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  1. AU="Payrastre, Laurence"
  2. AU="Pereira, Duane G"
  3. AU="Cristofaro, Rosa Carmela"
  4. AU="Wan, Xiaolin"
  5. AU="Renfu, Chen"
  6. AU="Pisani, Antonio Rosario"
  7. AU=Zhang Yue-Miao AU=Zhang Yue-Miao
  8. AU="Chen, Z P"
  9. AU="Pinzón-Navarro, Beatriz Adriana"
  10. AU="Dong, Chuan-Ding"
  11. AU="Gomes, Rafael"
  12. AU="Goncin, Una"
  13. AU="Chen, Yan-Nan"
  14. AU="Revuelta, Belen"
  15. AU="Parmar, Dharati"
  16. AU="Herrera-Mateo, Sergio"
  17. AU="Fejes, I"
  18. AU="Zhang, Zhuhua"
  19. AU="Taillé, C"
  20. AU="San Martín, Juan Víctor"
  21. AU=Sun Yi AU=Sun Yi
  22. AU="Wu, Changping"
  23. AU="Polette, Myriam"
  24. AU="Ian D. Hickson"
  25. AU="Raasch, Siegfried"
  26. AU="Liu, Miao-Miao"
  27. AU="Beschastnov, V V"
  28. AU="Mehdi Benamar"
  29. AU="Manzoor, Jaida"

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  1. Artikel ; Online: Health impact of combined pesticide exposures

    Gamet-Payrastre, Laurence

    2020  

    Abstract: Occupational or environmental exposure to pesticides is a public health concern. Numerous epidemiologic studies show that occupational exposure to these substances is positively correlated with an increased risk of developing certain diseases. ... ...

    Abstract Occupational or environmental exposure to pesticides is a public health concern. Numerous epidemiologic studies show that occupational exposure to these substances is positively correlated with an increased risk of developing certain diseases. Epidemiologic studies among consumers of organic food products (which have greatly reduced pesticide levels) show an inverse relation with the rates of some cancers and metabolic diseases. Experimental studies provide arguments of a plausible link between pesticides and health. Pesticides are biologically active compounds that can individually exert specific effects on different targets that play a major role in cellular function and by extension in the physiological functions of the body. Consumers are exposed to low doses of mixtures of pesticides. When combined, they can interact with one another and induce synergistic effects. Their interactions are complex phenomena involving a network of targets and mechanisms at both the cell and organ levels. It is thus difficult to predict the effects of any given pesticide cocktail, given the diversity of their effects and interaction levels and of the organism's adaptability and biological responses.
    Schlagwörter "Organics" in general
    Verlag John Libbey Eurotext
    Erscheinungsland dk
    Dokumenttyp Artikel ; Online
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  2. Artikel ; Online: Impact des mélanges de pesticides.

    Gamet-Payrastre, Laurence

    2019  

    Abstract: Les pesticides sont considérés comme des facteurs de risque pour la santé chez l’homme. Denombreuses études épidémiologiques montrent en effet une association entre l’expositionprofessionnelle aux pesticides et l’apparition de certaines pathologies. La ... ...

