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  1. Book ; Online ; E-Book: Biomarkers of postpartum psychiatric disorders

    Payne, Jennifer L. / Osborne, Lauren M.

    2020  

    Author's details edited by Jennifer L. Payne, Lauren M. Osborne
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (xiv, 221 Seiten), Illustrationen
    Publisher Academic Press, an imprint of Elsevier
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020258041
    ISBN 978-0-12-815836-4 ; 9780128155080 ; 0-12-815836-0 ; 0128155086
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Psychiatric Medication Use in Pregnancy and Breastfeeding.

    Payne, Jennifer L

    Obstetrics and gynecology clinics of North America

    2021  Volume 48, Issue 1, Page(s) 131–149

    Abstract: Active peripartum psychiatric illness is associated with adverse outcomes for exposed pregnancies/children. Likely due to high rates of obesity, pregnant women with psychiatric illness also have higher rates of preeclampsia, cesarean section, and ... ...

    Abstract Active peripartum psychiatric illness is associated with adverse outcomes for exposed pregnancies/children. Likely due to high rates of obesity, pregnant women with psychiatric illness also have higher rates of preeclampsia, cesarean section, and gestational diabetes. Postpartum depression is associated with lower IQ, slower language development, and behavioral problems in exposed children. Discontinuing psychiatric medications for pregnancy increases risk for relapse significantly, and the postpartum time period is high risk for developing psychiatric illness. Obstetricians-gynecologists are front-line providers for psychiatric care of women during peripartum. This article provides a framework and knowledge base for management of psychiatric illness during peripartum.
    MeSH term(s) Antidepressive Agents/therapeutic use ; Breast Feeding ; Cesarean Section/statistics & numerical data ; Depression, Postpartum/epidemiology ; Diabetes, Gestational/epidemiology ; Female ; Humans ; Mental Disorders/drug therapy ; Mental Disorders/epidemiology ; Obesity/epidemiology ; Peripartum Period ; Postpartum Period ; Pre-Eclampsia/epidemiology ; Pregnancy ; Pregnancy Complications/drug therapy ; Pregnancy Complications/epidemiology ; Pregnant Women ; Psychotropic Drugs/therapeutic use ; Risk Factors
    Chemical Substances Antidepressive Agents ; Psychotropic Drugs
    Language English
    Publishing date 2021-03-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1004315-9
    ISSN 1558-0474 ; 0889-8545
    ISSN (online) 1558-0474
    ISSN 0889-8545
    DOI 10.1016/j.ogc.2020.11.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Evaluating brexanolone for the treatment of postpartum depression.

    Payne, Jennifer L

    Expert opinion on pharmacotherapy

    2021  Volume 22, Issue 8, Page(s) 959–964

    Abstract: Introduction: Postpartum depression (PPD) is a serious and common complication of childbirth that can have deleterious effects not only on the mother but on the cognitive and behavioral development of exposed children. Brexanolone is a novel, soluble ... ...

    Abstract Introduction: Postpartum depression (PPD) is a serious and common complication of childbirth that can have deleterious effects not only on the mother but on the cognitive and behavioral development of exposed children. Brexanolone is a novel, soluble synthetic formulation of the natural hormone allopregnanolone and acts as a positive allosteric modulator of the gamma-aminobutyric acid A receptor (GABAA). Allopregnanolone levels dramatically decrease during the postpartum time-period and some studies indicate lower serum levels of allopregnanolone during pregnancy in women that go on to develop PPD.Areas covered: The author provides an overview of brexanolone as a treatment option for PPD including coverage of its pharmacokinetics, efficacy, safety, and tolerability. Furthermore, the author gives her expert perspectives on its use and its standing in the treatment armamentarium moving forward.Expert opinion: Brexanolone represents a breakthrough for psychiatry due to its novel mechanism of action, its rapid onset of action, and its sustained effects without continued administration. It is appropriate for use in women with moderate to severe PPD. Experience with the medication and further research is needed to clarify whether the current recommended dosing regimen is required for efficacy.
    MeSH term(s) Child ; Depression, Postpartum/drug therapy ; Drug Combinations ; Female ; Humans ; Pregnancy ; Pregnanolone ; beta-Cyclodextrins
    Chemical Substances Drug Combinations ; beta-Cyclodextrins ; brexanolone ; Pregnanolone (BXO86P3XXW)
    Language English
    Publishing date 2021-03-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2001535-5
    ISSN 1744-7666 ; 1465-6566
    ISSN (online) 1744-7666
    ISSN 1465-6566
    DOI 10.1080/14656566.2021.1897105
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Towards understanding the biology of premenstrual dysphoric disorder: From genes to GABA.

    Hantsoo, Liisa / Payne, Jennifer L

    Neuroscience and biobehavioral reviews

    2023  Volume 149, Page(s) 105168

    Abstract: Premenstrual dysphoric disorder (PMDD) is a severe mood disorder, with affective symptoms that rise and fall in concert with the hormonal fluctuations of the menstrual cycle. PMDD's pathophysiology is poorly understood. This review describes recent ... ...

