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  1. Book ; Online: Venezuela y su tradición rentista

    Banko, Catalina / Peña, Carlos / Peña, Carlos

    visiones, enfoques y evidencias

    2017  

    Keywords Mining industry ; Economic history ; Business ; Economics
    Language Spanish
    Size 1 Online-Ressource
    Publisher CLACSO
    Document type Book ; Online
    Note Spanish
    HBZ-ID HT030610478
    ISBN 9789877222432 ; 9877222434
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Capacity of Aqueous Solutions of the Ionic Liquid 1-Ethyl-3-methylimidazolium Acetate to Partially Depolymerize Lignin at Ambient Temperature and Pressure.

    Pena, Carlos A / Rodil, Eva / Rodríguez, Héctor

    Journal of agricultural and food chemistry

    2024  Volume 72, Issue 2, Page(s) 1136–1145

    Abstract: Lignin is a very attractive and abundant biopolymer with the potential to be a biorenewable source of a large number of value-added organic chemicals. The current state-of-the-art methods fail to provide efficient valorization of lignin in this regard ... ...

    Abstract Lignin is a very attractive and abundant biopolymer with the potential to be a biorenewable source of a large number of value-added organic chemicals. The current state-of-the-art methods fail to provide efficient valorization of lignin in this regard without the involvement of harsh conditions and auxiliary substances that compromise the overall sustainability of the proposed processes. Making an original approach from the set of mildest temperature and pressure conditions, this work identifies and explores the capacity of an aqueous solution of the nonvolatile ionic liquid 1-ethyl-3-methylimidazolium acetate ([C
    MeSH term(s) Ionic Liquids/chemistry ; Lignin/chemistry ; Temperature ; Biomass ; Water ; Acetates ; Phenols ; Guaiacol ; Benzaldehydes ; Imidazoles
    Chemical Substances Ionic Liquids ; Lignin (9005-53-2) ; 1-ethyl-3-methylimidazolium (TVE1D62MAK) ; vanillin (CHI530446X) ; Water (059QF0KO0R) ; Acetates ; Phenols ; Guaiacol (6JKA7MAH9C) ; Benzaldehydes ; Imidazoles
    Language English
    Publishing date 2024-01-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.3c04047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Takayasu Arteritis: A Difficult Diagnosis in a Patient With an Extensive Cardiovascular History.

    Peña, Carlos / Kalara, Niketa / Velagapudi, Pallavi / Poli, Fernando

    Cureus

    2023  Volume 15, Issue 7, Page(s) e41256

    Abstract: Large vessel vasculitides, such as Takayasu arteritis (TAK), are rare inflammatory conditions primarily affecting the aorta and its major branches. Its nonspecific symptoms and potential resemblance to atherosclerotic disease often pose diagnostic ... ...

    Abstract Large vessel vasculitides, such as Takayasu arteritis (TAK), are rare inflammatory conditions primarily affecting the aorta and its major branches. Its nonspecific symptoms and potential resemblance to atherosclerotic disease often pose diagnostic challenges. We present a case of a 57-year-old male with a history of extensive cardiovascular disease, initially attributed to atherosclerosis, resulting in several interventions, such as catheterization and major cardiac surgery, which didn't help improve his symptoms. Further evaluation revealed diffuse wall thickening of the aorta and its roots, as well as labs that suggested elevated inflammatory markers, comprehensive review of his chart and previous admissions, revealed that he had a well-documented aortitis for which he underwent a biopsy, which at the time was unrevealing. Furthermore, as he had significant aortic aneurysmal dilation, a thoracic cardiovascular surgeon remitted him to the rheumatology clinic, where he was placed on a prednisone taper and methotrexate regimen. Unfortunately, he redeveloped symptoms, and plans were made to transition to a tumor necrosis alpha (TNF-alpha) inhibitor. Our case highlights the importance of an accurate diagnosis and the prompt initiation of appropriate treatment in challenging cases of large vessel vasculitides. This case also underscores the need for heightened clinical awareness and interdisciplinary collaboration to ensure optimal patient care.
    Language English
    Publishing date 2023-07-01
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.41256
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: A Case of Antisynthetase Syndrome in the Setting of SARS-Cov-2 Infection.

    Peña, Carlos / Kalara, Niketa / Velagapudi, Pallavi

    Cureus

    2023  Volume 15, Issue 6, Page(s) e40588

    Abstract: Antisynthetase syndrome is a complex autoimmune disorder, and one of the key criteria for diagnosis is the presence of myositis. Additionally, evidence of interstitial lung disease (ILD) is another important indicator for diagnosis; other clinical ... ...

