Article ; Online: Effect of genetic factors on the response to vitamin D
Nutrition (Burbank, Los Angeles County, Calif.)
2020 Volume 75-76, Page(s) 110761
Abstract: Objectives: Supplementation provides the best means of improving vitamin D status; however, individual responses vary partly owing to genetics. The aim of this study was to determine whether 28 single nucleotide polymorphisms (SNPs) in six key vitamin D ...
| Abstract | Objectives: Supplementation provides the best means of improving vitamin D status; however, individual responses vary partly owing to genetics. The aim of this study was to determine whether 28 single nucleotide polymorphisms (SNPs) in six key vitamin D pathway genes (GC, DHCR7, CYP2 R1, CYP24 A1, CYP27 B1, VDR) were associated with differences in response to supplementation. Methods: Participants (N = 313; n = 160 vitamin D, n = 153 placebo) were part of VIDARIS (Vitamin D and Acute Respiratory Infections Study), a double-blind, randomized controlled trial involving oral monthly supplementation of either vitamin D Results: SNPs within GC, CYP2 R1, and CYP27 B1 were associated with 25(OH)D concentrations following supplementation. However, only two GC gene SNPs (rs2282679, rs1155563) were significant after adjustment for multiple testing. This effect disappeared after more than 2 mo of supplementation. None of the SNPs were significantly associated with Gc-globulin concentrations; however, there was a significant interaction with one SNP in DHCR7 (rs12785878), which was associated with reduced free 25(OH)D concentrations in the supplemented arm. Conclusion: Only variants of GC were associated with 25(OH)D concentrations after supplementation. This effect was modest and disappeared after >2 mo of supplementation, suggesting it may be time/dose-dependent and saturable. |
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| MeSH term(s) | Cholecalciferol ; Dietary Supplements ; Double-Blind Method ; Humans ; Vitamin D ; Vitamin D Deficiency/drug therapy ; Vitamin D Deficiency/genetics ; Vitamin D-Binding Protein/genetics |
| Chemical Substances | Vitamin D-Binding Protein ; Vitamin D (1406-16-2) ; Cholecalciferol (1C6V77QF41) |
| Language | English |
| Publishing date | 2020-02-12 |
| Publishing country | United States |
| Document type | Journal Article ; Randomized Controlled Trial |
| ZDB-ID | 639259-3 |
| ISSN | 1873-1244 ; 0899-9007 |
| ISSN (online) | 1873-1244 |
| ISSN | 0899-9007 |
| DOI | 10.1016/j.nut.2020.110761 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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