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  1. Article ; Online: Robert D. Sanders, B.Sc., M.B.B.S., Ph.D., F.R.C.A., Recipient of the 2020 James E. Cottrell, M.D., Presidential Scholar Award.

    Pearce, Robert A / Maze, Mervyn

    Anesthesiology

    2020  Volume 133, Issue 4, Page(s) 720–723

    MeSH term(s) Anesthesiology/history ; Awards and Prizes ; History, 20th Century ; History, 21st Century ; Humans ; Medical Laboratory Personnel/history ; Societies, Medical/history
    Language English
    Publishing date 2020-10-06
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 269-0
    ISSN 1528-1175 ; 0003-3022
    ISSN (online) 1528-1175
    ISSN 0003-3022
    DOI 10.1097/ALN.0000000000003512
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  2. Article ; Online: Changes in Memory, Sedation, and Receptor Kinetics Imparted by the β2-N265M and β3-N265M GABA

    Abdulzahir, Alifayaz / Klein, Steven / Lor, Chong / Perkins, Mark G / Frelka, Alyssa / Pearce, Robert A

    International journal of molecular sciences

    2023  Volume 24, Issue 6

    Abstract: Point mutations in the β2 (N265S) and β3 (N265M) subunits of γ-amino butyric acid type A receptors ( ... ...

    Abstract Point mutations in the β2 (N265S) and β3 (N265M) subunits of γ-amino butyric acid type A receptors (GABA
    MeSH term(s) Mice ; Animals ; Etomidate/pharmacology ; Point Mutation ; Receptors, GABA-A/genetics ; Propofol/pharmacology ; gamma-Aminobutyric Acid/genetics
    Chemical Substances Etomidate (Z22628B598) ; Receptors, GABA-A ; Propofol (YI7VU623SF) ; gamma-Aminobutyric Acid (56-12-2)
    Language English
    Publishing date 2023-03-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24065637
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  3. Article ; Online: Plasma HMGB1 levels in postoperative delirium.

    Kunkel, David / Parker, Margaret / Pearce, Robert A / Sanders, Robert D / Lennertz, Richard C

    British journal of anaesthesia

    2023  Volume 130, Issue 5, Page(s) e449–e451

    MeSH term(s) Humans ; Emergence Delirium ; HMGB1 Protein ; Cognition Disorders ; Cognitive Dysfunction ; Postoperative Complications
    Chemical Substances HMGB1 Protein
    Language English
    Publishing date 2023-02-28
    Publishing country England
    Document type Letter
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2023.02.002
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  4. Article ; Online: Isoflurane Potentiation of GABA

    Lor, Chong / Perouansky, Misha / Pearce, Robert A

    International journal of molecular sciences

    2020  Volume 21, Issue 24

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Anesthetics, Inhalation/pharmacology ; Animals ; Etomidate/pharmacology ; HEK293 Cells ; Humans ; Isoflurane/pharmacology ; Mice, Transgenic ; Patch-Clamp Techniques ; Point Mutation ; Propofol/pharmacology ; Receptors, GABA-A/genetics ; Receptors, GABA-A/metabolism ; Receptors, GABA-A/physiology ; Recombinant Proteins ; gamma-Aminobutyric Acid/pharmacology
    Chemical Substances Anesthetics, Inhalation ; Receptors, GABA-A ; Recombinant Proteins ; gamma-Aminobutyric Acid (56-12-2) ; Isoflurane (CYS9AKD70P) ; Propofol (YI7VU623SF) ; Etomidate (Z22628B598)
    Language English
    Publishing date 2020-12-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21249534
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  5. Article ; Online: Delirium and Cortical Complexity: Divergent Changes in Alpha and Theta Bands.

    Tanabe, Sean / Parker, Maggie / Lennertz, Richard / Pearce, Robert A / Banks, Matthew I / Sanders, Robert D

    The journals of gerontology. Series A, Biological sciences and medical sciences

    2022  Volume 77, Issue 11, Page(s) 2221–2222

    MeSH term(s) Humans ; Electroencephalography ; Brain Mapping ; Delirium/etiology
    Language English
    Publishing date 2022-08-06
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1223643-3
    ISSN 1758-535X ; 1079-5006
    ISSN (online) 1758-535X
    ISSN 1079-5006
    DOI 10.1093/gerona/glac165
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  6. Article ; Online: Dose-dependent suppression of hippocampal contextual memory formation, place cells, and spatial engrams by the NMDAR antagonist (R)-CPP.

