Article ; Online: Defining Pharmacological Targets by Analysis of Virus-Host Protein Interactions.
Advances in protein chemistry and structural biology
2017 Volume 111, Page(s) 223–242
Abstract: Viruses are obligate parasites that depend on cellular factors for replication. Pharmacological inhibition of essential viral proteins, mostly enzymes, is an effective therapeutic alternative in the absence of effective vaccines. However, this strategy ... ...
Abstract | Viruses are obligate parasites that depend on cellular factors for replication. Pharmacological inhibition of essential viral proteins, mostly enzymes, is an effective therapeutic alternative in the absence of effective vaccines. However, this strategy commonly encounters drug resistance mechanisms that allow these pathogens to evade control. Due to the dependency on host factors for viral replication, pharmacological disruption of the host-pathogen protein-protein interactions (PPIs) is an important therapeutic alternative to block viral replication. In this review we discuss salient aspects of PPIs implicated in viral replication and advances in the development of small molecules that inhibit viral replication through antagonism of these interactions. |
---|---|
MeSH term(s) | Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Host Microbial Interactions/drug effects ; Humans ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/pharmacology ; Viral Proteins/chemistry ; Viral Proteins/drug effects ; Viruses/chemistry ; Viruses/drug effects |
Chemical Substances | Antiviral Agents ; Small Molecule Libraries ; Viral Proteins |
Keywords | covid19 |
Language | English |
Publishing date | 2017-12-18 |
Publishing country | Netherlands |
Document type | Journal Article ; Review |
ISSN | 1876-1631 ; 1876-1623 |
ISSN (online) | 1876-1631 |
ISSN | 1876-1623 |
DOI | 10.1016/bs.apcsb.2017.11.001 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.