    Abstract Antisynthetase syndrome is a complex autoimmune disorder, and one of the key criteria for diagnosis is the presence of myositis. Additionally, evidence of interstitial lung disease (ILD) is another important indicator for diagnosis; other clinical features associated with antisynthetase syndrome include arthritis, unexplained and persistent fever, Raynaud's phenomenon, and the presence of mechanic's hands. We report a case of a 36-year-old male who presented to the emergency department with shortness of breath and proximal muscle weakness in the setting of severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection, as his inflammatory markers were elevated and he exhibited features suspicious for antisynthetase syndrome, he was started on methylprednisolone 40 mg intravenously every eight hours, and a myositis panel was checked. In addition, a chest computed tomography (CT) exhibited ground-glass opacities which were compatible with coronavirus disease 2019 (COVID-19). A magnetic resonance image (MRI) of both thighs was done, revealing significant swelling and confirming the suspicion of myositis as his muscle strength in his lower extremities took significant time to improve. As days passed, his muscle strength improved significantly and his creatine phosphatase kinase (CPK) values trended down, indicating that his myositis was improving as well. He was transitioned to oral prednisone 60 mg daily and was discharged home with a rheumatology follow-up to define long-term treatment. A myositis panel revealed anti-glycyl-transferRNA synthetase (EJ) autoantibody positivity and a diagnosis was established. Our case revealed how sometimes laboratory values do not necessarily correlate with disease severity and how we have to do a thorough history of present illness and physical exam to think about unusual diagnoses before putting laboratory data into context.
    Language English
    Publishing date 2023-06-18
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.40588
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Production of alginates with high viscosifying power and molecular weight by using the AT9 strain of Azotobacter vinelandii in batch cultures under different oxygen transfer conditions

    Medina, Abraham / Castillo, Tania / Flores, Celia / Núñez, Cinthia / Galindo, Enrique / Peña, Carlos

    Journal of Chemical Technology & Biotechnology. 2023 Feb., v. 98, no. 2 p.537-543

    2023  

    Abstract: BACKGROUND: Alginate is a polysaccharide constituted by β‐d‐mannuronic acid and α‐l‐guluronic which has several applications in the field of tissue engineering, drug delivery and other biomedical applications. This study aimed to evaluate the production, ...

    Abstract BACKGROUND: Alginate is a polysaccharide constituted by β‐d‐mannuronic acid and α‐l‐guluronic which has several applications in the field of tissue engineering, drug delivery and other biomedical applications. This study aimed to evaluate the production, molecular weight (MW) and viscosifying power of the alginate produced by the strain AT9 cultured in a 3‐L reactor, under three different oxygen transfer rates (OTR). RESULTS: An increase in the OTRₘₐₓ, in the range of 3.6–12.4 mmol L⁻¹ h⁻¹ promoted cellular growth and alginate production in the cultures, reaching a specific growth rate of 0.14 h⁻¹ and a maximal alginate concentration of 2.9 g L⁻¹ in cultures developed at 12.4 mmol L⁻¹ h⁻¹. By contrast, at low OTR (3.6 mmol L⁻¹ h⁻¹) a maximal molecular weight of 2927 kDa was obtained and at high OTRₘₐₓ (12.4 mmol L⁻¹ h⁻¹) the maximal acetylation degree (2–3%) was reached. As a result of the higher acetylation of the alginate, the viscosifying power was the highest (3.16 L g⁻¹). CONCLUSION: Overall, our results indicate that by controlling the OTRₘₐₓ it is possible to manipulate the MW, the acetylation degree and the viscosifying power of bacterial alginates produced by strain AT9. © 2022 The Authors. Journal of Chemical Technology and Biotechnology published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry (SCI).
    Keywords Azotobacter vinelandii ; acetylation ; alginates ; biotechnology ; cell growth ; drugs ; molecular weight ; oxygen ; specific growth rate
    Language English
    Dates of publication 2023-02
    Size p. 537-543.
    Publishing place John Wiley & Sons, Ltd.
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 1479465-2
    ISSN 1097-4660 ; 0268-2575
    ISSN (online) 1097-4660
    ISSN 0268-2575
    DOI 10.1002/jctb.7267
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Evolución de la coinfección por TB/VIH en la Región Metropolitana de Chile, 2005 a 2018.

    Olmos, Claudio / Stuardo, Valeria / Ramonda, Paulina / Peña, Carlos

    Revista medica de Chile

    2021  Volume 148, Issue 5, Page(s) 618–625

    Abstract: Background: Tuberculosis (TB)/HIV coinfection has a high mortality rate.: Aim: To describe socio-epidemiological characteristics of tuberculosis (TB)-HIV coinfection, and aspects associated with its prevalence, from 2005 to 2018.: Material and ... ...