    Abstract Premenstrual dysphoric disorder (PMDD) is a severe mood disorder, with affective symptoms that rise and fall in concert with the hormonal fluctuations of the menstrual cycle. PMDD's pathophysiology is poorly understood. This review describes recent research on potential biological contributors to PMDD, with a focus on neuroactive steroids, genetics, neuroimaging and cellular studies. Studies suggest that a key contributor is abnormal central nervous system (CNS) response to fluctuations in neuroactive steroid hormones. Imaging studies are limited but support alterations in serotonergic and GABA transmission. Genetic studies suggest heritability, yet specific genetic contributors have not been characterized. Finally, recent cutting-edge cellular studies indicate an underlying vulnerability to the effect of sex hormones at a cellular level. Overall the findings across studies do not yet fit together into a complete description of the underlying biology of PMDD. It is possible that PMDD consists of biological subtypes, and future research may benefit from a subtyping approach.
    MeSH term(s) Female ; Humans ; Premenstrual Dysphoric Disorder/genetics ; Premenstrual Syndrome/genetics ; Menstrual Cycle/genetics ; gamma-Aminobutyric Acid ; Biology
    Chemical Substances gamma-Aminobutyric Acid (56-12-2)
    Language English
    Publishing date 2023-04-12
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 282464-4
    ISSN 1873-7528 ; 0149-7634
    ISSN (online) 1873-7528
    ISSN 0149-7634
    DOI 10.1016/j.neubiorev.2023.105168
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  5. Article ; Online: Perinatal Depression: A Review and an Update.

    Stewart, Anne Louise / Payne, Jennifer L

    The Psychiatric clinics of North America

    2023  Volume 46, Issue 3, Page(s) 447–461

    Abstract: Perinatal depression is a common psychiatric condition that has negative effects on pregnancy and infant outcomes. Screening for the condition is relatively easy and should be done routinely in all medical care of the pregnant and postpartum woman and ... ...

    Abstract Perinatal depression is a common psychiatric condition that has negative effects on pregnancy and infant outcomes. Screening for the condition is relatively easy and should be done routinely in all medical care of the pregnant and postpartum woman and her infant. The risk-benefit analysis favors the use of antidepressant medications during pregnancy and lactation compared with the risk of untreated maternal depression. Other, nonpharmacological treatments will be discussed as well as new treatments, including a new class of medications that act on the inhibitory GABAergic neurotransmitter system.
    MeSH term(s) Pregnancy ; Female ; Infant ; Humans ; Depression ; Depression, Postpartum/drug therapy ; Depression, Postpartum/diagnosis ; Depressive Disorder/drug therapy ; Antidepressive Agents/therapeutic use ; Pregnancy Complications/drug therapy ; Pregnancy Complications/psychology
    Chemical Substances Antidepressive Agents
    Language English
    Publishing date 2023-05-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 431518-2
    ISSN 1558-3147 ; 0193-953X
    ISSN (online) 1558-3147
    ISSN 0193-953X
    DOI 10.1016/j.psc.2023.04.003
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  6. Article ; Online: Gender Diversity in the Psychiatric Workforce: It's Still a (White) Man's World in Psychiatry.

    Clark, Crystal T / Payne, Jennifer L

    Child and adolescent psychiatric clinics of North America

    2023  Volume 33, Issue 1, Page(s) 45–52

    Abstract: Academic psychiatry has slightly higher rates of women in the upper ranks and leadership positions than academic medicine as a whole but women continue to be seriously underrepresented. Psychiatry departments should take specific steps to address ... ...

    Abstract Academic psychiatry has slightly higher rates of women in the upper ranks and leadership positions than academic medicine as a whole but women continue to be seriously underrepresented. Psychiatry departments should take specific steps to address barriers for women in psychiatry including harassment and discrimination, Imposter Syndrome, lack of mentorship and sponsorship, work-life integration issues, and overinvolvement in nonpromotion generating activities. Addressing these barriers within academic psychiatry will improve the environment for all minorities.
    MeSH term(s) Male ; Humans ; Female ; Psychiatry ; Workforce ; Leadership ; Minority Groups
    Language English
    Publishing date 2023-11-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1313996-4
    ISSN 1558-0490 ; 1056-4993
    ISSN (online) 1558-0490
    ISSN 1056-4993
    DOI 10.1016/j.chc.2023.06.005
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  7. Article ; Online: Expression of the GFP-mammalian pleckstrin homology (PH) domain of the phospholipase C δ1 in Saccharomyces cerevisiae BY4741.

    Perrine-Walker, Francine / Payne, Jennifer

    Molecular biology reports

    2022  Volume 49, Issue 5, Page(s) 4123–4128

    Abstract: Background: Pleckstrin homology (PH) domains are common modules of ∼120 amino acids found in proteins involved in signalling, cytoskeletal organization, membrane transport, and modification of phospholipids. Previous live cell studies have involved the ... ...

