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Article ; Online: Is ambient air pollution a risk factor for fecundity?

Pedersen, Marie

2021 Volume 36, Issue 1, Page(s) 68–69

MeSH term(s)	Air Pollution/adverse effects ; Fertility ; Humans ; Particulate Matter/toxicity ; Risk Factors
Chemical Substances	Particulate Matter
Language	English
Publishing date	2021-12-24
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	639089-4
ISSN	1365-3016 ; 0269-5022 ; 1353-663X
ISSN (online)	1365-3016
ISSN	0269-5022 ; 1353-663X
DOI	10.1111/ppe.12851
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Zs.A 2231: Show issues

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Article ; Online: Is it still important to study if ambient air pollution triggers stillbirth?

Pedersen, Marie

Occupational and environmental medicine

2016 Volume 73, Issue 9, Page(s) 571–572

Language	English
Publishing date	2016-09
Publishing country	England
Document type	Journal Article
ZDB-ID	1180733-7
ISSN	1470-7926 ; 1351-0711
ISSN (online)	1470-7926
ISSN	1351-0711
DOI	10.1136/oemed-2016-103625
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Un I Zs.461: Show issues

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Article ; Online: Social Disconnectedness in Individuals with Cardiovascular Disease: Associations with Health Literacy and Treatment Burden.

Christiansen, Julie / Lasgaard, Mathias / Pedersen, Susanne S / Pedersen, Marie Hauge / Friis, Karina

International journal of behavioral medicine

2024

Abstract: Background: Knowledge is limited on associations between social disconnectedness (i.e. loneliness and social isolation), health literacy and perceived treatment burden in individuals with cardiovascular disease (CVD). However, understanding these ... ...

Abstract	Background: Knowledge is limited on associations between social disconnectedness (i.e. loneliness and social isolation), health literacy and perceived treatment burden in individuals with cardiovascular disease (CVD). However, understanding these associations may be important for clinical practice. Methods: This study used cross-sectional self-reported data from the 2017 Danish health and morbidity survey entitled 'How are you?', investigating the associations of loneliness and social isolation with low health literacy and high treatment burden in individuals with CVD (n = 2521; mean age = 65.7 years). Results: Logistic regression analysis showed that loneliness and social isolation were associated with low health literacy in terms of difficulties in 'understanding health information' (loneliness: adjusted odds ratio (AOR) = 1.32, 95% confidence intervals (CI) [1.16, 1.50]; social isolation: AOR = 1.47, 95% CI [1.24, 1.73]) and 'engaging with healthcare providers' (loneliness: AOR = 1.53, 95% CI [1.37, 1.70]; social isolation: AOR = 1.21, 95% CI [1.06, 1.40]) and associated with high treatment burden (loneliness: AOR = 1.49, 95% CI [1.35, 1.65]; social isolation: AOR = 1.20, 95% CI [1.06, 1.37]). Conclusions: Our findings show that loneliness and social isolation coexisted with low health literacy and high treatment burden in individuals with CVD. These findings are critical as socially disconnected individuals experience more health issues. Low health literacy and a high treatment burden may potentially exacerbate these issues.
Language	English
Publishing date	2024-03-13
Publishing country	England
Document type	Journal Article
ZDB-ID	1187972-5
ISSN	1532-7558 ; 1070-5503
ISSN (online)	1532-7558
ISSN	1070-5503
DOI	10.1007/s12529-024-10263-9
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Zs.A 5090: Show issues

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Article ; Online: Ambient air pollution and hypertensive disorders of pregnancy in Rome.

Pedersen, Marie / Nobile, Federica / Stayner, Leslie Thomas / de Hoogh, Kees / Brandt, Jørgen / Stafoggia, Massimo

Environmental research

2024 Volume 251, Issue Pt 1, Page(s) 118630

Abstract: Background: Ambient air pollution has been associated with hypertensive disorders of pregnancy (HDP), but few studies rely on assessment of fine-scale variation in air quality, specific subtypes and multi-pollutant exposures.: Aim: To study the ... ...

