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Article ; Online: Perioperative anaphylaxis and the principle of primum non nocere.

Pedersen, Karen / Green, Sarah

2024 Volume 132, Issue 6, Page(s) 1190–1193

Abstract: Perioperative anaphylaxis is a rare and unpredictable event that continues to cause patient harm. More work is needed to decrease the risk to patients through measures to limit sensitisation, optimise management and investigation, and ensure that ... ...

Abstract	Perioperative anaphylaxis is a rare and unpredictable event that continues to cause patient harm. More work is needed to decrease the risk to patients through measures to limit sensitisation, optimise management and investigation, and ensure that patients are not inadvertently re-exposed to allergens. Robust epidemiological data such as that provided by the consecutive GERAP surveys over the past 30 yr have been invaluable in defining the problem, identifying emerging allergens, acting as a catalyst for change, and stimulating research.
MeSH term(s)	Humans ; Anaphylaxis ; Perioperative Period ; Perioperative Care/methods ; Drug Hypersensitivity/diagnosis ; Intraoperative Complications/prevention & control
Language	English
Publishing date	2024-04-26
Publishing country	England
Document type	Journal Article ; Review ; Editorial
ZDB-ID	80074-0
ISSN	1471-6771 ; 0007-0912
ISSN (online)	1471-6771
ISSN	0007-0912
DOI	10.1016/j.bja.2024.03.024
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Article: Seed size and pubescence facilitate secondary dispersal by dung beetles

Pedersen, Karen M. / Blüthgen, Nico

Biotropica. 2022 Jan., v. 54, no. 1

2022

Abstract: In tropical forests, primary dispersal by animals is the most important form of seed dispersal. Dung beetles are secondary seed dispersers attracted to mammal feces. When they bury dung of frugivorous mammals, they move seeds to new sites, possibly ... ...

Abstract	In tropical forests, primary dispersal by animals is the most important form of seed dispersal. Dung beetles are secondary seed dispersers attracted to mammal feces. When they bury dung of frugivorous mammals, they move seeds to new sites, possibly protecting them from seed predation or pathogens, or moving to better micro‐climates and away from conspecifics. As a result, secondary dispersal by dung beetles potentially increases rates of seed survival and germination. Previous studies examined how dung beetles filter seeds by size. However, other seed traits have not been examined. We discovered that pubescent seeds covered with hairs on their surface hold a thin layer of dung and possibly “trick” the dung beetles into burying them like a dung ball. In a lowland tropical forest (Chocó Ecuador), we collected dung balls from dung beetles (Canthon angustatus, Oxysternon conspicillatum, Sulcophanaeus noctis, and Scybalocanthon trimaculatus), and fecal samples from brown‐headed spider monkeys (Ateles fusciceps fusciceps) and mantled howler monkey (Alouatta palliata). We characterized the traits of seed morphospecies found within samples and counted them. Our data show that larger size is coupled with a higher proportion of pubescence in seeds. The association between seed size and pubescence may extend beyond our study area supported by an analysis of the literature data for neotropical seeds at the genus level. Large pubescent seeds were more likely to be included in dung balls than smooth large seeds. Our results are consistent with the hypothesis that secondary dispersal by dung beetles exerts some selection pressure on the phenotype of endozoochorous seeds.
Keywords	Alouatta palliata ; Ateles ; Canthon ; Neotropics ; endozoochory ; feces ; frugivores ; germination ; mammals ; microclimate ; morphospecies ; phenotype ; seed predation ; seed size ; selection pressure ; spiders ; tropical forests ; Ecuador
Language	English
Dates of publication	2022-01
Size	p. 215-225.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	2052061-X
ISSN	1744-7429 ; 0006-3606
ISSN (online)	1744-7429
ISSN	0006-3606
DOI	10.1111/btp.13052
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Mammal dung-dung beetle trophic networks: an improved method based on gut-content DNA.

