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Article: Moving toward Extensively Drug-Resistant: Four-Year Antimicrobial Resistance Trends of

Jalali, Yashar / Liptáková, Adriána / Jalali, Monika / Payer, Juraj

2023 Volume 12, Issue 7

Abstract: ... A. ... ...

Abstract	A. baumannii
Language	English
Publishing date	2023-07-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics12071200
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Article: Initial use of subcutaneous plasma-derived C1 inhibitor in prophylaxis of acute attacks of hereditary angioedema in pregnant patients in Slovakia.

Hrubišková, Katarína / Jeseňák, Miloš / Payer, Juraj

Vnitrni lekarstvi

2023 Volume 69, Issue 4, Page(s) 265–268

Abstract: Hereditary angioedema (HAE) is a rare, inborn disease manifested with recurrent attacks of angioedema. They can affect the skin and subcutaneous tissue, mucous membranes (gastrointestinal, respiratory, and uropoietic tracts), and submucous tissue. Women ... ...

Title translation	Prvé použitie podkožného C1 inhibítora v profylaxii atakov hereditárneho angioedému u tehotných pacientok na Slovensku.
Abstract	Hereditary angioedema (HAE) is a rare, inborn disease manifested with recurrent attacks of angioedema. They can affect the skin and subcutaneous tissue, mucous membranes (gastrointestinal, respiratory, and uropoietic tracts), and submucous tissue. Women in reproductive age require specific management of the disease regarding both the course of the disease and treatment options. It is not only the treatment in female patients that is specific, but also the situations (pregnancy, breastfeeding). We present a case report of the initial use of a subcutaneous C1 inhibitor in the long-term prophylaxis of HAE attacks in two pregnant patients.
MeSH term(s)	Pregnancy ; Humans ; Female ; Angioedemas, Hereditary/drug therapy ; Angioedemas, Hereditary/prevention & control ; Subcutaneous Tissue ; Slovakia ; Angioedema
Language	English
Publishing date	2023-06-09
Publishing country	Czech Republic
Document type	Case Reports ; Journal Article
ZDB-ID	138213-5
ISSN	1801-7592 ; 0042-773X
ISSN (online)	1801-7592
ISSN	0042-773X
DOI	10.36290/vnl.2023.050
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Article: Pegvisomant in the treatment of acromegaly.

Ságová, Ivana / Mokáň, Marián / Payer, Juraj / Vaňuga, Peter

Vnitrni lekarstvi

2022 Volume 68, Issue E-7, Page(s) 17–22

Abstract: Despite improvements in surgical techniques, current radiotherapy options and development of long-acting somatostatin analogues, biochemical control of acromegaly is not achieved in some patients. The failure to achieve optimal serum growth hormone (RH) ... ...

Title translation	Pegvisomant v liečbe akromegálie.
Abstract	Despite improvements in surgical techniques, current radiotherapy options and development of long-acting somatostatin analogues, biochemical control of acromegaly is not achieved in some patients. The failure to achieve optimal serum growth hormone (RH) and insulin-like growth factor-1 (IGF-1) levels means increased morbidity and mortality of acromegaly patients. The RH receptor antagonist pegvisomant (PEG) is a genetically engineered RH analog that prevents of RH receptor dimerization, i.e. a process that is crucial for the action of RH at the cellular level. The effect of the treatment is suppression of IGF-1 production. In pilot studies, normalization of IGF-1 levels was achieved in up to 90 % of patients receiving PEG. However, PEG efficacy in clinical settings is slightly lower (65 to 97 %) than reported in the key studies. A rare side effect of treatment is elevations of liver transaminases. In addition, pituitary tumor growth progression has been reported in several cases. In this review article, we present long-term data on pegvisomant treatment and discuss its associated risks and benefits.
MeSH term(s)	Humans ; Acromegaly/drug therapy ; Insulin-Like Growth Factor I ; Human Growth Hormone/therapeutic use ; Somatostatin/therapeutic use
Chemical Substances	pegvisomant (N824AOU5XV) ; Insulin-Like Growth Factor I (67763-96-6) ; Human Growth Hormone (12629-01-5) ; Somatostatin (51110-01-1)
Language	English
Publishing date	2022-06-02
Publishing country	Czech Republic
Document type	Review ; Journal Article
ZDB-ID	138213-5
ISSN	1801-7592 ; 0042-773X
ISSN (online)	1801-7592
ISSN	0042-773X
DOI	10.36290/vnl.2022.101
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Article: Osteoporosis in diabetes mellitus patients.

