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  1. AU="Pearson, Amelia"
  2. AU="Yang, Zhiqi"
  3. AU="Chen, John"
  4. AU="Yildirim, Sinan"
  5. AU="Percopo, Caroline"
  6. AU="Nevian, Thomas"
  7. AU="Matthias Arnold"
  8. AU="Abbonante, Francesco"
  9. AU=Cao Yongsen
  10. AU="Mei, Guoliang"
  11. AU="G.Kang, "
  12. AU="Djimdé, Abdoulaye"
  13. AU="Bone, Nathaniel"
  14. AU="Zhou, Yuewen"
  15. AU="Lynch, Stephen M"
  16. AU=Collins Jannette
  17. AU=Kim Soo-Kyoung
  18. AU=Atkinson Sarah H.
  19. AU=Ma Chunlong
  20. AU="Park, Youngjin"
  21. AU="Lakbita, Omar"
  22. AU=ElGokhy Sherin M
  23. AU="Stegmaier, Sabine"
  24. AU="Simons, Gemma N"
  25. AU="Domínguez-Zorita, Sonia"
  26. AU="Nakashima, Ayaka"
  27. AU="Skorecki, Karl"
  28. AU=Ibrahim Salwa
  29. AU=Geocadin Romergryko G
  30. AU="Leroy, J"
  31. AU="Wilson, Peter H"
  32. AU="Cunha, Carla Baroni"

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  1. Artikel ; Online: The Knowledge of Autism Questionnaire-UK: Development and Initial Psychometric Evaluation.

    Langhorne, Sophie / Uglik-Marucha, Nora / Broadhurst, Charlotte / Lieven, Elena / Pearson, Amelia / Vitoratou, Silia / Leadbitter, Kathy

    Journal of autism and developmental disorders

    2024  

    Abstract: Tools to measure autism knowledge are needed to assess levels of understanding within particular groups of people and to evaluate whether awareness-raising campaigns or interventions lead to improvements in understanding. Several such measures are in ... ...

    Abstract Tools to measure autism knowledge are needed to assess levels of understanding within particular groups of people and to evaluate whether awareness-raising campaigns or interventions lead to improvements in understanding. Several such measures are in circulation, but, to our knowledge, there are no psychometrically-validated questionnaires that assess contemporary autism knowledge suitable to the UK context. We aimed to produce a brief measure to assess between-respondent variability and within-respondent change over time. A pool of questionnaire items was developed and refined through a multi-stage iterative process involving autism experts and a lay sample. Attention was paid to face validity, clarity, consensus on correct responses, and appropriate difficulty levels. Initial validation data was obtained from a lay sample of 201 people. Difficulty and discrimination ability were assessed using item response theory and low-performing items were removed. Dimensionality was evaluated with exploratory factor analysis, which revealed a one-factor structure of the questionnaire. Further items were removed where they did not load strongly on their main factor. This process resulted in a final 14-item questionnaire called the Knowledge of Autism Questionnaire-UK. Internal consistency was satisfactory, and the final questionnaire was able to distinguish between parents of autistic people and those without an affiliation to autism. The KAQ-UK is a new, freely-available measure of autism knowledge that could be used to assess between-respondent variability and within-respondent change over time. Further evaluation and validation of its measurement properties are required.
    Sprache Englisch
    Erscheinungsdatum 2024-05-02
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 391999-7
    ISSN 1573-3432 ; 0162-3257
    ISSN (online) 1573-3432
    ISSN 0162-3257
    DOI 10.1007/s10803-024-06332-3
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 765: Hefte anzeigen Standort:
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  2. Artikel: Endometriosis in the Mouse: Challenges and Progress Toward a 'Best Fit' Murine Model.

    Burns, Katherine A / Pearson, Amelia M / Slack, Jessica L / Por, Elaine D / Scribner, Alicia N / Eti, Nazmin A / Burney, Richard O

    Frontiers in physiology

    2022  Band 12, Seite(n) 806574

    Abstract: Endometriosis is a prevalent gynecologic condition associated with pelvic pain and infertility characterized by the implantation and growth of endometrial tissue displaced into the pelvis via retrograde menstruation. The mouse is a molecularly well- ... ...

    Abstract Endometriosis is a prevalent gynecologic condition associated with pelvic pain and infertility characterized by the implantation and growth of endometrial tissue displaced into the pelvis via retrograde menstruation. The mouse is a molecularly well-annotated and cost-efficient species for modeling human disease in the therapeutic discovery pipeline. However, as a non-menstrual species with a closed tubo-ovarian junction, the mouse poses inherent challenges as a preclinical model for endometriosis research. Over the past three decades, numerous murine models of endometriosis have been described with varying degrees of fidelity in recapitulating the essential pathophysiologic features of the human disease. We conducted a search of the peer-reviewed literature to identify publications describing preclinical research using a murine model of endometriosis. Each model was reviewed according to a panel of ideal model parameters founded on the current understanding of endometriosis pathophysiology. Evaluated parameters included method of transplantation, cycle phase and type of tissue transplanted, recipient immune/ovarian status, iterative schedule of transplantation, and option for longitudinal lesion assessment. Though challenges remain, more recent models have incorporated innovative technical approaches such as
    Sprache Englisch
    Erscheinungsdatum 2022-01-13
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2021.806574
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  3. Artikel ; Online: Factor XII promotes the thromboinflammatory response in a rat model of venoarterial extracorporeal membrane oxygenation.

    Kharnaf, Mousa / Zafar, Farhan / Hogue, Spencer / Rosenfeldt, Leah / Cantrell, Rachel L / Sharma, Bal Krishan / Pearson, Amelia / Sprague, Cassandra / Leino, Daniel / Abplanalp, William A / Zelek, Wioleta M / McCrae, Keith R / Shim, Young Jun / Morales, David / Tweddell, James / Qualls, Joseph E / Palumbo, Joseph S

    The Journal of thoracic and cardiovascular surgery

    2023  

    Abstract: Background: Factor XII (FXII) is a multifunctional protease capable of activating thrombotic and inflammatory pathways. FXII has been linked to thrombosis in extracorporeal membrane oxygenation (ECMO), but the role of FXII in ECMO-induced inflammatory ... ...

    Abstract Background: Factor XII (FXII) is a multifunctional protease capable of activating thrombotic and inflammatory pathways. FXII has been linked to thrombosis in extracorporeal membrane oxygenation (ECMO), but the role of FXII in ECMO-induced inflammatory complications has not been studied. We used novel gene-targeted FXII- deficient rats to evaluate the role of FXII in ECMO-induced thromboinflammation.
    Methods: FXII-deficient (FXII
    Results: FXII
    Conclusions: FXII initiates hemostatic system activation and key inflammatory sequelae in ECMO, suggesting that therapies targeting FXII could limit both thromboembolism and inopportune inflammatory complications in this setting.
    Sprache Englisch
    Erscheinungsdatum 2023-09-07
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 3104-5
    ISSN 1097-685X ; 0022-5223
    ISSN (online) 1097-685X
    ISSN 0022-5223
    DOI 10.1016/j.jtcvs.2023.08.045
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Uk I Zs.104: Hefte anzeigen Standort:
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    ab Jg. 2022: Lesesaal (EG)

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    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

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