    Zhu, Mengwen / Perkins, Mark G / Lennertz, Richard / Abdulzahir, Alifayaz / Pearce, Robert A

    Neuropharmacology

    2022  Volume 218, Page(s) 109215

    Abstract: We recently reported that the competitive NMDAR antagonist (R,S)-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP) does not suppress NMDAR-mediated field EPSPs ( ... ...

    Abstract We recently reported that the competitive NMDAR antagonist (R,S)-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP) does not suppress NMDAR-mediated field EPSPs (fEPSP
    MeSH term(s) Animals ; Mice ; Hippocampus ; Memory ; N-Methylaspartate/pharmacology ; Place Cells/metabolism ; Receptors, N-Methyl-D-Aspartate/metabolism
    Chemical Substances N-Methylaspartate (6384-92-5) ; Receptors, N-Methyl-D-Aspartate
    Language English
    Publishing date 2022-08-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 218272-5
    ISSN 1873-7064 ; 0028-3908
    ISSN (online) 1873-7064
    ISSN 0028-3908
    DOI 10.1016/j.neuropharm.2022.109215
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  7. Article ; Online: Delirium is associated with loss of feedback cortical connectivity.

    Gjini, Klevest / Casey, Cameron / Kunkel, David / Her, Maihlee / Banks, Matthew I / Pearce, Robert A / Lennertz, Richard / Sanders, Robert D

    Alzheimer's & dementia : the journal of the Alzheimer's Association

    2023  Volume 20, Issue 1, Page(s) 511–524

    Abstract: Introduction: Post-operative delirium (POD) is associated with increased morbidity and mortality but is bereft of treatments, largely due to our limited understanding of the underlying pathophysiology. We hypothesized that delirium reflects a ... ...

    Abstract Introduction: Post-operative delirium (POD) is associated with increased morbidity and mortality but is bereft of treatments, largely due to our limited understanding of the underlying pathophysiology. We hypothesized that delirium reflects a disturbance in cortical connectivity that leads to altered predictions of the sensory environment.
    Methods: High-density electroencephalogram recordings during an oddball auditory roving paradigm were collected from 131 patients. Dynamic causal modeling (DCM) analysis facilitated inference about the neuronal connectivity and inhibition-excitation dynamics underlying auditory-evoked responses.
    Results: Mismatch negativity amplitudes were smaller in patients with POD. DCM showed that delirium was associated with decreased left-sided superior temporal gyrus (l-STG) to auditory cortex feedback connectivity. Feedback connectivity also negatively correlated with delirium severity and systemic inflammation. Increased inhibition of l-STG, with consequent decreases in feed-forward and feed-back connectivity, occurred for oddball tones during delirium.
    Discussion: Delirium is associated with decreased feedback cortical connectivity, possibly resulting from increased intrinsic inhibitory tone.
    Highlights: Mismatch negativity amplitude was reduced in patients with delirium. Patients with postoperative delirium had increased feedforward connectivity before surgery. Feedback connectivity was diminished from left-side superior temporal gyrus to left primary auditory sensory area during delirium. Feedback connectivity inversely correlated with inflammation and delirium severity.
    MeSH term(s) Humans ; Feedback ; Evoked Potentials, Auditory/physiology ; Electroencephalography ; Inflammation ; Delirium ; Acoustic Stimulation/methods
    Language English
    Publishing date 2023-09-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2211627-8
    ISSN 1552-5279 ; 1552-5260
    ISSN (online) 1552-5279
    ISSN 1552-5260
    DOI 10.1002/alz.13471
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  8. Article ; Online: Wake Up, Neurons! Astrocytes Calling.

    Perouansky, Misha / MacIver, M Bruce / Pearce, Robert A

    Anesthesiology

    2019  Volume 130, Issue 3, Page(s) 361–363

    MeSH term(s) Animals ; Astrocytes/physiology ; Cells, Cultured ; Electron Transport Complex I/deficiency ; Electron Transport Complex I/genetics ; Humans ; Neurons/physiology
    Chemical Substances Ndufs4 protein, mouse ; Electron Transport Complex I (EC 7.1.1.2)
    Language English
    Publishing date 2019-02-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 269-0
    ISSN 1528-1175 ; 0003-3022
    ISSN (online) 1528-1175
    ISSN 0003-3022
    DOI 10.1097/ALN.0000000000002589
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  9. Article ; Online: Reduced Electroencephalogram Complexity in Postoperative Delirium.