    Title translation Evolution of tuberculosis/HIV coinfection in Metropolitan Santiago, Chile from 2005 to 2018.
    Abstract Background: Tuberculosis (TB)/HIV coinfection has a high mortality rate.
    Aim: To describe socio-epidemiological characteristics of tuberculosis (TB)-HIV coinfection, and aspects associated with its prevalence, from 2005 to 2018.
    Material and methods: Analysis of the registry of the tuberculosis control and elimination program of three public health services of metropolitan Santiago. The variables considered were: TB/HIV coinfection, age, sex, location of tuberculosis, bacteriological confirmation, incarceration, commune of residence, country of origin and effectiveness of the tuberculosis therapy.
    Results: We analyzed 7507 TB cases, of whom 12% corresponded to cases of coinfection. The number of coinfections doubled in the last 6 years. In 2018, 45% of coinfection cases occurred in migrants. Of the total cases evaluated, 53% were successfully treated and 28% died.
    Conclusions: The remarkable increase in TB/HIV coinfection, urgently demands new prevention and control strategies, aimed at the most vulnerable groups.
    MeSH term(s) Chile/epidemiology ; Cities/epidemiology ; Coinfection/epidemiology ; Female ; HIV Infections/epidemiology ; Humans ; Male ; Prevalence ; Socioeconomic Factors ; Tuberculosis/epidemiology
    Language Spanish
    Publishing date 2021-01-05
    Publishing country Chile
    Document type Journal Article
    ZDB-ID 732136-3
    ISSN 0717-6163 ; 0034-9887
    ISSN (online) 0717-6163
    ISSN 0034-9887
    DOI 10.4067/S0034-98872020000500618
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Eco-efficiency in Brazilian Amazonian agriculture: opportunity costs of degradation and protection of the environment.

    Rosano-Peña, Carlos / Teixeira, Joanílio Rodolpho / Kimura, Herbert

    Environmental science and pollution research international

    2021  Volume 28, Issue 44, Page(s) 62378–62389

    Abstract: Aiming to assist the environmental sustainability of the Brazilian Amazonian agriculture, this article developed an eco-efficiency index, indicating the possible limits to maximize economic and environmental objectives, taking into account the best ... ...

    Abstract Aiming to assist the environmental sustainability of the Brazilian Amazonian agriculture, this article developed an eco-efficiency index, indicating the possible limits to maximize economic and environmental objectives, taking into account the best practices in the municipalities of the region. Shadow prices of degraded areas and forest preservation were also estimated using data envelopment analysis with directional distance functions. The results indicate that, on average, the analyzed municipalities are able to expand the production and the forest areas by 38% and reduce degraded areas and their inputs in the same proportion. The shadow prices allowed the estimation of the annual opportunity cost of the degraded areas and the preservation of the forest on the farms. The first, US$ 3,131,571, represented 0.04% of the annual output value, indicating that the internalization of that cost should be a low burden for the eco-efficient producer. The second, the total cost of preserving 80% of the area of property, represented US$ 120,890,662 or 1.7% of the annual income of the biome producers studied. Therefore, the main conclusion of this work is that the internalization of negative and positive externalities of agricultural production in the Amazonian biome does not make agricultural production economically unfeasible in the region. In addition, the reimbursement of damages avoided by carbon sequestration, through the Clean Development Mechanism (CDM) established by the Kyoto Conference, should further increase the economic and environmental sustainability of agriculture in the area.
    MeSH term(s) Agriculture ; Brazil ; Efficiency ; Farms ; Income
    Language English
    Publishing date 2021-07-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-021-14867-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Sex differences in thermoregulation in mammals: Implications for energy homeostasis.

    Fernández-Peña, Carlos / Reimúndez, Alfonso / Viana, Félix / Arce, Victor M / Señarís, Rosa

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1093376

    Abstract: Thermal homeostasis is a fundamental process in mammals, which allows the maintenance of a constant internal body temperature to ensure an efficient function of cells despite changes in ambient temperature. Increasing evidence has revealed the great ... ...

    Abstract Thermal homeostasis is a fundamental process in mammals, which allows the maintenance of a constant internal body temperature to ensure an efficient function of cells despite changes in ambient temperature. Increasing evidence has revealed the great impact of thermoregulation on energy homeostasis. Homeothermy requires a fine regulation of food intake, heat production, conservation and dissipation and energy expenditure. A great interest on this field of research has re-emerged following the discovery of thermogenic brown adipose tissue and browning of white fat in adult humans, with a potential clinical relevance on obesity and metabolic comorbidities. However, most of our knowledge comes from male animal models or men, which introduces unwanted biases on the findings. In this review, we discuss how differences in sex-dependent characteristics (anthropometry, body composition, hormonal regulation, and other sexual factors) influence numerous aspects of thermal regulation, which impact on energy homeostasis. Individuals of both sexes should be used in the experimental paradigms, considering the ovarian cycles and sexual hormonal regulation as influential factors in these studies. Only by collecting data in both sexes on molecular, functional, and clinical aspects, we will be able to establish in a rigorous way the real impact of thermoregulation on energy homeostasis, opening new avenues in the understanding and treatment of obesity and metabolic associated diseases.
    MeSH term(s) Animals ; Male ; Female ; Humans ; Sex Characteristics ; Body Temperature Regulation ; Homeostasis ; Obesity/therapy ; Mammals
    Language English
    Publishing date 2023-03-08
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1093376
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Continuous Bioproduction of Alginate Bacterial under Nitrogen Fixation and Nonfixation Conditions