    Abstract Les pesticides sont considérés comme des facteurs de risque pour la santé chez l’homme. Denombreuses études épidémiologiques montrent en effet une association entre l’expositionprofessionnelle aux pesticides et l’apparition de certaines pathologies. La population générale estexposée via l’alimentation à des cocktails de pesticides à faibles doses et la question posée est desavoir quels sont les effets d’une telle exposition sur la santé. Les pesticides sont des composésbiologiquement actifs et exercent des effets sur diverses cibles cellulaires et moléculaires. Lesmélanges de pesticides conduisent à des effets variés et la base des interactions entre composés estcomplexe et implique un réseau de cibles et de mécanismes à différents niveaux. La complexité deseffets cocktails soulève différentes questions quant à leur prédiction. Notamment les notions demécanismes de toxicité additif, synergique ou antagoniste etc. Sont-elles adaptées pour parler desréseaux multiples des niveaux d’interactions ? Quelles étapes des mécanismes d’action de deuxproduits chimiques doivent être prises en considération pour assurer la fiabilité des modèles prédictifs,et comment intégrer l’ensemble des perturbations mécanistiques, toxicocinétique, moléculaires et lestranscrire vers une réponse apicale qui est la donnée la plus importante en termes d’évaluation desrisques toxicologiques. Par ailleurs nos résultats expérimentaux récents soulèvent la question du rôle dela chronicité de l’exposition dont les effets insidieux parce qu’ils se reproduisent de façon répétée toutau long de la vie peuvent conduire au dépassement des capacités de réparations d’adaptation dedétoxification de l’organisme conduisant à la dérégulation de l’homéostasie de l’organisme.
    Schlagwörter "Organics" in general
    Verlag INRAE
    Erscheinungsland dk
    Dokumenttyp Artikel ; Online
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  3. Artikel ; Online: Association between dietary pesticide exposure profiles and body weight change in French adults: Results from the NutriNet-Santé cohort.

    Berlivet, Justine / Payrastre, Laurence / Rebouillat, Pauline / Fougerat, Anne / Touvier, Mathilde / Hercberg, Serge / Lairon, Denis / Pointereau, Philippe / Guillou, Hervé / Vidal, Rodolphe / Baudry, Julia / Kesse-Guyot, Emmanuelle

    Environment international

    2024  Band 184, Seite(n) 108485

    Abstract: Background: Pesticides cause a wide range of deleterious health effects, including metabolic disorders. Little is known about the effects of dietary pesticide exposure on body weight (BW) change in the general population. We aimed to investigate the ... ...

    Abstract Background: Pesticides cause a wide range of deleterious health effects, including metabolic disorders. Little is known about the effects of dietary pesticide exposure on body weight (BW) change in the general population. We aimed to investigate the role of dietary pesticide exposure in BW change among NutriNet-Santé participants, focusing on potential sexual dimorphism.
    Methods: Participants completed a Food Frequency Questionnaire (2014), assessing conventional and organic food consumption. Dietary exposure from plant foods of 25 commonly used pesticides was estimated using a residue database, accounting for agricultural practices (conventional and organic). Exposure profiles based on dietary patterns were computed using Non-negative Matrix Factorization (NMF). Mixed models were used to estimate the associations between BW change and exposure to pesticide mixtures, overall and after stratification by sex and menopausal status.
    Results: The final sample included 32,062 participants (8,211 men, 10,637 premenopausal, and 13,214 postmenopausal women). The median (IQR) follow-up was 7.0 (4.4; 8.0) years. Four pesticides profiles were inferred. Overall, men and postmenopausal women lost BW during follow-up, whereas premenopausal women gained BW. Higher exposure to NMF3, reflecting a lower exposure to synthetic pesticides, was associated with a lower BW gain, especially in premenopausal women (β(95 %CI) = -0.04 (-0.07; 0) kg/year, p = 0.04). Higher exposure to NMF2, highly positively correlated with a mixture of synthetic pesticides (azoxystrobin, boscalid, chlorpropham, cyprodinil, difenoconazole, fenhexamid, iprodione, tebuconazole, and lamda-cyhalothrin), was associated with a higher BW loss in men (β(95 %CI) = -0.05 (-0.08; -0.03) kg/year, p < 0.0001). No associations were observed for NMF1 and 4.
    Conclusions: This study suggests a role of pesticide exposure, inferred from dietary patterns, on BW change, with sexually dimorphic actions, including a potential role of a lower exposure to synthetic pesticides on BW change in women. In men, exposure to a specific pesticide mixture was associated with higher BW loss. The underlying mechanisms need further elucidation.
    Mesh-Begriff(e) Male ; Adult ; Humans ; Female ; Pesticides/adverse effects ; Dietary Exposure ; Food, Organic ; Dietary Patterns ; Body Weight ; Diet
    Chemische Substanzen Pesticides
    Sprache Englisch
    Erscheinungsdatum 2024-02-08
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 554791-x
    ISSN 1873-6750 ; 0160-4120
    ISSN (online) 1873-6750
    ISSN 0160-4120
    DOI 10.1016/j.envint.2024.108485
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  4. Artikel ; Online: Continuous low-level dietary exposure to glyphosate elicits dose and sex-dependent synaptic and microglial adaptations in the rodent brain.

