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  1. Article ; Online: Metabolism in type 2 immune responses.

    Kabat, Agnieszka M / Pearce, Erika L / Pearce, Edward J

    Immunity

    2023  Volume 56, Issue 4, Page(s) 723–741

    Abstract: The immune response is tailored to the environment in which it takes place. Immune cells sense and adapt to changes in their surroundings, and it is now appreciated that in addition to cytokines made by stromal and epithelial cells, metabolic cues ... ...

    Abstract The immune response is tailored to the environment in which it takes place. Immune cells sense and adapt to changes in their surroundings, and it is now appreciated that in addition to cytokines made by stromal and epithelial cells, metabolic cues provide key adaptation signals. Changes in immune cell activation states are linked to changes in cellular metabolism that support function. Furthermore, metabolites themselves can signal between as well as within cells. Here, we discuss recent progress in our understanding of how metabolic regulation relates to type 2 immunity firstly by considering specifics of metabolism within type 2 immune cells and secondly by stressing how type 2 immune cells are integrated more broadly into the metabolism of the organism as a whole.
    MeSH term(s) Immune System ; Cytokines/immunology ; Humans ; Animals ; Th2 Cells/immunology ; Macrophages/immunology ; Adaptation, Physiological ; Adipose Tissue/immunology
    Chemical Substances Cytokines
    Language English
    Publishing date 2023-04-12
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2023.03.007
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  2. Article ; Online: Sulfasalazine: a risk factor for severe COVID-19?

    Konig, Maximilian F / Grzes, Katarzyna M / Robinson, Philip C / Pearce, Edward J

    The Lancet. Rheumatology

    2022  Volume 4, Issue 6, Page(s) e388–e389

    Language English
    Publishing date 2022-03-15
    Publishing country England
    Document type Journal Article
    ISSN 2665-9913
    ISSN (online) 2665-9913
    DOI 10.1016/S2665-9913(22)00067-4
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  3. Article ; Online: Metabolic orchestration of the wound healing response.

    Eming, Sabine A / Murray, Peter J / Pearce, Edward J

    Cell metabolism

    2021  Volume 33, Issue 9, Page(s) 1726–1743

    Abstract: Wound healing requires cooperation between different cell types, among which macrophages play a central role. In particular, inflammatory macrophages are engaged in the initial response to wounding, and alternatively activated macrophages are essential ... ...

    Abstract Wound healing requires cooperation between different cell types, among which macrophages play a central role. In particular, inflammatory macrophages are engaged in the initial response to wounding, and alternatively activated macrophages are essential for wound closure and the resolution of tissue repair. The links between temporal activation-induced changes in the metabolism of such macrophages and the influence this has on their functional states, along with the realization that metabolites play both intrinsic and extrinsic roles in the cells that produce them, has focused attention on the metabolism of wound healing. Here, we discuss macrophage metabolism during distinct stages of normal healing and its related pathologic processes, such as during cancer and fibrosis. Further, we frame these insights in a broader context of the current understanding of macrophage metabolic reprogramming linked to cellular activation and function. Finally, we discuss parallels between the metabolism of macrophages and fibroblasts, the latter being a key stromal cell type in wound healing, and consider the importance of the metabolic interplay between different cell types in the wound microenvironment.
    MeSH term(s) Fibroblasts ; Fibrosis ; Humans ; Macrophages/metabolism ; Wound Healing
    Language English
    Publishing date 2021-08-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2021.07.017
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  4. Article ; Online: Disrupting metabolism to treat autoimmunity.

    Matsushita, Mai / Pearce, Edward J

    Science (New York, N.Y.)

    2018  Volume 360, Issue 6387, Page(s) 377–378

    MeSH term(s) Autoimmunity ; Humans
    Language English
    Publishing date 2018--27
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.aat4984
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  5. Article ; Online: Cell-intrinsic metabolic regulation of mononuclear phagocyte activation: Findings from the tip of the iceberg.

    van Teijlingen Bakker, Nikki / Pearce, Edward J

    Immunological reviews

    2020  Volume 295, Issue 1, Page(s) 54–67

    Abstract: We have only recently started to appreciate the extent to which immune cell activation involves significant changes in cellular metabolism. We are now beginning to understand how commitment to specific metabolic pathways influences aspects of cellular ... ...

    Abstract We have only recently started to appreciate the extent to which immune cell activation involves significant changes in cellular metabolism. We are now beginning to understand how commitment to specific metabolic pathways influences aspects of cellular biology that are the more usual focus of immunological studies, such as activation-induced changes in gene transcription, post-transcriptional regulation of transcription, post-translational modifications of proteins, cytokine secretion, etc. Here, we focus on metabolic reprogramming in mononuclear phagocytes downstream of stimulation with inflammatory signals (such as LPS and IFNγ) vs alternative activation signals (IL-4), with an emphasis on work on dendritic cells and macrophages from our laboratory, and related studies from others. We cover aspects of glycolysis and its branching pathways (glycogen synthesis, pentose phosphate, serine synthesis, hexose synthesis, and glycerol 3 phosphate shuttle), the tricarboxylic acid pathway, fatty acid synthesis and oxidation, and mitochondrial biology. Although our understanding of the metabolism of mononuclear phagocytes has progressed significantly over the last 10 years, major challenges remain, including understanding the effects of tissue residence on metabolic programming related to cellular activation, and the translatability of findings from mouse to human biology.
    MeSH term(s) Animals ; Energy Metabolism ; Humans ; Macrophage Activation/genetics ; Macrophage Activation/immunology ; Macrophages/cytology ; Macrophages/immunology ; Macrophages/metabolism ; Mononuclear Phagocyte System/cytology ; Mononuclear Phagocyte System/immunology ; Mononuclear Phagocyte System/metabolism ; Phagocytes/cytology ; Phagocytes/immunology ; Phagocytes/metabolism
    Language English
    Publishing date 2020-04-03
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 391796-4
    ISSN 1600-065X ; 0105-2896
    ISSN (online) 1600-065X
    ISSN 0105-2896
    DOI 10.1111/imr.12848
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  6. Article ; Online: Parasitology: Rejuvenation through stem cells.

