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  1. Book: The Leydig cell in health and disease

    Payne, Anita H.

    (Contemporary endocrinology)

    2007  

    Author's details ed. by Anita H. Payne
    Series title Contemporary endocrinology
    Keywords Leydig Cells / physiology ; Testis / physiology ; Leydig cells
    Subject code 612.61
    Language English
    Size XII, 471 S. : Ill., graph. Darst., 26cm
    Publisher Humana Press
    Publishing place Totowa, NJ
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT014999487
    ISBN 1-58829-754-3 ; 978-1-58829-754-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2007 A 4088 order for loan Magazin

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  2. Book: The Leydig cell

    Payne, Anita H.

    1996  

    Author's details ed. by Anita H. Payne
    Keywords Leydig Cells
    Language English
    Size XIII, 802 S. : Ill., graph. Darst.
    Edition 1. ed.
    Publisher Cache River Press
    Publishing place Vienna, Ill
    Publishing country United States
    Document type Book
    HBZ-ID HT008383964
    ISBN 0-9627422-7-9 ; 978-0-9627422-7-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1998 A 2936 order for loan Magazin

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  3. Book ; Online: The Leydig Cell in Health and Disease

    Payne, Anita H. / Hardy, Matthew P.

    2007  

    Author's details edited by Anita H. Payne, Matthew P. Hardy
    Keywords Cell biology ; Endocrinology ; Human physiology
    Language English
    Publisher Humana Press Inc
    Publishing place Totowa, NJ
    Document type Book ; Online
    HBZ-ID TT050387160
    ISBN 978-1-588-29754-9 ; 978-1-597-45453-7 ; 1-588-29754-3 ; 1-597-45453-2
    DOI 10.1007/978-1-59745-453-7
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  4. Book: The Leydig cell in health and disease

    Payne, Anita H / Hardy, Matthew Phillip

    (Contemporary endocrinology)

    2007  

    Author's details edited by Anita H. Payne, Matthew P. Hardy
    Series title Contemporary endocrinology
    MeSH term(s) Leydig Cells/physiology ; Testis/physiology
    Language English
    Size xii, 471 p. :, ill., port.
    Publisher Humana Press
    Publishing place Totowa, NJ
    Document type Book
    ISBN 9781588297549 ; 1588297543 ; 9781597454537 ; 1597454532
    Database Catalogue of the US National Library of Medicine (NLM)

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  5. Article: Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones.

    Payne, Anita H / Hales, Dale B

    Endocrine reviews

    2004  Volume 25, Issue 6, Page(s) 947–970

    Abstract: Significant advances have taken place in our knowledge of the enzymes involved in steroid hormone biosynthesis since the last comprehensive review in 1988. Major developments include the cloning, identification, and characterization of multiple isoforms ... ...

    Abstract Significant advances have taken place in our knowledge of the enzymes involved in steroid hormone biosynthesis since the last comprehensive review in 1988. Major developments include the cloning, identification, and characterization of multiple isoforms of 3beta-hydroxysteroid dehydrogenase, which play a critical role in the biosynthesis of all steroid hormones and 17beta-hydroxysteroid dehydrogenase where specific isoforms are essential for the final step in active steroid hormone biosynthesis. Advances have taken place in our understanding of the unique manner that determines tissue-specific expression of P450aromatase through the utilization of alternative promoters. In recent years, evidence has been obtained for the expression of steroidogenic enzymes in the nervous system and in cardiac tissue, indicating that these tissues may be involved in the biosynthesis of steroid hormones acting in an autocrine or paracrine manner. This review presents a detailed description of the enzymes involved in the biosynthesis of active steroid hormones, with emphasis on the human and mouse enzymes and their expression in gonads, adrenal glands, and placenta.
    MeSH term(s) Adrenal Cortex Hormones/biosynthesis ; Adrenal Cortex Hormones/chemistry ; Animals ; Cholesterol/metabolism ; Cytochrome P-450 Enzyme System/genetics ; Cytochrome P-450 Enzyme System/metabolism ; Gene Expression Regulation, Enzymologic ; Gonadal Steroid Hormones/biosynthesis ; Gonadal Steroid Hormones/chemistry ; Humans ; Hydroxysteroid Dehydrogenases/genetics ; Hydroxysteroid Dehydrogenases/metabolism ; Mice ; Organ Specificity
    Chemical Substances Adrenal Cortex Hormones ; Gonadal Steroid Hormones ; Cytochrome P-450 Enzyme System (9035-51-2) ; Cholesterol (97C5T2UQ7J) ; Hydroxysteroid Dehydrogenases (EC 1.1.-)
    Language English
    Publishing date 2004-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 603096-8
    ISSN 1945-7189 ; 0163-769X
    ISSN (online) 1945-7189
    ISSN 0163-769X
    DOI 10.1210/er.2003-0030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1562: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Book: The Leydig cell

