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Article ; Online: Evaluation by SEM-EDS of the Presence of Manufacturing Residual Materials on Non-invasive Ventilation (NIV) Masks.

González-Mancera, Guillermina / Mervich-Sigal, Nicolas / Paz-Michel, Brenda A / Morales-García, Joaquin

Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada

2023 Volume 29, Issue Supplement_1, Page(s) 150–151

Language	English
Publishing date	2023-08-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1385710-1
ISSN	1435-8115 ; 1431-9276
ISSN (online)	1435-8115
ISSN	1431-9276
DOI	10.1093/micmic/ozad067.068
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Article ; Online: Nasopharyngeal and oropharyngeal rinses with neutral electrolyzed water prevents COVID-19 in front-line health professionals: A randomized, open-label, controlled trial in a general hospital in Mexico City.

Gutiérrez-García, Rafael / De La Cerda-Ángeles, Juan C / Cabrera-Licona, Ariana / Delgado-Enciso, Ivan / Mervitch-Sigal, Nicolas / Paz-Michel, Brenda A

Biomedical reports

2021 Volume 16, Issue 2, Page(s) 11

Abstract: The worldwide efforts that healthcare professionals are making in the COVID-19 pandemic is well known, and the high risk of illness and death that front-line staff experience on a daily basis is a reality, despite well-defined protocols for the use of ... ...

Abstract	The worldwide efforts that healthcare professionals are making in the COVID-19 pandemic is well known, and the high risk of illness and death that front-line staff experience on a daily basis is a reality, despite well-defined protocols for the use of personal protective equipment. In addition, it is well known that vaccination is still faraway to be achieved worldwide and that new variants are emerging, thus additional protective measures must be explored. A prospective open-label randomized controlled clinical trial was performed on front-line medical staff from the Dr. Enrique Cabrera General Hospital in México City to evaluate the effectiveness of nasopharyngeal and oropharyngeal rinses with a neutral electrolyzed water, known as SES, to reduce the risk of COVID-19 disease among front-line, not vaccinated medical staff. A total of 170 volunteers were enrolled and equally divided in a control group and SES group. All members of the trial wore the adequate personal protection equipment at all times while performing their duties, as required by standard COVID-19 safety protocols. Additionally, the SES group participants followed a prophylactic protocol with SES (oral and nasal rinses, three times a day for 4 weeks). All participants were monitored for COVID-19 symptoms and disease in a time-frame of 4 weeks and the incidence of illness per group was registered. The relative risk of disease, associated with each treatment was calculated. The presence of COVID-19-positive cases, in the group that received the nasal and oral rinses with SES was 1.2%, while in the group that did not do the SES rinses (control group), it was 12.7% (P=0.0039 and RR=0.09405; 95% CI of 0.01231-0.7183). The prophylactic protocol was demonstrated as a protective factor, in more than 90%, for developing the disease, and without adverse effects. Nasal and oral rinses with SES may be an efficient alternative to reinforce the protective measures against COVID-19 disease and should be further investigated. The present clinical trial was retrospectively registered in the Cuban public registry of clinical trials (RPCEC) database (March 16, 2021; PREVECOVID-19: RPCEC00000357).
Language	English
Publishing date	2021-12-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2763624-0
ISSN	2049-9442 ; 2049-9434
ISSN (online)	2049-9442
ISSN	2049-9434
DOI	10.3892/br.2021.1494
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Article: Clinical Characteristics in the Acute Phase of COVID-19 That Predict Long COVID: Tachycardia, Myalgias, Severity, and Use of Antibiotics as Main Risk Factors, While Education and Blood Group B Are Protective.

Guzman-Esquivel, Jose / Mendoza-Hernandez, Martha A / Guzman-Solorzano, Hannah P / Sarmiento-Hernandez, Karla A / Rodriguez-Sanchez, Iram P / Martinez-Fierro, Margarita L / Paz-Michel, Brenda A / Murillo-Zamora, Efren / Rojas-Larios, Fabian / Lugo-Trampe, Angel / Plata-Florenzano, Jorge E / Delgado-Machuca, Marina / Delgado-Enciso, Ivan

Healthcare (Basel, Switzerland)

2023 Volume 11, Issue 2

Abstract: Background: Risk factors for developing long COVID are not clearly established. The present study was designed to determine if any sign, symptom, or treatment of the acute phase, or personal characteristics of the patient, is associated with the ... ...

