LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 14

Search options

  1. Article: The effects of cysteamine and AET Cl HCl on the induction of meiotic chromosome rearrangements in irradiated male mice.

    Savkovic, N / Pecevski, J

    Canadian journal of genetics and cytology. Journal canadien de genetique et de cytologie

    1974  Volume 16, Issue 1, Page(s) 85–89

    MeSH term(s) Animals ; Chromosome Aberrations ; Chromosomes/radiation effects ; Cysteamine/pharmacology ; DNA/radiation effects ; Male ; Meiosis ; Mice ; Mice, Inbred C3H ; Radiation Dosage ; Radiation Genetics ; Spermatozoa/cytology ; Testis/cytology ; beta-Aminoethyl Isothiourea/pharmacology
    Chemical Substances beta-Aminoethyl Isothiourea (151-16-6) ; Cysteamine (5UX2SD1KE2) ; DNA (9007-49-2)
    Language English
    Publishing date 1974-03
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 218119-8
    ISSN 0008-4093
    ISSN 0008-4093
    DOI 10.1139/g74-008
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1266: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: The frequency of chromosomal translocations among the offspring of locally irradiated rats.

    Savković, N / Pecevski, J

    Canadian journal of genetics and cytology. Journal canadien de genetique et de cytologie

    1971  Volume 13, Issue 2, Page(s) 283–286

    MeSH term(s) Animals ; Chromosome Aberrations ; Karyotyping ; Male ; Meiosis ; Radiation Genetics ; Rats ; Spermatozoa/cytology ; Spermatozoa/radiation effects ; Testis/radiation effects
    Language English
    Publishing date 1971-06
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 218119-8
    ISSN 0008-4093
    ISSN 0008-4093
    DOI 10.1139/g71-046
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1266: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: In vivo genotoxicity of nitrates and nitrites in germ cells of male mice. I. Evidence for gonadal exposure and lack of heritable effects.

    Alavantić, D / Sunjevarić, I / Pecevski, J / Bozin, D / Cerović, G

    Mutation research

    1988  Volume 204, Issue 4, Page(s) 689–695

    Abstract: Effects of nitrate (doses of 600 and 1200 mg/kg/day during 14 days) and sodium nitrite (60 and 120 mg/kg/day during 14 days) on germ cells of male mice were investigated. The mode of application was stomach intubation. The germ cell stages analysed were ... ...

    Abstract Effects of nitrate (doses of 600 and 1200 mg/kg/day during 14 days) and sodium nitrite (60 and 120 mg/kg/day during 14 days) on germ cells of male mice were investigated. The mode of application was stomach intubation. The germ cell stages analysed were spermatids (for the heritable effects) and differentiating and stem-cell spermatogonia (for direct effects). A lack of heritable translocations, sperm abnormalities, as well as morphological changes, such as changes in eyes, coat colour, testes and body weight, was demonstrated in F1 males originating from treated P males. Significant effects in treated males were found with respect to: (1) sex-chromosomal univalency in the diakinesis-methaphase I stage after the treatment of stem spermatogonia (both doses of sodium nitrate and the higher dose of sodium nitrite), (2) sperm-head abnormalities after treatment of differentiating spermatogonia (the higher dose of sodium nitrate and both doses of sodium nitrite), and (3) fertility after treatment of spermatids (the higher dose of sodium nitrite). Nonmutagenic effects and possible carcinogenic potential of the tested doses are discussed.
    MeSH term(s) Animals ; Fertility/drug effects ; In Vitro Techniques ; Litter Size ; Male ; Mice ; Mutation/drug effects ; Nitrates/toxicity ; Nitrites/toxicity ; Sex Ratio ; Sperm Head/drug effects ; Spermatocytes/drug effects ; Spermatogenesis/drug effects ; Spermatogonia/drug effects ; Spermatozoa/drug effects ; Translocation, Genetic
    Chemical Substances Nitrates ; Nitrites
    Language English
    Publishing date 1988-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 206607-5
    ISSN 1873-135X ; 0027-5107 ; 1383-5718 ; 0165-1110 ; 0165-1161 ; 0165-7992 ; 0921-8777 ; 0165-1218 ; 1383-5726 ; 0167-8817 ; 0921-8734 ; 1383-5742
    ISSN (online) 1873-135X
    ISSN 0027-5107 ; 1383-5718 ; 0165-1110 ; 0165-1161 ; 0165-7992 ; 0921-8777 ; 0165-1218 ; 1383-5726 ; 0167-8817 ; 0921-8734 ; 1383-5742
    DOI 10.1016/0165-1218(88)90074-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1316: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: In vivo genotoxicity of nitrates and nitrites in germ cells of male mice. II. Unscheduled DNA synthesis and sperm abnormality after treatment of spermatids.

