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  1. Article ; Online: Automated analysis of intraoperative phase in laparoscopic cholecystectomy: A comparison of one attending surgeon and their residents.

    Humm, Gemma / Peckham-Cooper, Adam / Hamade, Ayman / Wood, Christopher / Dawas, Khaled / Stoyanov, Danail / Lovat, Laurence B

    Journal of surgical education

    2023  Volume 80, Issue 7, Page(s) 994–1004

    Abstract: Objective: This study compares the intraoperative phase times in laparoscopic cholecystectomy performed by an attending surgeon and supervised residents over 10-years to assess operative times as a marker of performance and any impact of case severity ... ...

    Abstract Objective: This study compares the intraoperative phase times in laparoscopic cholecystectomy performed by an attending surgeon and supervised residents over 10-years to assess operative times as a marker of performance and any impact of case severity on times.
    Design: Laparoscopic cholecystectomy videos were uploaded to Touch Surgery™ Enterprise, a combined software and hardware solution for securely recording, storing, and analysing surgical videos, which provide analytics of intraoperative phase times. Case severity and visualisation of the critical view of safety (CVS) were manually assessed using modified 10-point intraoperative gallbladder scoring system (mG10) and CVS scores, respectively. Attending and residents' times were compared unmatched and matched by mG10.
    Setting: Secondary analysis of anonymized laparoscopic cholecystectomy video, recorded as standard of care.
    Participants: Adult patients who underwent elective laparoscopic cholecystectomy a single UK hospital. Cases were performed by one attending and their residents.
    Results: 159 (attending=96, resident=63) laparoscopic cholecystectomy videos and intraoperative phase times were reviewed on Touch Surgery™ Enterprise and analyzed. Attending cases were more challenging (p=0.037). Residents achieved higher CVS scores (p=0.034) and showed longer dissection of hepatocystic triangle (HCT) times (p=0.012) in more challenging cases. Residents' total operative time (p=0.001) and dissection of HCT (p=0.002) times exceeded the attending's in low-severity matched cases (mG10=1). Residents' total operative times (p<0.001), port insertion/gallbladder exposure (p=0.032), and dissection of HCT (p<0.001) exceeded the attending's in matched cases (mG10=2). Residents' total operative (p<0.001), dissection of HCT (p<0.001), and gallbladder dissection (p=0.010) times exceeded the attendings in unmatched cases.
    Conclusions: Residents' total operative and dissection of HCT times significantly exceeded the attending's unmatched cases and low-severity matched cases which could suggest training need, however, also reflects an expected assessment of competence, and validates time as a marker of performance.
    MeSH term(s) Adult ; Humans ; Cholecystectomy, Laparoscopic/education ; Dissection ; Internship and Residency ; Surgeons
    Language English
    Publishing date 2023-05-09
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2277538-9
    ISSN 1878-7452 ; 1931-7204
    ISSN (online) 1878-7452
    ISSN 1931-7204
    DOI 10.1016/j.jsurg.2023.04.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Response to: Comment on 'Surgical experience and identification of errors in laparoscopic cholecystectomy'.

    Humm, Gemma L / Peckham-Cooper, Adam / Chang, Jessica / Fernandes, Roland / Fakih Gomez, Naim / Mohan, Helen / Nally, Deirdre / Thaventhiran, Anthony J / Zakeri, Roxanna / Gupte, Anaya / Crosbie, James / Wood, Christopher / Dawas, Khaled / Stoyanov, Danail / Lovat, Laurence B

    The British journal of surgery

    2024  Volume 111, Issue 2

    MeSH term(s) Humans ; Cholecystectomy, Laparoscopic ; Medical Errors
    Language English
    Publishing date 2024-01-23
    Publishing country England
    Document type Letter
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1093/bjs/znae027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Surgical experience and identification of errors in laparoscopic cholecystectomy.

    Humm, Gemma L / Peckham-Cooper, Adam / Chang, Jessica / Fernandes, Roland / Gomez, Naim Fakih / Mohan, Helen / Nally, Deirdre / Thaventhiran, Anthony J / Zakeri, Roxanna / Gupte, Anaya / Crosbie, James / Wood, Christopher / Dawas, Khaled / Stoyanov, Danail / Lovat, Laurence B

    The British journal of surgery

    2023  Volume 110, Issue 11, Page(s) 1535–1542

    Abstract: Background: Surgical errors are acts or omissions resulting in negative consequences and/or increased operating time. This study describes surgeon-reported errors in laparoscopic cholecystectomy.: Methods: Intraoperative videos were uploaded and ... ...