Pedersen, Karen M / von Beeren, Christoph / Oggioni, Arianna / Blüthgen, Nico

PeerJ

2024 Volume 12, Page(s) e16627

Abstract: Background: Dung beetles provide many important ecosystem services, including dung decomposition, pathogen control, soil aeration, and secondary seed dispersal. Yet, the biology of most dung beetles remains unknown. Natural diets are poorly studied, ... ...

Abstract	Background: Dung beetles provide many important ecosystem services, including dung decomposition, pathogen control, soil aeration, and secondary seed dispersal. Yet, the biology of most dung beetles remains unknown. Natural diets are poorly studied, partly because previous research has focused on choice or attraction experiments using few, easily accessible dung types from zoo animals, farm animals, or humans. This way, many links within natural food webs have certainly been missed. In this work, we aimed to establish a protocol to analyze the natural diets of dung beetles using DNA gut barcoding. Methods: First, the feasibility of gut-content DNA extraction and amplification of 12s rDNA from six different mammal dung types was tested in the laboratory. We then applied the method to beetles caught in pitfall traps in Ecuador and Germany by using 12s rDNA primers. For a subset of the dung beetles caught in the Ecuador sampling, we also used 16s rDNA primers to see if these would improve the number of species we could identify. We predicted the likelihood of amplifying DNA using gut fullness, DNA concentration, PCR primer, collection method, and beetle species as predictor variables in a dominance analysis. Based on the gut barcodes, we generated a dung beetle-mammal network for both field sites (Ecuador and Germany) and analyzed the levels of network specificity. Results: We successfully amplified mammal DNA from dung beetle gut contents for 128 specimens, which included such prominent species as Conclusion: We here present a reliable method of extracting and amplifying gut-content DNA from dung beetles. Identifying mammal dung
MeSH term(s)	Animals ; Coleoptera/genetics ; DNA, Ribosomal ; Ecosystem ; Feces ; Mammals
Chemical Substances	DNA, Ribosomal
Language	English
Publishing date	2024-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703241-3
ISSN	2167-8359 ; 2167-8359
ISSN (online)	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.16627
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Article: Australian and New Zealand Anaesthetic Allergy Group/Australian and New Zealand College of Anaesthetists perioperative anaphylaxis management guideline 2022.

Tran, Robyn / Pedersen, Karen / Kolawole, Helen / Roessler, Peter / Scolaro, Richard

Anaesthesia and intensive care

2024 Volume 52, Issue 3, Page(s) 147–158

Abstract: Perioperative anaphylaxis is a potentially life-threatening emergency that requires prompt recognition and institution of life-saving therapy. The Australian and New Zealand College of Anaesthetists and Australian and New Zealand Anaesthetic Allergy ... ...

Abstract	Perioperative anaphylaxis is a potentially life-threatening emergency that requires prompt recognition and institution of life-saving therapy. The Australian and New Zealand College of Anaesthetists and Australian and New Zealand Anaesthetic Allergy Group have partnered to develop the anaphylaxis management guideline along with crisis management cards that are recommended for use in suspected anaphylaxis in the perioperative setting. This is the third version of these guidelines with the second version having been published in 2016. This article contains the revised Australian and New Zealand Anaesthetic Allergy Group/Australian and New Zealand College of Anaesthetists perioperative anaphylaxis management guideline, with a brief review of the current evidence for the management of anaphylaxis in the perioperative environment.
MeSH term(s)	Anaphylaxis/therapy ; Humans ; New Zealand ; Australia ; Anesthetists ; Perioperative Care/methods
Language	English
Publishing date	2024-04-08
Publishing country	United States
Document type	Journal Article ; Practice Guideline
ZDB-ID	187524-3
ISSN	1448-0271 ; 0310-057X
ISSN (online)	1448-0271
ISSN	0310-057X
DOI	10.1177/0310057X231215823
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Article ; Online: Utvannet kjønnsbegrep?