    Alavantić, D / Sunjevarić, I / Cerović, G / Bozin, D / Pecevski, J

    Mutation research

    1988  Volume 204, Issue 4, Page(s) 697–701

    Abstract: Effects of both sodium nitrate (doses of 600 and 1200 mg/kg/day for 3 days) and sodium nitrite (doses of 60 and 120 mg/kg/day for 3 days) on spermatids of mice were investigated by measuring unscheduled DNA synthesis (UDS) 17 days after the end of ... ...

    Abstract Effects of both sodium nitrate (doses of 600 and 1200 mg/kg/day for 3 days) and sodium nitrite (doses of 60 and 120 mg/kg/day for 3 days) on spermatids of mice were investigated by measuring unscheduled DNA synthesis (UDS) 17 days after the end of treatment, and sperm-head abnormality 11 and 17 days after the end of treatment. Neither chemical induced the UDS response in early to mid spermatids (17 days). The only positive result in the sperm-head abnormality test was obtained for the dose of 120 mg/kg/day of sodium nitrite both at 11 and 17 days after treatment. The results presented are in accordance with those of our earlier experiments with the same chemicals, suggesting their nonmutagenic action on the tested germ-cell stages of male mice.
    MeSH term(s) Animals ; DNA/biosynthesis ; DNA Damage ; DNA Repair/drug effects ; In Vitro Techniques ; Male ; Mice ; Nitrates/toxicity ; Nitrites/toxicity ; Sperm Head/drug effects ; Sperm Head/ultrastructure ; Spermatids/drug effects
    Chemical Substances Nitrates ; Nitrites ; DNA (9007-49-2)
    Language English
    Publishing date 1988-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 206607-5
    ISSN 1873-135X ; 0027-5107 ; 1383-5718 ; 0165-1110 ; 0165-1161 ; 0165-7992 ; 0921-8777 ; 0165-1218 ; 1383-5726 ; 0167-8817 ; 0921-8734 ; 1383-5742
    ISSN (online) 1873-135X
    ISSN 0027-5107 ; 1383-5718 ; 0165-1110 ; 0165-1161 ; 0165-7992 ; 0921-8777 ; 0165-1218 ; 1383-5726 ; 0167-8817 ; 0921-8734 ; 1383-5742
    DOI 10.1016/0165-1218(88)90075-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1316: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: The effect of local irradiation of the gonads of infantile and adult male rats on the survival and regeneration of reproductive organs.

    Pecevski, J / Malcic, K

    Strahlentherapie

    1969  Volume 137, Issue 4, Page(s) 493–498

    MeSH term(s) Animals ; Male ; Radiation Genetics ; Rats ; Regeneration/radiation effects ; Spermatozoa/radiation effects ; Testis/pathology ; Testis/radiation effects ; Time Factors
    Language English
    Publishing date 1969-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 205169-2
    ISSN 0039-2073
    ISSN 0039-2073
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.40: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: Effect of oil of nutmeg on the fertility and induction of meiotic chromosome rearrangements in mice and their first generation.

    Pecevski, J / Savković, D / Radivojević, D / Vuksanović, L

    Toxicology letters

    1981  Volume 7, Issue 3, Page(s) 239–243

    Abstract: The dose-dependent effects of oil of nutmeg on the fertility and induction of chromosomal translocations in treated mice and their F1 males were examined. C3H male mice were treated with oil of nutmeg for 8 successive weeks at 60, 80, 100 and 400 mg/kg ... ...