Abstract	Background: Risk factors for developing long COVID are not clearly established. The present study was designed to determine if any sign, symptom, or treatment of the acute phase, or personal characteristics of the patient, is associated with the development of long COVID. Methods: A cohort study was carried out, randomly selecting symptomatic COVID-19 patients and not vaccinated. The severity of the acute illness was assessed through the number of compatible COVID-19 symptoms, hospitalizations, and the symptom severity score using a 10-point visual analog scale. Results: After multivariate analysis, a severity score ≥8 (RR 2.0, 95%CI 1.1-3.5, Conclusions: Further studies in diverse populations over time are needed to expand the knowledge that could lead us to prevent and/or treat long COVID.
Language	English
Publishing date	2023-01-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare11020197
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Article ; Online: Protective Effect of Neutral Electrolyzed Saline on Gentamicin-Induced Nephrotoxicity: Evaluation of Histopathologic Parameters in a Murine Model.

Aurelien-Cabezas, Nomely S / Paz-Michel, Brenda A / Jacinto-Cortes, Ivan / Delgado-Enciso, Osiris G / Montes-Galindo, Daniel A / Cabrera-Licona, Ariana / Zaizar-Fregoso, Sergio A / Paz-Garcia, Juan / Ceja-Espiritu, Gabriel / Melnikov, Valery / Guzman-Esquivel, Jose / Rodriguez-Sanchez, Iram P / Martinez-Fierro, Margarita L / Delgado-Enciso, Ivan

Medicina (Kaunas, Lithuania)

2023 Volume 59, Issue 2

Abstract: Background and ... ...

Abstract	Background and Objectives
MeSH term(s)	Animals ; Male ; Mice ; Rats ; Disease Models, Animal ; Fibrosis ; Gentamicins/metabolism ; Gentamicins/pharmacology ; Kidney/pathology ; Oxidative Stress ; Prospective Studies ; Rats, Wistar ; Saline Solution/pharmacology ; Single-Blind Method
Chemical Substances	Gentamicins ; Saline Solution
Language	English
Publishing date	2023-02-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina59020397
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Article: Improve cognitive impairment using mefenamic acid non-steroidal anti-inflammatory therapy: additional beneficial effect found in a controlled clinical trial for prostate cancer therapy.

Melnikov, Valery / Tiburcio-Jimenez, Daniel / Mendoza-Hernandez, Martha A / Delgado-Enciso, Josuel / De-Leon-Zaragoza, Luis / Guzman-Esquivel, Jose / Rodriguez-Sanchez, Iram P / Martinez-Fierro, Margarita L / Lara-Esqueda, Agustin / Delgado-Enciso, Osiris G / Jacinto-Cortes, Ivan / Zaizar-Fregoso, Sergio A / Paz-Michel, Brenda A / Murillo-Zamora, Efren / Delgado-Enciso, Ivan / Galvan-Salazar, Hector R

American journal of translational research

2021 Volume 13, Issue 5, Page(s) 4535–4543

Abstract: Inflammation is an essential component of prostate cancer (PCa), and mefenamic acid has been reported to decrease its biochemical progression. The current standard therapy for PCa is androgen deprivation therapy (ADT), which has side effects such as ... ...

Abstract	Inflammation is an essential component of prostate cancer (PCa), and mefenamic acid has been reported to decrease its biochemical progression. The current standard therapy for PCa is androgen deprivation therapy (ADT), which has side effects such as cognitive dysfunction, risk of Alzheimer's disease, and dementia. Published results of in vitro tests and animal models studies have shown that mefenamic acid could be used as a neuroprotector. Objective: Examine the therapeutic potential of mefenamic acid in cognitive impairment used in a controlled clinical trial. Clinical trial phase II was conducted on patients undergoing ADT for PCa. Two groups of 14 patients were included. One was treated with a placebo, while the other received mefenamic acid 500 mg PO every 12hrs for six months. The outcome was evaluated through the Mini-Mental State Examination (MMSE) score at six months. At the beginning of the study, both groups had similar MMSE scores (mefenamic acid vs. placebo: 26.0±2.5 vs. 27.0±2.6, P=0.282). The mefenamic acid group improved its MMSE score after six months compared with the placebo group (27.7±1.8 vs. 25.5±4.2, P=0.037). Treatment with mefenamic acid significantly increases the probability of maintained or raised cognitive function compared to placebo (92% vs. 42.9%, RR=2.2, 95% CI: 1.16-4.03, NNT=2.0, 95% CI: 1.26-4.81, P=0.014). Furthermore, 42.9% of the placebo group patients had relevant cognitive decline (a 2-point decrease in the MMSE score), while in patients treated with mefenamic acid, cognitive impairment was not present. This study is the first conducted on humans that suggests that mefenamic acid protects against cognitive decline.
Language	English
Publishing date	2021-05-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2471058-1
ISSN	1943-8141
ISSN	1943-8141
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Article ; Online: Efficacy of the use of mefenamic acid combined with standard medical care vs. standard medical care alone for the treatment of COVID‑19: A randomized double‑blind placebo‑controlled trial.