Abstract	Background: Ambient air pollution has been associated with hypertensive disorders of pregnancy (HDP), but few studies rely on assessment of fine-scale variation in air quality, specific subtypes and multi-pollutant exposures. Aim: To study the impact of long-term exposure to individual and mixture of air pollutants on all and specific subtypes of HDP. Methods: We obtained data from 130,470 liveborn singleton pregnacies in Rome during 2014-2019. Spatiotemporal land-use random-forest models at 1 km spatial resolution assigned to the maternal residential addresses were used to estimate the exposure to particulate matter (PM Results: For PM Conclusions: The results of our study suggest that PM
Language	English
Publishing date	2024-03-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2024.118630
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Zs.A 726: Show issues

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Article ; Online: Hemoglobin adducts of acrylamide in human blood - What has been done and what is next?

Pedersen, Marie / Vryonidis, Efstathios / Joensen, Andrea / Törnqvist, Margareta

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

2022 Volume 161, Page(s) 112799

Abstract: Acrylamide forms in many commonly consumed foods. In animals, acrylamide causes tumors, neurotoxicity, developmental and reproductive effects. Acrylamide crosses the placenta and has been associated with restriction of intrauterine growth and certain ... ...

Abstract	Acrylamide forms in many commonly consumed foods. In animals, acrylamide causes tumors, neurotoxicity, developmental and reproductive effects. Acrylamide crosses the placenta and has been associated with restriction of intrauterine growth and certain cancers. The impact on human health is poorly understood and it is impossible to say what level of dietary exposure to acrylamide can be deemed safe as the assessment of exposure is uncertain. The determination of hemoglobin (Hb) adducts from acrylamide is increasingly being used to improve the exposure assessment of acrylamide. We aim to outline the literature on Hb adduct levels from acrylamide in humans and discuss methodological issues and research gaps. A total of 86 studies of 27,966 individuals from 19 countries were reviewed. Adduct levels were highest in occupationally exposed individuals and smokers. Levels ranged widely from 3 to 210 pmol/g Hb in non-smokers from the general population and this wide range suggests that dietary exposure to acrylamide varies largely. Non-smokers from the US and Canada had slightly higher levels as compared with non-smokers from elsewhere, but differences within studies were larger than between studies. Large studies with exposure assessment of acrylamide and related adduct forming compounds from diet during early-life are encouraged for the evaluation of health effects.
MeSH term(s)	Acrylamide/blood ; Food Contamination ; Hemoglobins/chemistry ; Humans ; Risk Factors ; Smoking
Chemical Substances	Hemoglobins ; Acrylamide (20R035KLCI)
Language	English
Publishing date	2022-01-05
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2021.112799
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Zs.A 529: Show issues

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Article: Hemoglobin adducts of acrylamide in human blood – What has been done and what is next?

Pedersen, Marie / Vryonidis, Efstathios / Joensen, Andrea / Törnqvist, Margareta

Food and chemical toxicology. 2022 Mar., v. 161

2022

Abstract	Acrylamide forms in many commonly consumed foods. In animals, acrylamide causes tumors, neurotoxicity, developmental and reproductive effects. Acrylamide crosses the placenta and has been associated with restriction of intrauterine growth and certain cancers. The impact on human health is poorly understood and it is impossible to say what level of dietary exposure to acrylamide can be deemed safe as the assessment of exposure is uncertain. The determination of hemoglobin (Hb) adducts from acrylamide is increasingly being used to improve the exposure assessment of acrylamide. We aim to outline the literature on Hb adduct levels from acrylamide in humans and discuss methodological issues and research gaps. A total of 86 studies of 27,966 individuals from 19 countries were reviewed. Adduct levels were highest in occupationally exposed individuals and smokers. Levels ranged widely from 3 to 210 pmol/g Hb in non-smokers from the general population and this wide range suggests that dietary exposure to acrylamide varies largely. Non-smokers from the US and Canada had slightly higher levels as compared with non-smokers from elsewhere, but differences within studies were larger than between studies. Large studies with exposure assessment of acrylamide and related adduct forming compounds from diet during early-life are encouraged for the evaluation of health effects.
Keywords	acrylamides ; blood ; diet ; dietary exposure ; exposure assessment ; hemoglobin ; human health ; humans ; neurotoxicity ; occupational exposure ; placenta ; toxicology ; Canada
Language	English
Dates of publication	2022-03
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2021.112799
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The influence of early-life animal exposure on the risk of childhood atopic dermatitis, asthma and allergic rhinoconjunctivitis: findings from the Danish National Birth Cohort.