    Abstract The dose-dependent effects of oil of nutmeg on the fertility and induction of chromosomal translocations in treated mice and their F1 males were examined. C3H male mice were treated with oil of nutmeg for 8 successive weeks at 60, 80, 100 and 400 mg/kg body weight. The greatest reduction of fertility occurred in the group treated with 400 mg/kg; chromosomal translocation in directly treated animals was not found. The chromosomal translocations in F1 males, derived from males treated with oil of nutmeg at dose levels of 60, 80 and 100 mg/kg.
    MeSH term(s) Animals ; Condiments/toxicity ; Female ; Fertility/drug effects ; Male ; Meiosis/drug effects ; Mice ; Mice, Inbred C3H ; Mutagens ; Pregnancy ; Translocation, Genetic/drug effects
    Chemical Substances Mutagens
    Language English
    Publishing date 1981-01
    Publishing country Netherlands
    Document type Comparative Study ; Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 433788-8
    ISSN 1879-3169 ; 0378-4274
    ISSN (online) 1879-3169
    ISSN 0378-4274
    DOI 10.1016/0378-4274(81)90075-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1367: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: The effect of X-irradiation on the fertility and on the induction of meiotic chromosome rearrangements in mice and their first generation.

    Savković, N / Pecevski, J / Marić, N / Radivojević, D

    Strahlentherapie

    1980  Volume 156, Issue 6, Page(s) 437–440

    Abstract: The effect of whole-body or local irradiation with X-rays at a dose of 600 R on the induction of chromosomal translocations in the diakinesis metaphase I of the meiosis in treated and F1 males has been examined along with their fertility. Our results ... ...

    Abstract The effect of whole-body or local irradiation with X-rays at a dose of 600 R on the induction of chromosomal translocations in the diakinesis metaphase I of the meiosis in treated and F1 males has been examined along with their fertility. Our results show the high percentage of mortality in whole-body irradiated mice. The percentage of the fertility was 25% in whole-body, and 93.7% in locally irradiated males. The testis weight was also reduced. The percentage of chromosomal translocations in diakinesis, metaphase I, or the meiosis was higher after whole-body irradiation than after local irradiation. In F1 males both types of irradiation induced chromosomal translocations.
    MeSH term(s) Animals ; Fertility/radiation effects ; Male ; Meiosis/radiation effects ; Metaphase ; Mice ; Organ Size ; Radiation Dosage ; Testis/pathology ; Translocation, Genetic
    Language English
    Publishing date 1980-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 205169-2
    ISSN 0039-2073
    ISSN 0039-2073
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.40: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: The effect of mitomycin on the fertility and the induction of meiotic chromosome rearrangements in mice and their first generation progeny.

    Savković, N / Green, S / Pecevski, J / Marić, N

    Canadian journal of genetics and cytology. Journal canadien de genetique et de cytologie

    1977  Volume 19, Issue 3, Page(s) 387–393

    Abstract: The dose dependent effects of chronic application of Mitomycin C(MC) on the induction of chromosomal translocations in treated animals and F1 males and on their fertility have been examined. The C3H strain mice used in the present experiments were ... ...