    Pearce, Edward J

    Nature

    2013  Volume 494, Issue 7438, Page(s) 438–439

    MeSH term(s) Adult Stem Cells/cytology ; Animals ; Female ; Humans ; Male ; Parasites/cytology ; Pluripotent Stem Cells/cytology ; Schistosoma mansoni/cytology
    Language English
    Publishing date 2013-02-20
    Publishing country England
    Document type News ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/nature11953
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  7. Article ; Online: Cooperation of ILC2s and T

    Zaiss, Dietmar M W / Pearce, Edward J / Artis, David / McKenzie, Andrew N J / Klose, Christoph S N

    Nature reviews. Immunology

    2023  Volume 24, Issue 4, Page(s) 294–302

    Abstract: Type 2 immune responses form a critical defence against enteric worm infections. In recent years, mouse models have revealed shared and unique functions for group 2 innate lymphoid cells and T helper 2 cells in type 2 immune response to intestinal ... ...

    Abstract Type 2 immune responses form a critical defence against enteric worm infections. In recent years, mouse models have revealed shared and unique functions for group 2 innate lymphoid cells and T helper 2 cells in type 2 immune response to intestinal helminths. Both cell types use similar innate effector functions at the site of infection, whereas each population has distinct roles during different stages of infection. In this Perspective, we review the underlying mechanisms used by group 2 innate lymphoid cells and T helper 2 cells to cooperate with each other and suggest an overarching model of the interplay between these cell types over the course of a helminth infection.
    MeSH term(s) Animals ; Mice ; Humans ; Immunity, Innate ; Parasites/metabolism ; Lymphocytes ; Helminths/metabolism ; Helminthiasis ; Th2 Cells ; Cytokines
    Chemical Substances Cytokines
    Language English
    Publishing date 2023-10-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/s41577-023-00942-1
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  8. Article ; Online: MenTORing Immunity: mTOR Signaling in the Development and Function of Tissue-Resident Immune Cells.

    Jones, Russell G / Pearce, Edward J

    Immunity

    2017  Volume 46, Issue 5, Page(s) 730–742

    Abstract: Tissue-resident immune cells must balance survival in peripheral tissues with the capacity to respond rapidly upon infection or tissue damage, and in turn couple these responses with intrinsic metabolic control and conditions in the tissue ... ...

    Abstract Tissue-resident immune cells must balance survival in peripheral tissues with the capacity to respond rapidly upon infection or tissue damage, and in turn couple these responses with intrinsic metabolic control and conditions in the tissue microenvironment. The serine/threonine kinase mammalian/mechanistic target of rapamycin (mTOR) is a central integrator of extracellular and intracellular growth signals and cellular metabolism and plays important roles in both innate and adaptive immune responses. This review discusses the function of mTOR signaling in the differentiation and function of tissue-resident immune cells, with focus on the role of mTOR as a metabolic sensor and its impact on metabolic regulation in innate and adaptive immune cells. We also discuss the impact of metabolic constraints in tissues on immune homeostasis and disease, and how manipulating mTOR activity with drugs such as rapamycin can modulate immunity in these contexts.
    MeSH term(s) Adaptive Immunity ; Animals ; Energy Metabolism ; Humans ; Immune System/cytology ; Immune System/immunology ; Immune System/metabolism ; Immunity ; Immunity, Innate ; Organ Specificity/immunology ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism
    Chemical Substances TOR Serine-Threonine Kinases (EC 2.7.1.1)
    Language English
    Publishing date 2017-05-23
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2017.04.028
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  9. Article ; Online: Immunometabolism in 2017: Driving immunity: all roads lead to metabolism.

    Pearce, Edward J / Pearce, Erika L

    Nature reviews. Immunology

    2017  Volume 18, Issue 2, Page(s) 81–82

    MeSH term(s) Animals ; Glycolysis/immunology ; Host Microbial Interactions/immunology ; Humans ; Immune System/metabolism ; Killer Cells, Natural/immunology ; Killer Cells, Natural/metabolism ; Microbiota/immunology ; Microglia/immunology ; Microglia/metabolism ; Models, Immunological ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism
    Language English
    Publishing date 2017-12-11
    Publishing country England
    Document type Introductory Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/nri.2017.139
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  10. Article ; Online: Inflammation by way of macrophage metabolism.

    Kabat, Agnieszka M / Pearce, Edward J

    Science (New York, N.Y.)

    2017  Volume 356, Issue 6337, Page(s) 488–489

    MeSH term(s) Humans ; Inflammation ; Macrophage Activation ; Macrophages
    Language English
    Publishing date 2017--05
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.aan2691
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