    Tanabe, Sean / Parker, Maggie / Lennertz, Richard / Pearce, Robert A / Banks, Matthew I / Sanders, Robert D

    The journals of gerontology. Series A, Biological sciences and medical sciences

    2021  Volume 77, Issue 3, Page(s) 502–506

    Abstract: Delirium is associated with electroencephalogram (EEG) slowing and impairments in connectivity. We hypothesized that delirium would be accompanied by a reduction in the available cortical information (ie, there is less information processing occurring), ... ...

    Abstract Delirium is associated with electroencephalogram (EEG) slowing and impairments in connectivity. We hypothesized that delirium would be accompanied by a reduction in the available cortical information (ie, there is less information processing occurring), as measured by a surrogate, Lempil-Ziv Complexity (LZC), a measure of time-domain complexity. Two ongoing perioperative cohort studies (NCT03124303, NCT02926417) contributed EEG data from 91 patients before and after surgery; 89 participants were used in the analyses. After cleaning and filtering (0.1-50Hz), the perioperative change in LZC and LZC normalized (LZCn) to a phase-shuffled distribution were calculated. The primary outcome was the correlation of within-patient paired changes in delirium severity (Delirium Rating Scale-98 [DRS]) and LZC. Scalp-wide threshold-free cluster enhancement was employed for multiple comparison correction. LZC negatively correlated with DRS in a scalp-wide manner (peak channel r2 = .199, p < .001). This whole brain effect remained for LZCn, though the correlations were weaker (peak channel r2 = .076, p = .010). Delirium diagnosis was similarly associated with decreases in LZC (peak channel p < .001). For LZCn, the topological significance was constrained to the midline posterior regions (peak channel p = .006). We found a negative correlation of LZC in the posterior and temporal regions with monocyte chemoattractant protein-1 (peak channel r2 = .264, p < .001, n = 47) but not for LZCn. Complexity of the EEG signal fades proportionately to delirium severity implying reduced cortical information. Peripheral inflammation, as assessed by monocyte chemoattractant protein-1, does not entirely account for this effect, suggesting that additional pathogenic mechanisms are involved.
    MeSH term(s) Brain ; Chemokine CCL2 ; Clinical Studies as Topic ; Cohort Studies ; Delirium/diagnosis ; Delirium/etiology ; Electroencephalography ; Humans
    Chemical Substances Chemokine CCL2
    Language English
    Publishing date 2021-12-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1223643-3
    ISSN 1758-535X ; 1079-5006
    ISSN (online) 1758-535X
    ISSN 1079-5006
    DOI 10.1093/gerona/glab352
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  10. Article ; Online: Hippocampal β2-GABA

    Figueroa, Alexander G / Benkwitz, Claudia / Surges, Gabe / Kunz, Nicholas / Homanics, Gregg E / Pearce, Robert A

    Journal of neurophysiology

    2021  Volume 126, Issue 4, Page(s) 1090–1100

    Abstract: The general anesthetic etomidate, which acts through γ-aminobutyric acid type A ( ... ...

    Abstract The general anesthetic etomidate, which acts through γ-aminobutyric acid type A (GABA
    MeSH term(s) Anesthetics, Intravenous/pharmacology ; Animals ; Etomidate/pharmacology ; Hippocampus/drug effects ; Long-Term Potentiation/drug effects ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Neural Inhibition/drug effects ; Pyramidal Cells/drug effects ; Receptors, GABA-A/drug effects
    Chemical Substances Anesthetics, Intravenous ; Gabrb2 protein, mouse ; Gabrb3 protein, mouse ; Receptors, GABA-A ; Etomidate (Z22628B598)
    Language English
    Publishing date 2021-08-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80161-6
    ISSN 1522-1598 ; 0022-3077
    ISSN (online) 1522-1598
    ISSN 0022-3077
    DOI 10.1152/jn.00303.2021
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