    Contreras-Abara, Pablo / Castillo, Tania / Ponce, Belén / Urtuvia, Viviana / Peña, Carlos / Díaz-Barrera, Alvaro

    Fermentation. 2023 Apr. 28, v. 9, no. 5

    2023  

    Abstract: Alginate is a biomaterial produced by Azotobacter vinelandii, a diazotroph that, under nitrogen-fixing conditions, can fix nitrogen under high oxygen levels. In A. vinelandii, alginate is synthesized from fructose-6P via synthesis of precursor, ... ...

    Abstract Alginate is a biomaterial produced by Azotobacter vinelandii, a diazotroph that, under nitrogen-fixing conditions, can fix nitrogen under high oxygen levels. In A. vinelandii, alginate is synthesized from fructose-6P via synthesis of precursor, polymerization, and modification/exportation. Due to its viscosifying, gelling, and thickening characteristics, alginate is widely used in food, pharmaceutical, and cosmetical industries. This study aimed to develop a continuous bioprocess and a comparative analysis of alginate production under diazotrophic and nondiazotrophic conditions. Continuous cultures were developed at three dilution rates (0.06, 0.08 and 0.10 h⁻¹). In steady state, the respiratory activity, alginate production, alginate molecular weight and the genes encoding alginate polymerase were determined. Under the conditions studied, the specific oxygen uptake rate and respiratory quotient were similar. The diazotrophic conditions improved the conversion of sucrose to alginate and the specific productivity rate, which was 0.24 ± 0.03 g g⁻¹ h⁻¹. A higher alginate molecular weight (725 ± 20 kDa) was also achieved under diazotrophic conditions, which can be explained by an increase in the gene expression of genes alg8 and alg44 (encoding polymerase). The results of this work show the feasibility of enhancing alginate production (yields and specific productivity rates) and quality (molecular weight) under nitrogen-fixing conditions, opening the possibility of developing a continuous bioprocess to produce alginate with specific characteristics under conditions of diazotrophy.
    Keywords Azotobacter vinelandii ; alginates ; biocompatible materials ; bioprocessing ; fermentation ; gene expression ; molecular weight ; nitrogen ; nitrogen fixation ; nitrogen-fixing bacteria ; oxygen ; polymerization ; respiratory quotient ; sucrose
    Language English
    Dates of publication 2023-0428
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2813985-9
    ISSN 2311-5637
    ISSN 2311-5637
    DOI 10.3390/fermentation9050426
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: Liquid Systems Based on Tetra(n-butyl)phosphonium Acetate for the Non-dissolving Pretreatment of a Microcrystalline Cellulose (Avicel PH-101)

    Pena, Carlos A. / Puga, Alberto V. / Metlen, Andreas / Soto, Ana / Rodríguez, Héctor

    Biomacromolecules. 2022 Apr. 26, v. 23, no. 5

    2022  

    Abstract: A non-dissolving pretreatment consisting in the direct contact of cellulose and the ionic liquid tetra(n-butyl)phosphonium acetate, or its fluid mixtures with other phosphonium ionic liquids or with molecular liquids such as ethanol or DMSO, causes a ... ...

    Abstract A non-dissolving pretreatment consisting in the direct contact of cellulose and the ionic liquid tetra(n-butyl)phosphonium acetate, or its fluid mixtures with other phosphonium ionic liquids or with molecular liquids such as ethanol or DMSO, causes a reduction in the crystallinity of the popular microcrystalline cellulose-type Avicel PH-101 under mild conditions. At the same time, the degree of polymerization and the thermal stability of the pretreated Avicel remain essentially unaltered with respect to the untreated Avicel. The diminution of the crystallinity has been related to the increase of the reactivity of the pretreated Avicel samples via analysis of the kinetics of their enzymatic hydrolysis. For selected samples, this improved reactivity has been confirmed through their effective carboxymethylation under a simplified and milder reaction procedure.
    Keywords acetates ; cellulose ; crystal structure ; direct contact ; enzymatic hydrolysis ; ethanol ; ionic liquids ; liquids ; polymerization ; thermal stability
    Language English
    Dates of publication 2022-0426
    Size p. 1970-1980.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1526-4602
    DOI 10.1021/acs.biomac.1c01683
    Database NAL-Catalogue (AGRICOLA)

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