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  1. Article ; Online: Lactate Dehydrogenase Inhibitors Suppress Borrelia burgdorferi Growth In Vitro

    Lynch, Adam / Pearson, Patrick / Savinov, Sergey N. / Li, Andrew Y. / Rich, Stephen M.

    Pathogens. 2023 July 22, v. 12, no. 7 p.962-

    2023  

    Abstract: Borrelia burgdorferi, the causative agent of Lyme disease, has a highly reduced genome and relies heavily on glycolysis for carbon metabolism. As such, established inhibitors of lactate dehydrogenase (LDH) were evaluated in cultures to determine the ... ...

    Abstract Borrelia burgdorferi, the causative agent of Lyme disease, has a highly reduced genome and relies heavily on glycolysis for carbon metabolism. As such, established inhibitors of lactate dehydrogenase (LDH) were evaluated in cultures to determine the extent of their impacts on B. burgdorferi growth. Both racemic and enantiopure (AT-101) gossypol, as well as oxamate, galloflavin, and stiripentol, caused the dose-dependent suppression of B. burgdorferi growth in vitro. Racemic gossypol and AT-101 were shown to fully inhibit spirochetal growth at concentrations of 70.5 and 187.5 μM, respectively. Differences between racemic gossypol and AT-101 efficacy may indicate that the dextrorotatory enantiomer of gossypol is a more effective inhibitor of B. burgdorferi growth than the levorotatory enantiomer. As a whole, LDH inhibition appears to be a promising mechanism for suppressing Borrelia growth, part
    Keywords Borrelia burgdorferi ; Lyme disease ; carbon metabolism ; dose response ; enantiomers ; etiological agents ; genome ; glycolysis ; gossypol ; lactate dehydrogenase
    Language English
    Dates of publication 2023-0722
    Publishing place MDPI AG
    Document type Article ; Online
    Note Resource is Open Access
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12070962
    Database NAL-Catalogue (AGRICOLA)

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  2. Article: A Computer Vision-Based Approach for Tick Identification Using Deep Learning Models.

    Luo, Chu-Yuan / Pearson, Patrick / Xu, Guang / Rich, Stephen M

    Insects

    2022  Volume 13, Issue 2

    Abstract: A wide range of pathogens, such as bacteria, viruses, and parasites can be transmitted by ticks and can cause diseases, such as Lyme disease, anaplasmosis, or Rocky Mountain spotted fever. Landscape and climate changes are driving the geographic range ... ...

    Abstract A wide range of pathogens, such as bacteria, viruses, and parasites can be transmitted by ticks and can cause diseases, such as Lyme disease, anaplasmosis, or Rocky Mountain spotted fever. Landscape and climate changes are driving the geographic range expansion of important tick species. The morphological identification of ticks is critical for the assessment of disease risk; however, this process is time-consuming, costly, and requires qualified taxonomic specialists. To address this issue, we constructed a tick identification tool that can differentiate the most encountered human-biting ticks,
    Language English
    Publishing date 2022-01-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662247-6
    ISSN 2075-4450
    ISSN 2075-4450
    DOI 10.3390/insects13020116
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Tick Densities and Infection Prevalence on Coastal Islands in Massachusetts, USA: Establishing a Baseline.

    Snow, Allison A / Pearson, Patrick / Xu, Guang / Allen, David N / Santamaria, Roberto / Rich, Stephen M

    Insects

    2023  Volume 14, Issue 7

    Abstract: Tick-borne diseases and a tick-induced red meat allergy have become increasingly common in the northeastern USA and elsewhere. At the scale of local communities, few studies have documented tick densities or infection levels to characterize current ... ...

    Abstract Tick-borne diseases and a tick-induced red meat allergy have become increasingly common in the northeastern USA and elsewhere. At the scale of local communities, few studies have documented tick densities or infection levels to characterize current conditions and provide a baseline for further monitoring. Using the town of Nantucket, MA, as a case study, we recorded tick densities by drag sampling along hiking trails in nature preserves on two islands. Nymphal blacklegged ticks (
    Language English
    Publishing date 2023-07-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662247-6
    ISSN 2075-4450
    ISSN 2075-4450
    DOI 10.3390/insects14070628
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Lactate Dehydrogenase Inhibitors Suppress

    Lynch, Adam / Pearson, Patrick / Savinov, Sergey N / Li, Andrew Y / Rich, Stephen M

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 7

    Abstract: ... Borrelia ... ...

    Abstract Borrelia burgdorferi
    Language English
    Publishing date 2023-07-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12070962
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Differential Resistance of

    Pearson, Patrick / Rich, Connor / Siegel, Eric L / Brisson, Dustin / Rich, Stephen M

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 10

    Abstract: Reservoir host associations have been observed among and ... ...