    Abstract Background: Surgical errors are acts or omissions resulting in negative consequences and/or increased operating time. This study describes surgeon-reported errors in laparoscopic cholecystectomy.
    Methods: Intraoperative videos were uploaded and annotated on Touch SurgeryTM Enterprise. Participants evaluated videos for severity using a 10-point intraoperative cholecystitis grading score, and errors using Observational Clinical Human Reliability Assessment, which includes skill, consequence, and mechanism classifications.
    Results: Nine videos were assessed by 8 participants (3 junior (specialist trainee (ST) 3-5), 2 senior trainees (ST6-8), and 3 consultants). Participants identified 550 errors. Positive relationships were seen between total operating time and error count (r2 = 0.284, P < 0.001), intraoperative grade score and error count (r2 = 0.578, P = 0.001), and intraoperative grade score and total operating time (r2 = 0.157, P < 0.001). Error counts differed significantly across intraoperative phases (H(6) = 47.06, P < 0.001), most frequently at dissection of the hepatocystic triangle (total 282; median 33.5 (i.q.r. 23.5-47.8, range 15-63)), ligation/division of cystic structures (total 124; median 13.5 (i.q.r. 12-19.3, range 10-26)), and gallbladder dissection (total 117; median 14.5 (i.q.r. 10.3-18.8, range 6-26)). There were no significant differences in error counts between juniors, seniors, and consultants (H(2) = 0.03, P = 0.987). Errors were classified differently. For dissection of the hepatocystic triangle, thermal injuries (50 in total) were frequently classified as executional, consequential errors; trainees classified thermal injuries as step done with excessive force, speed, depth, distance, time or rotation (29 out of 50), whereas consultants classified them as incorrect orientation (6 out of 50). For ligation/division of cystic structures, inappropriate clipping (60 errors in total), procedural errors were reported by junior trainees (6 out of 60), but not consultants. For gallbladder dissection, inappropriate dissection (20 errors in total) was reported in incorrect planes by consultants and seniors (6 out of 20), but not by juniors. Poor economy of movement (11 errors in total) was reported more by consultants (8 out of 11) than trainees (3 out of 11).
    Conclusion: This study suggests that surgical experience influences error interpretation, but the benefits for surgical training are currently unclear.
    MeSH term(s) Humans ; Cholecystectomy, Laparoscopic/methods ; Dissection ; Gallbladder ; Ligation ; Reproducibility of Results
    Language English
    Publishing date 2023-08-23
    Publishing country England
    Document type Journal Article ; Video-Audio Media
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1093/bjs/znad256
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Consensus recommendations on balancing educational opportunities and service provision in surgical training: Association of Surgeons in Training Delphi qualitative study.

    Pucher, Philip H / Peckham-Cooper, Adam / Fleming, Christina / Mohamed, Walid / Clements, Joshua Michael / Nally, Deirdre / Humm, Gemma / Mohan, Helen M

    International journal of surgery (London, England)

    2020  Volume 84, Page(s) 207–211

    Abstract: Background: Ensuring the highest quality of surgical training remains a challenge as demands on health service provision rise. This study aimed to explore the differences and potential conflicts between service provision and dedicated training activity ... ...

    Abstract Background: Ensuring the highest quality of surgical training remains a challenge as demands on health service provision rise. This study aimed to explore the differences and potential conflicts between service provision and dedicated training activity provided by surgical trainees, and recommend solutions.
    Methods: Participants were drawn from the Association of Surgeons in Training (ASiT) national council. Nominal Group Technique (NGT) was employed by members of the ASiT executive addressing 3 key domains (1) defining differences between training and service tasks, (2) impact of service-provision on training and (3) ways to improve training. A two-round Delphi process was conducted via electronic survey to ASiT council. Consensus was considered achieved for any statement where 80% or more of respondents indicated agreement.
    Results: 47 statements were generated through NGT which were put to the Delphi process. Consensus was reached on a total of 24/47 statements. Educational or training tasks were identified as being activities which progressed a trainee's skill set, could be tailored to a trainee's own ability, and involved acting as a trainer to more junior colleagues. The negative impact of excess service provision included training quality, trainee mental health, and surgical trainee recruitment. Potential measures to improve training included increasing hospital staffing and resources, protected training times, trainee-specific or competency-based learning and training or incentivising trainers.
    Conclusion: This trainee-based study provides several consensus recommendations on the characteristics that define surgical training and how a balance between service provision and training can potentially be achieved. Policy makers and health systems may be guided by these to ensure high quality training and a satisfied workforce.
    MeSH term(s) Clinical Competence/standards ; Consensus ; Delivery of Health Care/standards ; Delphi Technique ; Education, Medical, Graduate/standards ; Female ; Humans ; Male ; Qualitative Research ; Surgeons/education ; Surgeons/standards ; Surveys and Questionnaires
    Language English
    Publishing date 2020-04-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1016/j.ijsu.2020.03.071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Clinical results of linezolid in arthroplasty and trauma MRSA related infections.