Jackuliak, Peter / Kovářová, Magdaléna / Kužma, Martin / Payer, Juraj

Vnitrni lekarstvi

2022 Volume 67, Issue 5, Page(s) 291–295

Abstract: Diabetes mellitus (DM) is currently a pandemic problem, and the number of diabetic patients is constantly increasing. There are known and established diabetic complication but it is also comorbidities associated with DM cannot be forgotten. One of these ... ...

Title translation	Osteoporóza u pacientov s diabetes mellitus.
Abstract	Diabetes mellitus (DM) is currently a pandemic problem, and the number of diabetic patients is constantly increasing. There are known and established diabetic complication but it is also comorbidities associated with DM cannot be forgotten. One of these is osteoporosis and osteoporotic fractures. In diabetic patients, the fractures are usually 2 to 6 times higher. In management of diabetes we should screen also the risk of osteoporosis and fractures. From a diabetic point of view, optimum glycaemic control should be achieved, however, we should take into account the effect of antidiabetic agents on bone. In this summary data on the diagnosis and treatment of osteoporosis in patients with DM as well as on the effect of antidiabetic agents on bone are presented.
MeSH term(s)	Bone Density ; Diabetes Complications ; Diabetes Mellitus ; Diabetes Mellitus, Type 2/complications ; Humans ; Hypoglycemic Agents/therapeutic use ; Osteoporosis/complications ; Osteoporotic Fractures/etiology
Chemical Substances	Hypoglycemic Agents
Language	English
Publishing date	2022-04-22
Publishing country	Czech Republic
Document type	Journal Article
ZDB-ID	138213-5
ISSN	1801-7592 ; 0042-773X
ISSN (online)	1801-7592
ISSN	0042-773X
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Article: Supplementation with myo-inositol and Selenium improves the clinical conditions and biochemical features of women with or at risk for subclinical hypothyroidism.

Payer, Juraj / Jackuliak, Peter / Kužma, Martin / Džupon, Matúš / Vaňuga, Peter

Frontiers in endocrinology

2022 Volume 13, Page(s) 1067029

Abstract: Purpose: The present study aims to evaluate the effect of myo-Inositol plus Selenium supplementation in patients affected by subclinical hypothyroidism.: Methods: One hundred and forty-eight patients were included in the study from 8 different ... ...

Abstract	Purpose: The present study aims to evaluate the effect of myo-Inositol plus Selenium supplementation in patients affected by subclinical hypothyroidism. Methods: One hundred and forty-eight patients were included in the study from 8 different centers of Slovakia, and treated for 6 months with a daily dose of 600 mg myo-Ins plus 83 mcg Se. The patients included at the enrollment were women of reproductive age (18-50), who exhibit values of TSH in the range 2.5-5 mU/l and positivity to antibodies TPO-Ab/TG-Ab, or otherwise values of TSH in the range 5-10 mU/l both with and without positivity to antibodies TPO-Ab/TG-Ab. Results: Patients affected by subclinical hypothyroidism exhibited a significant improvement of their condition when treated for 6 months with a combination of myo-Inositol and Selenium. The TSH values significantly ameliorated along with the index of autoimmunity and the thyroid status. In a sub-class of patients, the auto-antibody titer decreased after myo-inositol + Selenium administration. The treatment also induces a regularization of the menstrual cycle and a reduction of the cholesterol in the patients enrolled for the study. Furthermore, a significant improvement is observed in the perception of the symptoms associated with subclinical hypothyroidism over the treatment period. Conclusion: A dietary supplementation with of myo-Inositol and Selenium in the treatment of patients affected by subclinical hypothyroidism exhibits a beneficial role in the recovery of TSH values, in the improvement of the symptoms associated to this condition and in the maintenance of the thyroid functions.The trial was approved by the Ethical Committee from National Institute of Endocrinology and Diabetology of Lubochna, Slovakia, date 18.12.2018, registration number: 3124/2018.
MeSH term(s)	Humans ; Female ; Male ; Selenium/therapeutic use ; Hypothyroidism/drug therapy ; Inositol/therapeutic use ; Dietary Supplements ; Thyrotropin
Chemical Substances	Selenium (H6241UJ22B) ; Inositol (4L6452S749) ; Thyrotropin (9002-71-5)
Language	English
Publishing date	2022-11-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2022.1067029
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Article: Osteoporosis in premenopausal women.