    Cresto, Noemie / Courret, Margot / Génin, Athénaïs / Martin, Céline Marie Pauline / Bourret, Julie / Sakkaki, Sophie / de Bock, Frederic / Janvier, Alicia / Polizzi, Arnaud / Payrastre, Laurence / Ellero-Simatos, Sandrine / Audinat, Etienne / Perroy, Julie / Marchi, Nicola

    Environmental pollution (Barking, Essex : 1987)

    2024  Band 345, Seite(n) 123477

    Abstract: Prolonged exposure to low levels of dietary contaminants is a context in modern life that could alter organ physiology gradually. Here, we aimed to investigate the impact of continuous exposure to acceptable daily intake (ADI) and non-observable adverse ... ...

    Abstract Prolonged exposure to low levels of dietary contaminants is a context in modern life that could alter organ physiology gradually. Here, we aimed to investigate the impact of continuous exposure to acceptable daily intake (ADI) and non-observable adverse effect level (NOAEL) of glyphosate from gestation to adulthood using C57BL/6J mice and incorporating these levels into their food pellets. From adulthood, we analyzed neurophysiological and neuro-glia cellular adaptations in male and female animals. Using ex-vivo hippocampal slice electrophysiology, we found a reduced efficacy of Schaffer collateral-to-CA1 excitatory synapses in glyphosate-exposed dietary conditions, with ADI and NOAEL dose-dependent effects. Short-term facilitation of excitatory synaptic transmission was specifically increased in NOAEL conditions, with a predominant influence in males, suggesting a reduced probability of neurotransmitter release. Long-term synaptic potentiation (LTP) was decreased in NOAEL-exposed mice. Next, we explore whether these neurophysiological modifications are associated with neuro-glia changes in the somatosensory cortex and hippocampus. High-resolution confocal microscopy analyses unveil a dose-dependent increased density of excitatory Vglut1
    Mesh-Begriff(e) Mice ; Male ; Female ; Animals ; Microglia ; Glyphosate ; Rodentia ; Dietary Exposure ; Mice, Inbred C57BL ; Brain
    Chemische Substanzen Glyphosate (4632WW1X5A)
    Sprache Englisch
    Erscheinungsdatum 2024-01-31
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2024.123477
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  5. Artikel ; Online: Hepatoprotective effects of vitamin E against hexachlorobenzene-induced hepatotoxicity and oxidative stress in rats: histological, biochimical and antioxidant status changes.

    Chalouati, Hela / Ben Sâad, Mohamed Moncef / Payrastre, Laurence

    Toxicology mechanisms and methods

    2018  Band 29, Heft 1, Seite(n) 18–25

    Abstract: The protective effects of α-Tocopherol (vitamin E) on liver injury induced by hexachlorobenzene (HCB) were investigated in adult male rats of Wistar strain. Animals were randomly divided into six groups of eight rats each. Group 1 and 2 have received HCB, ...

