilities with dissected human cadaveric material.
    Methods: In light of these difficulties, we developed a novel means of creating high-resolution reproductions of prosected human cadaver orbits suitable for education and training.
    Results: 3D printed copies of cadaveric orbital dissections (superior, lateral and medial views) showing a range of anatomical features were created.
    Discussion: These 3D prints offer many advantages over plastinated specimens as they are suitable for rapid reproduction and as they are not human tissue they avoid cultural and ethical issues associated with viewing cadaver specimens. In addition, they are suitable for use in the office, home, laboratory or clinical setting in any part of the world for patient and doctor education.
    MeSH term(s) Anatomy/education ; Cadaver ; Dissection/education ; Education, Medical/methods ; Humans ; Ophthalmology/education ; Optometry/education ; Orbit/anatomy & histology ; Printing, Three-Dimensional
    Language English
    Publishing date 2015-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 80078-8
    ISSN 1468-2079 ; 0007-1161
    ISSN (online) 1468-2079
    ISSN 0007-1161
    DOI 10.1136/bjophthalmol-2014-306189
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Incidence and management of metabolic acidosis with sodium bicarbonate in the ICU: An international observational study.

    Fujii, Tomoko / Udy, Andrew A / Nichol, Alistair / Bellomo, Rinaldo / Deane, Adam M / El-Khawas, Khaled / Thummaporn, Naorungroj / Serpa Neto, Ary / Bergin, Hannah / Short-Burchell, Robert / Chen, Chin-Ming / Cheng, Kuang-Hua / Cheng, Kuo-Chen / Chia, Clemente / Chiang, Feng-Fan / Chou, Nai-Kuan / Fazio, Timothy / Fu, Pin-Kuei / Ge, Victor /
    Hayashi, Yoshiro / Holmes, Jennifer / Hu, Ting-Yu / Huang, Shih-Feng / Iguchi, Naoya / Jones, Sarah L / Karumai, Toshiyuki / Katayama, Shinshu / Ku, Shih-Chi / Lai, Chao-Lun / Lee, Bor-Jen / Liaw, Wen-Jinn / Ong, Chelsea T W / Paxton, Lisa / Peppin, Chloe / Roodenburg, Owen / Saito, Shinjiro / Santamaria, John D / Shehabi, Yahya / Tanaka, Aiko / Tiruvoipati, Ravindranath / Tsai, Hsiao-En / Wang, An-Yi / Wang, Chen-Yu / Yeh, Yu-Chang / Yu, Chong-Jen / Yuan, Kuo-Ching

    Critical care (London, England)

    2021  Volume 25, Issue 1, Page(s) 45

    Abstract: Background: Metabolic acidosis is a major complication of critical illness. However, its current epidemiology and its treatment with sodium bicarbonate given to correct metabolic acidosis in the ICU are poorly understood.: Method: This was an ... ...

    Abstract Background: Metabolic acidosis is a major complication of critical illness. However, its current epidemiology and its treatment with sodium bicarbonate given to correct metabolic acidosis in the ICU are poorly understood.
    Method: This was an international retrospective observational study in 18 ICUs in Australia, Japan, and Taiwan. Adult patients were consecutively screened, and those with early metabolic acidosis (pH < 7.3 and a Base Excess < -4 mEq/L, within 24-h of ICU admission) were included. Screening continued until 10 patients who received and 10 patients who did not receive sodium bicarbonate in the first 24 h (early bicarbonate therapy) were included at each site. The primary outcome was ICU mortality, and the association between sodium bicarbonate and the clinical outcomes were assessed using regression analysis with generalized linear mixed model.
    Results: We screened 9437 patients. Of these, 1292 had early metabolic acidosis (14.0%). Early sodium bicarbonate was given to 18.0% (233/1292) of these patients. Dosing, physiological, and clinical outcome data were assessed in 360 patients. The median dose of sodium bicarbonate in the first 24 h was 110 mmol, which was not correlated with bodyweight or the severity of metabolic acidosis. Patients who received early sodium bicarbonate had higher APACHE III scores, lower pH, lower base excess, lower PaCO
    Conclusions: Early metabolic acidosis is common in critically ill patients. Early sodium bicarbonate is administered by clinicians to more severely ill patients but without correction for weight or acidosis severity. Bicarbonate therapy in acidotic vasopressor-dependent patients may be beneficial and warrants further investigation.
    MeSH term(s) APACHE ; Acidosis/drug therapy ; Acidosis/epidemiology ; Aged ; Australia/epidemiology ; Female ; Humans ; Incidence ; Intensive Care Units/organization & administration ; Intensive Care Units/statistics & numerical data ; Internationality ; Japan/epidemiology ; Male ; Middle Aged ; Retrospective Studies ; Sodium Bicarbonate/administration & dosage ; Sodium Bicarbonate/pharmacology ; Sodium Bicarbonate/therapeutic use ; Taiwan/epidemiology
    Chemical Substances Sodium Bicarbonate (8MDF5V39QO)
    Language English
    Publishing date 2021-02-02
    Publishing country England
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-020-03431-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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