Payer, Juraj / Smaha, Juraj / Kužma, Martin / Killinger, Zdenko / Jackuliak, Peter

Vnitrni lekarstvi

2022 Volume 67, Issue 5, Page(s) 284–290

Abstract: In contrast to postmenopausal women diagnostic process and treatment of premenopausal osteoporosis in young women reamin poorly defined. A low bone mineral density in premenopausal women is not associated with the same risk of fractures as in ... ...

Title translation	Osteoporóza u premenopauzálnych žien.
Abstract	In contrast to postmenopausal women diagnostic process and treatment of premenopausal osteoporosis in young women reamin poorly defined. A low bone mineral density in premenopausal women is not associated with the same risk of fractures as in postmenopausal women, therefore diagnosis requires not only densitometric examination but depends on the consideration of other risk factors. Most cases of premenopausal osteoporosis are associated with chronic diseases affecting bone metabolism. Treatment of the underlying disease may improve bone density as well as bone quality. Rarely, a bone-specific antiporotic therapy may be used, although quality evidence is scarce. This article will review current opinion on definition, diagnosis and treatment of premenopausal osteoporosis.
MeSH term(s)	Bone Density ; Bone and Bones ; Female ; Fractures, Bone ; Humans ; Osteoporosis/diagnosis ; Osteoporosis/etiology ; Osteoporosis/therapy ; Osteoporosis, Postmenopausal ; Premenopause
Language	English
Publishing date	2022-04-22
Publishing country	Czech Republic
Document type	Journal Article
ZDB-ID	138213-5
ISSN	1801-7592 ; 0042-773X
ISSN (online)	1801-7592
ISSN	0042-773X
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Article: Vitamin D supplementation as an important factor in COVID-19 prevention and treatment: what evidence do we have?

Smaha, Juraj / Kužma, Martin / Jackuliak, Peter / Payer, Juraj

Vnitrni lekarstvi

2021 Volume 66, Issue 8, Page(s) 494–500

Abstract: The immunomodulatory effect of vitamin D and its potential in prevention and treatment of acute respiratory infections have long been of interest to many scientific teams around the world. Several meta-analyses in the last 10 years have confirmed the ... ...

Title translation	Suplementácia vitamínu D ako dôležitý faktor v prevencii a liečbe ochorenia COVID-19: aké máme dôkazy?
Abstract	The immunomodulatory effect of vitamin D and its potential in prevention and treatment of acute respiratory infections have long been of interest to many scientific teams around the world. Several meta-analyses in the last 10 years have confirmed the protective (albeit of modest size) effect of vitamin D against respiratory infections. Because of many overlapping risk factors for vitamin D deficiency and severe COVID-19 infection, many experts believe that vitamin D supplementation could play an important role in prevention and treatment of the new coronavirus disease. Based on available data on the immunological action of vitamin D, it is possible that vitamin D could modulate the bodys response to SARS-CoV-2 infection both in the early viraemic phase and in later hyperinflammatory phase typical for the severe course of the disease. The first available data from epidemiological studies suggest that low serum vitamin D levels are associated with increased susceptibility to the new coronavirus infection as well as with severe course of the disease.
MeSH term(s)	COVID-19 ; Coronavirus Infections ; Dietary Supplements ; Humans ; SARS-CoV-2 ; Vitamin D ; Vitamin D Deficiency/drug therapy ; Vitamin D Deficiency/prevention & control
Chemical Substances	Vitamin D (1406-16-2)
Language	English
Publishing date	2021-03-19
Publishing country	Czech Republic
Document type	Journal Article
ZDB-ID	138213-5
ISSN	1801-7592 ; 0042-773X
ISSN (online)	1801-7592
ISSN	0042-773X
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Article ; Online: Vitamin D Deficiency Prevalence in Hospitalized Patients with COVID-19 Significantly Decreased during the Pandemic in Slovakia from 2020 to 2022 Which Was Associated with Decreasing Mortality.

Smaha, Juraj / Jackuliak, Peter / Kužma, Martin / Max, Filip / Binkley, Neil / Payer, Juraj

Nutrients

2023 Volume 15, Issue 5

Abstract: The coronavirus disease 2019 (COVID-19) pandemic has led to changes in lifestyle, which could influence vitamin D status on a population level. The purpose of our study was to compare 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalized because ... ...