    Abstract The protective effects of α-Tocopherol (vitamin E) on liver injury induced by hexachlorobenzene (HCB) were investigated in adult male rats of Wistar strain. Animals were randomly divided into six groups of eight rats each. Group 1 and 2 have received HCB, dissolved in olive oil, at a dose of 4 mg or 16 mg/kg b.w., respectively. Group 3 and 4 were treated by the same doses of HCB (4 mg and 16 mg/kg b.w.) after 1 h of pretreatment with α-tocopherol at a dose of 100 mg kg
    Mesh-Begriff(e) Animals ; Antioxidants/metabolism ; Antioxidants/pharmacology ; Biomarkers/blood ; Chemical and Drug Induced Liver Injury/metabolism ; Chemical and Drug Induced Liver Injury/pathology ; Chemical and Drug Induced Liver Injury/prevention & control ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Hexachlorobenzene ; Lipid Peroxidation/drug effects ; Liver/drug effects ; Liver/enzymology ; Liver/pathology ; Liver Function Tests ; Male ; Oxidative Stress/drug effects ; Rats, Wistar ; Vitamin E/pharmacology
    Chemische Substanzen Antioxidants ; Biomarkers ; Vitamin E (1406-18-4) ; Hexachlorobenzene (4Z87H0LKUY)
    Sprache Englisch
    Erscheinungsdatum 2018-10-03
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2081252-8
    ISSN 1537-6524 ; 1537-6516 ; 1051-7235
    ISSN (online) 1537-6524
    ISSN 1537-6516 ; 1051-7235
    DOI 10.1080/15376516.2018.1506847
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  6. Artikel ; Online: Citizen science in environmental health research: A comparison with conventional approaches and creation of a guidance tool issued from the LILAS initiative.

    Laurent, Olivier / Gironza, Yara Carrejo / Ancelet, Sophie / Armant, Olivier / Bard, Denis / Baumgartner, Katia / Bortoli, Sylvie / Boudet, Céline / Chamaret, Philippe / Cormier, Stéphanie / David, Arthur / Desqueyroux, Hélène / Gerber, Mariette / Grimbuhler, Sonia / Mougin, Christian / Payrastre, Laurence / Schraub, Simon / Trousse, Brigitte / Reaud, Cynthia /
    Charron, Sylvie

    Environmental research

    2024  Band 252, Heft Pt 2, Seite(n) 118914

    Abstract: Context: Public interest for citizen science (CS) in environmental health is growing. The goals of environmental health research projects are diverse, as are the methods used to reach these goals. Opportunities for greater implication of the civil ... ...

    Abstract Context: Public interest for citizen science (CS) in environmental health is growing. The goals of environmental health research projects are diverse, as are the methods used to reach these goals. Opportunities for greater implication of the civil society and related challenges differ at each step of such projects. These methodological aspects need to be widely shared and understood by all stakeholders. The LILAS initiative (acronym for "application of citizen science approaches such as LIving LAbS to research on environmental exposures and chronic risks") aimed to 1) favor a mutual understanding of the main issues and research methods in environmental health, of their stakes for different actors, but also of the requirements, strengths and limitations of these methods and to 2) identify expected benefits and points of attention related to stronger degrees of participation as part of environmental health research projects.
    Methods: The LILAS initiative gathered institutional researchers, academics and civil society representatives interested in environmental exposures. Five meetings allowed to collectively identify different types of environmental health research studies and reflect about the benefits, limitations, and methodological issues related to the introduction of growing citizen participation as part of such studies. An analytic table matrix summarizing these aspects was co-created and filled by participants, as a tool devoted to help stakeholders with the definition of future CS research projects in environmental health.
    Results: For different fields of research (e.g.: studies for assessment of environmental exposures, interventions on these exposures, quantitative risk assessment, epidemiological studies), the matrix lists expected benefits for various stakeholders, the fundamental principles of research methods and related practical constraints, but also advantages and limitations related to the use of CS or conventional research approaches.
    Conclusion: The LILAS initiative allowed to develop a tool which provides consolidated grounds for the co-creation of research projects on environmental exposures involving CS.
    Sprache Englisch
    Erscheinungsdatum 2024-04-10
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2024.118914
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  7. Artikel: Les effets des mélanges de pesticides

    Gamet-Payrastre, Laurence / Céline Lukowicz

    Société française de nutrition Cahiers de Nutrition et de Dietetique. 2017,

    2017  

    Abstract: Pesticides are well thought out as risk factors for human health. The impact on consumers’ health who are exposed to low doses mixtures, is still poorly defined. Pesticides are biologically active compounds having effects on various cellula targets and ...