    Abstract Background: Pleckstrin homology (PH) domains are common modules of ∼120 amino acids found in proteins involved in signalling, cytoskeletal organization, membrane transport, and modification of phospholipids. Previous live cell studies have involved the use of the green-fluorescent protein (GFP) labelling of PH-domain of phospholipase C δ1 (PLC δ1) to study the interactions of molecules at the membrane interface.
    Methods and results: For this study, the aim was to construct and express the GFP-PH domain of PLC δ1 in the Saccharomyces cerevisiae BY4741. The transformants expressing GFP-PH domain of PLC δ1 displayed localised fluorescence to the cell periphery (plasma membrane) while the negative control expressed GFP within the cytoplasm only. No GFP was observed in the non-transformed yeast cells.
    Conclusions: Thus, this technique could be useful in future molecular interactions studies targeted specifically at the yeast cell membrane interface in live yeast cells.
    MeSH term(s) Animals ; Blood Proteins ; Cell Membrane/metabolism ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Mammals/metabolism ; Phospholipase C delta ; Phosphoproteins ; Pleckstrin Homology Domains ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Type C Phospholipases/chemistry ; Type C Phospholipases/metabolism
    Chemical Substances Blood Proteins ; Phosphoproteins ; platelet protein P47 ; Green Fluorescent Proteins (147336-22-9) ; Type C Phospholipases (EC 3.1.4.-) ; Phospholipase C delta (EC 3.1.4.11)
    Language English
    Publishing date 2022-05-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-022-07414-0
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  8. Article ; Online: Gender Diversity in the Psychiatric Workforce: It's Still a (White) Man's World in Psychiatry.

    Clark, Crystal T / Payne, Jennifer L

    The Psychiatric clinics of North America

    2022  Volume 45, Issue 2, Page(s) 271–278

    Abstract: Academic psychiatry has slightly higher rates of women in the upper ranks and leadership positions than academic medicine as a whole but women continue to be seriously underrepresented. Psychiatry departments should take specific steps to address ... ...

    Abstract Academic psychiatry has slightly higher rates of women in the upper ranks and leadership positions than academic medicine as a whole but women continue to be seriously underrepresented. Psychiatry departments should take specific steps to address barriers for women in psychiatry including harassment and discrimination, Imposter Syndrome, lack of mentorship and sponsorship, work-life integration issues, and overinvolvement in nonpromotion generating activities. Addressing these barriers within academic psychiatry will improve the environment for all minorities.
    MeSH term(s) Anxiety Disorders ; Female ; Humans ; Leadership ; Male ; Psychiatry ; Self Concept ; Workforce
    Language English
    Publishing date 2022-05-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 431518-2
    ISSN 1558-3147 ; 0193-953X
    ISSN (online) 1558-3147
    ISSN 0193-953X
    DOI 10.1016/j.psc.2022.03.005
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  9. Article ; Online: Reproductive psychiatry: giving birth to a new subspecialty.

    Payne, Jennifer L

    International review of psychiatry (Abingdon, England)

    2019  Volume 31, Issue 3, Page(s) 207–209

    MeSH term(s) Female ; Humans ; Mental Disorders/psychology ; Pregnancy ; Psychiatry/trends ; Reproductive Health ; Specialization
    Language English
    Publishing date 2019-06-21
    Publishing country England
    Document type Editorial
    ZDB-ID 1018090-4
    ISSN 1369-1627 ; 0954-0261
    ISSN (online) 1369-1627
    ISSN 0954-0261
    DOI 10.1080/09540261.2018.1579991
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  10. Article ; Online: Psychopharmacology in Pregnancy and Breastfeeding.

    Payne, Jennifer L

    The Medical clinics of North America

    2019  Volume 103, Issue 4, Page(s) 629–650

    Abstract: The use of psychotropic drugs during pregnancy and breastfeeding remains a controversial topic. There are several reasons for the controversy, ranging from the misperception that pregnancy is protective against mental illness, to the notion that women ... ...

    Abstract The use of psychotropic drugs during pregnancy and breastfeeding remains a controversial topic. There are several reasons for the controversy, ranging from the misperception that pregnancy is protective against mental illness, to the notion that women should be "pure" during pregnancy and avoid all extraneous substance use, and finally, to the stigma and misunderstanding of psychiatric illness and underestimation of how serious it can be. Fortunately, the currently available data are reassuring for most psychiatric medications-properly controlled studies indicate little to no risk for most (but not all) psychiatric medications.
    MeSH term(s) Breast Feeding ; Female ; Humans ; Infant Behavior/drug effects ; Infant, Newborn ; Mental Disorders/drug therapy ; Pregnancy ; Pregnancy Complications/drug therapy ; Psychopharmacology/standards ; Psychotropic Drugs/adverse effects ; Psychotropic Drugs/therapeutic use ; Puerperal Disorders/drug therapy ; United States
    Chemical Substances Psychotropic Drugs
    Language English
    Publishing date 2019-05-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 215710-x
    ISSN 1557-9859 ; 0025-7125
    ISSN (online) 1557-9859
    ISSN 0025-7125
    DOI 10.1016/j.mcna.2019.02.009
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