Guzman-Esquivel, Jose / Galvan-Salazar, Hector R / Guzman-Solorzano, Hannah P / Cuevas-Velazquez, Andrea C / Guzman-Solorzano, Jose A / Mokay-Ramirez, Karen A / Paz-Michel, Brenda A / Murillo-Zamora, Efren / Delgado-Enciso, Josuel / Melnikov, Valery / Delgado-Enciso, Osiris G / Rodriguez-Sanchez, Iram P / Martinez-Fierro, Margarita L / Rojas-Larios, Fabian / Walle-Guillen, Mireya / Cardenas-Aguilar, Citlaly B / Beas-Guzman, Oscar / Chaviano-Conesa, Daniel / Garcia-Garcia, Hossana S /

Delgado-Enciso, Ivan

International journal of molecular medicine

2022 Volume 49, Issue 3

Abstract: Mefenamic acid is a non‑steroidal anti‑inflammatory drug exhibiting a wide range of anti‑inflammatory, antipyretic, analgesic and probable antiviral activities. The present study evaluated the efficacy of treatment with mefenamic acid combined with ... ...

Abstract	Mefenamic acid is a non‑steroidal anti‑inflammatory drug exhibiting a wide range of anti‑inflammatory, antipyretic, analgesic and probable antiviral activities. The present study evaluated the efficacy of treatment with mefenamic acid combined with standard medical care vs. standard medical care plus a placebo in ambulatory patients with coronavirus disease 2019 (COVID‑19; nasal/oropharyngeal swabs reverse transcription‑PCR test results positive for severe acute respiratory syndrome coronavirus 2). The present study is a phase II prospective, two‑arm, parallel‑group, randomized, double‑blind placebo‑controlled clinical trial which analyzed 36 patients. Two aspects were evaluated during the 14‑day follow‑up period: i) The time for reaching a patient acceptable symptom state (PASS), and ii) the last day of each COVID‑19 symptom presentation. Adverse effects were evaluated. The clinical severity for all the patients in the study was mild (88.9%) and moderate (11.1%). The control (placebo) group achieved PASS on day 8.0±1.3, compared with day 4.4±0.8 in the mefenamic acid group (P=0.020, Kaplan‑Meier analyses using log‑rank tests). Patients that received mefenamic acid plus standard medical care had a ~16‑fold higher probability of achieving PASS on day 8 (adjusted RR, 15.57; 95% CI, 1.22‑198.71; P=0.035), compared with the placebo plus standard medical care group. All symptoms lasted for fewer days in the mefenamic acid group, compared with the placebo group; however, only the symptoms of headache (P=0.008), retro‑orbital eye pain (P=0.049), and sore throat (P=0.029) exhibited statistically significant differences. The experimental treatment produced no severe adverse effects. On the whole, the present study demonstrates that the administration of mefenamic acid markedly reduced the symptomatology and time to reach PASS in ambulatory patients with COVID‑19. Due to its probable antiviral effects and potent anti‑inflammatory mechanisms, mefenamic acid may prove to be useful in the treatment of COVID‑19, in combination with other drugs, including the new antivirals (remdesivir, molnupiravir, or favipiravir). However, future studies are also required to confirm these findings.
MeSH term(s)	Ambulatory Care ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Antiviral Agents/therapeutic use ; COVID-19/complications ; COVID-19/drug therapy ; COVID-19/therapy ; Combined Modality Therapy ; Double-Blind Method ; Eye Pain/etiology ; Headache/etiology ; Humans ; Mefenamic Acid/therapeutic use ; Pharyngitis/etiology ; Prospective Studies ; Treatment Outcome
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Antiviral Agents ; Mefenamic Acid (367589PJ2C)
Language	English
Publishing date	2022-01-14
Publishing country	Greece
Document type	Clinical Trial, Phase II ; Comparative Study ; Journal Article ; Randomized Controlled Trial
ZDB-ID	1444428-8
ISSN	1791-244X ; 1107-3756
ISSN (online)	1791-244X
ISSN	1107-3756
DOI	10.3892/ijmm.2022.5084
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Article: Systemic Administration of Neutral Electrolyzed Saline as a Novel Treatment for Rheumatoid Arthritis Reduces Mechanical and Inflammatory Damage to the Joints: Preclinical Evaluation in Mice.