Abstract	The coronavirus disease 2019 (COVID-19) pandemic has led to changes in lifestyle, which could influence vitamin D status on a population level. The purpose of our study was to compare 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalized because of severe COVID-19 during two waves of the pandemic (2020/21 vs. 2021/22). A total of 101 patients from the 2021/22 wave were compared with 101 sex- and age-matched subjects from the 2020/21 wave. Patients from both groups were hospitalized during the winter season from 1 December to 28 February. Men and women were analyzed together and separately. The mean 25(OH)D concentration increased from 17.8 ± 9.7 ng/mL to 25.2 ± 12.6 ng/mL between waves. The prevalence of vitamin D deficiency (<20 ng/mL) decreased from 82% to 54%. The prevalence of adequate serum 25(OH)D concentration (>30 ng/mL) increased from 10% to 34% (
MeSH term(s)	Male ; Humans ; Female ; Pandemics ; COVID-19/epidemiology ; Prevalence ; Slovakia ; Vitamin D Deficiency ; Vitamin D ; Vitamins
Chemical Substances	Vitamin D (1406-16-2) ; Vitamins
Language	English
Publishing date	2023-02-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15051132
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Article: Microscopic polyangiitis.

Tobiáš, Daniel / Brázdilová, Kristína / Killinger, Zdenko / Payer, Juraj

Vnitrni lekarstvi

2020 Volume 66, Issue 4, Page(s) 249–252

Abstract: Microscopic polyangiitis is a rare, systemic, necrotizing, pauci-immune, ANCA associated small vessel vasculitis, with no evidence of granulomatous inflammation. Diagnosing microscopic polyangiitis is often difficult because of it´s presentation by a ... ...

Title translation	Mikroskopická polyangiitída.
Abstract	Microscopic polyangiitis is a rare, systemic, necrotizing, pauci-immune, ANCA associated small vessel vasculitis, with no evidence of granulomatous inflammation. Diagnosing microscopic polyangiitis is often difficult because of it´s presentation by a number of non-specific symptoms. We treated a 35-year old patient, who was admitted for migrating arthritis and fever with papulous rash. In this case, we want to point out the importance of considering the diagnosis of MPA and similar rare diseases in the process of differential diagnosis, mainly in patients presenting with non-specific symptoms, because the mortality of this disease without adequate treatment is alarmingly high.
MeSH term(s)	Adult ; Antibodies, Antineutrophil Cytoplasmic ; Diagnosis, Differential ; Glomerulonephritis/diagnosis ; Humans ; Microscopic Polyangiitis/diagnosis
Chemical Substances	Antibodies, Antineutrophil Cytoplasmic
Language	English
Publishing date	2020-09-25
Publishing country	Czech Republic
Document type	Case Reports ; Journal Article
ZDB-ID	138213-5
ISSN	1801-7592 ; 0042-773X
ISSN (online)	1801-7592
ISSN	0042-773X
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Article: What is hiden behind autoinflammation?

Hrubišková, Katarína / Jeseňák, Miloš / Payer, Juraj

Vnitrni lekarstvi

2020 Volume 66, Issue 3, Page(s) 35–43

Abstract: Autoinflammatory diseases represent a group of disorders that are distinct from autoimmune diseases, infections and malignancies. They are characterised by attacks of unprovoked noninfectious inflammation. A key feature of autoinflammatory diseases is ... ...

Title translation	Čo sa skrýva za autoinflamáciou?
Abstract	Autoinflammatory diseases represent a group of disorders that are distinct from autoimmune diseases, infections and malignancies. They are characterised by attacks of unprovoked noninfectious inflammation. A key feature of autoinflammatory diseases is dysregulation of innate immune system and overproduction of pro-inflammatory cytokines. The best-characterized group of autoinflammatory diseases arises from mutations in single genes. They are typically manifested by recurrent attacks of fever and serositis as well as arthralgia, myalgia and skin exanthema.
MeSH term(s)	Autoimmune Diseases/genetics ; Cytokines ; Fever ; Hereditary Autoinflammatory Diseases/genetics ; Humans ; Inflammation
Chemical Substances	Cytokines
Language	English
Publishing date	2020-09-25
Publishing country	Czech Republic
Document type	Journal Article
ZDB-ID	138213-5
ISSN	1801-7592 ; 0042-773X
ISSN (online)	1801-7592
ISSN	0042-773X
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