Pinot De Moira, Angela / Pearce, Neil / Pedersen, Marie / Nybo Andersen, Anne-Marie

International journal of epidemiology

2023 Volume 52, Issue 4, Page(s) 1231–1242

Abstract: Background: Early-life animal exposure has been associated with both protective and harmful effects on asthma and allergic disease. We aimed to explore factors that may modify associations of early-life animal exposure with asthma and allergic disease, ... ...

Abstract	Background: Early-life animal exposure has been associated with both protective and harmful effects on asthma and allergic disease. We aimed to explore factors that may modify associations of early-life animal exposure with asthma and allergic disease, so as to better understand these differences in findings. Methods: We used data from ≤84 478 children from the Danish National Birth Cohort recruited during pregnancy between 1996 and 2002, and linked registry data up to the child's 13th birthday. Adjusted Cox models were used to examine associations of early-life cat, dog, rabbit, rodent, bird and livestock exposure with atopic dermatitis, asthma and allergic rhinoconjunctivitis overall, and by source of exposure (domestic or occupation), parental history of asthma or allergy, maternal education level and timing of exposure. Results: Overall, associations between animal exposure and the three outcomes of interest were weak. However, dog exposure was associated with marginally lower risk of atopic dermatitis and asthma [adjusted hazard ratio (aHR) = 0.81, 95% CI: 0.70-0.94 and 0.88, 95% CI: 0.82-0.94, respectively], whereas prenatal domestic bird exposure was associated with slightly increased risk of asthma (aHR = 1.18, 95% CI: 1.05-1.32). Source of exposure, parental history of asthma or allergy and timing of exposure modified associations. Early-life animal exposure did not appear to increase the risk of allergic rhinoconjunctivitis (aHR range = 0.88, 95% CI: 0.81-0.95 to 1.00, 95% CI: 0.91-1.10). Conclusions: The overall weak associations observed between animal exposure and atopic dermatitis, asthma and allergic rhinoconjunctivitis were modified by type of animal, source of exposure, parental history of asthma or allergy and timing of exposure, suggesting that these factors should be considered when assessing the risks associated with early-life animal exposure.
MeSH term(s)	Animals ; Dogs ; Female ; Humans ; Pregnancy ; Rabbits ; Asthma/complications ; Birth Cohort ; Denmark/epidemiology ; Dermatitis, Atopic/epidemiology ; Dermatitis, Atopic/complications ; Hypersensitivity/epidemiology ; Child
Language	English
Publishing date	2023-04-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	187909-1
ISSN	1464-3685 ; 0300-5771
ISSN (online)	1464-3685
ISSN	0300-5771
DOI	10.1093/ije/dyad040
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Zs.A 893: Show issues

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Article ; Online: Sex and Estrous Cycle Are Not Mediators of S-Ketamine's Rapid-Antidepressant Behavioral Effects in a Genetic Rat Model of Depression.

Arjmand, Shokouh / Vadstrup Pedersen, Marie / Silva, Nicole R / Landau, Anne M / Joca, Sâmia / Wegener, Gregers

The international journal of neuropsychopharmacology

2023 Volume 26, Issue 5, Page(s) 350–358

Abstract: Background: Recent preclinical and clinical studies have shed light on the possible impact of sex and estrous/menstrual cycle on ketamine's antidepressant action but with incongruous results. The preclinical studies that have shown the effects of ... ...