    Payne, Anita H

    1996  

    Author's details ed. by Anita H. Payne
    Language English
    Size XIII, 802 S, Ill., graph. Darst, 29 cm
    Publisher Cache River Press
    Publishing place Vienna, IL
    Document type Book
    ISBN 0962742279 ; 9780962742279
    Database Former special subject collection: coastal and deep sea fishing

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  7. Article: AP-2 gamma and the homeodomain protein distal-less 3 are required for placental-specific expression of the murine 3 beta-hydroxysteroid dehydrogenase VI gene, Hsd3b6.

    Peng, Lihong / Payne, Anita H

    The Journal of biological chemistry

    2001  Volume 277, Issue 10, Page(s) 7945–7954

    Abstract: The enzyme 3 beta-hydroxysteroid dehydrogenase/isomerase (3 beta-HSD) is essential for the biosynthesis of all active steroid hormones. It exists as multiple isoforms in humans and rodents, each the product of a distinct gene. Human 3 beta-HSD I in ... ...

    Abstract The enzyme 3 beta-hydroxysteroid dehydrogenase/isomerase (3 beta-HSD) is essential for the biosynthesis of all active steroid hormones. It exists as multiple isoforms in humans and rodents, each the product of a distinct gene. Human 3 beta-HSD I in placenta is essential for placental progesterone biosynthesis and thus is essential for the maintenance of pregnancy. The murine ortholog, 3 beta-HSD VI, is the only isoform expressed in giant trophoblast cells during the first half of mouse pregnancy. This study was designed to identify the cis-acting element(s) and the associated transcription factors required for trophoblast-specific expression of 3 beta-HSD VI. Transfection studies in placental and nonplacental cells identified a novel 66-bp trophoblast-specific enhancer element located between -2896 and -2831 of the 3 beta-HSD VI promoter. DNase protection analysis of the enhancer element identified three trophoblast-specific binding sites, FPI, FPII, and FPIII. Electrophoretic mobility shift assays with oligonucleotides representing the protected sequences, FPI and FPIII, and nuclear extracts isolated from human JEG-3 cells and from mouse trophoblast cells, demonstrated the same binding pattern that was distinct from the binding pattern with mouse Leydig cell nuclear proteins. Further electrophoretic mobility shift assays identified AP-2 gamma and the homeodomain protein, Dlx 3, as the transcription factors that specifically bind to FPI and FPIII, respectively. Site-specific mutations in each of the binding sites eliminated enhancer activity indicating that AP-2 gamma and Dlx 3, together with an additional transcription factor(s) that are conserved between humans and mice, are required for trophoblast-specific expression of 3 beta-HSD VI.
    MeSH term(s) 17-Hydroxysteroid Dehydrogenases/genetics ; Animals ; Binding Sites ; COS Cells ; Cell Line ; Cell Nucleus/metabolism ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/physiology ; Deoxyribonuclease I/metabolism ; Enhancer Elements, Genetic ; Exons ; Homeodomain Proteins/chemistry ; Homeodomain Proteins/physiology ; Humans ; Luciferases/metabolism ; Mice ; Mice, Inbred C57BL ; Models, Genetic ; Molecular Sequence Data ; Mutagenesis, Site-Directed ; Mutation ; Placenta/enzymology ; Placenta/metabolism ; Plasmids/metabolism ; Promoter Regions, Genetic ; Protein Binding ; Protein Isoforms ; Protein Structure, Tertiary ; RNA, Messenger/metabolism ; Time Factors ; Transcription Factor AP-2 ; Transcription Factors/chemistry ; Transcription Factors/physiology ; Transcription, Genetic ; Transfection
    Chemical Substances DNA-Binding Proteins ; Distal-less homeobox proteins ; Homeodomain Proteins ; Protein Isoforms ; RNA, Messenger ; TFAP2C protein, human ; Tfap2c protein, mouse ; Transcription Factor AP-2 ; Transcription Factors ; 17-Hydroxysteroid Dehydrogenases (EC 1.1.-) ; 3 (or 17)-beta-hydroxysteroid dehydrogenase (EC 1.1.1.51) ; Luciferases (EC 1.13.12.-) ; Deoxyribonuclease I (EC 3.1.21.1)
    Language English
    Publishing date 2001-12-31
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.M106765200
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.108: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Book ; Online: The Leydig Cell in Health and Disease

