Article ; Online: Functional activity of Th-17 lymphocytes in pulmonary tuberculosis.
Bulletin of experimental biology and medicine
2014 Volume 156, Issue 6, Page(s) 743–745
Abstract: Increased content of CD4(+)CD161(+)IL-17A(+) Th17 lymphocytes in the peripheral blood was found in patients with pulmonary tuberculosis irrespective of the clinical form (infiltrative, disseminated) and variant of the disease (drug-sensitive, drug- ... ...
Abstract | Increased content of CD4(+)CD161(+)IL-17A(+) Th17 lymphocytes in the peripheral blood was found in patients with pulmonary tuberculosis irrespective of the clinical form (infiltrative, disseminated) and variant of the disease (drug-sensitive, drug-resistant). The elevated content of Th17 cells in pulmonary tuberculosis is associated with hypersecretion of Th17-associated cytokines IL-17A and IL-22 in vitro that was most pronounced (in case of IL-17A) in patients with disseminated pulmonary tuberculosis. |
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MeSH term(s) | Adult ; CD4 Antigens/metabolism ; Cells, Cultured ; Female ; Humans ; Interleukin-17/metabolism ; Interleukins/metabolism ; Male ; Middle Aged ; Mycobacterium tuberculosis/immunology ; NK Cell Lectin-Like Receptor Subfamily B/metabolism ; Th17 Cells/immunology ; Tuberculosis, Pulmonary/immunology ; Young Adult ; Interleukin-22 |
Chemical Substances | CD4 Antigens ; IL17A protein, human ; Interleukin-17 ; Interleukins ; KLRB1 protein, human ; NK Cell Lectin-Like Receptor Subfamily B |
Language | English |
Publishing date | 2014-05-03 |
Publishing country | United States |
Document type | Journal Article |
ZDB-ID | 390407-6 |
ISSN | 1573-8221 ; 0007-4888 ; 0365-9615 |
ISSN (online) | 1573-8221 |
ISSN | 0007-4888 ; 0365-9615 |
DOI | 10.1007/s10517-014-2438-8 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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