Zaizar-Fregoso, Sergio A / Paz-Michel, Brenda A / Rodriguez-Hernandez, Alejandrina / Paz-Garcia, Juan / Aurelien-Cabezas, Nomely S / Tiburcio-Jimenez, Daniel / Melnikov, Valery / Murillo-Zamora, Efren / Delgado-Enciso, Osiris G / Cabrera-Licona, Ariana / Guzman-Esquivel, José / Barajas-Saucedo, Carlos E / Rodriguez-Sanchez, Iram P / Martinez-Fierro, Margarita L / Moy-López, Norma A / Lara-Esqueda, Agustin / Guzman-Muñiz, Jorge / Delgado-Machuca, Marina / Delgado-Enciso, Ivan

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 1717614

Abstract: Rheumatoid arthritis is globally present in about 1% of the population. This autoinflammatory disease modifies the connective tissue, causing pain and inflammation of the joints. Over time, it causes the loss of joint cartilage and bone mass, decreasing ... ...

Abstract	Rheumatoid arthritis is globally present in about 1% of the population. This autoinflammatory disease modifies the connective tissue, causing pain and inflammation of the joints. Over time, it causes the loss of joint cartilage and bone mass, decreasing the patient's quality of life. Treatment options now available either give symptomatic alleviation or alter the disease process. Nonetheless, adherence to chronic treatment is typically limited due to adverse effects. As a result, new therapy approaches, such as systemic administration of neutral electrolyzed saline to improve patients' quality of life, are being investigated. The study is a randomized prospective preclinical trial with a single-blind and a 4-arm parallel group using a collagen-induced mice model to generate rheumatoid arthritis. It was carried out on 36 male BALB/c mice, with the primary outcome measure being a scoring system for histopathologic assessment. When all groups are compared, there are significant differences. In addition, the animal model was validated by the healthy group. The animals treated with neutral electrolyzed saline had much less cartilage degradation, bone erosion, pannus development, and inflammation than the placebo-treated mice. Serum IL-6 levels were evaluated in parallel with disease severity expressed as synovitis grading of the affected joints. Spearman's rank correlation coefficient (Rs) = 0.399 (
Language	English
Publishing date	2022-06-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/1717614
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Article: Patient-Reported Health Outcomes After Treatment of COVID-19 with Nebulized and/or Intravenous Neutral Electrolyzed Saline Combined with Usual Medical Care Versus Usual Medical care alone: A Randomized, Open-Label, Controlled Trial.

Delgado-Enciso, Ivan / Paz-Garcia, Juan / Barajas-Saucedo, Carlos E / Mokay-Ramírez, Karen A / Meza-Robles, Carmen / Lopez-Flores, Rodrigo / Delgado-Machuca, Marina / Murillo-Zamora, Efren / Toscano-Velazquez, Jose A / Delgado-Enciso, Josuel / Melnikov, Valery / Walle-Guillen, Mireya / Galvan-Salazar, Hector R / Delgado-Enciso, Osiris G / Cabrera-Licona, Ariana / Guzman-Esquivel, José / Montes-Galindo, Daniel A / Hemandez-Rangel, Alejandra E / Montes-Diaz, Patricia /

Rodriguez-Sanchez, Iram P / Martinez-Fierro, Margarita L / Garza-Veloz, Idalia / Tiburcio-Jimenez, Daniel / Zaizar-Fregoso, Sergio A / Ramirez-Flores, Mario / Gaytan-Sandoval, Gustavo / Martinez-Perez, Carlos R / Espinoza-Gómez, Francisco / Rojas-Larios, Fabián / Hirsch-Meillon, Michael J / Barrios-Navarro, Enrique / Oviedo-Rodriguez, Vladimir / Baltazar Rodriguez, Luz M / Paz-Michel, Brenda A

Research square

2020

Abstract: Background: ...

Abstract	Background:
Keywords	covid19
Language	English
Publishing date	2020-09-10
Publishing country	United States
Document type	Preprint
DOI	10.21203/rs.3.rs-68403/v1
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Article ; Online: Safety and efficacy of a COVID-19 treatment with nebulized and/or intravenous neutral electrolyzed saline combined with usual medical care vs. usual medical care alone: A randomized, open-label, controlled trial.