Nylehn, Pernille / Brattgjerd, Marianne / Skotnes, Tina / Pedersen, Karen-Anna

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke

2023 Volume 143, Issue 5

Title translation	Is the concept of gender being diluted?.
Language	Norwegian
Publishing date	2023-03-27
Publishing country	Norway
Document type	Journal Article
ZDB-ID	603504-8
ISSN	0807-7096 ; 0029-2001
ISSN (online)	0807-7096
ISSN	0029-2001
DOI	10.4045/tidsskr.23.0174
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Article: Morphometric changes on dung beetle

Marín-Armijos, Diego / Chamba-Carrillo, Adolfo / Pedersen, Karen M

Ecology and evolution

2023 Volume 13, Issue 2, Page(s) e9831

Abstract: The conversion of forest into grassland can induce differentiation in the functional morphology of resilient species. To assess this effect, we have chosen a dung ... ...

Abstract	The conversion of forest into grassland can induce differentiation in the functional morphology of resilient species. To assess this effect, we have chosen a dung beetle
Language	English
Publishing date	2023-02-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2635675-2
ISSN	2045-7758
ISSN	2045-7758
DOI	10.1002/ece3.9831
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Book ; Online: Handbook of research on building, growing, and sustaining quality e-learning programs

Pedersen, Karen / Shelton, Kaye

2017

Abstract: This book highlights several significant elements of e-learning, including program planning, quality standards, and online course development, as well as institutional, student, and faculty support"--Provided by publisher ... Garnering faculty buy-in to ... ...

Institution	IGI Global
Author's details	Kaye Shelton and Karen Pedersen, editors
Abstract	"This book highlights several significant elements of e-learning, including program planning, quality standards, and online course development, as well as institutional, student, and faculty support"--Provided by publisher Garnering faculty buy-in to improve online program quality: implementation of the online learning consortium scorecard to encourage shared governance / Terry Pollard -- Exploring Chinese faculty perceptions of quality standards for online education / Dave Dai, John M. Dirkx -- Improving U.S. college graduation rates with quality online and blended degree completion programs: lessons learned / Lisa Braverman -- From 0 to 60: the case study of a school of education's successful "online start-up" / Raffaella Borasi, Eric Fredericksen, Dave Miller -- Moving e-learning forward: a study of the impact of the continual changing landscape of e-learning / Deb Gearhart -- A new model of online student service in the digital age: increasing retention based on service satisfaction / Sallie A. Reissman -- DELES analysis of e-learning environments: satisfaction guaranteed? / Hunter Keeney [and 3 others] -- The relationship between individual student attributes and online course completion / Wendy Mays Elmore [and 3 others] -- Exploration of faculty's perceptions on technology change: implications for faculty preparedness to teach online courses / Veronica Outlaw, Margaret L. Rice, Vivian H. Wright -- Arranging and rearranging practice in digital spaces: professional learning amongst teacher educators / Laurette S. M. Bristol, Merilyn Childs -- Ensuring quality: the faculty role in online higher education / Arthur Richardson Smith -- Ready-to-teach online courses: understanding faculty roles and attitudes / Pamela K. Quinn, Diane Mason, Kaye Shelton -- A framework to assess appropriate interaction to meet accreditation quality guidelines / Anymir Orellana -- Improving the quality of online learning environments: the value of an online specific design model / Komar Parveen Khan -- Building quality online courses: online course development partnership and model / Veronica Outlaw, Margaret L. Rice, Vivian H. Wright -- E-learning and the disciplines: lessons from applied linguistics / Mark Kellison Warford -- Designing blended learning strategies for rich content / Dionysios Politis, Miltiadis Tsalighopoulos, Georgios Kyriafinis
Keywords	Instructional systems/Design ; Web-based instruction/Design
Language	English
Size	1 Online-Ressource (PDFs (411 pages)), illustrations
Publisher	IGI Global
Publishing place	Hershey, Pennsylvania (701 E. Chocolate Avenue, Hershey, PA 17033, USA)
Document type	Book ; Online
Note	Includes bibliographical references and index ; Restricted to subscribers or individual electronic text purchasers
ISBN	1522508775 ; 9781522508779 ; 9781522508786 ; 1522508783
Database	ECONomics Information System

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Article ; Online: Long-term functional and structural outcomes in patients with primary congenital glaucoma-A Danish nationwide study.