    Abstract Pesticides are well thought out as risk factors for human health. The impact on consumers’ health who are exposed to low doses mixtures, is still poorly defined. Pesticides are biologically active compounds having effects on various cellula targets and their combinations lead to a broad spectrum of responses: addition, synergy, antagonism and potentiation. When combined, pesticides can interact at different levels on specific targets linked to their chemical class (mechanism of toxicity) and/or on toxicokinetic level. In addition, the cocktail effect can be derived from an interaction network involving different cellular targets. The bases of the interaction between pesticides compounds are complex and the question still remains as to the notion of toxicity mechanisms (additive, synergistic etc) are well adapted to talk about the multiple interaction levels networks.
    Schlagwörter antagonism ; bioactive compounds ; human health ; pesticides ; risk factors ; toxicity
    Sprache Englisch
    Umfang p. .
    Erscheinungsort Elsevier Masson SAS
    Dokumenttyp Artikel
    Anmerkung Pre-press version
    ZDB-ID 840946-8
    ISSN 0007-9960
    ISSN 0007-9960
    DOI 10.1016/j.cnd.2017.03.002
    Datenquelle NAL Katalog (AGRICOLA)

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  8. Artikel ; Online: Dual-Hit: Glyphosate exposure at NOAEL level negatively impacts birth and glia-behavioural measures in heterozygous shank3 mutants.

    Sakkaki, Sophie / Cresto, Noemie / Chancel, Raphaël / Jaulmes, Maé / Zub, Emma / Blaquière, Marine / Sicard, Pierre / Maurice, Tangui / Ellero-Simatos, Sandrine / Gamet-Payrastre, Laurence / Marchi, Nicola / Perroy, Julie

    Environment international

    2023  Band 180, Seite(n) 108201

    Abstract: The omnipresence of environmental contaminants represents a health danger with ramifications for adverse neurological trajectories. Here, we tested the dual-hit hypothesis that continuous exposure to non-observable adverse effect level (NOAEL) glyphosate ...

    Abstract The omnipresence of environmental contaminants represents a health danger with ramifications for adverse neurological trajectories. Here, we tested the dual-hit hypothesis that continuous exposure to non-observable adverse effect level (NOAEL) glyphosate from pre-natal to adulthood represents a risk factor for neurological-associated adaptations when in the presence of the heterozygote or homozygote mutation of the Shank3 synaptic gene. Ultrasound analysis of pregnant dams revealed patterns of pre-natal mortality with effects dependent on wild-type, Shank3
    Sprache Englisch
    Erscheinungsdatum 2023-09-17
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 554791-x
    ISSN 1873-6750 ; 0160-4120
    ISSN (online) 1873-6750
    ISSN 0160-4120
    DOI 10.1016/j.envint.2023.108201
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  9. Artikel ; Online: Editorial trend: adverse outcome pathway (AOP) and computational strategy - towards new perspectives in ecotoxicology.

    Baudiffier, Damien / Audouze, Karine / Armant, Olivier / Frelon, Sandrine / Charles, Sandrine / Beaudouin, Remy / Cosio, Claudia / Payrastre, Laurence / Siaussat, David / Burgeot, Thierry / Mauffret, Aourell / Degli Esposti, Davide / Mougin, Christian / Delaunay, Delphine / Coumoul, Xavier

    Environmental science and pollution research international

    2023  Band 31, Heft 5, Seite(n) 6587–6596

    Abstract: The adverse outcome pathway (AOP) has been conceptualized in 2010 as an analytical construct to describe a sequential chain of causal links between key events, from a molecular initiating event leading to an adverse outcome (AO), considering several ... ...