    Joel, James / Graham, Simon Matthew / Peckham-Cooper, Adam / Korres, Nectarios / Tsouchnica, Helen / Tsiridis, Eleftherios

    World journal of orthopedics

    2014  Volume 5, Issue 2, Page(s) 151–157

    Abstract: Aim: To analyse the management of patients treated with linezolid for orthopaedic infections.: Methods: Twenty-two patients with orthopaedic related infections receiving a course of linezolid were reviewed retrospectively. Patients were classified ... ...

    Abstract Aim: To analyse the management of patients treated with linezolid for orthopaedic infections.
    Methods: Twenty-two patients with orthopaedic related infections receiving a course of linezolid were reviewed retrospectively. Patients were classified into either post trauma, post arthroplasty and non trauma related infections. A diagnosis of infection was based on clinical findings, positive microbiological specimens, and positive signs of infection on radiological imaging and raised inflammatory markers. Pathogens isolated, inflammatory markers both at presentation and at final follow up, length of linezolid treatment, adverse drug reactions, concomitant anti-microbial therapy, length of hospital stay and any surgical interventions were recorded.
    Results: Infections were classified as post arthroplasty (n = 10), post trauma surgery (n = 8) or non-trauma related infections (n = 4). Twenty patients (91%) underwent surgical intervention as part of their treatment. The number of required surgical procedures ranged from 1 to 6 (mean = 2.56). Mean total length of stay per admission was 28.5 d (range 1-160 d). Furthermore, the mean duration of treatment with linezolid of patients who had resolution of symptoms was 31 d (range 10-84 d). All patients within this group were discharged on oral linezolid. Pathogens isolated included methicillin resistant Staphylococcus aureus, coagulase negative staphylococci, coliforms, enterococcus, Staphylococcus epidermidis, streptococcus viridans, Escherichia coli, group B streptococcus and pseudomonas. An overall 77% of patients demonstrated resolution of infections at follow-up, with mean C-reactive protein reducing from 123 mg/L to 13.2 mg/L.
    Conclusion: This study demonstrates that the use of linezolid offers excellent efficacy in orthopaedic related infections when used alongside appropriate surgical management.
    Language English
    Publishing date 2014-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2649712-8
    ISSN 2218-5836
    ISSN 2218-5836
    DOI 10.5312/wjo.v5.i2.151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The non-medical workforce and its role in surgical training: Consensus recommendations by the Association of Surgeons in Training.

    Gokani, Vimal J / Peckham-Cooper, Adam / Bunting, David / Beamish, Andrew J / Williams, Adam / Harries, Rhiannon L

    International journal of surgery (London, England)

    2016  Volume 36 Suppl 1, Page(s) S14–S19

    Abstract: Changes in the delivery of the healthcare structure have led to the expansion of the non-medical workforce (NMW). The non-medical practitioner in surgery (a healthcare professional without a medical degree who undertakes specialist training) is a ... ...

    Abstract Changes in the delivery of the healthcare structure have led to the expansion of the non-medical workforce (NMW). The non-medical practitioner in surgery (a healthcare professional without a medical degree who undertakes specialist training) is a valuable addition to a surgical firm. However, there are a number of challenges regarding the successful widespread implementation of this role. This paper outlines a number of these concerns, and makes recommendations to aid the realisation of the non-medical practitioner as a normal part of the surgical team. In summary, the Association of Surgeons in Training welcomes the development of the non-medical workforce as part of the surgical team in order to promote enhanced patient care and improved surgical training opportunities. However, establishing a workforce of independent/semi-independent practitioners who compete for the same training opportunities as surgeons in training may threaten the UK surgical training system, and therefore the care of our future patients.
    MeSH term(s) Attitude of Health Personnel ; Charities ; Curriculum ; Humans ; Ireland ; Nurse Practitioners/education ; Physician-Nurse Relations ; Societies, Medical ; Specialties, Surgical/education ; United Kingdom
    Language English
    Publishing date 2016-11
    Publishing country England
    Document type Consensus Development Conference ; Editorial
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1016/j.ijsu.2016.09.090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Neoadjuvant Intravenous Oncolytic Vaccinia Virus Therapy Promotes Anticancer Immunity in Patients.