    Abstract Reservoir host associations have been observed among and within
    Language English
    Publishing date 2023-10-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12101238
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: White-Tailed Deer Serum Kills the Lyme Disease Spirochete,

    Pearson, Patrick / Rich, Connor / Feehan, Martin J R / Ditchkoff, Stephen S / Rich, Stephen M

    Vector borne and zoonotic diseases (Larchmont, N.Y.)

    2023  Volume 23, Issue 5, Page(s) 303–305

    Abstract: ... Borrelia ... ...

    Abstract Borrelia burgdorferi
    MeSH term(s) Animals ; Humans ; Borrelia burgdorferi ; Deer ; Ixodes ; Lyme Disease/veterinary ; Borrelia burgdorferi Group
    Language English
    Publishing date 2023-03-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2047199-3
    ISSN 1557-7759 ; 1530-3667
    ISSN (online) 1557-7759
    ISSN 1530-3667
    DOI 10.1089/vbz.2022.0095
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6137: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Tick Densities and Infection Prevalence on Coastal Islands in Massachusetts, USA: Establishing a Baseline

    Snow, Allison A. / Pearson, Patrick / Xu, Guang / Allen, David N. / Santamaria, Roberto / Rich, Stephen M.

    Insects. 2023 July 12, v. 14, no. 7

    2023  

    Abstract: Tick-borne diseases and a tick-induced red meat allergy have become increasingly common in the northeastern USA and elsewhere. At the scale of local communities, few studies have documented tick densities or infection levels to characterize current ... ...

    Abstract Tick-borne diseases and a tick-induced red meat allergy have become increasingly common in the northeastern USA and elsewhere. At the scale of local communities, few studies have documented tick densities or infection levels to characterize current conditions and provide a baseline for further monitoring. Using the town of Nantucket, MA, as a case study, we recorded tick densities by drag sampling along hiking trails in nature preserves on two islands. Nymphal blacklegged ticks (Ixodes scapularis Say) were most abundant at shadier sites and least common in grasslands and scrub oak thickets (Quercus ilicifolia). Lone star ticks (Amblyomma americanum L.) were common on Tuckernuck Island and rare on Nantucket Island, while both tick species were more numerous in 2021 compared to 2020 and 2022. We tested for pathogens in blacklegged nymphs at five sites over two years. In 2020 and 2021, infection levels among the four Nantucket Island sites averaged 10% vs. 19% for Borrelia burgdorferi, 11% vs. 15% for Babesia microti, and 17% (both years) for Anaplasma phagocytophilum, while corresponding levels were significantly greater on Tuckernuck in 2021. Our site-specific, quantitative approach represents a practical example of how potential exposure to tick-borne diseases can be monitored on a local scale.
    Keywords Amblyomma americanum ; Anaplasma phagocytophilum ; Babesia microti ; Borrelia burgdorferi ; Ixodes scapularis ; Quercus ilicifolia ; case studies ; hypersensitivity ; quantitative analysis ; red meat ; shrublands ; ticks ; Massachusetts
    Language English
    Dates of publication 2023-0712
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2662247-6
    ISSN 2075-4450
    ISSN 2075-4450
    DOI 10.3390/insects14070628
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: A Computer Vision-Based Approach for Tick Identification Using Deep Learning Models

    Luo, Chu-Yuan / Pearson, Patrick / Xu, Guang / Rich, Stephen M.

    Insects. 2022 Jan. 22, v. 13, no. 2

    2022  

    Abstract: A wide range of pathogens, such as bacteria, viruses, and parasites can be transmitted by ticks and can cause diseases, such as Lyme disease, anaplasmosis, or Rocky Mountain spotted fever. Landscape and climate changes are driving the geographic range ... ...

    Abstract A wide range of pathogens, such as bacteria, viruses, and parasites can be transmitted by ticks and can cause diseases, such as Lyme disease, anaplasmosis, or Rocky Mountain spotted fever. Landscape and climate changes are driving the geographic range expansion of important tick species. The morphological identification of ticks is critical for the assessment of disease risk; however, this process is time-consuming, costly, and requires qualified taxonomic specialists. To address this issue, we constructed a tick identification tool that can differentiate the most encountered human-biting ticks, Amblyomma americanum, Dermacentor variabilis, and Ixodes scapularis, by implementing artificial intelligence methods with deep learning algorithms. Many convolutional neural network (CNN) models (such as VGG, ResNet, or Inception) have been used for image recognition purposes but it is still a very limited application in the use of tick identification. Here, we describe the modified CNN-based models which were trained using a large-scale molecularly verified dataset to identify tick species. The best CNN model achieved a 99.5% accuracy on the test set. These results demonstrate that a computer vision system is a potential alternative tool to help in prescreening ticks for identification, an earlier diagnosis of disease risk, and, as such, could be a valuable resource for health professionals.
    Keywords Amblyomma americanum ; Dermacentor variabilis ; Ixodes scapularis ; Lyme disease ; anaplasmosis ; artificial intelligence ; climate ; computer vision ; data collection ; fever ; geographical distribution ; landscapes ; neural networks ; risk ; ticks
    Language English
    Dates of publication 2022-0122
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2662247-6
    ISSN 2075-4450
    ISSN 2075-4450
    DOI 10.3390/insects13020116
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Kruppel-family zinc finger proteins as emerging epigenetic biomarkers in head and neck squamous cell carcinoma.