Brynskov, Troels / Bach-Holm, Daniella / Kappelgaard, Per / Siersma, Volkert / Pedersen, Karen Bjerg / Kessel, Line

Acta ophthalmologica

2023 Volume 102, Issue 2, Page(s) 228–237

Abstract: Purpose: Evaluation of long-term functional and structural outcomes in patients with primary congenital glaucoma (PCG) based on visual acuity (VA), visual field (VF) using standard automated perimetry, and peripapillary retinal nerve fibre layer ... ...

Abstract	Purpose: Evaluation of long-term functional and structural outcomes in patients with primary congenital glaucoma (PCG) based on visual acuity (VA), visual field (VF) using standard automated perimetry, and peripapillary retinal nerve fibre layer thickness (pRNFL). Methods: We retrospectively reviewed medical records of all patients diagnosed with PCG in Denmark from 1977 to 2016. Severe vision loss was defined as VA <6/60 and/or VF >20 decibels (dB). Prognostic factors were evaluated in a correlation matrix. Results: The median age of the 94 patients (153 PCG eyes) was 12 years (IQR 9-16). In PCG eyes 62% had VA ≥6/18 but 22% had <6/60. VA in the better seeing eye was ≥6/18 in 90% and <6/60 in 5%. VF was measured in 59 PCG eyes and the median mean defect was 5.1 dB (IQR 2.1-9.6) with 52% better than 6 dB and 9% worse than 20 dB. Generalized pRNFL was reduced below the age-expected 1st percentile in 29% of the 58 PCG eyes where pRNFL was measured. Poor VA, poor VF and reduced pRNFL were all correlated (p = 0.0001). More surgeries (p < 0.0001) and longer diagnostic delay (p = 0.004) were associated with poorer vision and to a lesser degree with poor VF pRNFL. Conclusion: In Denmark, most patients with bilateral PCG retain VA ≥6/18 in the better seeing eye. Poor VA was associated with poor VF. Longer diagnostic delay and more surgeries were associated with a poorer prognosis.
MeSH term(s)	Humans ; Child ; Adolescent ; Retrospective Studies ; Delayed Diagnosis ; Retinal Ganglion Cells ; Visual Field Tests ; Hydrophthalmos ; Denmark/epidemiology ; Tomography, Optical Coherence ; Intraocular Pressure
Language	English
Publishing date	2023-10-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2408333-1
ISSN	1755-3768 ; 1755-375X
ISSN (online)	1755-3768
ISSN	1755-375X
DOI	10.1111/aos.15772
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Article ; Online: Changes in weight, body composition and metabolic parameters after switch to dolutegravir/lamivudine compared with continued treatment with dolutegravir/abacavir/lamivudine for virologically suppressed HIV infection (The AVERTAS trial): a randomised, open-label, superiority trial in Copenhagen, Denmark.

Pedersen, Karen Brorup Heje / Knudsen, Andreas / Møller, Søren / Siebner, Hartwig Roman / Hove, Jens Dahlgaard / Gerstoft, Jan / Benfield, Thomas

BMJ open

2023 Volume 13, Issue 8, Page(s) e075673

Abstract: Introduction: With longer life expectancy in people living with HIV (PLWH) on antiretroviral therapy, cardiovascular disease (CVD) has become a common cause of mortality among them. Abacavir has been associated with an increased risk of myocardial ... ...