    Samson, Adel / West, Emma J / Carmichael, Jonathan / Scott, Karen J / Turnbull, Samantha / Kuszlewicz, Bethany / Dave, Rajiv V / Peckham-Cooper, Adam / Tidswell, Emma / Kingston, Jennifer / Johnpulle, Michelle / da Silva, Barbara / Jennings, Victoria A / Bendjama, Kaidre / Stojkowitz, Nicolas / Lusky, Monika / Prasad, K R / Toogood, Giles J / Auer, Rebecca /
    Bell, John / Twelves, Chris J / Harrington, Kevin J / Vile, Richard G / Pandha, Hardev / Errington-Mais, Fiona / Ralph, Christy / Newton, Darren J / Anthoney, Alan / Melcher, Alan A / Collinson, Fiona

    Cancer immunology research

    2022  Volume 10, Issue 6, Page(s) 745–756

    Abstract: Improving the chances of curing patients with cancer who have had surgery to remove metastatic sites of disease is a priority area for cancer research. Pexa-Vec (Pexastimogene Devacirepvec; JX-594, TG6006) is a principally immunotherapeutic oncolytic ... ...

    Abstract Improving the chances of curing patients with cancer who have had surgery to remove metastatic sites of disease is a priority area for cancer research. Pexa-Vec (Pexastimogene Devacirepvec; JX-594, TG6006) is a principally immunotherapeutic oncolytic virus that has reached late-phase clinical trials. We report the results of a single-center, nonrandomized biological end point study (trial registration: EudraCT number 2012-000704-15), which builds on the success of the presurgical intravenous delivery of oncolytic viruses to tumors. Nine patients with either colorectal cancer liver metastases or metastatic melanoma were treated with a single intravenous infusion of Pexa-Vec ahead of planned surgical resection of the metastases. Grade 3 and 4 Pexa-Vec-associated side effects were lymphopaenia and neutropaenia. Pexa-Vec was peripherally carried in plasma and was not associated with peripheral blood mononuclear cells. Upon surgical resection, Pexa-Vec was found in the majority of analyzed tumors. Pexa-Vec therapy associated with IFNα secretion, chemokine induction, and resulted in transient innate and long-lived adaptive anticancer immunity. In the 2 patients with significant and complete tumor necrosis, a reduction in the peripheral T-cell receptor diversity was observed at the time of surgery. These results support the development of presurgical oncolytic vaccinia virus-based therapies to stimulate anticancer immunity and increase the chances to cure patients with cancer.
    MeSH term(s) Humans ; Leukocytes, Mononuclear ; Liver Neoplasms/therapy ; Neoadjuvant Therapy ; Oncolytic Virotherapy/methods ; Oncolytic Viruses/genetics ; Vaccinia virus/genetics
    Language English
    Publishing date 2022-04-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2732489-8
    ISSN 2326-6074 ; 2326-6066
    ISSN (online) 2326-6074
    ISSN 2326-6066
    DOI 10.1158/2326-6066.CIR-21-0171
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Management of palpable but radiologically occult breast abnormalities.

    Sundara Rajan, Sreekumar / White, Jonathan / Peckham-Cooper, Adam / Lane, Sally / Lansdown, Mark

    Acta cytologica

    2012  Volume 56, Issue 3, Page(s) 266–270

    Abstract: Objective: To examine the utility of palpation-guided fine-needle aspiration cytology (pgFNAC) in the context of clinically palpable but radiologically occult breast abnormalities in this era of digital mammography and high sensitivity ultrasound.: ... ...