Delgado-Enciso, Ivan / Paz-Garcia, Juan / Barajas-Saucedo, Carlos E / Mokay-Ramírez, Karen A / Meza-Robles, Carmen / Lopez-Flores, Rodrigo / Delgado-Machuca, Marina / Murillo-Zamora, Efren / Toscano-Velazquez, Jose A / Delgado-Enciso, Josuel / Melnikov, Valery / Walle-Guillen, Mireya / Galvan-Salazar, Hector R / Delgado-Enciso, Osiris G / Cabrera-Licona, Ariana / Danielewicz-Mata, Eduardo J / Mandujano-Diaz, Pablo J / Guzman-Esquivel, José / Montes-Galindo, Daniel A /

Perez-Martinez, Henry / Jimenez-Villegaz, Jesus M / Hernandez-Rangel, Alejandra E / Montes-Diaz, Patricia / Rodriguez-Sanchez, Iram P / Martinez-Fierro, Margarita L / Garza-Veloz, Idalia / Tiburcio-Jimenez, Daniel / Zaizar-Fregoso, Sergio A / Gonzalez-Alcaraz, Fidadelfo / Gutierrez-Gutierrez, Laydi / Diaz-Lopez, Luciano / Ramirez-Flores, Mario / Guzman-Solorzano, Hannah P / Gaytan-Sandoval, Gustavo / Martinez-Perez, Carlos R / Espinoza-Gómez, Francisco / Rojas-Larios, Fabián / Hirsch-Meillon, Michael J / Baltazar-Rodriguez, Luz M / Barrios-Navarro, Enrique / Oviedo-Rodriguez, Vladimir / Mendoza-Hernandez, Martha A / Prieto-Diaz-Chavez, Emilio / Paz-Michel, Brenda A

Experimental and therapeutic medicine

2021 Volume 22, Issue 3, Page(s) 915

Abstract: Coronavirus disease 2019 (COVID-19) is currently the major public health problem worldwide. Neutral electrolyzed saline solution that contains reactive chlorine and oxygen species may be an effective therapeutic. In the present study, the treatment ... ...

Abstract	Coronavirus disease 2019 (COVID-19) is currently the major public health problem worldwide. Neutral electrolyzed saline solution that contains reactive chlorine and oxygen species may be an effective therapeutic. In the present study, the treatment efficacy of intravenous and/or nebulized neutral electrolyzed saline combined with usual medical care vs. usual medical care alone was evaluated in ambulatory patients with COVID-19. A prospective, 2-arm, parallel-group, randomized, open-label, multi-center, phase I-II clinical trial including 214 patients was performed. The following two outcomes were evaluated during the 20-day follow-up: i) The number of patients with disease progression; and ii) the patient acceptable symptom state. Serial severe acute respiratory syndrome coronavirus 2 naso/oro-pharyngeal detection by reverse transcription-quantitative (RT-q) PCR was performed in certain patients of the experimental group. Biochemical and hematologic parameters, as well as adverse effects, were also evaluated in the experimental group. The experimental treatment decreased the risk of hospitalization by 89% [adjusted relative risk (RR)=0.11, 95% confidence interval (CI): 0.03-0.37, P<0.001] and the risk of death by 96% (adjusted RR=0.04, 95% CI: 0.01-0.42, P=0.007) and also resulted in an 18-fold higher probability of achieving an acceptable symptom state on day 5 (adjusted RR=18.14, 95% CI: 7.29-45.09, P<0.001), compared with usual medical care alone. Overall, neutral electrolyzed saline solution was better than usual medical care alone. Of the patients analyzed, >50% were negative for the virus as detected by RT-qPCR in naso/oro-pharyngeal samples on day 4, with only a small number of positive patients on day 6. Clinical improvement correlated with a decrease in C-reactive protein, aberrant monocytes and increased lymphocytes and platelets. Cortisol and testosterone levels were also evaluated and a decrease in cortisol levels and an increase in the testosterone-cortisol ratio were observed on days 2 and 4. The experimental treatment produced no serious adverse effects. In conclusion, neutral electrolyzed saline solution markedly reduced the symptomatology and risk of progression in ambulatory patients with COVID-19. The present clinical trial was registered in the Cuban public registry of clinical trials (RPCEC) database (May 5, 2020; no. TX-COVID19: RPCEC00000309).
Language	English
Publishing date	2021-06-29
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2683844-8
ISSN	1792-1015 ; 1792-0981
ISSN (online)	1792-1015
ISSN	1792-0981
DOI	10.3892/etm.2021.10347
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