    Payne, Anita H / Hardy, Matthew Phillip

    (Contemporary Endocrinology)

    2007  

    Abstract: Nearly ten years after they published the first book devoted entirely to the Leydig cell, Matthew Hardy and Anita Payne have collaborated again to provide a comprehensive study of this fascinating and important cell type. The Leydig Cell in Health and ... ...

    Author's details edited by Anita H. Payne, Matthew P. Hardy
    Series title Contemporary Endocrinology
    Abstract Nearly ten years after they published the first book devoted entirely to the Leydig cell, Matthew Hardy and Anita Payne have collaborated again to provide a comprehensive study of this fascinating and important cell type. The Leydig Cell in Health and Disease presents all of the developments in our understanding of Leydig cell biology and explores a wide variety of current and potential clinical applications. All aspects of Leydig cell biology, development, regulation, and physiology are explored in thirty-one expertly written chapters. The Leydig Cell in Health and Disease explores topics of great interest to the private sector, including the possible application of steroidogenesis discoveries to androgen synthesis or suppressing Leydig cell function as a key mechnanism in the development of a male contraceptive. This in-depth volume is an invaluable resource for information on the science and application of Leydig cell biology and function.

    This book provides a comprehensive study of the Leydig cell, a fascinating and important cell type. It presents all of the developments in our understanding of Leydig cell biology and explores a wide variety of current and potential clinical applications. All aspects of Leydig cell biology, development, regulation, and physiology are explored in thirty-one expertly written chapters. This in-depth volume is an invaluable resource.
    MeSH term(s) Leydig Cells/physiology ; Testis/physiology
    Keywords Cytology ; Endocrinology ; Human physiology ; Medicine
    Language English
    Size Online-Ressource, v.: digital
    Document type Book ; Online
    Note Includes bibliographical references and index
    ISBN 9781588297549 ; 9781597454537 ; 1588297543 ; 1597454532
    DOI 10.1007/978-1-59745-453-7
    Database Special collection on veterinary medicine and general parasitology

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    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Book ; Online: The Leydig Cell in Health and Disease

    Payne, Anita H / Hardy, Matthew P

    (Contemporary Endocrinology)

    2007  

    Abstract: Nearly ten years after they published the first book devoted entirely to the Leydig cell, Matthew Hardy and Anita Payne have collaborated again to provide a comprehensive study of this fascinating and important cell type. The Leydig Cell in Health and ... ...

    Author's details edited by Anita H. Payne, Matthew P. Hardy
    Series title Contemporary Endocrinology
    Abstract Nearly ten years after they published the first book devoted entirely to the Leydig cell, Matthew Hardy and Anita Payne have collaborated again to provide a comprehensive study of this fascinating and important cell type. The Leydig Cell in Health and Disease presents all of the developments in our understanding of Leydig cell biology and explores a wide variety of current and potential clinical applications. All aspects of Leydig cell biology, development, regulation, and physiology are explored in thirty-one expertly written chapters. The Leydig Cell in Health and Disease explores topics of great interest to the private sector, including the possible application of steroidogenesis discoveries to androgen synthesis or suppressing Leydig cell function as a key mechnanism in the development of a male contraceptive. This in-depth volume is an invaluable resource for information on the science and application of Leydig cell biology and function.