Abstract	Background: Recent preclinical and clinical studies have shed light on the possible impact of sex and estrous/menstrual cycle on ketamine's antidepressant action but with incongruous results. The preclinical studies that have shown the effects of ovarian sex hormones have not done so in animal models of depression. Thus, the aim of the present study is to scrutinize the acute behavioral responses to a subanesthetic dose of S-ketamine in males vs females and in different estrous phases in free-cycling females in a well-powered translational approach. Methods: We evaluated the behavioral sensitivity to 20 mg/kg S-ketamine (i.p.) in male and female Flinders Sensitive Line rats (FSLs) and their counterpart Flinders Resistant Line rats (FRLs) subjected to the open field and forced swim tests. Female rats were disaggregated into different estrous phases, and the behavioral outcomes were compared. Results: Acute administration of S-ketamine had robust antidepressant-like effects in FSLs. Within our study power, we could not detect sex- or estrous cycle-specific different antidepressant-like responses to S-ketamine in FSLs. Fluctuations in the levels of ovarian sex hormones across different estrous cycles did not behaviorally affect S-ketamine's rapid-acting antidepressant mode of action. No sex-related or estrous cycle-related impact on behavioral despair was observed even among FRLs and saline-treated FSLs. Conclusions: We conclude that physiological oscillations of estrogen and progesterone levels neither amplify nor diminish the behavioral antidepressant-like effect of S-ketamine. In addition, fluctuations of ovarian sex hormones do not predispose female animals to exhibit enhanced or reduced depressive-like and anxiety-like behaviors.
MeSH term(s)	Rats ; Male ; Female ; Animals ; Depression/drug therapy ; Antidepressive Agents/pharmacology ; Ketamine/pharmacology ; Estrous Cycle
Chemical Substances	Esketamine (50LFG02TXD) ; Antidepressive Agents ; Ketamine (690G0D6V8H)
Language	English
Publishing date	2023-05-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1440129-0
ISSN	1469-5111 ; 1461-1457
ISSN (online)	1469-5111
ISSN	1461-1457
DOI	10.1093/ijnp/pyad016
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Zs.A 5187: Show issues

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Article ; Online: Corrigendum to "Indoor home environments of Danish children and the socioeconomic position and health of their parents: A descriptive study" [Environ. Int. 160 (2022) 107059].

Groot, Jonathan / Keller, Amélie / Pedersen, Marie / Sigsgaard, Torben / Loft, Steffen / Nybo Andersen, Anne-Marie

Environment international

2023 Volume 173, Page(s) 107855

Language	English
Publishing date	2023-03-13
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	554791-x
ISSN	1873-6750 ; 0160-4120
ISSN (online)	1873-6750
ISSN	0160-4120
DOI	10.1016/j.envint.2023.107855
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Zs.A 3131: Show issues

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Article ; Online: Adrenocorticotropic hormone secretion in response to anticipatory stress and venepuncture: The role of menstrual phase and oral contraceptive use.

Pedersen, Marie Vadstrup / Hansen, Line Mathilde Brostrup / Garforth, Ben / Zak, Paul J / Winterdahl, Michael

Behavioural brain research

2023 Volume 452, Page(s) 114550

Abstract: Introduction: Oral contraceptives (OCs) are primarily known for their effects on the reproductive system, but they can also impact the hypothalamic-pituitary-adrenal (HPA) axis. The present study aimed to compare plasma adrenocorticotropic hormone (ACTH) ...

Abstract	Introduction: Oral contraceptives (OCs) are primarily known for their effects on the reproductive system, but they can also impact the hypothalamic-pituitary-adrenal (HPA) axis. The present study aimed to compare plasma adrenocorticotropic hormone (ACTH) responses to the anticipatory stress of participating in a scientific experiment and venepuncture in OC users versus naturally cycling (NC) women, with a focus on variations throughout the menstrual cycle. Methods: We recruited 131 young women (average age 20.5) and obtained blood samples to measure plasma ACTH concentrations immediately after venepuncture and again after 15 min of group activities designed to facilitate interpersonal attachment and stress-buffering. Results: ACTH levels decreased in 70% of all participants throughout the group activities. A two-way repeated measures ANOVA highlighted a significant interaction between time and OC use, indicating differential changes in ACTH levels during social interaction between OC users and NC women. Further, the post-hoc analysis revealed that a period of stress-buffering group activities significantly decreased ACTH levels in NC women during menstrual and secretory phases, but not during the proliferative phase. In contrast, OC users did not display a decrease during group activities, regardless of the phase. Conclusion: This study underscores the influence of OC use on stress regulation, demonstrating that OCs not only modulate reproductive functions but also impact ACTH stress reactivity. Additionally, it emphasizes the importance of considering hormonal contraceptive use and menstrual cycle phases when assessing female stress responses.
MeSH term(s)	Female ; Humans ; Young Adult ; Adrenocorticotropic Hormone ; Contraceptives, Oral/pharmacology ; Follicular Phase ; Luteal Phase ; Menstrual Cycle/physiology
Chemical Substances	Adrenocorticotropic Hormone (9002-60-2) ; Contraceptives, Oral
Language	English
Publishing date	2023-06-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	449927-x
ISSN	1872-7549 ; 0166-4328
ISSN (online)	1872-7549
ISSN	0166-4328
DOI	10.1016/j.bbr.2023.114550
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