Abstract	Introduction: With longer life expectancy in people living with HIV (PLWH) on antiretroviral therapy, cardiovascular disease (CVD) has become a common cause of mortality among them. Abacavir has been associated with an increased risk of myocardial infarction, but the mechanism is unknown. Additionally, abacavir may be obesogenic which could mediate an additional risk factor of CVD. We aim to investigate if discontinuation of abacavir will have a favourable impact on body weight and cardiac parameters in PLWH. Methods and analysis: Randomised, controlled, superiority trial of virologically suppressed PLWH on dolutegravir, abacavir and lamivudine (DTG/ABC/3TC) for ≥6 months. In total, 70 PLWH will be randomised 1:2 to either continue DTG/ABC/3TC or to switch to dolutegravir and lamivudine (DTG/3TC) providing the power of 80% at alpha 5% to detect a mean difference in weight change of 2 kg (Δ) given an SD of 2.7 kg. Follow-up will be 48 weeks. Data will be collected at baseline and week 48. Primary outcome will be change in mean body weight from baseline to week 24 and 48 evaluated in a linear mixed model. Secondary outcomes will be changes in cardiac, inflammatory and metabolic parameters, fat distribution, coagulation, endothelial, platelet function, quality of life and virological control from baseline to week 48. Measurements include CT of thorax and abdomen, external carotid artery ultrasound, liver elastography and dual energy X-ray absorptiometry and blood analysis. Plasma HIV RNA will be measured at baseline, week 4, 24 and 48. Forty participants (20 from each arm) will be included in a substudy involving cardiac MRI at baseline and week 48. Twenty non-HIV-infected controls will be included with a single scan to compare with baseline scan data. Ethics and dissemination: Result from this study will lead to a better understanding of the association between antiretroviral therapy and the impact on weight and risk of CVD. Findings will be useful for both clinicians and PLWH in the guidance of a more individualised HIV treatment. Results from the main study and the substudies will be submitted for publication in a peer-reviewed journal(s). The AVERTAS study is approved by the Ethics Committee of the Capital Region, Denmark (H-20011433), Danish Medicines Agency (EudraCT no. 2019-004999-19) and Regional Data Protection Centre (P-2020-207). Trial registration number: Pre-results registration at ClinicalTrials.gov Identifier: NCT04904406, registered 27 May 2021. Protocol version: Protocol version 9.0, 4 April 2023, approved 10-05-2023 by Ethics Committee of the Capital Region, Denmark (H-20011433). Danish Medicines Agency (EudraCT no. 2019-004999-19). Regional Data Protection Centre (P-2020-207) ClinicalTrials.gov.
MeSH term(s)	Humans ; Body Composition ; Body Weight ; Cardiovascular Diseases ; Denmark ; HIV Infections/drug therapy ; Lamivudine/therapeutic use ; Quality of Life
Chemical Substances	abacavir (WR2TIP26VS) ; dolutegravir (DKO1W9H7M1) ; Lamivudine (2T8Q726O95)
Language	English
Publishing date	2023-08-21
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-075673
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Article ; Online: The lived experiences of emotionally insecure nursing students: A qualitative study.

Vestphal, Tina Kirstine / Pedersen, Karen Steenvinkel / Pedersen, Birthe D

Nurse education in practice

2019 Volume 43, Page(s) 102694

Abstract: Research shows that students who feel emotionally insecure are at risk of dropping out of nursing educational program. It is, therefore, important to support student resilience in the international nursing education. The aim of this study was to ... ...

Abstract	Research shows that students who feel emotionally insecure are at risk of dropping out of nursing educational program. It is, therefore, important to support student resilience in the international nursing education. The aim of this study was to investigate the lived experiences of undergoing a nursing education as an emotionally insecure student. The method was conducted within a phenomenological-hermeneutic approach, inspired by the French philosopher Paul Ricoeur's theory of narrative and interpretation, which is conducted in a three-phased structure: Naïve reading, structural analysis and critical interpretation and discussion. Seven participants were included in the study. The findings show that feeling emotionally insecure can be linked to not feeling good enough and feeling misunderstood - yet, with hidden resources. Nurse educators must be aware that emotionally insecure students can easily feel shame, must be willing to help clear up potential misunderstandings and should be curious about resources that might be hidden, such as competence awareness. Hidden resources might be related to protective factors and resilience. The study points to ways in which the relation between nurse educators and students can affect resilience, and that students are not solely either resilient or emotionally insecure; resilience may exist within vulnerability.
Language	English
Publishing date	2019-12-23
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	2058575-5
ISSN	1873-5223 ; 1471-5953
ISSN (online)	1873-5223
ISSN	1471-5953
DOI	10.1016/j.nepr.2019.102694
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