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  1. Article ; Online: Corrigendum: A TNFR2-specific TNF fusion protein with improved

    Gamboa Vargas, Juan / Wagner, Jennifer / Shaikh, Haroon / Lang, Isabell / Medler, Juliane / Anany, Mohamed / Steinfatt, Tim / Peña Mosca, Josefina / Haack, Stephanie / Dahlhoff, Julia / Büttner-Herold, Maike / Graf, Carolin / Viera, Estibaliz Arellano / Einsele, Hermann / Wajant, Harald / Beilhack, Andreas

    Frontiers in immunology

    2023  Volume 14, Page(s) 1352525

    Abstract: This corrects the article DOI: 10.3389/fimmu.2022.888274.]. ...

    Abstract [This corrects the article DOI: 10.3389/fimmu.2022.888274.].
    Language English
    Publishing date 2023-12-18
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1352525
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Brain-to-gut trafficking of alpha-synuclein by CD11c

    McFleder, Rhonda L / Makhotkina, Anastasiia / Groh, Janos / Keber, Ursula / Imdahl, Fabian / Peña Mosca, Josefina / Peteranderl, Alina / Wu, Jingjing / Tabuchi, Sawako / Hoffmann, Jan / Karl, Ann-Kathrin / Pagenstecher, Axel / Vogel, Jörg / Beilhack, Andreas / Koprich, James B / Brotchie, Jonathan M / Saliba, Antoine-Emmanuel / Volkmann, Jens / Ip, Chi Wang

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 7529

    Abstract: Inflammation in the brain and gut is a critical component of several neurological diseases, such as Parkinson's disease (PD). One trigger of the immune system in PD is aggregation of the pre-synaptic protein, α-synuclein (αSyn). Understanding the ... ...

    Abstract Inflammation in the brain and gut is a critical component of several neurological diseases, such as Parkinson's disease (PD). One trigger of the immune system in PD is aggregation of the pre-synaptic protein, α-synuclein (αSyn). Understanding the mechanism of propagation of αSyn aggregates is essential to developing disease-modifying therapeutics. Using a brain-first mouse model of PD, we demonstrate αSyn trafficking from the brain to the ileum of male mice. Immunohistochemistry revealed that the ileal αSyn aggregations are contained within CD11c
    MeSH term(s) Male ; Animals ; Mice ; alpha-Synuclein/genetics ; Parkinson Disease/genetics ; Brain ; Disease Models, Animal ; Ileum
    Chemical Substances alpha-Synuclein
    Language English
    Publishing date 2023-11-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-43224-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Fibroblastic reticular cells mitigate acute graft-versus-host disease via MHCII-dependent maintenance of regulatory T cells.

    Shaikh, Haroon / Pezoldt, Joern / Mokhtari, Zeinab / Gamboa Vargas, Juan / Le, Duc-Dung / Peña Mosca, Josefina / Arellano-Viera, Estibaliz / Kern, Michael Ag / Graf, Caroline / Beyersdorf, Niklas / Lutz, Manfred B / Riedel, Angela / Büttner-Herold, Maike / Zernecke, Alma / Einsele, Hermann / Saliba, Antoine-Emmanuel / Ludewig, Burkhard / Huehn, Jochen / Beilhack, Andreas

    JCI insight

    2022  

    Abstract: Acute graft-versus-host disease (aGvHD) is a life-threatening complication of allogeneic hematopoietic cell transplantation (allo-HCT) inflicted by alloreactive T cells primed in secondary lymphoid organs (SLOs) and subsequent damage to aGvHD target ... ...

    Abstract Acute graft-versus-host disease (aGvHD) is a life-threatening complication of allogeneic hematopoietic cell transplantation (allo-HCT) inflicted by alloreactive T cells primed in secondary lymphoid organs (SLOs) and subsequent damage to aGvHD target tissues. In recent years, regulatory T cell (Treg) transfer and/or expansion has emerged as a promising therapy to modulate aGvHD. However, cellular niches essential for fostering Tregs to prevent aGvHD have not been explored, yet. Here, we tested whether and to what extent MHC class II (MHCII) expressed on Ccl19+ fibroblastic reticular cells (FRCs) shape the donor CD4+ T cell response during aGvHD. Animals lacking MHCII expression on Ccl19-Cre-expressing FRCs (MHCIIΔCcl19) showed aberrant CD4+ T cells activation in the effector phase resulting in exacerbated aGvHD that was associated with significantly reduced expansion of Foxp3+ Tregs and invariant natural killer T (iNKT) cells. Skewed Treg maintenance in MHCIIΔCcl19 mice resulted in loss of protection from aGvHD provided by adoptively transferred donor Tregs. In contrast, although FRCs upregulated co-stimulatory surface receptors, degraded and processed exogenous antigens after myeloablative irradiation, FRCs were dispensable to activate alloreactive CD4+ T cells in two mouse models of aGvHD. In sum, these data reveal an immunoprotective, MHCII-mediated function of FRC niches in secondary lymphoid organs (SLOs) after allo-HCT and highlights a hitherto unknown framework of cellular and molecular interactions that regulate CD4+ T cell alloimmunity.
    Language English
    Publishing date 2022-10-13
    Publishing country United States
    Document type Journal Article
    ISSN 2379-3708
    ISSN (online) 2379-3708
    DOI 10.1172/jci.insight.154250
    Database MEDical Literature Analysis and Retrieval System OnLINE

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