    Abstract The dose dependent effects of chronic application of Mitomycin C(MC) on the induction of chromosomal translocations in treated animals and F1 males and on their fertility have been examined. The C3H strain mice used in the present experiments were treated with MC during eight successive weeks in doses of 0.05 mg/kg and 0.1 mg/kg of body weight. 75 males were treated (25 males per dose and 25 males as controls). Immediately after the chronic treatment they were mated with normal females and were tested for their reproductive performance. The fertility of males was estimated from the number of pregnant females after one week of being together. After that all males were sacrificed and prepared for cytological analysis. No chromosomal translocations were found in diakinesis-metaphase I of meiosis. Data from the study of fertility showed that all treated males were fertile, but all females were not pregnant. The tests of all sterile, semisterile and fertile F1 males showed that F1 males could not be identified as heterozygous translocation carriers.
    MeSH term(s) Animals ; Chromosomes/drug effects ; Dose-Response Relationship, Drug ; Female ; Fertility/drug effects ; Male ; Meiosis ; Mice ; Mice, Inbred C3H ; Mitomycins/pharmacology ; Testis/cytology ; Translocation, Genetic
    Chemical Substances Mitomycins
    Language English
    Publishing date 1977-09
    Publishing country Canada
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 218119-8
    ISSN 0008-4093
    ISSN 0008-4093
    DOI 10.1139/g77-042
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1266: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: Meiotic chromosomal translocations in male induced by X-irradiation.

    Savković, N / Pecevski, J / Vuksanović, L / Radivojević, D / Alavantić, D

    Strahlentherapie

    1983  Volume 159, Issue 1, Page(s) 51–53

    Abstract: The dose-response curve for reciprocal translocations induced by acute exposure of spermatogonial stem cells to X-rays in treated mice and their F-1 sons was examined. Male mice were totally irradiated with doses of 1 Gy; 5 X 1 Gy and 5 Gy. The obtained ... ...

    Abstract The dose-response curve for reciprocal translocations induced by acute exposure of spermatogonial stem cells to X-rays in treated mice and their F-1 sons was examined. Male mice were totally irradiated with doses of 1 Gy; 5 X 1 Gy and 5 Gy. The obtained results show that frequency of the chromosomal translocations in directly treated animals is dose dependent. The percentage of animals irradiated with 1 Gy which had the chromosomal translocations was 60, while this percentage in animals irradiated with single and fractionated dose of 5 Gy was 100. The frequency of chromosomal translocations varies from 1.5% to 8.0%. Multivalent configurations in F-1 males were observed after exposure to 5 Gy only. The incidence of F-1 translocated males was 17.5%.
    MeSH term(s) Animals ; Male ; Meiosis/radiation effects ; Mice ; Mice, Inbred C3H ; Radiation Genetics ; Spermatogonia/radiation effects ; Spermatozoa/radiation effects ; Translocation, Genetic
    Language English
    Publishing date 1983-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 205169-2
    ISSN 0039-2073
    ISSN 0039-2073
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.40: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article: Effect of saccharin on the induction of chromosomal translocations in male mice and their F1 offspring.

    Pecevski, J / Vuksanović, L / Savković, N / Alavantić, D / Radivojević, D

    Toxicology letters

    1983  Volume 19, Issue 3, Page(s) 267–271

    Abstract: The dose-dependent effects of sodium saccharin on the fertility and the induction of chromosomal translocations in treated mice and their F1 males were examined. C3H X 101 mice were treated with saccharin for 2 successive weeks at doses of 200 and 500 mg/ ...

    Abstract The dose-dependent effects of sodium saccharin on the fertility and the induction of chromosomal translocations in treated mice and their F1 males were examined. C3H X 101 mice were treated with saccharin for 2 successive weeks at doses of 200 and 500 mg/kg of body wt. Data from the fertility study showed that saccharin did not induce any significant effect on fertility. Cytological analysis of meiotic cells showed no chromosomal rearrangements. Semisterility and sterility were noted in F1 males of saccharin-treated animals. In semi-sterile and sterile F1 males of saccharin-treated animals chromosomal translocations were not found.
    MeSH term(s) Animals ; Infertility, Male/chemically induced ; Infertility, Male/genetics ; Male ; Mice ; Mice, Inbred C3H ; Saccharin/genetics ; Saccharin/toxicity ; Spermatogenesis/drug effects ; Translocation, Genetic/drug effects
    Chemical Substances Saccharin (FST467XS7D)
    Language English
    Publishing date 1983-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 433788-8
    ISSN 1879-3169 ; 0378-4274
    ISSN (online) 1879-3169
    ISSN 0378-4274
    DOI 10.1016/0378-4274(83)90129-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1367: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top