    Pearson, Patrick / Smith, Kendra / Sood, Nilita / Chia, Elizabeth / Follett, Alicia / Prystowsky, Michael B / Kirby, Simon / Belbin, Thomas J

    Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale

    2023  Volume 52, Issue 1, Page(s) 41

    Abstract: Background: Krüppel-type zinc finger protein genes located on chromosome 19q13 are aberrantly hypermethylated with high frequency in all anatomic sub-sites of head and neck cancers as well as other epithelial tumours resulting in decreased expression.!## ...

    Abstract Background: Krüppel-type zinc finger protein genes located on chromosome 19q13 are aberrantly hypermethylated with high frequency in all anatomic sub-sites of head and neck cancers as well as other epithelial tumours resulting in decreased expression.
    Methods: We examined prognostic significance of ZNF154 and ZNF132 expression and DNA methylation in independent patient cohort of about 500 head and neck cancer patients in the Cancer Genome Atlas (TCGA). We also overexpressed these genes in HEK-293 cells, as well as the oral cancer cell line UM-SCC-1.
    Results: In 20 patients from the TCGA cohort of HNSCC patients where ZNF154 and ZNF132 DNA methylation and RNA expression could be compared in tumor and adjacent normal tissue, there was increased DNA methylation and decreased expression of both ZNF154 and ZNF132 in primary tumours. Low ZNF154 and low ZNF132 expression were associated with shorter overall survival in both head and neck squamous cell carcinoma (HNSCC) and lung adenocarcinoma (LUAC patients). While expression of these proteins in HEK-293 cells produced full-length protein, only truncated copies could be expressed in head and neck cancer cells (UM-SCC-1). The truncated version of ZNF154 protein increased doubling time and reduced cell migration in UM-SCC-1 cancer cells.
    Conclusions: Both ZNF132 and ZNF154 represent novel clinically significant biomarkers in head and neck cancer with potential tumour suppressive properties. Future studies will address the underlying molecular mechanisms by which ZNF154 expression in HNSCC contributes to the control of cell growth and migration.
    MeSH term(s) Humans ; Squamous Cell Carcinoma of Head and Neck/genetics ; HEK293 Cells ; Head and Neck Neoplasms/genetics ; Prognosis ; Biomarkers, Tumor/genetics ; Epigenesis, Genetic ; Zinc Fingers/genetics ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Kruppel-Like Transcription Factors/genetics
    Chemical Substances Biomarkers, Tumor ; ZNF154 protein, human ; Kruppel-Like Transcription Factors
    Language English
    Publishing date 2023-05-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2434004-2
    ISSN 1916-0216 ; 1916-0208 ; 0381-6605
    ISSN (online) 1916-0216
    ISSN 1916-0208 ; 0381-6605
    DOI 10.1186/s40463-023-00640-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1130: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Ixodes scapularis

    Siegel, Eric L / Xu, Guang / Li, Andrew Y / Pearson, Patrick / D'hers, Sebastián / Elman, Noel / Mather, Thomas N / Rich, Stephen M

    Insects

    2023  Volume 15, Issue 1

    Abstract: Ticks are vectors of many human and animal zoonotic disease-causing agents causing significant global health and economic strain. Repellents and acaricides are integral to the human capacity for personal protection from tick bites. Nootkatone, a ... ...

    Abstract Ticks are vectors of many human and animal zoonotic disease-causing agents causing significant global health and economic strain. Repellents and acaricides are integral to the human capacity for personal protection from tick bites. Nootkatone, a naturally occurring sesquiterpene found in the Alaskan cedar tree, grapefruit, and other sources, has been documented to be a potent acaricide. Research has also noted repellent effects against some tick species. In this study, our aim was to investigate the effect of synthetic, high-purity (+)-nootkatone on adult
    Language English
    Publishing date 2023-12-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662247-6
    ISSN 2075-4450
    ISSN 2075-4450
    DOI 10.3390/insects15010008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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