    This book provides a comprehensive study of the Leydig cell, a fascinating and important cell type. It presents all of the developments in our understanding of Leydig cell biology and explores a wide variety of current and potential clinical applications. All aspects of Leydig cell biology, development, regulation, and physiology are explored in thirty-one expertly written chapters. This in-depth volume is an invaluable resource.
    MeSH term(s) Leydig Cells/physiology ; Testis/physiology
    Keywords Cytology ; Endocrinology ; Human physiology ; Medicine ; Medizin / Gesundheit # Sonstiges ; Technik / Wissen # Biologie
    Language English
    Size Online-Ressource, v.: digital
    Publisher Humana Press Inc
    Publishing place Totowa, NJ
    Document type Book ; Online
    Note Includes bibliographical references and index
    ISBN 9781588297549 ; 9781597454537 ; 1588297543 ; 1597454532
    DOI 10.1007/978-1-59745-453-7
    Database Former special subject collection: coastal and deep sea fishing

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    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article: Growth Differentiation Factor 9 (GDF9) Stimulates Proliferation and Inhibits Steroidogenesis by Bovine Theca Cells: Influence of Follicle Size on Responses to GDF9

    Spicer, Leon J / Aad, Pauline Y / Allen, Dustin T / Mazerbourg, Sabine / Payne, Anita H / Hsueh, Aaron J

    Biology of reproduction. 2008 Feb., v. 78, no. 2

    2008  

    Abstract: Ovarian follicular development is controlled by numerous paracrine and endocrine regulators, including oocyte-derived growth differentiation factor 9 (GDF9), and a localized increase in bioavailable insulin-like growth factor 1 (IGF1). The effects of ... ...

    Abstract Ovarian follicular development is controlled by numerous paracrine and endocrine regulators, including oocyte-derived growth differentiation factor 9 (GDF9), and a localized increase in bioavailable insulin-like growth factor 1 (IGF1). The effects of GDF9 on function of theca cells collected from small (3-6 mm) and large (8-22 mm) ovarian follicles were investigated. In small-follicle theca cells cultured in the presence of both LH and IGF1, GDF9 increased cell numbers and DNA synthesis, as measured by a ³H-thymidine incorporation assay, and dose-dependently decreased both progesterone and androstenedione production. Theca cells from large follicles had little or no response to GDF9 in terms of cell proliferation or steroid production induced by IGF1. Small-follicle theca cell studies indicated that GDF9 decreased the abundance of LHR and CYP11A1 mRNA in theca cells, but had no effect on IGF1R, STAR, or CYP17A1 mRNA abundance or the percentage of cells staining for CYP17A1 proteins. GDF9 activated similar to mothers against decapentaplegics (SMAD) 2/3-induced CAGA promoter activity in transfected theca cells. Small-follicle theca cells had more ALK5 mRNA than large-follicle theca cells. Small-follicle granulosa cells appeared to have greater GDF9 mRNA abundance than large-follicle granulosa cells, but theca cells had no detectable GDF9 mRNA. We conclude that theca cells from small follicles are more responsive to GDF9 than those from large follicles and that GDF9 mRNA may be produced by granulosa cells in cattle. Because GDF9 increased theca cell proliferation and decreased theca cell steroidogenesis, oocyte- and granulosa cell-derived GDF9 may simultaneously promote theca cell proliferation and prevent premature differentiation of the theca interna during early follicle development.
    Language English
    Dates of publication 2008-02
    Size p. 243-253.
    Publishing place Society for the Study of Reproduction, Inc.
    Document type Article
    ZDB-ID 1118-6
    ISSN 1529-7268 ; 0006-3363
    ISSN (online) 1529-7268
    ISSN 0006-3363
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 4292: Show issues

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