    Abstract Objective: To examine the utility of palpation-guided fine-needle aspiration cytology (pgFNAC) in the context of clinically palpable but radiologically occult breast abnormalities in this era of digital mammography and high sensitivity ultrasound.
    Methods: Women undergoing pgFNAC from January 2005 to December 2007 were identified from the histopathology database and correlated with clinical and radiological findings recorded prospectively in electronic patient records.
    Results: 142 cases matching our selection criteria were identified with a mean age of 43 (SD ±13.7) years; 83 patients had focal lumps and 59 had non-focal lumpiness. In the latter, pgFNAC showed C1 cytology in 45 (76.3%), C2 in 13 (22%) and C3 in 1 (1.7%) patient. In 83 patients with a focal discrete lump, pgFNAC revealed C1 cytology in 65 (78.3%), C2 in 14 (16.9%), and 2 patients each had C3 and C4 cytology. Core biopsy was undertaken in the latter 4 patients, invasive cancer was found in 1 patient each with C3 and C4 cytology and benign pathology in the rest. To date, none of the patients discharged has developed pre-malignant or malignant lesions in the ipsilateral breast.
    Conclusion: In patients presenting with clinically palpable but radiologically occult breast abnormality, pgFNAC can identify those who need further investigation or who can be safely discharged.
    MeSH term(s) Adult ; Biopsy, Fine-Needle ; Breast/pathology ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/pathology ; Breast Neoplasms/therapy ; Databases, Factual ; Female ; Humans ; Mammography/methods ; Middle Aged ; Neoplasm Invasiveness/diagnosis ; Neoplasm Invasiveness/diagnostic imaging ; Neoplasm Invasiveness/pathology ; Palpation ; Prospective Studies ; Retrospective Studies
    Language English
    Publishing date 2012
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 80003-x
    ISSN 1938-2650 ; 0001-5547
    ISSN (online) 1938-2650
    ISSN 0001-5547
    DOI 10.1159/000337435
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Chronic wound sepsis due to retained vacuum assisted closure foam.

    Beral, Daniel / Adair, Robert / Peckham-Cooper, Adam / Tolan, Damian / Botterill, Ian

    BMJ (Clinical research ed.)

    2009  Volume 338, Page(s) b2269

    MeSH term(s) Abdominal Wall ; Aged ; Chronic Disease ; Female ; Foreign Bodies ; Humans ; Negative-Pressure Wound Therapy/adverse effects ; Sepsis/etiology ; Surgical Wound Dehiscence/therapy ; Surgical Wound Infection/etiology ; Tomography, X-Ray Computed ; Vacuum
    Language English
    Publishing date 2009-06-24
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.b2269
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Management of Palpable but Radiologically Occult Breast Abnormalities

    Sundara Rajan, Sreekumar / White, Jonathan / Peckham-Cooper, Adam / Lane, Sally / Lansdown, Mark

    Acta Cytologica

    2012  Volume 56, Issue 3, Page(s) 266–270

    Abstract: Objective: To examine the utility of palpation-guided fine-needle aspiration cytology (pgFNAC) in the context of clinically palpable but radiologically occult breast abnormalities in this era of digital mammography and high sensitivity ultrasound. ... ...

    Institution Departments of Breast Surgery General Surgery and Histopathology, Leeds Teaching Hospitals National Health Service Trust, Leeds, UK
    Abstract Objective: To examine the utility of palpation-guided fine-needle aspiration cytology (pgFNAC) in the context of clinically palpable but radiologically occult breast abnormalities in this era of digital mammography and high sensitivity ultrasound. Methods: Women undergoing pgFNAC from January 2005 to December 2007 were identified from the histopathology database and correlated with clinical and radiological findings recorded prospectively in electronic patient records. Results: 142 cases matching our selection criteria were identified with a mean age of 43 (SD ±13.7) years; 83 patients had focal lumps and 59 had non-focal lumpiness. In the latter, pgFNAC showed C1 cytology in 45 (76.3%), C2 in 13 (22%) and C3 in 1 (1.7%) patient. In 83 patients with a focal discrete lump, pgFNAC revealed C1 cytology in 65 (78.3%), C2 in 14 (16.9%), and 2 patients each had C3 and C4 cytology. Core biopsy was undertaken in the latter 4 patients, invasive cancer was found in 1 patient each with C3 and C4 cytology and benign pathology in the rest. To date, none of the patients discharged has developed pre-malignant or malignant lesions in the ipsilateral breast. Conclusion: In patients presenting with clinically palpable but radiologically occult breast abnormality, pgFNAC can identify those who need further investigation or who can be safely discharged.
    Keywords Radiology ; Fine needle aspiration cytology ; Biopsy ; Breast neoplasms
    Language English
    Publishing date 2012-04-26
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Nongynecologic Cytopathology
    ZDB-ID 80003-x
    ISSN 1938-2650 ; 0001-5547
    ISSN (online) 1938-2650
    ISSN 0001-5547
    DOI 10.1159/000337435
    Database Karger publisher's database

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