    Abstract The adverse outcome pathway (AOP) has been conceptualized in 2010 as an analytical construct to describe a sequential chain of causal links between key events, from a molecular initiating event leading to an adverse outcome (AO), considering several levels of biological organization. An AOP aims to identify and organize available knowledge about toxic effects of chemicals and drugs, either in ecotoxicology or toxicology, and it can be helpful in both basic and applied research and serve as a decision-making tool in support of regulatory risk assessment. The AOP concept has evolved since its introduction, and recent research in toxicology, based on integrative systems biology and artificial intelligence, gave it a new dimension. This innovative in silico strategy can help to decipher mechanisms of action and AOP and offers new perspectives in AOP development. However, to date, this strategy has not yet been applied to ecotoxicology. In this context, the main objective of this short article is to discuss the relevance and feasibility of transferring this strategy to ecotoxicology. One of the challenges to be discussed is the level of organisation that is relevant to address for the AO (population/community). This strategy also offers many advantages that could be fruitful in ecotoxicology and overcome the lack of time, such as the rapid identification of data available at a time t, or the identification of "data gaps". Finally, this article proposes a step forward with suggested priority topics in ecotoxicology that could benefit from this strategy.
    Mesh-Begriff(e) Ecotoxicology/methods ; Adverse Outcome Pathways ; Artificial Intelligence ; Risk Assessment/methods
    Sprache Englisch
    Erscheinungsdatum 2023-11-15
    Erscheinungsland Germany
    Dokumenttyp Editorial
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-023-30647-w
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  10. Artikel ; Online: Household exposure to pesticides and risk of leukemia in children and adolescents: Updated systematic review and meta-analysis.

    Van Maele-Fabry, Geneviève / Gamet-Payrastre, Laurence / Lison, Dominique

    International journal of hygiene and environmental health

    2018  Band 222, Heft 1, Seite(n) 49–67

    Abstract: Background: The role that pesticides in the domestic environment might play in the etiology of childhood leukemia remains a subject of controversy. Recent studies often reached inconsistent conclusions.: Objective: To update our earlier systematic ... ...

    Abstract Background: The role that pesticides in the domestic environment might play in the etiology of childhood leukemia remains a subject of controversy. Recent studies often reached inconsistent conclusions.
    Objective: To update our earlier systematic review on the association between residential/household/domestic exposure to pesticides and childhood leukemia, and to explore potential sources of heterogeneity not previously assessed.
    Methods: A systematic search of studies published in English between January 2009 and June 2018 was conducted in MEDLINE, and a "snowball searching" was performed from the reference list of identified publications and from Web of Science citations. Risk estimates were extracted from 15 case-control studies published between 1987 and 2018. The quality of the publications was assessed by using a modified version of the Downs and Black (1998) checklist. A random-effect meta-analysis model was used to calculate summary odds ratios (SOR) and separate analyses were conducted for acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), unspecified AL/leukemia and any leukemia types. Stratification by critical exposure period, exposure location, pesticide biocide category, child age at diagnosis, study quality, specific exposures, type of pest treated, and geographic location were performed.
    Results: A statistically significant association between residential pesticide exposure and childhood leukemia was observed by combining all studies (SOR: 1.57; 95% CI: 1.27-1.95) without evidence of publication bias. Statistically significant increased risks were observed for all types of leukemia, and specifically for exposure during pregnancy, indoor exposure, prenatal exposure to insecticides and whatever the age at diagnosis. Statistical significance was also reached for high quality studies, pet treatments, professional pest control treatment and use of insect repellants, mosquito treatment and for studies from USA/Canada or International. The highest increased risks were observed for AML among children aged 2 years or less, as well as for unspecified leukemia type observed after prenatal indoor exposure.
    Conclusions: A positive association between domestic pesticide exposure and childhood leukemia is confirmed. Although the literature provides moderate to low-quality of evidence, these new results further justify the need of limiting the use of household pesticides during pregnancy and childhood.
    Mesh-Begriff(e) Environmental Exposure/adverse effects ; Housing ; Humans ; Leukemia/chemically induced ; Pesticides/toxicity ; Risk Assessment
    Chemische Substanzen Pesticides
    Sprache Englisch
    Erscheinungsdatum 2018-09-26
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 2009176-X
    ISSN 1618-131X ; 1438-4639
    ISSN (online) 1618-131X
    ISSN 1438-4639
    DOI 10.1016/j.ijheh.2018.08.004
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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